Patents by Inventor Fei Shen

Fei Shen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11884632
    Abstract: The present disclosure discloses a method for preparing caprolactam including: (1) contacting cyclohexanone oxime with a catalyst to carry out reaction in the presence of ethanol and under the condition of gas phase Beckmann rearrangement reaction of cyclohexanone oxime; (2) separating the reaction product obtained in step (1) to produce an ethanol solution of crude caprolactam, and then separating the ethanol solution of crude caprolactam to obtain ethanol and crude caprolactam; (3) removing impurities with boiling points lower than that of caprolactam in the crude caprolactam to obtain a light component removal product; (4) mixing the light component removal product with a crystallization solvent to carry out crystallization and solid-liquid separation to obtain a crystalline crystal; (5) subjecting the crystalline crystal to a hydrogenation reaction; wherein the crystallization solvent contains 0.1-2 wt % of ethanol.
    Type: Grant
    Filed: March 25, 2021
    Date of Patent: January 30, 2024
    Assignee: ZHEJIANG HENGYI PETROCHEMICAL RESEARCH INSTITUTE CO., LTD.
    Inventors: Shibiao Cheng, Songlin Wang, Xi Li, Han Wang, Fei Shen, Xinping Zhang, Zhaobin Jiang, Zhimin Hu
  • Publication number: 20240026431
    Abstract: Described herein are standards and methods of normalizing amplicon size bias. These standards may comprise unique molecular identifiers. In some embodiments, the standards and methods are for use with next generation sequencing (NGS) assays. Also described herein are methods for quantifying DNA damage in a sample comprising DNA using fluorescence or for determining the presence of DNA damage in a library.
    Type: Application
    Filed: September 25, 2023
    Publication date: January 25, 2024
    Applicant: Illumina, Inc.
    Inventors: Andrew B. Kennedy, Lena Storms, Fei Shen, Olivia Benice, Eric Murtfeldt, Kaitlin Pugliese, Michael Howard
  • Patent number: 11851718
    Abstract: The disclosure provides an InDel marker genotype database of whole genome of Malus and use in specific identification of germplasm resources thereof, belonging to the technical field of molecular biology. The constructing method of the genotype database comprises: genotyping InDel markers of genomic DNA samples of Malus germplasm resources by using primer pairs and multiplex PCR; recording one line data for each Malus germplasm resource according to the genotype of InDel marker; collecting all germplasm resources records to obtain an InDel marker genotype database of the whole genome of Malus. The whole genome InDel marker genotype database of Malus provided by the disclosure can identify the specificity of apple germplasm simply, efficiently and stably, thus overcoming the limitation that DUS test is easily influenced by environment, and providing a powerful tool for the protection of new apple varieties and the management of germplasm resources.
    Type: Grant
    Filed: December 29, 2020
    Date of Patent: December 26, 2023
    Assignee: CHINA AGRICULTURAL UNIVERSITY
    Inventors: Xinzhong Zhang, Xuan Wang, Fei Shen, Ruiting Chen, Zhenhai Han, Yi Wang, Ting Wu, Xuefeng Xu, Wei Li, Changpeng Qiu, Xi Zhang
  • Publication number: 20230335055
    Abstract: The present disclosure relates to the field of display technology, and provides a display device and a driving method therefor. The driving method includes: providing a display device including a plurality of sub-pixels, each sub-pixel including an OLED light-emitting element, a light-emitting control transistor configured to transmit a driving current to the OLED light-emitting element, and a reset transistor coupled to an anode of the OLED light-emitting element; inputting a periodic cut-off signal to the light-emitting control transistor; determining the effective light-emitting phase of each frame period for the sub-pixel; and during the effective light-emitting phase of each frame period for the sub-pixel, inputting a reset signal to the reset transistor corresponding to one or more cut-off signal.
    Type: Application
    Filed: June 18, 2021
    Publication date: October 19, 2023
    Applicant: Everdisplay Optronics (Shanghai) Co.,Ltd.
    Inventors: Keitaro YAMASHITA, JehYen KANG, Xiangshu LI, Fei SHEN
  • Publication number: 20230322961
    Abstract: Provided herein are novel anti-CD28×anti-PSMA antibodies and methods of using such antibodies for the treatment of PSMA-associated cancers. Subject anti-CD28×anti-PSMA antibodies are capable of agonistically binding to CD28 costimulatory molecules on T cells and PSMA on tumor cells. Thus, such antibodies selectively enhance anti-tumor activity at tumor sites while minimizing peripheral toxicity. The subject antibodies provided herein are particularly useful in combination with other anti-cancer therapies (e.g., anti-CD3×anti-PSMA antibodies) for the treatment of prostate cancers.
