Abstract: An automated machining system comprising a CNC machine and a processor configured to automatically identify one or more features to be machined into a workpiece to form a part; determine a set of tools suitable for performing a removal operation associated with machining each feature; identify those tools necessary for performing roughing and finishing removal operations for each feature; generate various sequences of removal operations suitable for machining all of the one or more features; calculate a cost of performing each removal operation sequence; determine which of the removal operations sequences is optimal; generate corresponding toolpaths for machining the features into the workpiece; and provide instructions to the CNC machine for automatically implementing the optimal removal operation sequence and corresponding toolpaths to machine the features into the workpiece to form the part. A system for automatic generation and optimization of machining strategies.

Abstract: The invention discloses an NDT device for pipeline, belonging to the field of NDT, including a mobile carrier, which moves with fluid in pipeline or is moved by an actuator; a probe testing assembly, which includes a testing component installed on the mobile carrier and having a testing element in which testing probe is encapsulated; a data processing unit, a first signal conditioning unit and a second signal conditioning unit, wherein the testing probe includes an excitation coil, a receiving coil and a passive resonance coil between the excitation coil and the receiving coil. For the invention, no more magnetizing treatment device is needed for testing, so that the system volume is greatly reduced, thereby reducing the requirement of the testing system of the invention on the internal cleanliness of a pipeline, improving flexibility of equipment in the pipeline of the testing system, and greatly reducing the system cost.

Abstract: An optical element driving mechanism is provided and includes a fixed assembly, a movable assembly, a driving assembly and a circuit assembly. The movable assembly is configured to connect an optical element, the movable assembly is movable relative to the fixed assembly, and the optical element has an optical axis. The driving assembly is configured to drive the movable assembly to move relative to the fixed assembly. The circuit assembly includes a plurality of circuits and is affixed to the fixed assembly.

Abstract: A whole-process automatic soil tabletting machine is provided. The machine includes a device body. A tabletting platform is arranged at a bottom of the device body, a first station on which a heating device is arranged, second and third stations are arranged on the tabletting platform. A top plate is arranged at a top of the device body. A soil crushing cutter and a punch head are installed on the top plate. The soil crushing cutter and the punch head are arranged above the first and second stations respectively. The tabletting platform is installed with a groove disc where sample preparation grooves and a cleaning groove are formed. The sample preparation grooves and the cleaning groove correspond to the first station, the second station or the third station. The cleaning groove and each sample preparation groove are for placing a cleaning container and a soil sample container, respectively.

Abstract: A centrifugal compressor and a refrigerating device. The centrifugal compressor includes: a shell, which has a fluid inlet and a fluid outlet; a motor assembly including a stator and a rotor, the rotor including a vertically arranged rotor shaft; a centrifugal compression mechanism, an impeller of which is connected with the rotor shaft so as to be driven by the motor assembly, wherein the centrifugal compression mechanism is arranged downstream of the fluid inlet to receive fluid, compress and pressurize the fluid, and output the pressurized fluid in a direction away from the motor assembly; and a guide member, which receives the pressurized fluid from the centrifugal compression mechanism, and which defines a flow passage alone or together with a part of the shell, wherein the flow passage is configured such that the pressurized fluid from the centrifugal compression mechanism passes through and cools the motor assembly.

Abstract: Embodiments of the present invention provide isolated proteins comprising antigen binding domains that bind kallikrein related peptidase 2 (hK2), including monospecific and bispecific antibodies. Additional embodiments of the invention provide polynucleotides encoding the hk2-specific proteins, vectors, host cells, and methods of making and using them.

Abstract: The present disclosure provides for chimeric antigen receptors (CARs) that specifically target a human Kallikrein-2 (hK2), and immunoresponsive cells comprising such CARs, for the treatment of cancer.

Abstract: The present disclosure is directed to decoupling library capture (template seeding) from cluster generation to optimise both processes. This is achieved by introducing orthogonality between the seeding and clustering primer.

Abstract: A method and an apparatus for controlling a shutoff device, and a shutoff device. The method is applied to a processor of the shutoff device. The method includes: determining whether a heartbeat signal is received continuously during a first preset period; if so, controlling the N main switching transistors to be turned on, and determining whether the heartbeat signal is not received continuously during a second preset period; and if so, controlling the N main switching transistors to be turned off, and controlling the release circuit to be turned on to release a voltage on the bus. A release circuit is controlled to release voltage on the bus to the ground, thereby rapidly reducing the voltage on the bus, avoiding person danger and safety accidents caused by the long-term presence of the direct current high voltage on the bus, and improving the safety and reliability of a photovoltaic system.

Abstract: A method and an apparatus for controlling a shutoff device, and a shutoff device. The shutoff device includes N main switching transistors and N bypass switching transistors. The method includes: controlling the N main switching transistors to be turned on after receiving a heartbeat signal; determining whether a power supply voltage of a processor is less than a first under-voltage protection voltage; and if so, controlling the N main switching transistors to be turned off, and controlling the N bypass switching transistors to be turned on. Thus, N photovoltaic modules and N main switching transistors corresponding to a shutoff device are separated from multiple photovoltaic module groups, so that the photovoltaic module groups corresponding to other shutoff devices can normally output DC voltage to an inverter, and the inverter can normally output AC power for integration into a power grid, thereby ensuring the normal operation of the photovoltaic system.

