Abstract: The present disclosure provides antisense compounds, methods, and compositions for increasing FXN gene expression. The present disclosure provides antisense compounds, methods, and compositions for the treatment, prevention, or amelioration of diseases, disorders, and conditions associated with FXN in a subject in need thereof. Also contemplated are antisense compounds and methods for the preparation of a medicament for the treatment, prevention, or amelioration of a disease, disorder, or condition associated with FXN.

Abstract: The present disclosure provides a power end housing for a plunger pump and a plunger pump including the power end housing. The power end housing includes: an integrated crankcase, where the crankcase includes a plurality of bearing seats and supported by support vertical plates, the support vertical plates are spaced apart in an axial direction of the bearing seats, and the crankcase includes a first reinforcing rib between every two support vertical plates, wherein an angle between a direction of a maximum resultant force on the bearing seats and an axial direction of a plunger of the plunger pump is ?max, an angle between the first reinforcing rib and the axial direction of the plunger is a first angle, and the first angle is greater than or equal to 0.8 ?max and less than or equal to 1.2 ?max.

Abstract: A flip-chip light-emitting diode (LED) includes: a substrate having a patterned surface formed with a protrusion unit including first and second protrusions; a light-emitting epitaxial layer that is disposed on the second protrusions and that includes first and second semiconductor layers and an active layer interposed therebetween; first and second electrodes connected to the first and second semiconductor layers, respectively; and a passivation layer having an epitaxial-covering portion and a substrate-covering portion. The substrate-covering portion of the passivation layer has a top surface with hillocks having a height lower than that of the second protrusions. A high-voltage light-emitting device is also disclosed.

Abstract: The invention discloses a multi-dimensional feature acquisition device for acquiring the features of shallow-needle acupuncture techniques. The multi-dimensional feature acquisition device includes a pressing pressure signal acquisition module and a data processing module. The pressing pressure signal acquisition module is used for acquiring pressing pressure signals during the shallow-needle acupuncture. The data processing module is electrically connected to the pressing pressure signal acquisition module to receive, analyze and process the pressing pressure signals, and obtain pressing-pressure parameters, thereby providing reference pressing pressure parameters for the shallow acupuncture instrument. The shallow acupuncture instrument does not enter the vibration working mode when the pressing pressure value is not within the required range.

Abstract: The invention relates to the technical field of shallow-needle acupuncture in Traditional Chinese Medicine, and discloses a control device of a shallow acupuncture instrument, as well as a system and a method for simulating the features of the shallow-needle acupuncture techniques. The shallow acupuncture instrument includes a vibration device and a control device. The control device includes a microcontroller and a power amplifier circuit. The microcontroller is used to process the waveform based on vibration parameters acquired from external inputs, obtain the waveform data of vibration modes, and transmit the waveform data to the amplifier circuit. When the first pressure parameter acquired by the vibration device reaches the preset working threshold, the power amplifier circuit drives the vibration device to vibrate after amplifying the waveform data of vibration modes.

Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a user equipment (UE) may receive information indicating whether hybrid automatic repeat request (HARQ) feedback is disabled for one or more HARQ processes. The UE may receive a downlink communication. The downlink communication may include a HARQ process identifier that indicates a HARQ process to be used for the downlink communication. The UE may selectively provide HARQ feedback for the downlink communication based at least in part on the HARQ identifier and information indicating whether HARQ feedback is disabled for the HARQ process. Numerous other aspects are provided.

Abstract: Using machine learning and data sampling to optimize data reduction, including: collecting a plurality of data samples from data stored in a storage system; calculating, based on the plurality of data samples, a deduplication ratio; calculating, based on the plurality of data samples, a compression ratio; and performing a data reduction resource allocation in the storage system based on the deduplication ratio and the compression ratio.

Abstract: A spraying system, a method and an apparatus for controlling the spraying system, an electronic device, a computer-readable storage medium, and an air conditioner are provided. The spray system includes a water outlet device, a spraying branch, a backflow branch, and a nozzle; a water outlet of the water outlet device, the spraying branch, and the nozzle are communicated sequentially; a solenoid valve is arranged in the spraying branch and/or the backflow branch, and the solenoid valve is used for controlling turning on and turning off of the spraying branch and/or the backflow branch; when the spraying branch is turned on, liquid flowing out of the water outlet device flows out of the nozzle through the spraying branch; when the backflow branch is turned on, the liquid flowing out of the water outlet device flows into the water outlet device through the backflow branch.

Abstract: The invention discloses a vibrator structure of a shallow acupuncture instrument. The vibrator structure includes a vibrating head and a vibration generation component. The vibrating head is in contact with the vibration generation component. The bottom of the vibrating head is in contact with the vibration generation component, and its tip is contacting acupuncture recipient. The vibration generational component is electrically connected to a power amplifier circuit which amplifies electric signals corresponding to vibration parameters. The amplified electric signals, corresponding to the vibration parameters, drive the vibration generation component to vibrate. The generated vibration is then transmitted to the vibrating head, thereby reproducing the vibration waves of shallow-needle acupuncture techniques.

Abstract: The method includes: obtaining at least one of gas data and pipeline data based on a gas device object platform; assessing a health state of the appurtenances based on at least one of the gas data and the pipeline data; the health state including at least one of a drainer state and a compensator state; determining at least one maintenance parameter of the appurtenances based on the health state; dynamically adjusting at least one transportation parameter of gas based on the health state and the at least one maintenance parameter; sending at least one adjusted transportation parameter to a gas operation user platform; and determining a maintenance program based on the at least one maintenance parameter, and the at least one adjusted transportation parameter, and uploading the maintenance program to a government safety supervision and management platform.