    Type: Application
    Filed: May 3, 2023
    Publication date: October 12, 2023
    Inventors: John R. Desjarlais, Gregory Moore, Michael Hedvat, Juan Diaz, Veronica Gusti Zeng, Matthew Adam Dragovich, Joseph Erhardt, Theresa McDevitt, Fouad Moussa, Pankaj Seth, Fei Shen, Adam Zwolak
  • Publication number: 20230287476
    Abstract: Degradable polyester bead are described comprising a plurality of transposome complexes immobilized to the surface thereof, wherein each transposome complex comprises a transposase bound to a first polynucleotide and a second polynucleotide, wherein the first polynucleotide comprises a 3? portion comprising a transposon end sequence and a tag, and the second polynucleotide comprises a 5? portion that is complementary to and hybridized to the transposon end sequence, and wherein the polyester bead has a melting point of from 50° C. to 65° C. Flow cells and methods related to these polyester beads are described. Also described herein are compositions comprising a bead and at least one nanoparticle and methods of use of such compositions comprising transposome complexes immobilized to nanoparticles.
    Type: Application
    Filed: January 6, 2023
    Publication date: September 14, 2023
    Applicant: Illumina, Inc.
    Inventors: Yir-Shyuan Wu, Tarun Kumar Khurana, Elisabet Rosàs-Canyelles, Fei Shen, Jeffrey Brodin, Lena Storms, Jeffrey S. Fisher
  • Publication number: 20230265218
    Abstract: Provided herein are novel anti-CD28×anti-PSMA antibodies and methods of using such antibodies for the treatment of PSMA-associated cancers. Subject anti-CD28×anti-PSMA antibodies are capable of agonistically binding to CD28 costimulatory molecules on T cells and PSMA on tumor cells. Thus, such antibodies selectively enhance anti-tumor activity at tumor sites while minimizing peripheral toxicity. The subject antibodies provided herein are particularly useful in combination with other anti-cancer therapies (e.g., anti-CD3×anti-PSMA antibodies) for the treatment of prostate cancers.
    Type: Application
    Filed: February 22, 2023
    Publication date: August 24, 2023
    Inventors: John R. Desjarlais, Gregory Moore, Michael Hedvat, Juan Diaz, Veronica Gusti Zeng, Matthew Adam Dragovich, Joseph Erhardt, Theresa McDevitt, Fouad Moussa, Pankaj Seth, Fei Shen, Adam Zwolak
  • Publication number: 20230193269
    Abstract: The present invention relates to splice modulating oligonucleotides (oligomers) that are complementary to the CARD9 pre-mRNA, for inhibiting the inclusion of a CARD9 exon 11 in CARD9 mRNA. The oligonucleotides of the invention are useful in the treatment of inflammatory diseases such as IBD.
    Type: Application
    Filed: May 22, 2020
    Publication date: June 22, 2023
    Inventors: Peter HAGEDORN, Lars JOENSON, Anja Moehart HOEG, Jonas VIKESSA, Fergus BYRNE, Jay FINE, Mouhamadou MBOW, Joe Adam WAHLE, Elliott Sanford KLEIN, Kristina Mary SAI, Fei SHEN
  • Patent number: 11645954
    Abstract: A curved display screen forming method includes: modeling to obtain a virtual display layer, and segmenting the display layer to obtain a size of a virtual display module; mapping the size of the virtual display module to obtain a size of a materialized display module; reducing edges of the materialized display module, and arranging an adjustment protrusion on each edge of the materialized display module; modeling to obtain a virtual adjustment layer, wherein a virtual plate of the virtual adjustment layer corresponds to the plurality of virtual display modules, obtaining a size of the virtual plate; converting the size of the virtual plate from a curved surface to a plane to obtain a planar size of the materialized plate; and assembling the materialized display module and the materialized plate to form a curved display screen.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: May 9, 2023
    Assignee: NANJING LOPU TECHNOLOGY CO., LTD.