Abstract: A computer-implemented method for defect analysis is provided. The computer-implemented method includes calculating a plurality of weight-of-evidence (WOE) scores respectively for a plurality of device operations with respect to defects occurred during a fabrication period, a higher WOE score indicating a higher correlation between a defect and a device operation; and ranking the plurality of WOE scores to obtain a list of selected device operations highly correlated with the defects occurred during the fabrication period, device operations in the list of selected device operations having a WOE score greater than a first threshold score. A respective one of the plurality of device operations is a respective device defined by a respective operation site at which the respective device perform a respective operation.

Abstract: A determining method and apparatus for a neutral system working voltage includes a power system having three phase wires and three capacitor banks. Each bank has one terminal connected to one phase wire, and the other terminals form a neutral point. A phase voltage of each phase wire is periodically sampled, obtaining sampling value groups of real-time phase voltages. Each phase voltage group includes a sampling value of a phase voltage of each phase wire by measuring each phase wire. Unbalance rates between the banks are based on the groups of sampling values. The unbalance rate is a ratio between capacitances of every two phase wires. The isolated neutral system working voltage is based on the unbalance rates. The unbalance rates between banks are based on the sampling values measured in real time. The working voltage is based on the unbalance rates, permitting subsequent operations to be accurately performed.

Abstract: Provided herein are novel anti-CD28 x anti-PSMA antibodies and methods of using such antibodies for the treatment of PSMA-associated cancers. Subject anti-CD28 x anti-PSMA antibodies are capable of agonistically binding to CD28 costimulatory molecules on T cells and PSMA on tumor cells. Thus, such antibodies selectively enhance anti-tumor activity at tumor sites while minimizing peripheral toxicity. The subject antibodies provided herein are particularly useful in combination with other anti-cancer therapies (e.g., anti-CD3 x anti-PSMA antibodies) for the treatment of prostate cancers.

Abstract: Methods for on-flow cell selective capture and enrichment of clustered beads, general capture strategies on bead mobility on flow cell surfaces, sorting clustered and unclustered beads, and flow cell reusability for bead immobilization onto flow cells.

Abstract: Embodiments of the present invention provide isolated proteins comprising antigen binding domains that bind kallikrein related peptidase 2 (hK2), including monospecific and bispecific antibodies. Additional embodiments of the invention provide polynucleotides encoding the hk2-specific proteins, vectors, host cells, and methods of making and using them.

Abstract: A PCIe controller and a loopback path using the PCIe controller. The PCIe controller includes: a transport layer transmission module, a transport layer reception module, a memory access module, and a memory, wherein the transport layer transmission module includes a first loopback control module, the transport layer reception module includes a second loopback control module, and the first loopback control module is coupled to the second loopback control module; the memory access module is coupled to the transport layer transmission module and the transport layer reception module, and the memory access module is also coupled to the memory.

Abstract: A liquid dispenser sensing distance self-learning method includes in response to a self-learning request, entering a self-learning mode. The method also includes, in the self-learning mode, determining a shortest distance between a reference object and a sensing component; determining and storing a sensing distance based on the shortest distance; and identifying, by a first indication device, a state of the self-learning mode. The method also includes, in response to a sensing request, entering a sensing mode; obtaining a detected distance between the reference object and the sensing component; comparing the detected distance with the sensing distance; and identifying, by a second indication device, a comparison result of the detected distance and the sensing distance.

Abstract: The present disclosure discloses a method for preparing caprolactam including: (1) contacting cyclohexanone oxime with a catalyst to carry out reaction in the presence of ethanol and under the condition of gas phase Beckmann rearrangement reaction of cyclohexanone oxime; (2) separating the reaction product obtained in step (1) to produce an ethanol solution of crude caprolactam, and then separating the ethanol solution of crude caprolactam to obtain ethanol and crude caprolactam; (3) removing impurities with boiling points lower than that of caprolactam in the crude caprolactam to obtain a light component removal product; (4) mixing the light component removal product with a crystallization solvent to carry out crystallization and solid-liquid separation to obtain a crystalline crystal; (5) subjecting the crystalline crystal to a hydrogenation reaction; wherein the crystallization solvent contains 0.1-2 wt % of ethanol.

Abstract: Described herein are standards and methods of normalizing amplicon size bias. These standards may comprise unique molecular identifiers. In some embodiments, the standards and methods are for use with next generation sequencing (NGS) assays. Also described herein are methods for quantifying DNA damage in a sample comprising DNA using fluorescence or for determining the presence of DNA damage in a library.

Abstract: The disclosure provides an InDel marker genotype database of whole genome of Malus and use in specific identification of germplasm resources thereof, belonging to the technical field of molecular biology. The constructing method of the genotype database comprises: genotyping InDel markers of genomic DNA samples of Malus germplasm resources by using primer pairs and multiplex PCR; recording one line data for each Malus germplasm resource according to the genotype of InDel marker; collecting all germplasm resources records to obtain an InDel marker genotype database of the whole genome of Malus. The whole genome InDel marker genotype database of Malus provided by the disclosure can identify the specificity of apple germplasm simply, efficiently and stably, thus overcoming the limitation that DUS test is easily influenced by environment, and providing a powerful tool for the protection of new apple varieties and the management of germplasm resources.