Abstract: Compositions and methods of producing vaccines, including methods wherein whole organism vaccines are provided with limited replication abilities, thereby increasing vaccine safety and efficacy, through the use of non-natural, unnatural, or non-naturally encoded amino acids.

Abstract: A wearable device is provided, including a shell, a body installed in the shell to implement a function of the wearable device, and a detachable part. The detachable part is detachably installed on the shell. An air hole is provided on the shell, a first end of the air hole is located on a surface of the shell that faces the body, and a second end of the air hole is located on a surface of the shell that faces away from the body. The detachable part and the shell jointly form a dirt collection groove and at least one air channel, the air hole communicates with the at least one air channel through the dirt collection groove, and an end of the air channel that faces away from the dirt collection groove communicates with an external environment of the shell.

Abstract: A system is provided that encodes one or more dynamic haptic effects. The system defines a dynamic haptic effect as including a plurality of key frames, where each key frame includes an interpolant value and a corresponding haptic effect. An interpolant value is a value that specifies where an interpolation occurs. The system generates a haptic effect file, and stores the dynamic haptic effect within the haptic effect file.

Abstract: The disclosure relates to a method for constructing a plasma Deoxyribonucleic acid (DNA) sequencing library. The method includes: extracting a plasma DNA; making the plasma DNA ligate to a sequencing linker, and purifying a ligation product; performing Polymerase Chain Reaction (PCR) amplification for the purified ligation product, purifying the PCR amplification product, and obtaining the plasma DNA sequencing library, wherein, the method does not include the step of performing 5?-terminus phosphorylation for the plasma DNA.

Abstract: The disclosure relates a method for constructing a plasma Deoxyribonucleic acid (DNA) sequencing library. The method includes: extracting a plasma DNA; making the plasma DNA ligate to a sequencing linker, and purifying a ligation product; performing Polymerase Chain Reaction (PCR) amplification for the purified ligation product, purifying the PCR amplification product, and obtaining the plasma DNA sequencing library, wherein, the method does not include the step of performing 5?-terminus phosphorylation for the plasma DNA. The kit provided by the disclosure includes: a reagent which ligates a plasma DNA to a sequencing linker, including the sequencing linker, a ligase and a ligation buffer; and reagents and instruments for purifying the ligation product; a reagent which performs PCR amplification for a purified ligation product, and reagents and instruments for purifying the PCR amplification product; wherein, the kit does not include the reagent which performs 5?-terminus phosphorylation for the plasma DNA.

Abstract: A kitchen appliance (10) is disclosed for cooking a meat product (1). The kitchen appliance comprises a heating element (11) adapted to heat a medium (13) for transferring heat to the meat product; a sensor (15, 25) for detecting loss of water from a contact surface of the meat product with the medium; and a controller (17) conductively coupled to the sensor. The controller is adapted to process a sensor signal produced by the sensor; and generate a control signal indicative of the meat product reaching a defined cooking state in response to the processed sensor signal being indicative of a loss of water associated with the desired cooking state from the contact surface of the meat product. A method of monitoring cooking of a meat product by such a kitchen appliance is also disclosed.

Abstract: In an example method, a computer system receives a query for data stored in a relational database management system. The query includes one or more first functions of a first programming language, and one or more second functions specifying computer code of a second programming language different from the first programming language. The computer system generates a logical query plan based on the query, including one or more first logical nodes corresponding to the one or more first functions, and one or more second logical nodes corresponding to the one or more second functions in an interconnected logical tree. The computer system generates a physical execution plan based on the logical query plan, and executes the physical execution plan to retrieve the data stored in the relational database management system.

Abstract: The present invention provides for novel compounds of Formulas I and II and pharmaceutically acceptable salts and co-crystals thereof which have glucokinsae activator activity. The present invention further provides for pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucokinase activator is indicated, including Type 1 and 2 diabetes, impaired glucose tolerance, insulin resistance and hyperglycemia. The present invention also provides for processes of making the compounds of Formulas I and II, including salts and co-crystals thereof, and pharmaceutical compositions comprising the same.

Abstract: The present disclosure is directed to an optical device including at least one temperature-dependent tunable element for controlling a wavelength of an optical signal, a first sensor configured to indirectly monitor the optical signal, a second sensor configured to directly monitor the optical signal, and a control circuit. The tunable element may be one of (i) a laser for transmitting an outgoing optical signal and (ii) an optical filter coupled to a photodetector for receiving an incoming optical signal. The control circuit may be configured to receive first and second inputs from the first and second sensors, respectively, adjust the tuned wavelength of the tunable element from a first preselected wavelength to a second preselected wavelength based on the first input received from the first sensor, and maintain the tunable element at the second preselected frequency based on the second input received from the second sensor.