    Inventors: Xiaobing Shen, Bin Zhu, Lili Ji, Fei Shen, Lingling Jiang
  • Publication number: 20230099384
    Abstract: The present disclosure provides a genomics-assisted prediction method for apple fruit quality traits and disease resistance and use thereof, and belongs to the technical field of plant genetics, genomics and breeding. The method is achieved by molecular markers. There are a total of 319 molecular markers, including 318 single-nucleotide polymorphism (SNP) markers and 1 InDel marker; and the molecular markers are associated with 16 traits of the Malus genus, including fruit ripening date, fruit shape, fruit cover color degree, fruit weight, soluble solid content, fruit juice pH value, malate content, chlorogenate content, procyanidin B2 content, flesh firmness at harvest, flesh crispness at harvest, flesh firmness retainability, flesh crispness retainability, fruit ring rot disease resistance, Glomerella leaf blotch resistance, and spur tree architecture.
    Type: Application
    Filed: January 19, 2022
    Publication date: March 30, 2023
    Inventors: Xinzhong Zhang, Fei Shen, Bei Wu, Zhenhai Han, Xuefeng Xu, Yi Wang, Ting Wu, Wei Li, Changpeng Qiu, Xi Zhang
  • Patent number: 11587504
    Abstract: A driving method includes: generating and outputting a frame image signal to an organic light emitting device, wherein the frame image signal includes an active data region and a blank region based on a time sequence; in the active data region of the frame image signal, using a timing controller to write a data voltage into the gate of the thin film transistor, store it in a storage capacitor, and apply it to the organic light emitting device through the thin film transistor; and in response to reaching the blank region of the frame image signal as determined by the timing controller, changing the first voltage at the cathode of the organic light emitting device to compensate the operating current of the organic light emitting device.
    Type: Grant
    Filed: July 21, 2021
    Date of Patent: February 21, 2023
    Assignee: Everdisplay Optronics (Shanghai) Co., Ltd
    Inventors: Xiangshu Li, JehYen Kang, Fei Shen, Keitaro Yamashita
  • Patent number: 11584237
    Abstract: Disclosed are a mobile Internet-based integrated vehicle energy replenishment system and method, and a storage medium.
    Type: Grant
    Filed: February 7, 2018
    Date of Patent: February 21, 2023
    Assignee: NIO CO., LTD.
    Inventors: Bin Li, Lihong Qin, Fei Shen, Xin Zhou, Jinxing Qiang, Jianxing Zhang, Xu He, Xiang Ma, Yicheng Wu, Xiaobin Pan
  • Patent number: 11577220
    Abstract: The present disclosure discloses a cellulose nanocrystal-supported sodium alginate adsorbent and use thereof in enriching organic phosphorus in wastewater, belonging to the technical field of environmental engineering. Cellulose nanocrystals are prepared from papermaking deinking sludge through chemical conditioning, drying, crushing, chemical oxidation and microwave assisted separation, and then supported on alginate under weakly acidic conditions to provide the cellulose nanocrystals with the ability to enrich organic phosphorus in wastewater. By using this method, the content of organic phosphorus in the wastewater can be significantly reduced, the total phosphorus in the effluent can be reduced, and the wastewater treatment effluent can satisfy the discharge standard. The enriched organic phosphorus can be recycled as a phosphorus resource through incineration.
    Type: Grant
    Filed: June 21, 2022
    Date of Patent: February 14, 2023
    Assignee: JIANGNAN UNIVERSITY
    Inventors: Shuo Wang, Qixin Liu, Fei Shen, Ji Li, Yong Wang, Xuesong Yi
  • Patent number: 11568823
    Abstract: The present disclosure relates to the field of display technology, and provides driving methods of a display panel and a display device.
    Type: Grant
    Filed: August 10, 2021
    Date of Patent: January 31, 2023
    Assignee: Everdisplay Optronics (Shanghai) Co., Ltd
    Inventors: Fei Shen, Xiangshu Li, Xiangyu Jiang, JehYen Kang, Shaodong Ma, Keitaro Yamashita
  • Publication number: 20230016633
    Abstract: Embodiments of the present application relate to substrate comprising a surface-bound azido functionalized organosilane wherein the substrate is free or substantially free of a hydrogel or a hydrophilic polymer. Methods of preparing such substrate surface for sequencing applications are also disclosed.
