Abstract: The present invention provides a method for determining the efficacy of anti-tumor drugs in a time-efficient manner, comprising the following steps: (1) transferring a primary tumor cell into an implant device; (2) implanting the implant device comprising the primary tumor cell into an animal; (3) administering a candidate drug to the animal; (4) determining the sensitivity of the tumor cell to the candidate drug.

Abstract: A door closer is provided. The door closer includes a first connecting plate and a second connecting plate. The first connecting plate is connectable to an external door frame, the second connecting plate is connectable to a door body connecting portion. Connecting rod assemblies and return springs are mounted in the door body connecting portion. One end of the connecting rod assembly passes through the second connecting plate and is hinged to the first connecting plate. When a door is opened, an external door body drives the first connecting plate and the second connecting plate to overturn, and after the connecting rod assembly pulls the door body connecting portion, the return spring is compressed. When the door is closed, the return spring pulls the door body to close automatically.

Abstract: Provided are activatable proprotein homodimers comprising two separate but identical polypeptide chains, each chain comprising a fragment antigen-binding (Pab) region that specifically binds to human PD-1 or human PD-L1 or buman B7H3, a hinge/Pc domain, a linker, an IL-2 protein, a protease cleavable linker, and an IL-2R? protein. Also provided are related pharmaceutical compositions and methods of use thereof.

Abstract: Provided are activatable proprotein homodimers comprising two separate but identical polypeptide chains, each chain comprising a fragment antigen-binding (Fab) region that specifically binds to human PD-1 or human PD-L1 or human B7H3, a hinge/Fc domain, a linker, an IL-15 protein, a protease cleavable linker, and an IL-15R? protein. Also provided are related pharmaceutical compositions and methods of use thereof.

Abstract: The disclosure relates to an automatic measuring system and a method thereof for drilling fluid parameters measurement. The system includes i. mud container, configured for test drilling fluid preparation and samples collection; ii. heat jacket, configured to keep the drilling fluid in the tank warm iii. heat exchanger, configured to simulate the practical conditions; iv. plunger pump, configured to pump the test drilling fluid to the flowing test device; v. flow test device, configured to simulate the flowing states of drilling fluid in the borehole annulus and drilling string, and also measure the pressure and flow rate of drilling fluid vi. control module, configured to obtain rheological parameters and the best rheological mode of the drilling fluid in the borehole annulus and drilling string based on the pressure and flow rate.

Abstract: Disclosed herein is a spatially decoupled redox flow water electrolyzer, that has a hydrogen-producing catholyte section formed from a catholyte tank, having a cathode, and a hydrogen generation compartment, where the catholyte tank and the hydrogen generation compartment are fluidly connected to one another by a fluid pathway, so as to facilitate the circulation of a liquid catholyte from the catholyte tank to the hydrogen generation compartment and back to the catholyte tank and an oxygen-producing anolyte section formed from an anolyte tank, having an anode, and an oxygen producing compartment, where the anolyte tank and the oxygen producing compartment are fluidly connected to one another by a fluid pathway, so as to facilitate the circulation of a liquid anolyte from the anolyte tank to the oxygen producing compartment and back to the anolyte tank, an anion-exchange membrane is disposed between the catholyte and anolyte tanks and a current collector attached to the catholyte and anolyte tanks.

Abstract: A system includes a processor. The processor estimates a pattern of a flow of a mixture of drilling fluid and cuttings in an annulus of a wellbore. The flow is estimated as a stationary bed flow, a dispersed flow, or a transitional flow relative to the stationary bed and dispersed flows. The processor estimates parameters based on the estimated pattern of the flow, and determines a plurality of dimensionless parameters including a first dimensionless parameter corresponding to an effect of turbulence on the flow and a second dimensionless parameter corresponding to an effect of gravity on the flow, based on the estimated parameters. The processor characterizes the pattern of the flow as the stationary bed flow, the dispersed flow, or the transitional flow, based on the dimensionless parameters, and models the flow based on the estimated pattern if it is determined that the characterized pattern matches the estimated pattern.

Abstract: Systems, methods, and computer-readable media are described for intelligent, real-time monitoring and managing of changes in oilfield equilibrium to optimize production of desired hydrocarbons and economic viability of the field. In some examples, a method can involve generating, based on a topology of a field of wells, a respective graph for the wells, each respective graph including computing devices coupled with one or more sensors and/or actuators. The method can involve collecting, via the computing devices, respective parameters associated with one or more computing devices, sensors, actuators, and/or models, and identifying a measured state associated with the computing devices, sensors, actuators, and/or models.

Abstract: The present disclosure provides a device and method for diagnosing risk of insufficient hole cleaning problem during drilling wells. The method includes obtaining the measured pressure via several measuring points, and obtaining actually measured value of each measuring point; calculate the theoretical pressure at each measuring points by using the real-time operational data as inputs, evaluating a hole cleaning condition by applying a difference between a theoretical pressure drop and a measured pressure drop to a developed pressure driven hole cleaning model, which gives the risk of insufficient hole cleaning problems and problematic locations. The theoretical pressure drop between two adjacent measurement points along wellbore includes the pressure drop caused by friction effect and hydrostatic effect. However, suspended cuttings in actual drilling fluid may significantly change the pressure drop along wellbore.

Abstract: A door closer is provided. The door closer includes a first connecting plate and a second connecting plate. The first connecting plate is connectable to an external door frame, the second connecting plate is connectable to a door body connecting portion. Connecting rod assemblies and return springs are mounted in the door body connecting portion. One end of the connecting rod assembly passes through the second connecting plate and is hinged to the first connecting plate. When a door is opened, an external door body drives the first connecting plate and the second connecting plate to overturn, and after the connecting rod assembly pulls the door body connecting portion, the return spring is compressed. When the door is closed, the return spring pulls the door body to close automatically.

