Abstract: The present invention relates to a macrocyclic EGFR inhibitor and preparation method therefor and pharmaceutical use thereof. In particular, the present invention relates to an EGFR inhibitor having a structure of formula (I), a pharmaceutical composition thereof, a use thereof as an EGFR inhibitor, and a use thereof in the preparation of a drug for treating and/or preventing tumors or metastatic diseases associated at least partially with EGFR L858R/C797S double mutation, EGFR Del19/C797S double mutation, L858R/T790M/C797S triple mutation and Del19/T790M/C797S triple mutation, especially in the preparation of a drug for treating and/or preventing hyperproliferative diseases and disorders inducing cell death. Each substituent of formula (I) is as defined in the description.

Abstract: Methods for performing signal collection on fluorescence emitted by an object to be subjected to detection in a sample comprise: performing photoelectric detection on fluorescence emitted by the object to generate an electrical signal; integrating the electrical signal; collecting the integrated electrical signal; and in response to a trigger indication, releasing, within a time period, more than 90% of charges accumulated in a charge integrator that integrates the electrical signal, wherein the time period is less than 15% of a full width at half maximum of a time-domain waveform corresponding to fluorescence intensity. By releasing most of the accumulated charges in a timely manner within a short time during the process of integrating an electrical signal generated during fluorescence detection, the problem of the dynamic range of a fluorescence detector being insufficient is effectively solved, such that the dynamic range can be expanded.

Abstract: A communication method for use in a first Internet of things (IoT) device includes: the first IoT device generates a first task request and a second task request, where the first task request indicates to process data of a first service, the second task request indicates to process data of a second service, each of the first service and the second service is a service that requires long-term communication and whose service volume is less than a first threshold, and the first service is different from the second service; and the first IoT device schedules the first task request and the second task request to a first thread for processing. In this way, thread scheduling of the task request can be implemented, and a plurality of services can be supported.

Abstract: The present disclosure relates to transcription modulator molecule compounds, compositions, and methods of treating various genetic diseases including spinocerebellar ataxias and Huntington's disease.

Abstract: The present invention relates to KRAS G12D inhibitors and the uses thereof. In particular, the present invention relates to KRAS G12D inhibitors having structures shown as formula (I), a preparation method therefor, a pharmaceutical composition containing same, the use thereof as KRAS G12D inhibitors, and the use thereof in treatment and/or prevention of cancers or tumors related to KRAS G12D, each substituent in formula (I) being as defined in the description.

Abstract: A power circuit, a method for driving the same, and a display device are provided. The power circuit is applied to a display device including a driving circuit configured to input a reset image to a display panel under an effect of a first polarity signal. The power circuit includes: a voltage input terminal configured to provide a power voltage to the display panel during a power-on phase, and stop providing the power voltage during a power-off phase; a first unidirectional conduction circuit configured to: transmit a signal from the voltage input terminal to a first output terminal, and block a signal from the first output terminal to the voltage input terminal; a storage circuit configured to store a charge of the first output terminal; and a detection circuit configured to input the first polarity signal to the driving circuit when the voltage input terminal loses power.

Abstract: A tank is secured under the keel of a floating structure for offshore energy development. The tank is filled with ballast material that supplements or replaces the ballast already present on the floating structure, thereby gaining larger topsides payload capacity for the floating structure or increasing stability and motion performance of the floating structure.

Abstract: A downwind starting method for a permanent magnet synchronous motor without a back electromotive force sampling circuit includes utilizing a back electromotive force generated by a rotating magnetic field that is generated through downwind rotation of the permanent magnet rotor before starting the permanent magnet synchronous motor cutting the plurality of phase windings of the stator assembly to control a lower switch transistor of one of the phase windings to be turned on while turning off lower switch transistors of the remaining phase windings, detecting whether a current is generated, and recording time when the current is generated; repeating the above operations until time when a current is generated for each phase winding is obtained; summing the time when the current is generated for each phase winding to obtain an electrical cycle, and calculating an electrical frequency of the motor by using the electrical cycle; and utilizing the electrical frequency and the time when the current is generated for

Abstract: The present disclosure relates to the technical field of a heat pump device, and discloses an upturned electric control box mounting structure, which comprises a connecting frame and an electric control box assembly, wherein the electric control box assembly is connected to the connecting frame in an upturned manner, a fixing mechanism and a supporting mechanism are provided on the connecting frame. The present disclosure further discloses a heat pump device applying the structure, which comprises a tank body, a water tank assembly and a hydraulic module, wherein the above-mentioned upturned electric control box mounting structure is mounted on the tank body, and the water tank assembly and the hydraulic module are electrically connected with the electric control box assembly.

Abstract: A generator circuit breaker includes a main current branch, a current-limiting transfer branch, a freewheeling branch and a fast switch. The main current branch includes a high-speed mechanical switch S1 and a high-speed mechanical switch S2 in parallel, wherein two ends of each of breaks of the high-speed mechanical switch S1 and the high-speed mechanical switch S2 are directly connected with wire outlet ends of the circuit breaker respectively. One end of the current-limiting transfer branch is connected in parallel to one end of the main current branch and the other end of the current-limiting transfer branch is connected with the other end of the main current branch via a fast switch S3, wherein the current-limiting transfer branch includes a transfer capacitor C, an inductor L, thyristor components T1 and T2, and a current-limiting resistor R.

