Abstract: The present application provides anti-VISTA constructs that bind to VISTA (e.g., anti-VISTA antibodies), nucleic acid molecules encoding an amino acid sequence of the anti-VISTA, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of preparing the anti-VISTA construct, pharmaceutical compositions containing the anti-VISTA construct, and methods of using the anti-VIS-TA construct or compositions.

Abstract: The present invention relates to new anti-PD-1 (Programmed cell death 1) antibodies and antigen-binding fragments thereof for therapeutic and diagnostic methods and compositions using them.

Abstract: A liquid reactivity detection device and method. The liquid reactivity detection device includes: a breathing signal acquisition module, a hemodynamic signal acquisition module and a liquid reactivity detection module. The breathing signal acquisition module and the hemodynamic signal acquisition module work in cases where the subject is in any one of the following breathing modes: a spontaneous breathing mode, a spontaneous breathing combined with mechanical ventilation mode, and a mechanical ventilation mode. The hemodynamic signal acquisition module is configured to acquire at least one hemodynamic signal of the subject. The breathing signal acquisition module is configured to acquire at least one breathing signal of the subject. The liquid reactivity detection module is configured to determine the liquid reactivity of the subject according to the breathing signal and the hemodynamic signal.

Abstract: Disclosed are antibodies and fragments thereof that target the A-domain of Neuropilin-1 (Nrp1A). Also disclosed are methods of using the anti-Nrp1A antibodies for the treatment of various diseases or disorders.

Abstract: A gas turbine engine having a compressor section for compressing air flowing therethrough to provide a compressed air flow, a combustor including a combustion chamber, the combustion chamber configured to combust a mixture of a fuel flow and the compressed air flow to generate combustion products, a turbine section having at least one turbine driven by the combustion products, and a damper in fluid communication with the combustion chamber to dampen an instability generated in the combustion chamber by the combustion products. The damper defined by nds?nƒp, ap?dpn, and ab?dp?*dp?ea, where nds is a number of damper cavities in series, nƒp is a number of discrete frequencies to be damped, ap is an acoustic damping potential, dpn is a neck open area ratio, ab is an acoustic damping broadness, dp? is a damper volume, and dp?ea is a damper volume expansion angle.

Abstract: A gas turbine engine includes a compressor section for compressing air flowing therethrough to provide a compressed air flow, a combustor including a combustion chamber, the combustion chamber configured to combust a mixture of a fuel flow and the compressed air flow to generate combustion products, and a turbine section having at least one turbine driven by the combustion products. The gas turbine engine includes a multicavity damper in fluid communication with the combustion chamber to dampen an instability generated in the combustion chamber by the combustion products. The multicavity damper has a plurality of cavity volumes and the length of each cavity volume is different.

Abstract: A combustor for a turbine engine includes a wall defining a combustion chamber, and an acoustic damper. The acoustic damper includes a housing in fluid communication with the combustion chamber through an opening provided in the wall, the housing defining a cavity and having one or more neck holes in fluid communication with the combustion chamber, and a mechanism configured to vary a damping acoustic frequency of the acoustic damper so as to vary the damping acoustic frequency of the acoustic damper to align with an acoustic frequency of acoustic vibrations generated in the combustion chamber to attenuate an acoustic instability within the combustion chamber.

Abstract: An air conditioning system includes an outdoor unit and an indoor unit. The outdoor unit includes a compressor, an outdoor heat exchanger, a first expansion valve, a third expansion valve, and a subcooling heat exchanger. The indoor unit includes an indoor heat exchanger and a second expansion valve. In a cooling mode, the outdoor unit is configured to adjust an opening degree of the first expansion valve according to a relationship between a first difference and a first preset value; adjust an opening degree of the second expansion valve according to a relationship between a second difference and a second preset value; and adjust an opening degree of the third expansion valve according to a relationship between a third difference and a third preset value.

Abstract: A gas turbine engine includes a compressor section for compressing air flowing therethrough to provide a compressed air flow, a combustor including a combustion chamber, the combustion chamber configured to combust a mixture of a fuel flow and the compressed air flow to generate combustion products, and a turbine section having at least one turbine driven by the combustion products. The gas turbine engine includes a multicavity damper in fluid communication with the combustion chamber to dampen an instability generated in the combustion chamber by the combustion products. The multicavity damper has a plurality of cavity volumes and the length of each cavity volume is different.

Abstract: The present invention relates to new anti-PD-1 (Programmed cell death 1) antibodies and antigen-binding fragments thereof for therapeutic and diagnostic methods and compositions using them.

