Patents by Inventor Fen Zhang

Fen Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190100597
    Abstract: This disclosure provides pentameric and hexameric CD20 binding molecules and methods of using such molecules to direct complement-mediated, T-cell-mediated, or both complement-mediated and T-cell-mediated killing of CD20-expressing cells.
    Type: Application
    Filed: March 4, 2015
    Publication date: April 4, 2019
    Applicant: IGM Biosciences, Inc.
    Inventors: Bruce Keyt, Omar Duramad, Beatrice Tien-Yi Wang, Ramesh Baliga, Fen Zhang
  • Patent number: 10189990
    Abstract: A composition includes specific amounts of a poly(phenylene ether), a polystyrene-poly(ethylene-butylene)-polystyrene triblock copolymer, an organophosphate ester, and compound that improves adhesion to potting silicone sealant. The adhesion promoter can be a phenolic compound, a hydroxysilyl-terminated polydiorganosiloxane, or a combination thereof. The composition is particularly useful for molding parts of photovoltaic junction boxes that utilize potting silicone sealant as an internal electrical insulator.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: January 29, 2019
    Assignee: SABIC GLOBAL TECHNOLOGIES B.V.
    Inventors: Fen Zhang, Mingcheng Guo
  • Publication number: 20190002566
    Abstract: The present invention concerns modified recombinant J-chain polypeptides, binding molecules, such as antibodies comprising the same, and their uses.
    Type: Application
    Filed: September 19, 2018
    Publication date: January 3, 2019
    Inventors: Bruce Alan Keyt, Leonard George Presta, Fen Zhang, Ramesh Baliga
  • Publication number: 20180355169
    Abstract: A composition includes specific amounts of a poly(phenylene ether), a polystyrene-poly(ethylene-butylene)-polystyrene triblock copolymer, an organophosphate ester, and compound that improves adhesion to potting silicone sealant. The adhesion promoter can be a phenolic compound, a hydroxysilyl-terminated polydiorganosiloxane, or a combination thereof. The composition is particularly useful for molding parts of photovoltaic junction boxes that utilize potting silicone sealant as an internal electric al insulator.
    Type: Application
    Filed: March 17, 2016
    Publication date: December 13, 2018
    Inventors: Fen Zhang, Mingcheng Guo
  • Publication number: 20180208643
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Application
    Filed: March 19, 2018
    Publication date: July 26, 2018
    Inventors: Donna M. AMBROSINO, Gregory J. BABCOCK, Teresa BROERING, Robert GRAZIANO, Hector Javier HERNANDEZ, Israel LOWY, Robert MANDELL, Deborah MOLRINE, William D. THOMAS, Jr., Hui-Fen ZHANG
  • Patent number: 10030069
    Abstract: Recombinant monoclonal antibodies to human cytomegalovirus (CMV) gB protein are described. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: July 24, 2018
    Assignee: Trellis Bioscience, LLC
    Inventors: Lawrence M. Kauvar, Stote Ellsworth, William Usinger, Krista Maureen McCutcheon, Ying-Ping Jiang, Fen Zhang, Bo Chen, Gizette Sperinde, Minha Park, Orit Foord
  • Patent number: 9951134
    Abstract: The present invention concerns modified recombinant J-chain polypeptides, binding molecules, such as antibodies, comprising the same, and their uses.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: April 24, 2018
    Assignee: IGM BIOSCIENCES A/S
    Inventors: Bruce Keyt, Leonard George Presta, Fen Zhang, Ramesh Baliga
  • Publication number: 20180072886
    Abstract: A poly(phenylene ether) composition comprises, based on the total weight of the poly(phenylene ether), addition polymer, impact modifier, and flame retardant: 40 to 90 weight percent of a poly(phenylene ether); 1 to 20 weight percent of an addition polymer comprising repeat units derived from a glycidyl ester of an ?,?-ethylenically unsaturated acid; 1 to 20 weight percent of an impact modifier other than the addition polymer; and 5 to 20 weight percent of a flame retardant comprising an organophosphate ester. The composition is useful for molding articles.
    Type: Application
    Filed: May 25, 2015
    Publication date: March 15, 2018
    Inventors: Fen Zhang, Mingcheng Guo
  • Publication number: 20170283510
    Abstract: The present invention concerns modified recombinant J-chain polypeptides, binding molecules, such as antibodies comprising the same, and their uses.
    Type: Application
    Filed: April 2, 2015
    Publication date: October 5, 2017
    Inventors: Bruce KEYT, Leonard George PRESTA, Fen ZHANG, Ramesh BALIGA
  • Publication number: 20170204165
    Abstract: Recombinant monoclonal antibodies to human cytomegalovirus (CMV) gB protein are described. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.
