Patents by Inventor FEN LIU

FEN LIU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250139957
    Abstract: Train a text-to-image machine learning model by using a training dataset. The training dataset includes images and respective natural language descriptions of those images. The training causes the text-to-image machine learning model to be overfit on the training dataset. Store the trained overfit text-to-image machine learning model. Submit a given natural language description to the stored overfit text-to-image machine learning model. In response to the submitting, receive as output from the overfit text-to-image learning machine learning model an output image. The output image is a reproduction of a corresponding image from the training dataset and corresponds to the submitted natural language description.
    Type: Application
    Filed: October 31, 2023
    Publication date: May 1, 2025
    Inventors: Zhong Fang Yuan, Tong Liu, Yi Ming Wang, Yu Zui You, Yan Fen Liu
  • Publication number: 20250018040
    Abstract: Polypeptides, proteins, and chimeric antigen receptors (CARs) that specifically bind to human mesothelin582-598 (IP-NGYLVLDLSMQEALS) (SEQ ID NO: 1) are disclosed. Anti-mesothelin binding moieties, nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, and conjugates relating to the poly peptides, proteins, and CARS are disclosed. Methods of reducing mesothelin shed from cell membranes, methods of detecting the presence of cancer, and methods of treating or preventing cancer are also disclosed.
    Type: Application
    Filed: December 16, 2022
    Publication date: January 16, 2025
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Ira H. Pastan, Masanori Onda, Mitchell Ho, Xiu-fen Liu, Tapan Bera, Anirban Chakraborty
  • Patent number: 12168785
    Abstract: Provided is a recombinant KOD polymerase, which is the following A) or B): the polymerase shown in A) is a protein having DNA polymerase activity that is obtained by modifying amino acid residues in at least one of the following 18 positions in a wild-type KOD DNA polymerase amino acid sequence: 675th, 385th, 710th, 674th, 735th, 736th, 606th, 709th, 347th, 349th, 590th, 676th, 389th, 589th, 680th, 384th, 496th and 383rd; the polymerase described by B) is a protein having DNA polymerase activity that is derived from A) by adding a tag sequence to an end of the amino acid sequence of the protein shown in A).
    Type: Grant
    Filed: September 3, 2018
    Date of Patent: December 17, 2024
    Assignee: BGI SHENZHEN
    Inventors: Lili Zhai, Lin Wang, Wenwei Zhang, Yuliang Dong, Yue Zheng, Fen Liu
  • Publication number: 20240330675
    Abstract: Validity of a trained artificial intelligence model is verified. The verifying the validity includes generating a training dataset from the trained artificial intelligence model using reverse data generation of the trained artificial intelligence model. The training dataset generated using the reverse data generation is compared with a test dataset used to evaluate the trained artificial intelligence model. The comparing is to determine a relationship between the training dataset that was generated and the test dataset. Data from the test dataset determined to have a predefined relationship with the training dataset is removed to obtain a new test dataset. The new test dataset is used to verify the validity of the trained artificial intelligence model.
    Type: Application
    Filed: March 27, 2023
    Publication date: October 3, 2024
    Inventors: Zhong Fang YUAN, Tong LIU, Shuang Yin LIU, Jun WANG, Yan Fen LIU
  • Publication number: 20240293407
    Abstract: Disclosed herein are methods for treating cancers in a subject. The method includes determining the plasma level of arginine in the subject, followed by administering to the subject an arginine deprivation therapy alone or in combination with an anti-cancer agent based on the determined plasma level of arginine. According to some embodiments of the present disclosure, the anti-cancer agent is selected from the group consisting of FOLFOX, docetaxel, cisplatin, pemetrexed, pembrolizumab, and a combination thereof.
    Type: Application
    Filed: March 3, 2023
    Publication date: September 5, 2024
    Inventors: Hung-Wen CHEN, Shaw Tsen CHEN, Hui-Fen LIU, Chih-Ling KUO, Chiung-Fang SHIU
  • Publication number: 20240166964
    Abstract: A diesel fuel additive includes a cetane number improver and an at least one organometallic combustion catalyst in solution and/or at least one metal-oxide combustion catalyst in suspension.
    Type: Application
    Filed: May 26, 2023
    Publication date: May 23, 2024
    Inventors: Tony BRAMPTON, Edward J. LEE, Ru-Fen LIU, Campbell MCCONNELL
  • Publication number: 20240145685
    Abstract: This application provides an electrode sheet and an electrochemical device. The electrode sheet includes a current collector and a functional coating located on at least one surface of the current collector. The functional coating includes a first coating, a second coating and an active material layer that are sequentially stacked on a surface of the current collector. The first coating includes a conductive agent, a binder and a first functional filler, and the second coating includes a conductive agent, a binder and a second functional filler. A mass ratio of the binder in the first coating to the first coating is a1, a mass ratio of the binder in the second coating to the second coating is a2, and a mass ratio of the binder in the active material layer to the active material layer is a3, and a1>a2>a3.
    Type: Application
    Filed: December 28, 2023
    Publication date: May 2, 2024
    Inventors: Fan YANG, Yanyun ZHAI, Jian ZHANG, Kongyan XIE, Fen LIU, Jinshuai YANG, Chong PENG
  • Publication number: 20240092197
    Abstract: A distributor includes: an outer housing; a direct current charging interface, an electronic control terminal interface, and a battery terminal interface disposed in the outer housing. A first contactor and a second contactor are connected between the electronic control terminal interface and the battery terminal interface. A third contactor and a pre-charge resistor form a pre-charge branch. A fourth contactor is connected between the direct current charging interface and the battery terminal interface; a fifth contactor is connected between a negative terminal of the direct current charging interface and a negative terminal of the battery terminal interface; and the five contactors and a pre-charge resistor are disposed in the outer housing.
