Abstract: Embodiments of the present invention provide isolated proteins comprising antigen binding domains that bind kallikrein related peptidase 2 (hK2), including monospecific and bispecific antibodies. Additional embodiments of the invention provide polynucleotides encoding the hk2-specific proteins, vectors, host cells, and methods of making and using them.

Abstract: A PCIe controller and a loopback path using the PCIe controller. The PCIe controller includes: a transport layer transmission module, a transport layer reception module, a memory access module, and a memory, wherein the transport layer transmission module includes a first loopback control module, the transport layer reception module includes a second loopback control module, and the first loopback control module is coupled to the second loopback control module; the memory access module is coupled to the transport layer transmission module and the transport layer reception module, and the memory access module is also coupled to the memory.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for speech synthesis. The methods, systems, and apparatus include actions of obtaining an audio representation of speech of a target speaker, obtaining input text for which speech is to be synthesized in a voice of the target speaker, generating a speaker vector by providing the audio representation to a speaker encoder engine that is trained to distinguish speakers from one another, generating an audio representation of the input text spoken in the voice of the target speaker by providing the input text and the speaker vector to a spectrogram generation engine that is trained using voices of reference speakers to generate audio representations, and providing the audio representation of the input text spoken in the voice of the target speaker for output.

Abstract: A liquid dispenser sensing distance self-learning method includes in response to a self-learning request, entering a self-learning mode. The method also includes, in the self-learning mode, determining a shortest distance between a reference object and a sensing component; determining and storing a sensing distance based on the shortest distance; and identifying, by a first indication device, a state of the self-learning mode. The method also includes, in response to a sensing request, entering a sensing mode; obtaining a detected distance between the reference object and the sensing component; comparing the detected distance with the sensing distance; and identifying, by a second indication device, a comparison result of the detected distance and the sensing distance.

Abstract: In accordance with some embodiments, there is provided an apparatus. The apparatus includes a conductive loop; a first conductive member electromagnetically coupled to the conductive loop and galvanically coupled to a radio frequency circuit; a second conductive member arranged across and electromagnetically coupled to the conductive loop; and a third conductive member arranged across and electromagnetically coupled to the conductive loop, the third conductive member being spaced apart from the second conductive member and electromagnetically coupled to the first conductive member.

Abstract: A lifting device for building a steel structure hoistway and a method for building a steel structure hoistway. The lifting device includes a lifting mechanism and a crane mechanism. The lifting mechanism includes a bottom platform, a middle platform and a top platform. The crane mechanism is arranged on the top platform of the lifting mechanism, and includes a base and a crane on the base. The base is arranged on the top platform and is rotatable relative to the top platform along a vertical axis, and the hanger frame of the crane is movable between a vertical orientation and an inclined orientation. The lifting mechanism is configured to ascend and descend in the constructed steel structure hoistway, and the crane mechanism is configured to lift building materials, such as steel beams, steel columns, etc., for use in building the steel structure hoistway to their designed installation locations.

Abstract: The present disclosure discloses a method for preparing caprolactam including: (1) contacting cyclohexanone oxime with a catalyst to carry out reaction in the presence of ethanol and under the condition of gas phase Beckmann rearrangement reaction of cyclohexanone oxime; (2) separating the reaction product obtained in step (1) to produce an ethanol solution of crude caprolactam, and then separating the ethanol solution of crude caprolactam to obtain ethanol and crude caprolactam; (3) removing impurities with boiling points lower than that of caprolactam in the crude caprolactam to obtain a light component removal product; (4) mixing the light component removal product with a crystallization solvent to carry out crystallization and solid-liquid separation to obtain a crystalline crystal; (5) subjecting the crystalline crystal to a hydrogenation reaction; wherein the crystallization solvent contains 0.1-2 wt % of ethanol.

Abstract: Described herein are standards and methods of normalizing amplicon size bias. These standards may comprise unique molecular identifiers. In some embodiments, the standards and methods are for use with next generation sequencing (NGS) assays. Also described herein are methods for quantifying DNA damage in a sample comprising DNA using fluorescence or for determining the presence of DNA damage in a library.

Abstract: The disclosure provides an InDel marker genotype database of whole genome of Malus and use in specific identification of germplasm resources thereof, belonging to the technical field of molecular biology. The constructing method of the genotype database comprises: genotyping InDel markers of genomic DNA samples of Malus germplasm resources by using primer pairs and multiplex PCR; recording one line data for each Malus germplasm resource according to the genotype of InDel marker; collecting all germplasm resources records to obtain an InDel marker genotype database of the whole genome of Malus. The whole genome InDel marker genotype database of Malus provided by the disclosure can identify the specificity of apple germplasm simply, efficiently and stably, thus overcoming the limitation that DUS test is easily influenced by environment, and providing a powerful tool for the protection of new apple varieties and the management of germplasm resources.

Abstract: The present disclosure relates to the field of display technology, and provides a display device and a driving method therefor. The driving method includes: providing a display device including a plurality of sub-pixels, each sub-pixel including an OLED light-emitting element, a light-emitting control transistor configured to transmit a driving current to the OLED light-emitting element, and a reset transistor coupled to an anode of the OLED light-emitting element; inputting a periodic cut-off signal to the light-emitting control transistor; determining the effective light-emitting phase of each frame period for the sub-pixel; and during the effective light-emitting phase of each frame period for the sub-pixel, inputting a reset signal to the reset transistor corresponding to one or more cut-off signal.