    Type: Application
    Filed: March 20, 2017
    Publication date: July 20, 2017
    Applicant: Trellis Bioscience, LLC
    Inventors: Lawrence M. KAUVAR, Stote ELLSWORTH, William USINGER, Krista Maureen MCCUTCHEON, Ying-Ping JIANG, Fen ZHANG, Bo CHEN, Gizette SPERINDE, Minha PARK, Orit FOORD
  • Publication number: 20170183409
    Abstract: The present invention concerns modified recombinant J-chain polypeptides, binding molecules, such as antibodies, comprising the same, and their uses.
    Type: Application
    Filed: March 7, 2017
    Publication date: June 29, 2017
    Inventors: Bruce Keyt, Leonard George Presta, Fen Zhang, Ramesh Baliga
  • Patent number: 9688744
    Abstract: Recombinant monoclonal antibodies to human cytomegalovirus (CMV) gB protein are described. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: June 27, 2017
    Assignee: Trellis Bioscience, LLC
    Inventors: Lawrence M. Kauvar, Stote Ellsworth, William Usinger, Krista Maureen McCutcheon, Ying-Ping Jiang, Fen Zhang, Bo Chen, Gizette Sperinde, Minha Park, Orit Foord
  • Publication number: 20160368971
    Abstract: The present invention concerns IgA multi-specific binding molecules. In particular, the invention concerns multi-specific, including bispecific, binding molecules comprising IgA heavy chain sequences, and methods for their preparation and use.
    Type: Application
    Filed: February 10, 2015
    Publication date: December 22, 2016
    Inventors: Bruce Keyt, Leonard George Presta, Fen Zhang, Stephen F. Carroll
  • Publication number: 20160222132
    Abstract: The present invention concerns binding molecules having a penta- or hexameric ring structure, such as for example, isolated IgM antibodies with five or six bispecific binding units, and methods and means for making and using the same. The invention further concerns multi-specific binding molecules having a penta- or hexameric ring structure, such as, for example, isolated IgM antibodies with five or six bispecific binding units, and methods and means for making and using the same.
    Type: Application
    Filed: September 4, 2014
    Publication date: August 4, 2016
    Applicant: IGM BIOSCIENES, INC
    Inventors: Bruce Keyt, Fen Zhang, Leonard Presta, Rency Yoshimura
  • Patent number: 9377464
    Abstract: The present invention provides a method of producing a crystalline rare earth phosphate nanostructure. The method comprising: providing a rare earth metal precursor solution and providing a phosphate precursor solution; placing a porous membrane between the metal precursor solution and the phosphate precursor solution, wherein metal cations of the metal precursor solution and phosphate ions of the phosphate precursor solution react, thereby producing a crystalline rare earth metal phosphate nanostructure.
    Type: Grant
    Filed: April 2, 2014
    Date of Patent: June 28, 2016
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE OF UNIVERSITY OF NEW YORK
    Inventors: Stanislaus Wong, Fen Zhang
  • Publication number: 20160152694
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Application
    Filed: October 29, 2015
    Publication date: June 2, 2016
    Inventors: Donna M. AMBROSINO, Gregory J. BABCOCK, Teresa BROERING, Robert GRAZIANO, Hector Javier HERNANDEZ, Israel LOWY, Robert MANDELL, Deborah MOLRINE, William D. THOMAS, JR., Hui-Fen ZHANG
  • Patent number: 9217029
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: December 22, 2015
    Assignees: UNIVERSITY OF MASSACHUSETTS, E. R. SQUIBB & SONS, L.L.C.
    Inventors: Donna M. Ambrosino, Gregory J. Babcock, Teresa Broering, Robert Graziano, Hector Javier Hernandez, Israel Lowy, Robert Mandell, Deborah Molrine, William D. Thomas, Jr., Hui-Fen Zhang
  • Publication number: 20150252099
    Abstract: Recombinant monoclonal antibodies to human cytomegalovirus (CMV) gB protein are described. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.
    Type: Application
    Filed: April 27, 2015
    Publication date: September 10, 2015
    Inventors: Lawrence M. KAUVAR, Stote ELLSWORTH, William USINGER, Krista Maureen MCCUTCHEON, Ying-Ping JIANG, Fen ZHANG, Bo CHEN, Gizette SPERINDE, Minha PARK, Orit FOORD
  • Patent number: 9017668
    Abstract: Antibodies to human Cytomegalovirus (CMV) gB protein have been isolated from human B cells. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: April 28, 2015
    Assignee: Trellis Bioscience, LLC
    Inventors: Lawrence M. Kauvar, Stote Ellsworth, William Usinger, Krista Maureen McCutcheon, Ying-Ping Jiang, Fen Zhang, Bo Chen, Gizette Sperinde, Minha Park, Orit Foord
  • Patent number: 9014099
    Abstract: A packet switched domain service processing method and device. The method is applied to a mobile terminal and includes allocating a plurality of Packet Data Protocol (PDP) link resources to a plurality of Packet Switched (PS) domain services, and using a plurality of PS domain services transmitting data on the PDP link resources allocated thereto, in order to improve data transmission rate.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: April 21, 2015
    Assignee: ZTE Corporation
    Inventors: Fen Zhang, Kai Chen