Abstract: The disclosure provides compounds of formula (II) having the structure: Compounds of formula (II) are fractalkine receptor agonists and useful in treating, preventing or minimizing metastasis in a subject diagnosed with cancer. The compounds of the disclosure are further useful in treating central nervous system diseases (such as, but not limited to, HIV Associated Neurocognitive Disorders (HAND), and/or Alzheimer's disease), pain, inflammation (such as, but not limited to, arthritis), cardiovascular disease (such as, but not limited to, undesired vascular smooth muscle proliferation, atherosclerosis, coronary vascular endothelial dysfunction, and/or coronary artery disease), and/or multiple sclerosis.

Abstract: A refining process includes steps of subjecting crude caprolactam to a first evaporative crystallization and a first solid-liquid separation to obtain a first caprolactam crystal and a first crystallization mother liquor; washing the first caprolactam crystal to obtain a second caprolactam crystal; optionally concentrating the first crystallization mother liquor to perform a second evaporative crystallization and a second solid-liquid separation to obtain a third caprolactam crystal and a second crystallization mother liquor; subjecting the third caprolactam crystal to a second washing to obtain a fourth caprolactam; optionally concentrating the second crystallization mother liquor to perform thermostatic crystallization, performing separation to obtain a fifth caprolactam crystal and a third crystallization mother liquor; washing the fifth caprolactam crystal to obtain a sixth caprolactam crystal; and subjecting the second caprolactam crystal to a hydrogenation reaction.

Abstract: The disclosure provides an InDel marker genotype database of whole genome of Malus and use in specific identification of germplasm resources thereof, belonging to the technical field of molecular biology. The constructing method of the genotype database comprises: genotyping InDel markers of genomic DNA samples of Malus germplasm resources by using primer pairs and multiplex PCR; recording one line data for each Malus germplasm resource according to the genotype of InDel marker; collecting all germplasm resources records to obtain an InDel marker genotype database of the whole genome of Malus. The whole genome InDel marker genotype database of Malus provided by the disclosure can identify the specificity of apple germplasm simply, efficiently and stably, thus overcoming the limitation that DUS test is easily influenced by environment, and providing a powerful tool for the protection of new apple varieties and the management of germplasm resources.

Abstract: A PCIe controller and a loopback path using the PCIe controller. The PCIe controller includes: a transport layer transmission module, a transport layer reception module, a memory access module, and a memory, wherein the transport layer transmission module includes a first loopback control module, the transport layer reception module includes a second loopback control module, and the first loopback control module is coupled to the second loopback control module; the memory access module is coupled to the transport layer transmission module and the transport layer reception module, and the memory access module is also coupled to the memory.

Abstract: The disclosure provides compounds of formula (I) having the structure: Compounds of formula (I) are fractalkine receptor agonists and useful in treating, preventing or minimizing metastasis in a subject diagnosed with cancer. The compounds of the invention are further useful in treating central nervous system diseases (such as, but not limited to, HIV Associated Neurocognitive Disorders (HAND), and/or Alzheimer's disease), pain, inflammation (such as, but not limited to, arthritis), cardiovascular disease (such as, but not limited to, undesired vascular smooth muscle proliferation, atherosclerosis, coronary vascular endothelial dysfunction, and/or coronary artery disease), and/or multiple sclerosis.

Abstract: The present disclosure discloses a method for preparing caprolactam including: (1) contacting cyclohexanone oxime with a catalyst to carry out reaction in the presence of ethanol and under the condition of gas phase Beckmann rearrangement reaction of cyclohexanone oxime; (2) separating the reaction product obtained in step (1) to produce an ethanol solution of crude caprolactam, and then separating the ethanol solution of crude caprolactam to obtain ethanol and crude caprolactam; (3) removing impurities with boiling points lower than that of caprolactam in the crude caprolactam to obtain a light component removal product; (4) mixing the light component removal product with a crystallization solvent to carry out crystallization and solid-liquid separation to obtain a crystalline crystal; (5) subjecting the crystalline crystal to a hydrogenation reaction; wherein the crystallization solvent contains 0.1-2 wt % of ethanol.

Abstract: The present disclosure provides for chimeric antigen receptors (CARs) that specifically target a human Kallikrein-2 (hK2), and immunoresponsive cells comprising such CARs, for the treatment of cancer.

Abstract: The present disclosure relates to the field of display technology, and provides driving methods of a display panel and a display device.

Abstract: The present disclosure provides a driving method of a display device and a display device. The driving method includes: generating and outputting a frame image signal to an organic light emitting device, wherein the frame image signal includes an active data region and a blank region based on a time sequence; in the active data region of the frame image signal, using a timing controller to write a data voltage into the gate of the thin film transistor, store it in a storage capacitor, and apply it to the organic light emitting device through the thin film transistor; and in response to reaching the blank region of the frame image signal as determined by the timing controller, changing the first voltage at the cathode of the organic light emitting device to compensate the operating current of the organic light emitting device.

Abstract: The present invention relates to antisense LNA oligonucleotides (oligomers) complementary to CARD9 pre-mRNA intron and exon sequences, which are capable of inhibiting the expression of CARD9 protein. Inhibition of CARD9 expression is beneficial for a range of medical disorders including inflammatory bowel disease, pancreatitis, IgA nephropathy, primary sclerosing cholangitis, cardiovascular disease, cancer and diabetes.

