Abstract: The present disclosure relates to a viral vector having an exogenous RNA segment with a hairpin-like structure, for example having two or more base-paired regions separated by one or more non-base-paired regions. The exogenous RNA segment may have a secondary structure, minimum free energy, average positional entropy or other attributes within specified ranges, or with values similar to one or more hairpin-like structures of a reference wild type virus.

Abstract: The present disclosure provides a broad-spectrum bispecific antibody against novel coronaviruses, comprising a first targeting domain D1 targeting a first epitope of a SARS-CoV-2 RBD domain, and a second targeting domain D2 targeting a second epitope of the SARS-CoV-2 RBD domain. The bispecific antibody of the present disclosure has a broad-spectrum neutralizing activity and can effectively neutralize SARS-CoV-2 and various highly infectious and harmful SARS-CoV-2 variant strains, thus showing significant application value in the prevention, treatment, and/or detection of infections caused by novel coronaviruses.

Abstract: A printed circuit board, which may be included an electronic communication device, includes a substrate, a bonding layer, a copper foil, and a filler. The substrate is provided with a cavity, and the cavity penetrates through the substrate. Two surfaces of the substrate are covered with the copper foil. The copper foil is bonded to the substrate by using the bonding layer. An outer surface of the copper foil is plated with a conductive metal layer. The filler is located inside the cavity. The substrate is provided with a through hole, and the through hole penetrates through the substrate and the bonding layer. A hole wall of the through hole is plated with a conductive metal layer. In this application, a dielectric constant Dk and a dielectric loss Df of the printed circuit board can be effectively reduced, and cost control is ensured.

Abstract: A desk frame for a desk and such a desk; the frame including two leg assemblies and a telescopic crossbar therebetween, an upper portion of each assembly provided with a support portion; the telescopic crossbar including first and second crossbars which are fitted together and extendable/retractable relative to each other; a partition groove is provided on the first crossbar, configured to divide it into upper and lower crossbars; when the telescopic crossbar is extended, a fitted section of the second crossbar is lifted by the lower crossbar so its upper end is higher than the support portions, and a fitted section of the upper crossbar is lifted by the second so its upper end is higher, whereby the frame presses against the desktop to provide support. Further, a partial structure of the telescopic crossbar is lifted to press against the desktop, thereby enhancing strength of the crossbar against the desktop.

Abstract: The present invention provides a WRN helicase inhibitor as represented by the compound in formula (I) or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof.

Abstract: Provided is a compound of formula (I) serving as a WRN inhibitor, as well as a compound or a pharmaceutically acceptable salt, isotopic variant, tautomer, or stereoisomer thereof. Further provided are a pharmaceutical composition including said compound and a use thereof in the treatment of a cancer.

Abstract: The present disclosure relates to a head-mounted display device, including: a head-mounted display portion, and a control portion in signal connection with the head-mounted display portion; the control portion includes a main battery, an auxiliary battery, and a switching circuit module connected to the main and auxiliary batteries. The switching circuit module is used for power supply switching between the main battery and the auxiliary battery, and includes a first trigger connector and a second trigger connector having a first state and a second state; in the first state, the first trigger connector and the second trigger connector are in an off-state, the main battery supplies power; in the second state, the first trigger connector and the second trigger connector are in an on-state to trigger a switching signal to switch to the auxiliary battery for power supply. The present disclosure further relates to a communication command system.

Abstract: A exhausted-tobacco tablet that includes a solid solution of soluble fiber and one or more sugar alcohols, the solid solution having a glass transition temperature of less than 40° C., and exhausted-tobacco is dispersed in the solid solution, and one or more additives dispersed in the solid solution such that at least one additive is released from the tablet when the tablet is chewed or dissolved within an adult tobacco consumer's oral cavity.

Abstract: The present disclosure relates to a display device, a door body and a cabinet body. The display device includes: an information collecting assembly configured to collect environment information; a communication module configured to perform wireless-communication linking to an Internet-of-Things device, to transmit the environment information to the Internet-of-Things device, and receive multimedia information sent by the Internet-of-Things device; and a display module configured to display the multimedia information, wherein the multimedia information includes audio-video advertisement information.

Abstract: Disclosed are a fused tricyclic derivative and a pharmaceutical application thereof. Specifically disclosed are a compound represented by formula (III) and a pharmaceutically acceptable salt thereof.

Abstract: This application provides a photovoltaic inverter and a rotary switch. The photovoltaic inverter includes the rotary switch. The rotary switch includes a switch body. The switch body includes an insulation housing and a plurality of pins. Ends of the plurality of pins extending out of the insulation housing are connected to a circuit board. The rotary switch is a multipole switch. Each pole of the rotary switch includes two pins. The insulation housing is provided with a groove or a boss between two pins that are located on a same side and that are of two adjacent poles. Alternatively, a portion that is of each pin and that is located between the insulation housing and the circuit board is surrounded by a rib.