Abstract: The present invention includes compositions and methods comprising viral vector systems for multiplexed activation of endogenous genes as immunotherapy and viral-based immune-gene therapy.

Abstract: Provided are an antenna of a mobile terminal, and a mobile terminal. The antenna includes a dielectric substrate, a ground plate located on one side of the dielectric substrate, and a near-feed unit, a near-ground unit and a coupling unit that are arranged on the other side of the dielectric substrate; the near-ground unit has one end connected to the coupling unit and the other end connected to the ground plate; the coupling unit and the near-ground unit are equivalent to a Left-Handed (LH) inductor; the near-feed unit is equivalent to a Right-Handed (RH) inductor; the coupling unit is coupled to the near-feed unit and is equivalent to an LH capacitor; the coupling unit is coupled to the ground plate and is equivalent to an RH capacitor; and the near-feed unit, the near-ground unit, the coupling unit and the ground plate form a Composite Right-Left-Handed Transmission Line (CRLH-TL) structure.

Abstract: An abnormal trend detection system for detecting one or more hazards may provide for a safe and effective drilling operation as any of the one or more hazards may be avoided. Several indicators may be defined including a first, second, third and fourth indicator. The indicators are used to identify in a trend analysis abnormal trends. One or more thresholds may be defined. When a trend analysis indicates that a threshold has been reached or exceeded an alarm may be triggered, a drilling operation may be altered or a combination thereof.

Abstract: A method for sidelink data retransmission can include receiving a first negative acknowledgement (NACK) at a base station (BS) from a receiver user equipment (Rx UE). The NACK corresponds to an original transmission of sidelink data over a sidelink from a transmitter user equipment (Tx UE). The method can further include selecting one or both of the BS and the Tx UE to perform a first retransmission of the sidelink data to the Rx UE. A method of sidelink synchronization can include selecting at a UE a timing reference with a highest priority among available sidelink synchronization timing references according to a rule indicating timing references listed from high priority to low priority: gNB or eNB; UE directly synchronized to gNB or eNB; UE in directly synchronized to gNB or eNB; GNSS; UE directly synchronized to GNSS; UE indirectly synchronized to GNSS; and remaining UEs.

Abstract: A method includes receiving a plurality of drilling parameters from a drilling operation, wherein the plurality of drilling parameters. The drilling parameters include a cuttings bed height and a friction factor between a drill string and a wellbore. The method further includes applying the plurality of drilling parameters to a friction model. The friction model utilizes a function of the cuttings bed height to determine a comprehensive friction factor. The comprehensive friction factor is applied to the plurality of drilling parameters to determine a required torque or hook load of the drill string. The method further includes providing an indication of a stuck pipe event.

Abstract: The invention relates to an automatic measuring system and a use method thereof for drilling fluid parameters measurement under high temperature and high-pressure conditions. The system is composed of six parts: i. mud container, used both for test drilling fluid preparation and the tested samples collection; ii. heat jacket, which is arranged on the outer surface of the fluid tank and used to keep the drilling fluid in the tank warm by heating; iii. heat exchanger, receive the test drilling fluid from the tank and heat it to simulate the practical conditions; iv. plunger pump, which is used to pump the test drilling fluid to the flowing test device; v. moveable test device, used to simulate the flowing states of drilling fluid in the borehole annulus and drilling string, and also measure the pressure and flow rate of drilling fluid in the inlet and outlet of the test device; vi.

Abstract: The present invention provides a method for determining the efficacy of anti-tumor drugs in a time-efficient manner, comprising the following steps: (1) transferring a primary tumor cell into an implant device; (2) implanting the implant device comprising the primary tumor cell into an animal; (3) administering a candidate drug to the animal; (4) determining the sensitivity of the tumor cell to the candidate drug.

Abstract: Embodiments of the subject technology provide for receiving real-time drilling data comprising different drilling parameters measured during a drilling operation. The subject technology calculates a kick detection parameter based at least in part on the different drilling parameters. The subject technology detects an occurrence of a kick during the drilling operation when the kick detection parameter deviates from a trend formed by previously calculated kick detection parameters. Further, the subject technology activates an alarm during the drilling operation in response to detected occurrence of the kick to facilitate preventing a blowout.

Abstract: A method for sidelink data retransmission can include receiving a first negative acknowledgement (NACK) at a base station (BS) from a receiver user equipment (Rx UE). The NACK corresponds to an original transmission of sidelink data over a sidelink from a transmitter user equipment (Tx UE). The method can further include selecting one or both of the BS and the Tx UE to perform a first retransmission of the sidelink data to the Rx UE. A method of sidelink synchronization can include selecting at a UE a timing reference with a highest priority among available sidelink synchronization timing references according to a rule indicating timing references listed from high priority to low priority: gNB or eNB; UE directly synchronized to gNB or eNB; UE in directly synchronized to gNB or eNB; GNSS; UE directly synchronized to GNSS; UE indirectly synchronized to GNSS; and remaining UEs.

Abstract: Systems, methods, and computer-readable media are described for intelligent, real-time monitoring and managing of changes in oilfield equilibrium to optimize production of desired hydrocarbons and economic viability of the field. In some examples, a method can involve generating, based on a topology of a field of wells, a respective graph for the wells, each respective graph including computing devices coupled with one or more sensors and/or actuators. The method can involve collecting, via the computing devices, respective parameters associated with one or more computing devices, sensors, actuators, and/or models, and identifying a measured state associated with the computing devices, sensors, actuators, and/or models.