Abstract: Provided herein are novel anti-CD28×anti-PSMA antibodies and methods of using such antibodies for the treatment of PSMA-associated cancers. Subject anti-CD28×anti-PSMA antibodies are capable of agonistically binding to CD28 costimulatory molecules on T cells and PSMA on tumor cells. Thus, such antibodies selectively enhance anti-tumor activity at tumor sites while minimizing peripheral toxicity. The subject antibodies provided herein are particularly useful in combination with other anti-cancer therapies (e.g., anti-CD3×anti-PSMA antibodies) for the treatment of prostate cancers.

Abstract: Degradable polyester bead are described comprising a plurality of transposome complexes immobilized to the surface thereof, wherein each transposome complex comprises a transposase bound to a first polynucleotide and a second polynucleotide, wherein the first polynucleotide comprises a 3? portion comprising a transposon end sequence and a tag, and the second polynucleotide comprises a 5? portion that is complementary to and hybridized to the transposon end sequence, and wherein the polyester bead has a melting point of from 50° C. to 65° C. Flow cells and methods related to these polyester beads are described. Also described herein are compositions comprising a bead and at least one nanoparticle and methods of use of such compositions comprising transposome complexes immobilized to nanoparticles.

Abstract: Provided herein are novel anti-CD28×anti-PSMA antibodies and methods of using such antibodies for the treatment of PSMA-associated cancers. Subject anti-CD28×anti-PSMA antibodies are capable of agonistically binding to CD28 costimulatory molecules on T cells and PSMA on tumor cells. Thus, such antibodies selectively enhance anti-tumor activity at tumor sites while minimizing peripheral toxicity. The subject antibodies provided herein are particularly useful in combination with other anti-cancer therapies (e.g., anti-CD3×anti-PSMA antibodies) for the treatment of prostate cancers.

Abstract: The present invention relates to splice modulating oligonucleotides (oligomers) that are complementary to the CARD9 pre-mRNA, for inhibiting the inclusion of a CARD9 exon 11 in CARD9 mRNA. The oligonucleotides of the invention are useful in the treatment of inflammatory diseases such as IBD.

Abstract: A curved display screen forming method includes: modeling to obtain a virtual display layer, and segmenting the display layer to obtain a size of a virtual display module; mapping the size of the virtual display module to obtain a size of a materialized display module; reducing edges of the materialized display module, and arranging an adjustment protrusion on each edge of the materialized display module; modeling to obtain a virtual adjustment layer, wherein a virtual plate of the virtual adjustment layer corresponds to the plurality of virtual display modules, obtaining a size of the virtual plate; converting the size of the virtual plate from a curved surface to a plane to obtain a planar size of the materialized plate; and assembling the materialized display module and the materialized plate to form a curved display screen.

Abstract: The present disclosure provides a genomics-assisted prediction method for apple fruit quality traits and disease resistance and use thereof, and belongs to the technical field of plant genetics, genomics and breeding. The method is achieved by molecular markers. There are a total of 319 molecular markers, including 318 single-nucleotide polymorphism (SNP) markers and 1 InDel marker; and the molecular markers are associated with 16 traits of the Malus genus, including fruit ripening date, fruit shape, fruit cover color degree, fruit weight, soluble solid content, fruit juice pH value, malate content, chlorogenate content, procyanidin B2 content, flesh firmness at harvest, flesh crispness at harvest, flesh firmness retainability, flesh crispness retainability, fruit ring rot disease resistance, Glomerella leaf blotch resistance, and spur tree architecture.

Abstract: A driving method includes: generating and outputting a frame image signal to an organic light emitting device, wherein the frame image signal includes an active data region and a blank region based on a time sequence; in the active data region of the frame image signal, using a timing controller to write a data voltage into the gate of the thin film transistor, store it in a storage capacitor, and apply it to the organic light emitting device through the thin film transistor; and in response to reaching the blank region of the frame image signal as determined by the timing controller, changing the first voltage at the cathode of the organic light emitting device to compensate the operating current of the organic light emitting device.

Abstract: Disclosed are a mobile Internet-based integrated vehicle energy replenishment system and method, and a storage medium.

Abstract: The present disclosure discloses a cellulose nanocrystal-supported sodium alginate adsorbent and use thereof in enriching organic phosphorus in wastewater, belonging to the technical field of environmental engineering. Cellulose nanocrystals are prepared from papermaking deinking sludge through chemical conditioning, drying, crushing, chemical oxidation and microwave assisted separation, and then supported on alginate under weakly acidic conditions to provide the cellulose nanocrystals with the ability to enrich organic phosphorus in wastewater. By using this method, the content of organic phosphorus in the wastewater can be significantly reduced, the total phosphorus in the effluent can be reduced, and the wastewater treatment effluent can satisfy the discharge standard. The enriched organic phosphorus can be recycled as a phosphorus resource through incineration.