Abstract: The present invention provides a pallet carrier, comprising a carrier frame structure; a fork structure disposed on the carrier frame structure; a driving wheel structure comprising driving wheels that are articulated to the carrier frame structure, wherein each one of the driving wheels is set as a one-piece wheel structure integrated with a driving motor and a hub. The pallet carrier has the advantages of simple structure and work reliability.

Abstract: The present disclosure is directed to an optical device including at least one temperature-dependent tunable element for controlling a wavelength of an optical signal, a first temperature control circuit for controlling a temperature of a first region of the optical device; and a second temperature control circuit for controlling a temperature of a second region of the optical device. The second region may include a portion of the first region. The second region may be smaller than the first region. The tunable element may be positioned in the second region such that a temperature of the tunable element is controlled based on the second temperature control circuit controlling the temperature of the second region. The tunable element may be one of (i) a laser for transmitting an outgoing optical signal and (ii) an optical filter coupled to a photodetector for receiving an incoming optical signal.

Abstract: Described herein are novel anti-CD3 antibodies conjugated to folate and uses thereof treatment of diseases or conditions that would benefit from such conjugate are provided.

Abstract: The present invention provides an electric pullet truck in the technical field of land transportation equipment. The electric pullet truck comprises a frame including two forks; a steering drive assembly including i) a drive wheel component disposed behind the frame; ii) an oil cylinder component to drive the forks up, which includes a cylinder body and a plunger which could telescopically move within the cylinder body, wherein the cylinder body is fixedly connected with the drive wheel component; iii) a supporting seat component including an annular sleeve and two support arms extending from both sides of the annular sleeve, wherein the annular sleeve is covered outside of a lower portion of the oil cylinder body; and iv) a handle seat component fixedly connected with an upper portion of the cylinder body. The electric pullet truck of the invention has advantages like a high degree of integration and smooth steering.

Abstract: A system is provided that encodes one or more dynamic haptic effects. The system defines a dynamic haptic effect as including a plurality of key frames, where each key frame includes an interpolant value and a corresponding haptic effect. An interpolant value is a value that specifies where an interpolation occurs. The system generates a haptic effect file, and stores the dynamic haptic effect within the haptic effect file.

Abstract: An apparatus for abatement of gases is provided. The apparatus includes a toroidal plasma chamber having a plurality of inlets and an outlet, and at least one chamber wall. One or more magnetic cores are disposed relative to the toroidal plasma chamber. The plasma chamber confines a toroidal plasma. A second gas inlet is positioned on the toroidal plasma chamber between a first gas inlet and the gas outlet at a distance d from the gas outlet, such that a toroidal plasma channel volume between the first gas inlet and the second gas inlet in the is substantially filled by the inert gas, the distance d based on a desired residence time of the gas to be abated.

Abstract: The present invention provides for novel compounds of Formulas I and II and pharmaceutically acceptable salts and co-crystals thereof which have glucokinsae activator activity. The present invention further provides for pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucokinase activator is indicated, including Type 1 and 2 diabetes, impaired glucose tolerance, insulin resistance and hyperglycemia. The present invention also provides for processes of making the compounds of Formulas I and II, including salts and co-crystals thereof, and pharmaceutical compositions comprising the same.

Abstract: A plug connector includes a dielectric body having a docking surface, a circuit board mounted to a rear of the dielectric body, a plurality of first terminals and a second terminal. The plurality of the first terminals are fastened to the dielectric body. Top surfaces of front ends of the plurality of the first terminals are exposed to the docking surface of the dielectric body. Rear ends of the plurality of the first terminals project beyond a rear surface of the dielectric body and are soldered to the circuit board. The second terminal is fastened to the dielectric body. A front end of the second terminal elastically projects beyond the docking surface of the dielectric body, and a rear end of the second terminal projects beyond the rear surface of the dielectric body and is soldered to the circuit board.

Abstract: An apparatus for abatement of gases is provided. The apparatus includes a toroidal plasma chamber having a plurality of inlets and an outlet, and at least one chamber wall. One or more magnetic cores are disposed relative to the toroidal plasma chamber. The plasma chamber confines a toroidal plasma. A second gas inlet is positioned on the toroidal plasma chamber between a first gas inlet and the gas outlet at a distance d from the gas outlet, such that a toroidal plasma channel volume between the first gas inlet and the second gas inlet in the is substantially filled by the inert gas, the distance d based on a desired residence time of the gas to be abated.