    Type: Application
    Filed: November 28, 2023
    Publication date: March 21, 2024
    Inventors: Tuodi HUANG, Penghui XUE, Zunjie LI, Fen LIU, Chao LIU
  • Publication number: 20240084063
    Abstract: A solvent-free resin composition and uses thereof are provided. The resin composition includes: (A) a maleic acid-modified liquid hydrocarbon resin; (B) a first filler having a D50 particle size of 1 ?m to 4 ?m; and (C) a second filler having a D50 particle size of 5 ?m to 10 ?m. The solvent-free resin composition can be used to fill the holes of printed circuit boards.
    Type: Application
    Filed: October 24, 2022
    Publication date: March 14, 2024
    Inventors: Jui-Hsiang TANG, Shur-Fen LIU
  • Publication number: 20240084135
    Abstract: A resin composition and uses thereof are provided. The resin composition includes: (A) an epoxy resin; (B) a bismaleimide resin; and (C) a first flame retardant having a structure of formula (I): Wherein Ar is a C3 to C18 heteroaryl or a C6 to C18 aryl; R1 is H or a C1 to C18 alkyl; and R2 and R3 are independently H, a C1 to C18 alkyl, a C3 to C18 heteroaryl, or a C6 to C18 aryl.
    Type: Application
    Filed: December 7, 2022
    Publication date: March 14, 2024
    Inventors: Tsung-Hsien LIN, Shur-Fen LIU, Pin CHIEN, Kai-Cheng YANG
  • Publication number: 20240060135
    Abstract: The present invention provides therapeutic and diagnostic methods and compositions for cancer (e.g., bladder cancer (e.g., UC) or kidney cancer (e.g., RCC)). The invention provides methods of identifying an individual having a cancer who is likely to respond to treatment with an anti-cancer therapy comprising a PD-L1 axis binding antagonist, methods for selecting a therapy for an individual having a cancer, methods of identifying an individual having a cancer who is less likely to respond to treatment with an anti-cancer therapy comprising a PD-L1 axis binding antagonist monotherapy, methods of monitoring the response of an individual having a cancer to treatment with an anti-cancer therapy comprising a PD-L1 axis binding antagonist, and methods of treating an individual having cancer, based on expression levels of a biomarker of the invention (e.g., one or more genes set forth in any one of Tables 1-7, e.g., IL8).
    Type: Application
    Filed: September 30, 2022
    Publication date: February 22, 2024
    Inventors: Li-Fen LIU, Sanjeev MARIATHASAN, Chi Yung YUEN, Mahrukh HUSENI
  • Publication number: 20240006618
    Abstract: A method for making a bi-metallic electrocatalyst produces a non-platinum group metal (non-PGM), bimetallic oxide crystalline catalyst showing low overpotential in both oxygen evolution reactions (OER) and oxygen reduction reactions (ORR) in a metal-air battery and/or fuel cell applications. The bimetallic oxide is formed to be in electrical communication with a catalyst support particle, and with the catalyst support particle, in turn, in electrical communication with an air-permeable electrode. A metal-air storage cell, optionally configured as part of a battery, includes a bi-metallic electrocatalyst. An electrical management system includes a metal-air storage cell.
    Type: Application
    Filed: July 13, 2023
    Publication date: January 4, 2024
    Inventor: Ru-Fen LIU
  • Publication number: 20240000952
    Abstract: Disclosed herein are methods and kits for identifying responsiveness or non-responsiveness of a cancer subject to arginine deprivation therapy. The method includes determining the presence of a G/G genotype of rs13338697 of the target nucleic acid in a biological sample derived from the subject by use of a polymerase chain reaction (PCR)-based method, in which the presence of the G/G genotype of rs13338697 of the target nucleic acid is an indication that the subject is responsive to the arginine deprivation therapy.
    Type: Application
    Filed: April 14, 2022
    Publication date: January 4, 2024
    Inventors: Hung-Wen CHEN, Hui-Fen LIU, Chau-Ting YEH, Yu-De CHU, Chun-Hung CHOU
  • Patent number: D1011483
    Type: Grant
    Filed: December 10, 2021
    Date of Patent: January 16, 2024
    Assignee: AS America, Inc.
    Inventors: Emilie Williams, Jian Zhang, Fen Liu
  • Patent number: D1018787
    Type: Grant
    Filed: December 10, 2021
    Date of Patent: March 19, 2024
    Assignee: AS America, Inc.
    Inventors: Emilie Williams, Jian Zhang, Fen Liu
  • Patent number: D1018790
    Type: Grant
    Filed: December 10, 2021
    Date of Patent: March 19, 2024
    Assignee: AS America, Inc.
    Inventors: Emilie Williams, Jian Zhang, Fen Liu
  • Patent number: D1034912
    Type: Grant
    Filed: January 12, 2021
    Date of Patent: July 9, 2024
    Assignee: AS America, Inc.
    Inventors: Jian Zhang, Fen Liu, Emilie Williams
  • Patent number: D1035834
    Type: Grant
    Filed: December 10, 2021
    Date of Patent: July 16, 2024
    Assignee: AS America, Inc.
    Inventors: Emilie Williams, Jian Zhang, Fen Liu
  • Patent number: D1035835
    Type: Grant
    Filed: December 10, 2021
    Date of Patent: July 16, 2024
    Assignee: AS America, Inc.
    Inventors: Emilie Williams, Jian Zhang, Fen Liu
  • Patent number: D1035839
    Type: Grant
    Filed: December 10, 2021
    Date of Patent: July 16, 2024
    Assignee: AS America, Inc.
    Inventors: Emilie Williams, Jian Zhang, Fen Liu