Abstract: Provided in the present disclosure is a method for using a four-plasmid system to prepare modified immune effector cells. The method comprises: forming a lentivirus by using four plasmids within 293T cells, extracting and obtaining the lentivirus, then transfecting immune effector cells by using the lentivirus, and expressing a chimeric antigen receptor. Also provided in the present disclosure is a use of the immune effector cell obtained by using the described method and of a composition containing the immune effector cell.

Abstract: A liquid crystal mixture applied in light modulating devices includes at least one compound selected from the group of compounds of formula I, at least one compound selected from the group of compounds of formula II and/or formula III, and at least one chiral compound. A light modulating device includes the liquid crystal mixture, where the light modulating device has reduced haze in the transparent state while increased opacity in the light scattering state.

Abstract: Provided is a triazolopyridazine derivative, a preparation method therefor, a pharmaceutical composition thereof, and an application thereof. The triazolopyridazine derivative is represented by formula I. The triazolopyridazine derivative has excellent inverse agonistic activity, thermodynamic solubility, bioavailability, and pharmacokinetic properties; thus having promising application prospects.

Abstract: Techniques for cache management involve: determining respective elimination scores of a plurality of entries in a cache based at least in part on compression rates of data blocks corresponding to the plurality of entries, the elimination score being proportional to the compression rate; and removing, from the cache, at least one entry with a relatively low elimination score among the plurality of entries. Such techniques are able to optimize the retention and elimination strategies for entries in a cache, thus increasing payoffs for using the cache.

Abstract: Multi-phase electrochemical cells and related systems and methods are generally described.

Abstract: An embodiment of the present disclosure relates to a method of controlling a power amplifier (PA). The PA can comprise a main PA path and an auxiliary PA path. The auxiliary PA path can have a plurality of turn-on settings. The method can comprise: determining a power back off gain and a lower bound gain for the PA; and performing an iterative auxiliary PA turn-on setting selection process. The selection process can comprise: determining an instantaneous power input to the PA; based on the instantaneous power input, choosing a turn-on setting in the plurality of turn-on settings of the auxiliary PA path that causes an instantaneous gain of the PA to be between the power back off gain and the lower bound gain; and applying the chosen turn-on setting to the auxiliary PA path.

Abstract: A measuring device for pore throat pressure of Jamin effect based on mechanochromic materials is provided and includes: a bubble pressurization part, configured to inject bubbles into a microscopic visualization test part; the microscopic visualization test part including a mechanochromic material and a pore throat structure, configured to characterize changes of pore throat pressure during bubble injection; a waste liquid recycling part, configured to recycle bubble waste liquid passing through the microscopic visualization test part; a data acquisition and analysis part, configured to acquire changing data of the pore throat pressure in the microscopic visualization test part and analyze the changing data to obtain the pore throat pressure. The device is simple in structure and easy to operate, and provides a method for measuring an internal surface pressure of an object. The method can realize a real time measurement of the pore throat pressure of Jamin effect.

Abstract: The present invention provides a TNA-based probe for detecting and imaging a target miRNA in living cells. TNA-based probe is composed of a fluorophore-labeled TNA reporter strand partially hybridizing to a quencher-labeled TNA recognition strand which is designed to be antisense to the target RNA transcript via pair pairing. Upon cellular entry without the need of harmful transfection treatment, the quencher-labeled TNA recognition strand binds to targeted transcript, and these target binding events displace the reporter strand from the quencher, resulting in a discrete “turning-on” of the fluorescence. The extent of fluorescence enhancement is quantifiably related to the target RNA expression level. Additionally, the TNA-based probe shows rapid detection response, excellent selectivity and specificity toward target miRNAs and is able to distinguish the target molecules with 1-2 base mismatches.

Abstract: Data augmentation is described to train an artificial intelligence model that includes analyzing a first data set to measure an amount of data in the data set and the variation in the amount of data in the first data set to determine deficiencies for training an artificial intelligence model. Augmenting data is added for the first data set having an amount of data measured that fails to meet a threshold value. Deficiencies in the variation in the amount of data in the first data set are augmented using augmentation methods outside the variation scope of the first data set to provide a second data set of augmented data. An artificial intelligence model is trained with a combined data set of the first data set, and the second data set of augmented data when the first and second data set have an amount of data meeting the threshold value.

