Abstract: The present invention relates to a pharmaceutical composition containing alkynyl compound, a preparation method thereof and its application. The present invention discloses a pharmaceutical composition comprising an active pharmaceutical ingredient and an available pharmaceutical excipient; The active pharmaceutical ingredient is 3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide, or its pharmaceutical acceptable salt; The available pharmaceutical excipients includes diluents and lubricants. The pharmaceutical composition can effectively improve the bioavailability of the alkynyl compound, has good dissolution and stability, and improve the drug safety.

Abstract: Provided is a portable automated chest-abdominal compression (CC-AC) device used in confined spaces and a manipulation method thereof, comprising: a compression mechanism having a strap fixing module, a compression plate connected to the strap fixing module and a compression piston arranged on one side of the compression plate; a detection module having a displacement sensor and a pressure sensor; a control module receiving compression depth and pressure, and obtaining a compensation value of time of a single compression according to the compression depth and a target depth, thereby controlling an action of a driving mechanism during the CC process; constructing an abdominal mechanics model according to the compression depth and pressure, and compensating the compression depth according to the target pressure by using the abdominal mechanics model, thereby controlling the action of the driving mechanism during the AC process.

Abstract: Provided is a detection method for a spinning workshop, an electronic device and a storage medium; relating to the field of data processing. The method includes: performing image collection on a process control device of a spinning box in the spinning workshop to obtain an image to be processed; extracting a first image feature from the image to be processed; and processing the first image feature based on a decoder network to obtain a fault detection result. The decoder network comprises a plurality of decoder modules connected in series in sequence. Each decoder module includes a decoder layer and an adaptive classification head. The adaptive classification head is configured to perform classified prediction on an output feature of the decoder layer to obtain a first fault classification result. The fault detection result output by the decoder network includes a second fault classification result and a fault position.

Abstract: A package substrate and package assembly including a package substrate including a substrate body including electrical routing features therein and a surface layer and a plurality of first and second contact points on the surface layer including a first pitch and a second pitch, respectively, wherein the plurality of first contact points and the plurality of second contact points are continuous posts to the respective ones of the electrical routing features. A method including forming first conductive vias in a package assembly, wherein the first conductive vias include substrate conductive vias to electrical routing features in a package substrate and bridge conductive vias to bridge surface routing features of a bridge substrate; forming a first surface layer and a second surface layer on the package substrate; and forming second conductive vias through each of the first surface layer and the second surface layer to the bridge conductive vias.

Abstract: Computer-implemented peer-engagement through graphical definition of contact-generating events in a virtualized metaverse includes visually presenting to a user, on an interactive interface, a multi-dimensional scene of a virtual environment. The user provides input to graphically define one or more contact-generating events within the multi-dimensional scene, which events are detected as being triggered by one or more virtualized avatars in the multi-dimensional scene. According to the triggering of the events and other predefined contact-engaging criteria, a contact-initiating prompt may be transmitted to a peer user associated with the one or more virtualized avatars in the multi-dimensional scene.

Abstract: An amine-functionalized adsorbent and a method for preparing the same are provided. The amine-functionalized adsorbent includes a metal-organic framework (MOF) material and polymeric amine, the crystal structure of the MOF material is a three-dimensional cage-like pore structure, and the polymeric amine is loaded inside the three-dimensional cage-like pore structure. The amine-functionalized adsorbent has high adsorption capacity and rapid adsorbing speed of carbon dioxide at room temperature.

Abstract: A negative electrode for a lithium-ion battery includes a negative electrode current collector, a negative electrode active layer disposed over the negative electrode current collector, and a ceramic particle-containing layer disposed over the negative electrode active layer. The negative electrode active layer is composed of negative electrode active material. Advantageously, the ceramic particle-containing layer is composed of ceramic particles and a binder where the binder is composed of the residues of cross-linkable monomers.

Abstract: An antenna structure and a manufacturing method therefor are disclosed. The antenna structure may include: a feed power dividing plate provided with a slot, an inner wall of the slot is metallized, and pads are arranged on two sides of the slot; and an isolating bar provided with a pin configured to be inserted into the slot, the isolating bar being welded to the feed power dividing plate through the pads based on a through-hole reflow soldering process.

Abstract: A signal processing method applied to a transmit end includes obtaining an LDPC encoded signal based on a to-be-sent signal; then, modulating the LDPC encoded signal into a PAM8 symbol; and further, sending the PAM8 symbol to a receive end through a network cable.

Abstract: The present disclosure provides a method for performing a programming operation on a memory cell connected to a bit line and controlled by a word line. The method includes applying a first programming voltage signal to the word line to program the memory cell into a first state, applying a first voltage to the bit line, performing a verify operation when the memory cell is in a second state, determining a classification of the memory cell based on the verify operation, applying a second voltage to the bit line based on the determined classification, applying a second programming voltage signal to the word line to program the memory cell into the first state, applying a third voltage to the bit line, applying a third programming voltage signal to the word line to program the memory cell into the first state, and applying a fourth voltage to the bit line.