    Type: Application
    Filed: June 13, 2022
    Publication date: January 19, 2023
    Inventors: Xiaoyu Ma, Weixian Xi, Jeffrey S. Fisher, Fei Shen, Wayne N. George, Brian D. Mather
  • Patent number: 11535117
    Abstract: Provided are a method and device for estimating the utility of replacement of a battery pack for an electric vehicle, and a charging management method and system based on the method and device. The method comprises the following steps: acquiring state data associated with a first battery pack and a second battery pack, the state data comprising usage history of the first battery pack and performance parameters of the first battery pack and the second battery pack; and determining a utility value according to the state data, wherein the utility value is used to characterize a degree of impact of an operation of replacing the first battery pack with the second battery pack on the service efficiency and service life of a battery pack set to which the first battery pack and the second battery pack belong. The method facilitates improving the service efficiency of a managed battery in a battery swap mode and extending the overall service life thereof.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: December 27, 2022
    Assignee: NIO (ANHUI) HOLDING CO., LTD.
    Inventors: Bin Li, Lihong Qin, Chendong Huang, Fei Shen, Xiaojia Deng
  • Patent number: 11501614
    Abstract: Embodiments of the present invention provide a skip-scanning identification method and apparatus, a self-service cash register terminal and system. The method includes: obtaining a video of a user scanning an item; determining posture data of the user based on the obtained video; determining, according to the posture data of the user, a time period in which a scanning action of the user takes place; receiving a scanning result of the item; and determining whether the user has skipped scanning the item based on the scanning result and the time period.
    Type: Grant
    Filed: February 26, 2021
    Date of Patent: November 15, 2022
    Assignee: ALIBABA GROUP HOLDING LIMITED
    Inventors: Jie Wen, Yetao Fu, Wensheng Jiang, Yu Zhu, Yang Liu, Fei Shen, Xiaowei Zhao, Hui Liu, Hao Yang
  • Publication number: 20220356266
    Abstract: A population of antibodies, wherein less than 80% of the oligosaccharides covalently attached to the population of the antibodies via N297 residues thereof comprise a core fucose residue; and wherein the population of the antibodies comprises an antibody which Fc region comprises K338A and T437R mutations, or K248E and T437R mutations.
    Type: Application
    Filed: April 16, 2021
    Publication date: November 10, 2022
    Applicant: JANSSEN BIOTECH, INC.
    Inventors: Rajkumar GANESAN, Adam ZWOLAK, Jason HO, Natasa OBERMAJER, Michael DIEM, Sanjaya SINGH, Sathyadevi VENKATARAMANI, Theresa MCDEVITT, Fei SHEN
  • Publication number: 20220323932
    Abstract: The present disclosure discloses a cellulose nanocrystal-supported sodium alginate adsorbent and use thereof in enriching organic phosphorus in wastewater, belonging to the technical field of environmental engineering. Cellulose nanocrystals are prepared from papermaking deinking sludge through chemical conditioning, drying, crushing, chemical oxidation and microwave assisted separation, and then supported on alginate under weakly acidic conditions to provide the cellulose nanocrystals with the ability to enrich organic phosphorus in wastewater. By using this method, the content of organic phosphorus in the wastewater can be significantly reduced, the total phosphorus in the effluent can be reduced, and the wastewater treatment effluent can satisfy the discharge standard. The enriched organic phosphorus can be recycled as a phosphorus resource through incineration.
    Type: Application
    Filed: June 21, 2022
    Publication date: October 13, 2022
    Inventors: Shuo WANG, Qixin LIU, Fei SHEN, Ji LI, Yong WANG, Xuesong YI
  • Patent number: 11459302
    Abstract: A refining process includes steps of subjecting crude caprolactam to a first evaporative crystallization and a first solid-liquid separation to obtain a first caprolactam crystal and a first crystallization mother liquor; washing the first caprolactam crystal to obtain a second caprolactam crystal; optionally concentrating the first crystallization mother liquor to perform a second evaporative crystallization and a second solid-liquid separation to obtain a third caprolactam crystal and a second crystallization mother liquor; subjecting the third caprolactam crystal to a second washing to obtain a fourth caprolactam; optionally concentrating the second crystallization mother liquor to perform thermostatic crystallization, performing separation to obtain a fifth caprolactam crystal and a third crystallization mother liquor; washing the fifth caprolactam crystal to obtain a sixth caprolactam crystal; and subjecting the second caprolactam crystal to a hydrogenation reaction.
    Type: Grant
    Filed: March 22, 2021
    Date of Patent: October 4, 2022
    Assignee: ZHEJIANG HENGYI PETROCHEMICAL RESEARCH INSTITUTE CO., LTD.
    Inventors: Shibiao Cheng, Songlin Wang, Fei Shen, Han Wang, Xi Li, Xinping Zhang, Dejia Ma, Xiaokang Hu, Zong Li, Yixuan He