Abstract: The present disclosure provides a driving method and system for an OLED display panel. The driving method for the OLED display panel includes: controlling a gate line driving circuit of the display panel for each frame image to sequentially output a scanning signal to each gate line of the display panel; and when the gate line driving circuit of the display panel starts to output the scanning signal to one gate line, timing from a starting scanning time of the same scanning gate line; and after the scanning time of the current scanning gate line reaches a preset fixed scanning time, controlling the gate line driving circuit of the display panel to stop outputting the scanning signal to the current scanning gate line. Therefore, the present disclosure does not need to change the gamma curve when the refresh frequency is changed, and screen flicker will not occur, and a seamless dynamic refresh switching of the display panel is realized.

Abstract: The present disclosure discloses a MFI topological structure silicon molecular sieve, a preparation method thereof and a catalyst containing the MFI topological structure silicon molecular sieve, wherein the molecular sieve containing a silicon element, an oxygen element and a metallic element, the ions of said metallic element have a Lewis acid characteristic; the content of the metallic element in the molecular sieve is within a range of 5-100 ?g/g based on the total amount of the molecular sieve; the BET specific surface area of the molecular sieve is within a range of 400-500 m2/g.

Abstract: A driving method includes: determining a starting luminance LS of a to-be-adjusted frame image; determining an average luminance LAVE(n) of the to-be-adjusted frame image during a nth duty period; determining a reference luminance flow rate ?L that indicates a current change rate of a storage capacitor storing a data signal for a display element; determining a time length TF of a reference frame image; determining a number k of black strips in the to-be-adjusted frame image; calculating a duty ratio of a pulse driving signal of the to-be-adjusted frame image during the nth duty period based on the starting luminance LS, the average luminance LAVE(n), the reference luminance flow rate ?L, the time length TF, and the number k of the black strips; and driving to display the to-be-adjusted frame image by the adjusted pulse driving signal.

Abstract: A PCIe controller and a loopback path using the PCIe controller. The PCIe controller includes: a transport layer transmission module, a transport layer reception module, a memory access module, and a memory, wherein the transport layer transmission module includes a first loopback control module, the transport layer reception module includes a second loopback control module, and the first loopback control module is coupled to the second loopback control module; the memory access module is coupled to the transport layer transmission module and the transport layer reception module, and the memory access module is also coupled to the memory.

Abstract: A curved display screen forming method includes: modeling to obtain a virtual display layer, and segmenting the display layer to obtain a size of a virtual display module; mapping the size of the virtual display module to obtain a size of a materialized display module; reducing edges of the materialized display module, and arranging an adjustment protrusion on each edge of the materialized display module; modeling to obtain a virtual adjustment layer, wherein a virtual plate of the virtual adjustment layer corresponds to the plurality of virtual display modules, obtaining a size of the virtual plate; converting the size of the virtual plate from a curved surface to a plane to obtain a planar size of the materialized plate; and assembling the materialized display module and the materialized plate to form a curved display screen.

Abstract: Provided is a nanoparticle including a scaffold, a single template site for bonding a template polynucleotide to the scaffold, and a plurality of accessory sites for bonding accessory oligonucleotides to the scaffold, wherein the scaffold is selected from one or more scaffold DNA molecules and one or more scaffold polypeptides, the single template site for bonding a template polynucleotide to the scaffold is selected from a covalent template bonding site and a noncovalent template bonding site and the plurality of accessory sites for bonding accessory oligonucleotides to the scaffold are selected from covalent accessory oligonucleotide bonding sites and noncovalent accessory oligonucleotide bonding sites. Also provided are methods of using the nanoparticle.

Abstract: Embodiments of the present invention provide a skip-scanning identification method and apparatus, a self-service cash register terminal and system. The method includes: obtaining a video of a user scanning an item; determining posture data of the user based on the obtained video; determining, according to the posture data of the user, a time period in which a scanning action of the user takes place; receiving a scanning result of the item; and determining whether the user has skipped scanning the item based on the scanning result and the time period.

Abstract: A driving method includes: determining a starting luminance LS of a to-be-adjusted frame image; determining an average luminance LAVE(n) of the to-be-adjusted frame image during a nth duty period; determining a reference luminance flow rate ?L that indicates a current change rate of a storage capacitor storing a data signal for a display element; determining a time length TF of a reference frame image; determining a number k of black strips in the to-be-adjusted frame image; calculating a duty ratio of a pulse driving signal of the to-be-adjusted frame image during the nth duty period based on the starting luminance LS, the average luminance LAVE(n), the reference luminance flow rate ?L, the time length TF, and the number k of the black strips; and driving to display the to-be-adjusted frame image by the adjusted pulse driving signal.

Abstract: The present disclosure provides a driving method and system for an OILED display panel. The driving method for the OLED display panel includes: controlling a gate line driving circuit of the display panel for each frame image to sequentially output a scanning signal to each gate line of the display panel; and when the gate line driving circuit of the display panel starts to output the scanning signal to one gate line, timing from a starting scanning time of the same scanning gate line; and after the scanning time of the current scanning gate line reaches a preset fixed scanning time, controlling the gate line driving circuit of the display panel to stop outputting the scanning signal to the current scanning gate line. Therefore, the present disclosure does not need to change the gamma curve when the refresh frequency is changed, and screen flicker will not occur, and a seamless dynamic refresh switching of the display panel is realized.

Abstract: A high barrier packaging film has an outer layer of a high molecular polymer or a spunbond nonwoven fabric comprising a high molecular polymer, a passive barrier layer of the same high molecular polymer with nanoparticles of bentonite clay dispersed therein, an active barrier layer of the same high molecular polymer with desiccant particles dispersed therein, and a lamination layer of the same high molecular polymer. The outer layer, passive barrier layer and active barrier layer are compound laminated with the lamination layer to form the high barrier packaging film. Because the layers are all formed of a same polymer, such as polyethylene, and because there are no metal components in the layers used to create the film, the high barrier packaging film is readily recyclable.