Abstract: This application provides a photovoltaic inverter and a power conversion apparatus. The photovoltaic inverter includes: a housing, a circuit board, a rotary switch, a photovoltaic connector, a signal connector, and an alternating current connector. The housing includes a shell and a cover plate. The shell and the cover plate enclose an accommodating chamber. The shell includes a first side plate and a second side plate that are adjacent. The circuit board is disposed in the accommodating chamber. The rotary switch, the photovoltaic connector, the signal connector, and the alternating current connector are all connected to the circuit board through a rigid metal conductor. The photovoltaic connector, the signal connector, and the alternating current connector are installed on the first side plate. The signal connector is located between the photovoltaic connector and the alternating current connector. The rotary switch is installed on the second side plate.

Abstract: An adaptive positioning apparatus for thin-walled nozzles is provided, including a forming die, a positioning sleeve and a mandrel. An outer profile of the forming die matches an inner profile of the thin-walled nozzle. The forming die is forced by a spring to surround the positioning sleeve. The positioning sleeve is fixed to the mandrel by a set screw. An inner side of the forming die has a curved surface. By adjusting a relative position between the forming die and the positioning sleeve, a truncated-cone portion of the positioning sleeve expands the forming die outwardly, such that the forming die abuts against the inner profile of the thin-walled nozzle, thereby achieving support of the thin-walled nozzle. An adaptive positioning method for a thin-walled nozzle is also provided.

Abstract: Disclosed are a cell electricity quantity balancing module, a balancing method, a heating method and an apparatus, solving problems of complex circuits, poor flexibility, and inability to balance thermal management in the prior art. The module includes two cell side coils, a balancing coil, and three DC/AC converters corresponding to coils, where an AC terminal of a first DC/AC converter is connected in parallel with one cell side coil, a DC terminal is connected in parallel with positive and negative poles of a first adjacent cell; an AC terminal of a second DC/AC converter is connected in parallel with the other cell side coil, a DC terminal is connected in parallel with positive and negative poles of a second adjacent cell; and an AC terminal of a third DC/AC converter is connected in parallel with the balancing coil, a DC terminalis connected in parallel with a direct currentbus.

Abstract: Disclosed is a system of measurement for optical loss that includes the light source unit that is further provided to the first fiber port assembly. The first fiber port assembly is connected with the first grating coupler unit. The first grating coupler unit is connected with the splitter unit. The splitter unit diverts the light to the plurality of routes. The plurality of route is combined with the combiner module. The combiner module is connected with the second grating coupler unit. The second grating coupler unit is connected with the second fiber port assembly. The second fiber port assembly is connected with an optical power detector module.

Abstract: A chiral bimetallic cooperative catalysis system containing a chelating ligand and use thereof in asymmetric synthesis of bedaquiline are provided. Specifically, in the chiral bimetallic cooperative catalysis system, an equilibrium constant of a reaction is increased by the chelating ligand formed by an achiral secondary amine and chiral lithium aminoalcohol, thereby promoting an addition reaction between 6-bromo-3-benzyl-2-methoxyquinoline (I) and 3-dimethylamino-1-naphthyl-1-propanone (II) to move forward. By means of the bimetallic cooperative catalysis system, the yield of the target product (1R,2S)-bedaquiline is obviously increased.

Abstract: A method for encapsulating an active material may include contacting an absorbing matrix material with a first solution to impregnate the absorbing matrix material with the first active material, where the first solution includes the first active material and a first solvent. The contacting may include at least one of soaking the absorbing matrix material in the first solution and spraying the absorbing matrix material with the first solution. The method may further include contacting the impregnated absorbing matrix material with a second solution that is the same as or different form the first solution. The second solution may include a second active material and a second solvent. The method may further include one or more drying steps to remove the first solvent and/or the second solvent.

Abstract: An oral pouch product includes a wrapper and a filler. The wrapper defines a cavity. The filler is in the cavity. The filler includes a dry mixture and a liquid mixture. The dry mixture includes a cellulosic material and a water-soluble filler. The liquid mixture includes oil, water, and liquid nicotine. The oil includes a triglyceride, a diglyceride, a monoglyceride, or any combination thereof. The liquid nicotine is dissolved in the oil and the water.

Abstract: A mobile device includes a primary battery and a secondary battery, and the mobile device further includes: a power supply control module and a main control module connected to each other, where the power supply control module is respectively connected to the primary battery and the secondary battery; and the main control module is configured to control the primary battery to supply power to the mobile device when it is determined that the primary battery and the mobile device are in the power-on state; and control a power supply of the mobile device to be switched from the primary battery to the secondary battery when it is determined that the primary battery and the mobile device are in the power-off state.