Abstract: A tool for a bone implant includes a rod and an adaptor. The rod includes a coupling portion having a through-hole. The rod further includes a measuring arm connected to the coupling portion and a force applying arm connected to the coupling portion. The measuring arm includes a first extension section having a first indicator portion, and the force applying arm includes a second extension section having a second indicator portion. The force applying arm is elastically deformable away from the measuring arm to displace the second extension section relative to the first extension section. The adaptor is coupled in the through-hole and includes an outer ring and an inner ring. The outer ring is rotatable relative to the inner ring in a single direction.

Abstract: The present disclosure relates to a multilayer composite that may include a first porous layer, and a first barrier layer overlying the first porous layer. The first barrier layer may include a polyaramid material, a polyimide material, or any combination thereof. The multilayer composite may have a flame resistance rating of at least about 180° C. and a 50% strain compression rating of not greater than about 600 kPa.

Abstract: A motor and a vehicle are provided. The motor has a housing, a stator, a first end cove, a second end cover, a first oil injection ring, a rotor, a first end plate, and a second end plate. The rotor includes a rotor core, a rotor oil path formed in the rotor core, a rotor magnet steel, a rotation shaft, and a rotation shaft oil path formed in the rotation shaft. A first oil groove is defined on an inner side surface of the first end plate opposite to the rotor core, and is in communication with the rotation shaft oil path and the rotor oil path, respectively. A first end plate oil outlet is defined in an outer side surface of the first end plate and communicates the first oil groove with an inner cavity of the housing.

Abstract: A grass trimming head includes a housing assembly and a spool. The housing assembly is formed with a housing cavity and an outer aperture for allowing a cutting line to be inserted from an outside of the housing assembly into the housing cavity. At least a portion of the spool is arranged inside the housing cavity, and the spool is rotatable with respect to the housing assembly about a central axis. The spool is formed with an inner aperture for allowing the cutting line to be inserted into the spool or a clamping portion configured to fix the cutting line.

Abstract: A measuring device for pore throat pressure of Jamin effect based on mechanochromic materials is provided and includes: a bubble pressurization part, configured to inject bubbles into a microscopic visualization test part; the microscopic visualization test part including a mechanochromic material and a pore throat structure, configured to characterize changes of pore throat pressure during bubble injection; a waste liquid recycling part, configured to recycle bubble waste liquid passing through the microscopic visualization test part; a data acquisition and analysis part, configured to acquire changing data of the pore throat pressure in the microscopic visualization test part and analyze the changing data to obtain the pore throat pressure. The device is simple in structure and easy to operate, and provides a method for measuring an internal surface pressure of an object. The method can realize a real time measurement of the pore throat pressure of Jamin effect.

Abstract: Techniques involve: determining, based on sizes of a storage space used by a file system at a set of historical moments and a current moment, predicted sizes of a storage space to be used by the file system at a plurality of future moments. The techniques further involve: determining sizes of an available storage space and available durations of a set of candidate future moments in the plurality of future moments based on the predicted sizes. The techniques further involve: determining, based on the sizes of the available storage space and the available durations of the set of candidate future moments, predicted values that characterize available storage capacities of the set of candidate future moments. The techniques further involve: determining a target moment from the set of candidate future moments based on the predicted values to recycle at least part of an available storage space of the target moment.

Abstract: An optical element driving mechanism is provided and includes a fixed assembly, a movable assembly, a driving assembly and a circuit assembly. The movable assembly is configured to connect an optical element, the movable assembly is movable relative to the fixed assembly, and the optical element has an optical axis. The driving assembly is configured to drive the movable assembly to move relative to the fixed assembly. The circuit assembly includes a plurality of circuits and is affixed to the fixed assembly.

Abstract: Embodiments of the disclosure relate generally to thermal control and management in hardware devices. A thermal control system includes a thermal node, a thermal bridge, and a thermal controller. The thermal node is configured to receive heat generated in a device. The thermal controller is configured to in response to an environment temperature of the thermal controller being greater than a first threshold temperature, cause heat transfer from the thermal node to a first heat sink and prevent heat transfer from the thermal node to a second heat sink. The thermal controller is also configured to, in response to the environment temperature of the thermal controller being greater than a second threshold temperature, cause heat transfer from the thermal node to the second heat sink and prevent heat transfer from the thermal node to the first heat sink.

Abstract: This disclosure pertains to coated drug compositions and methods of preparing coated drug compositions with a low temperature silicon oxide coating. Specifically, the instant application discloses a method to coat active pharmaceutical ingredient particles using a silicon precursor and a catalyst at a low temperature.