Abstract: The present disclosure discloses a bionic cuttlefish-typed underwater detection robot, including a bionic “cuttlefish”-typed body structure, a piezoelectric energy capture device, a circuit rectification and storage assembly and a power control assembly. The bionic “cuttlefish”-typed body structure includes a head and a main body; the piezoelectric energy capture device includes piezoelectric ceramic elements arranged around the main body and PVDF floating belts, and an end of each piezoelectric ceramic element is connected to a spherical spoiler component, the PVDF floating belts are evenly distributed at a tail end of the main body. The present disclosure adopts piezoelectric ceramic elements with spoiler components and PVDF floating belts to generate electricity, converts wave energy and ocean current energy into electric energy, powers the power control assembly of the detection robot.

Abstract: Systems and methods include segmentation of a first image of a subject to identify locations of anatomical structures of the subject, determination of a region of interest of the subject based on the locations of anatomical structures, determination of a coil-mixing matrix based on the region of interest, control of an MR scanner to acquire radial trajectory k-space data of the subject from each of a plurality of RF coils of the MR scanner, application of the coil-mixing matrix to the radial trajectory k-space data of the subject acquired from each of the plurality of RF coils to generate first radial trajectory k-space data, reconstruction of a second image of the subject based on the first radial trajectory k-space data, and display of the second image.

Abstract: The present disclosure discloses a bionic cuttlefish-typed underwater detection robot, including a bionic “cuttlefish”-typed body structure, a piezoelectric energy capture device, a circuit rectification and storage assembly and a power control assembly. The bionic “cuttlefish”-typed body structure includes a head and a main body; the piezoelectric energy capture device includes piezoelectric ceramic elements arranged around the main body and PVDF floating belts, and an end of each piezoelectric ceramic element is connected to a spherical spoiler component, the PVDF floating belts are evenly distributed at a tail end of the main body. The present disclosure adopts piezoelectric ceramic elements with spoiler components and PVDF floating belts to generate electricity, converts wave energy and ocean current energy into electric energy, powers the power control assembly of the detection robot.

Abstract: This disclosure relates to methods, devices and systems for real-time recognition of restoration of spontaneous circulation (ROSC) in cardio-pulmonary resuscitation (CPR) process. Recognition mechanisms in both time domain and frequency domain are provided for the ROSC recognition, where the time-domain recognition logic may detect the ROSC by recognizing envelope features of sampled signals in the time domain, and the frequency-domain recognition logic may detect the ROSC by recognizing spectral peaks at different frequency points continuously or significant variations of amplitude of spectral peaks in the frequency spectrum.

Abstract: An optical system includes an objective lens module, an image inverting module, and an eyepiece module. The objective lens module includes a first lens group, a second lens group, a third lens group, a fourth lens group, and a fifth lens group. The optical system satisfies at least one of the following conditions: 0.45?LG4D/LG1D?0.8; 0.015 mm?1?1/fG3?0.045 mm?1; 0.045 mm?1?|1/fG4|?0.07 mm?1; 0.35?|fG4/fG3|?0.75; 0.15?fG1/f?1.6; wherein LG4D is an effective optical diameter of the fourth lens group, LG1D is an effective optical diameter of the first lens group, fG1 is an effective focal length of the first lens group, fG3 is an effective focal length of the third lens group, fG4 is an effective focal length of the fourth lens group, and f is an effective focal length of the objective lens module.

Abstract: This invention relates to binding molecules that bind specifically Vascular Endothelial Growth Factor (VEGF) and Tropomyosin receptor kinase B (TrkB) and their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of diseases of the eye.

Abstract: Systems and techniques for persistent calibration of an electronic device configured to implement an extended reality (XR) system involve estimating and validating visual-inertial odometry (VIO) calibration parameters during an active XR session of the electronic device. Validating the estimated VIO calibration parameters involves performing a strict calibration qualification of the estimated VIO calibration parameters using a thresholding module, machine learning module, or both. An initial calibration qualification is performed concurrently with the strict calibration qualification based on VIO performance. If the estimated VIO calibration parameters pass the strict calibration qualification and initial calibration qualification, they are stored for use to calibrate the device in future XR sessions. Persistent calibration of time alignment between the inertial management unit and the image sensor of the electronic device is also performed during active XR sessions upon detection of time alignment issues.

Abstract: The present invention relates to antibodies and fragments thereof that target semaphorin 3A (Sema3A). More specifically, anti-Sema3A antibodies and methods of use for the treatment of various diseases or disorders are disclosed.

Abstract: This invention relates to binding molecules that bind specifically Vascular Endothelial Growth Factor (VEGF) and Tropomyosin receptor kinase B (TrkB) and their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of diseases of the eye.