Abstract: Non-terrestrial networks (NTNs) may establish uplink (UL) and downlink (DL) radio frame timing structures to efficiently account for propagation delay and propagation delay variation associated with communications in the NTN. NTNs may manage (synchronize) radio frame timing structures of base stations (e.g., satellites) and user equipment (UEs) in the NTN. Further, UEs may determine timing advance (TA) values to be applied to UL transmissions based on their respective scheduling offset (e.g., offset in UL and DL radio frame timing structures), as well as based on propagation delay or round trip time (RTT). As such, served UEs may determine UL timing such that UL transmissions from the UEs to a satellite arrives at the satellite in a time synchronized manner. In other cases, a satellite may determine UL timing, based on reception timing, such that various UEs in the NTN may implement uniform UL and DL radio frame timing structures.

Abstract: A method, base station (BS), user equipment (UE), apparatus, and computer program product for wireless communication are provided. A BS and a UE may communicate using a narrowband Internet of Things (NB-IoT) communication system. However, a frequency, time, and/or power associated with transmission of a SIB1-NB on a non-anchor carrier may not be configured for NB-IoT. In some aspects, the BS may determine parameters, such as a time domain location parameter, a frequency domain location parameter, a quantity of repetitions, a power boosting parameter, and/or the like for a transmission in NB-IoT. In some aspects, a UE may determine to transmit a connection request message on a different carrier than a random access channel message.

Abstract: A method for determining updates in a building management system (BMS) is shown. The method includes receiving, via an on premise server, configuration data associated with at least part of the BMS. The method includes storing the configuration data within a cloud server communicably coupled with the on premise server. The method includes determining, via a difference engine within the cloud server, information comprising a delta between the configuration data and one or more previous sets of configuration data stored within the cloud server. The method includes providing, to the on premise server, the information to an interface.

Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a user equipment (UE) may obtain emission control information that indicates a first emission control configuration associated with a first operating configuration and a second emission control configuration associated with a second operating configuration. The UE may transmit, using the first emission control configuration or the second emission control configuration based at least in part on a UE operating configuration associated with the UE, a communication. Numerous other aspects are described.

Abstract: A communication method and a communication apparatus are provided. The communication method includes: A first communication apparatus and a second communication apparatus determine a first identifier based on a second identifier, where a length of the first identifier is less than a length of the second identifier, and the second identifier is an identifier of the first communication apparatus. The second communication apparatus sends a first message; and correspondingly, the first communication apparatus receives the first message, where the first message includes the first identifier. The first communication apparatus wakes up. According to embodiments of this application, a quantity of bits occupied by the identifier of the first communication apparatus in the first message can be reduced, so that a capacity of the first message is increased, and the first message can be used to wake up more communication apparatuses.

Abstract: This application provides a communication method and apparatus. The method includes: A terminal device receives a wake-up signal from a network device, where the wake-up signal includes a first identifier; and when the first identifier is an identifier of the terminal device, the terminal device receives paging-related information based on a length of the first identifier or initiates random access based on a length of the first identifier. In the technical solutions provided in this application, the terminal device may receive the paging-related information or initiate random access based on the length of the identifier of the terminal device in the wake-up signal, to reduce power consumption.

Abstract: The present disclosure provides a filter, an adapter, and a microvolume ultrafiltration bottle. The filter comprises a tubular structure that penetrates vertically. The inner wall of the tubular structure gradually converges from top to bottom towards the centerline to form an inverted tapered inner cavity structure, with a tapered hole at the bottom of the inverted tapered inner cavity structure. A filter disc connection part is arranged at the lower end of the tubular structure, and a bottom flow guiding channel or bottom flow guiding zone is arranged between the tapered hole and the filter disc connection part. The inner wall of the lower end of the adapter is connected with the filter. The microvolume ultrafiltration bottle comprises a bottle body and the adapter arranged at the bottle mouth and extending downwards into the bottle body, with the filter connected with the bottom of the adapter.

Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a user equipment (UE) may transmit, to a distributed unit (DU) of a network node associated with a non-terrestrial network (NTN), an uplink transmission, wherein the DU is onboard a satellite and a central unit (CU) of the network node is on ground. The UE may receive, from the DU, a downlink transmission based at least in part on a delayed downlink channel monitoring window, wherein the delayed downlink channel monitoring window is based at least in part on a first time offset and a second time offset, the first time offset is associated with a UE-DU round-trip time (RTT), and the second time offset is associated with a CU-DU RTT. Numerous other aspects are described.

Abstract: The invention relates to peptides, proteins, nucleic acids, and cells for use in immunotherapeutic methods. In particular, the invention relates to the immunotherapy of cancer. The invention provides T cell receptors (TCRs), tumor infiltrating lymphocytes (TILs), and vaccines that recognize HERV-K. The invention provides TCR sequences generated from tumor infiltrating lymphocytes that recognize HERV-K antigens as peptides bound to the Major Histocompatibility Complex (MHC), resulting in an interaction between the HLA-peptide complex and the CDS TCR. Peptides bound to molecules of the MHC, or peptides as such, can also be targets of antibodies, soluble TCRs, and other binding molecules.

Abstract: An oscillating tool includes a housing; a motor in the housing; a first blade clamp; a blade clamp shaft; and a second blade clamp on the blade clamp shaft. The blade clamp shaft includes a latching portion to engage a seat. The oscillating tool also includes a blade clamp spring configured to bias the latching portion into engagement with the seat.