Abstract: An EGFR inhibitor having the structure of formula (I), a preparation method therefor, a pharmaceutical composition containing same, a use of same as an EGFR inhibitor, and a use of same in preparing a drug for treating and/or preventing a cancer, a tumor, or a metastatic disease at least partially related to an EGFR exon 20 insertion, deletion, or other mutation, and in particular a use in preparing a drug for treating and/or preventing a hyperproliferative disease and an induced cell death disorder. Each substituent of formula (I) has the same definition as in the description.

Abstract: An image registration method using a fast differential evolution sample consensus algorithm based on historical records: 1: image acquisition: acquiring a to-be-registered image and a reference image; 2: feature extraction: respectively extracting point features of the to-be-registered image and the reference image by using a SIFT algorithm; 3: feature matching: performing coarse feature matching between the to-be-registered point feature set and the reference point feature set to obtain a sample set; 4: parameter setting; 5: sorting the sample set in ascending order, and initializing a sample inlier archive AS and a model inlier archive AM; 6: first-time initialization of a population; 7: updating a fast test execution threshold uT; 8: mutation phase; 9: selection phase; 10: mutation operator parameter update; 11: resident initialization of the population; 12: repeating 7-11; 13: selecting the best individual from the population to perform spatial transformation on the to-be-registered image to obtain a regi

Abstract: A paging message transmission method includes: receiving indication information from a core network device, the indication information is used to indicate a target transmission manner; and sending a first paging message to UE in the target transmission manner. The target transmission manner includes at least one of: for a second paging message of one SIM card, retransmitting the second paging message at X first transmission locations, transmitting the second paging message in an offset manner based on a predetermined offset and/or in a predetermined offset direction, or transmitting the second paging message at a second transmission location. The second transmission location is different from an original transmission location that is used to transmit the second paging message, M and X are integers greater than 1, N is a positive integer, and N is less than or equal to M.

Abstract: A fusion protein CrtZW and an application in catalyzing a production of astaxanthin from ?-carotene are provided, which relates to the field of astaxanthin synthesis technology. The sequence of the fusion protein CrtZW is shown in SEQ ID NO. 4. The fusion protein can catalyze the synthesis of astaxanthin from ?-carotene in one step and is suitable for large-scale production.

Abstract: A washing machine includes: a housing having an opening; an outer tub installed in the housing and having an outer tub opening formed corresponding to the opening; a window gasket of which two ends are respectively connected with the outer tub opening and the opening of the housing to form a laundry loading port for laundry loading and unloading; and a machine door installed on the housing for opening and closing to the laundry loading port. A shielding part is disposed on the outer tub, configured to protrude radially and inward and at least partially located on an inner side of the outer tub opening, and the shielding part is used for shielding a gap between the window gasket and the machine door.

Abstract: Provided is a puncture assistance system, a puncture assistance device, a puncture needle position correction system, and a surgical robot. The system includes a processor configured to: obtain a scan image of a target object; the scan image including at least one of a preoperative image, a first image from a first time period, and a second image from a second time period; the first time period is earlier than the second time period; generate puncture guidance information based on puncture status information and the scan image; guide a puncture operation based on the puncture guidance information; and display the puncture guidance information.

Abstract: A tank is secured under the keel of a floating structure for offshore energy development. The tank is filled with ballast material that supplements or replaces the ballast already present on the floating structure, thereby gaining larger topsides payload capacity for the floating structure or increasing stability and motion performance of the floating structure.

Abstract: The present application provides an inductor structure, a circuit board and an electronic device. The inductor structure includes a magnetic core column and a wire. The magnetic core column includes a first part, a second part and a third part arranged sequentially along a first direction, the first part has a first side wall facing away from the second part, and the third part has a second side wall facing away from the second part. The wire is wound around the magnetic core column and is configured to be electrically connected to the circuit board.

Abstract: A data driving integrated circuit includes a digital-to-analog converter configured to receive a respective digital data signal from a timing controller and convert the respective digital data signal to a respective analog data signal, which is output to a display panel through a respective data line; an analog-to-digital converter configured to receive a respective analog sensing signal from a respective sensing line in the display panel and convert respective analog sensing signal to a respective digital sensing signal, which is output to the timing controller; a first sensing switch configured to control a connection between a first reference voltage line and the respective sensing line; a second sensing switch configured to control a connection between a second reference voltage line and the respective sensing line; and a third sensing switch configured to control the connection between the analog-to-digital converter and the respective sensing line.

Abstract: Disclosed is a noise-reducing instant heating and drying-type faucet, including a water inlet device, a hot air water outlet device and a filter cap assembly, where the hot air water outlet device is located at the upper end of the water inlet device, the hot air water outlet device includes a housing, the housing has an empty cavity, an air inlet is formed on one side of the empty cavity, an air outlet is formed on the other side thereof, a gesture control assembly is installed at the inner upper end of the housing, a hot air heating assembly configured for mixing hot and cold air is installed inside the empty cavity, the hot air heating assembly has a separate heating chamber, and one end of the heating chamber is connected to the air inlet, and the other end thereof is connected to the air outlet.