Abstract: A method for asymmetrically preparing L-phosphinothricin by oxidation-reduction reaction through biological multienzyme coupling, where D,L-phosphinothricin as a raw material is catalyzed by an enzyme catalysis system to obtain L-phosphinothricin, wherein the enzyme catalysis system comprises a D-amino acid oxidase mutant for catalyzing D-phosphinothricin in D,L-phosphinothricin into 2-carbonyl-4-[hydroxy(methyl)phosphono] butyric acid and a transaminase for catalytic reduction of the 2-carbonyl-4-[hydroxy(methyl)phosphono] butyric acid into L-phosphinothricin; the D-amino acid oxidase mutant is obtained by mutation of D-amino acid oxidase in wild strain Rhodotorula taiwanensis at one of the following sites: (1) M213S-N54V-F58E; (2) M213S-N54V-F58E-D207A; (3) M213S-N54V-F58E-D207A-S60T.

Abstract: Provided is an imageable composition for a photosensitive negative-working lithographic printing plate, and a platemaking method therefor. The imageable composition includes the following components in parts by mass: 25-65 parts of a free radical polymerizable compound, 0.5-25 parts of a photoinitiator, 10-60 parts of a binder, and 1-20 parts of a development accelerator. The platemaking method may comprise coating a substrate, which may have a hydrophilic surface or a hydrophilic layer, with an imageable composition to obtain a photosensitive negative-working lithographic printing plate precursor. The method may additionally include exposing the lithographic printing plate precursor by using laser light and according to a required image, so as to form an exposed region and an unexposed region. Further the method may include removing the unexposed region from the exposed printing plate precursor by means of a development process, so as to obtain a required lithographic printing plate.

Abstract: Described herein are PHD inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of inflammatory bowel disease.

Abstract: A display substrate includes: a first base substrate; scanning lines a side of the first base substrate, extending in a first direction; and arranged in a second direction data lines at the same side of the first base substrate as the scanning lines and in a different layers from the scanning lines, extending in the second direction and arranged in the first direction; a common electrode layer at a side of the scanning lines and the data lines facing away from the first base substrate; and a first light shielding layer in contact with the common electrode layer, and including first light shielding portions extending in the second direction. The first direction intersects with the second direction. The first light shielding portions are in areas between adjacent sub-pixels in the first direction.

Abstract: Described herein are PHD inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of anemia.

Abstract: Techniques for verifying a reliability of map data are discussed herein. In some examples, map data can be used by a vehicle, such as an autonomous vehicle, to traverse an environment. Sensor data (e.g., image data, lidar data, etc.) can be received from a sensor associated with a vehicle and may be used to generate an estimated map and confidence values associated with the estimated map. When the sensor data is image data, images data from multiple perspectives or different time instances may be combined to generate the estimated map. The estimated map may be compared to a stored map or to a proposed vehicle trajectory or corridor to determine a reliability of the stored map data.

Abstract: Methods of forming devices comprise forming a dielectric layer on a substrate, the dielectric layer comprising at least one feature defining a gap including sidewalls and a bottom. A self-assembled monolayer (SAM) is formed on the bottom of the gap, and a barrier layer is formed on the SAM before selectively depositing a metal liner on the barrier layer. The SAM is removed after selectively depositing the metal liner on the barrier layer.

Abstract: A packet processing method includes: allocating a portion of storage space in a memory circuit as a storage pool including first storage blocks; storing a packet in one of the first storage blocks when a data size of the packet is less than or equal to a predetermined value, and releasing the one of the first storage blocks to the storage pool after the packet is processed; requesting an increase in a number of the first storage blocks from a kernel when a number of remaining storage blocks in the first storage blocks that do not store data is less than a threshold value; and requesting second storage block from the kernel to increase a data capacity of the storage pool to store the packet when the data size is greater than the predetermined value, and releasing the second storage block to the kernel after the packet is processed.

Abstract: The present invention relates to the field of energy chemical industry, and disclosed are a gliding arc plasma reactor, and a method for converting methane by means of plasma. The reactor comprises a reactor chamber and a gliding arc plasma generator arranged in the reactor chamber, wherein the gliding arc plasma generator comprises at least two arc surface electrodes which are symmetrically distributed, such that a discharge area can be formed between the arc surface electrodes. According to the gliding arc plasma reactor provided in the present invention, the conversion rate of methane can be significantly improved when methane is converted into olefin; the selectivity of ethylene in the product is improved; and carbon deposition is significantly reduced. In addition, compared with a traditional process for preparing olefin from methane, no CO2 is generated; the ignition and explosion risk is avoided; and the reactor is safer and more environmentally friendly.