Abstract: Disclosed are 1-(arylmethyl)quinazoline-2,4(1H,3H)-diones represented by the Formula (I): wherein Ar, R1-R6, are defined herein. Compounds having Formula (I) are PARP inhibitors. Therefore, compounds of the invention may be used to treat clinical conditions that are responsive to the inhibition of PARP activity.

Abstract: Disclosed are 1-(arylmethyl)quinazoline-2,4(1H,3H)-diones represented by the Formula (I): wherein Ar, R1-R6 are defined herein. Compounds having Formula (I) are PARP inhibitors. Therefore, compounds of the invention may be used to treat clinical conditions that are responsive to the inhibition of PARP activity.

Abstract: A method performed by a network node or a wireless communications device for determining a reporting threshold related to proximity based positioning in a wireless communications network. For each of a plurality of candidate reporting thresholds the network node or the wireless communications device calculates a corresponding localization accuracy metric based on a deployment information related to a deployment of the wireless communications network, an evaluation position related to the evaluation of a received signal, a propagation model relating the evaluation position and the evaluation of the received signal, and the respective candidate reporting threshold. The network node or the wireless communications device then determines the reporting threshold based on the plurality of corresponding localization accuracy metrics.

Abstract: A method, apparatus and a storage medium for dynamically patching a function are provided. The method includes that: N long jump instructions at initial instructions of a modified patched function are restored to original instructions of the patched function according to a pre-tag of a currently running task, wherein N is an integer more than or equal to 3; and when the currently running task quits running, the N original instructions at the start of the initial instructions are modified into the long jump instructions in order to dynamically patch the function.

Abstract: Disclosed are 1-(arylmethyl)quinazoline-2,4(1H,3H)-diones represented by the Formula (I): wherein Ar, R1-R6 are defined herein. Compounds having Formula (I) are PARP inhibitors. Therefore, compounds of the invention may be used to treat clinical conditions that are responsive to the inhibition of PARP activity.

Abstract: A method, apparatus and a storage medium for dynamically patching a function are provided. The method includes that: N long jump instructions at initial instructions of a modified patched function are restored to original instructions of the patched function according to a pre-tag of a currently running task, wherein N is an integer more than or equal to 3; and when the currently running task quits running, the N original instructions at the start of the initial instructions are modified into the long jump instructions in order to dynamically patch the function.

Abstract: Disclosed are 3-aryl-6-aryl-[1,2,4]triazolo[4,3-a]pyridines thereof, represented by the Formula (I) wherein Ar1, Ar2, R1-R3 are defined herein. Compounds having Formula (I) are inhibitors of cell proliferation. Therefore, compounds of the invention may be used to treat clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

Abstract: Described are methods, systems, and apparatus for reducing storage system polling when collecting and providing storage system state data. A plurality of poll requests for storage system state data is received. For each poll request of the plurality of poll requests, a poll request arrival time associated with the poll request is stored. A first poll is initiated to collect first storage system state data for a first poll request of the plurality of poll requests. A first poll start time associated with the first poll is stored. The first poll is completed, forming the first storage system state data. For each poll request of the plurality of poll requests, the first storage system state data is provided for the poll request provided that the poll request arrival time is before the first poll start time.

Abstract: Disclosed are novel N-(3-heteroarylaryl)-4-arylarylcarboxamides and analogs thereof, represented by the Formula I: wherein C cyclic group, D1-D4, Q1, Q2, R5 are defined herein. Compounds having Formula (I) are hedgehog pathway inhibitors. Therefore, compounds of the invention may be used to treat clinical conditions that are responsive to the inhibition of hedgehog activity, such as cancer.

Abstract: An improved method of analyzing software issues may include retrieving and storing selected data elements from the operating system kernel data prior to performing a memory dump. The method of retrieving the selected kernel data may include creating a thread dedicated to collecting the data and storing it in a memory location for analysis after the memory dump. The operating system kernel data may be analyzed in conjunction with the prior art dump data to identify a root cause of the software issue.

Abstract: Disclosed are 1-(arylmethyl)quinazoline-2,4(1H,3H)-diones thereof, represented by the Formula (I) wherein Ar, R1-R6 are defined herein. Compounds having Formula (I) are PARP inhibitors. Therefore, compounds of the invention may be used to treat clinical conditions that are responsive to the inhibition of PARP activity.

Abstract: Disclosed are 3-aryl-6-aryl-[1,2,4]triazolo[4,3-?]pyridines thereof, represented by the Formula (I) wherein Ar1, Ar2, R1—R3 are defined herein. Compounds having Formula (I) are inhibitors of cell proliferation. Therefore, compounds of the invention may be used to treat clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

Abstract: An ultrasound scanner is equipped with one or more fuzzy control units that can perform adaptive system parameter optimization anywhere in the system. In one embodiment, an ultrasound system comprises a plurality of ultrasound image generating subsystems configured to generate an ultrasound image, the plurality of ultrasound image generating subsystems including a transmitter subsystem, a receiver subsystem, and an image processing subsystem; and a fuzzy logic controller communicatively coupled with at least one of the plurality of ultrasound imaging generating subsystems.

Abstract: An ultrasound scanner is equipped with one or more fuzzy control units that can perform adaptive system parameter optimization anywhere in the system. In one embodiment, an ultrasound system comprises a plurality of ultrasound image generating subsystems configured to generate an ultrasound image, the plurality of ultrasound image generating subsystems including a transmitter subsystem, a receiver subsystem, and an image processing subsystem; and a fuzzy logic controller communicatively coupled with at least one of the plurality of ultrasound imaging generating subsystems.

Abstract: A nano-particle containing apparatus, a nano-particle detection system and a method are disclosed. The nano-particle containing apparatus includes a casing, an air extracting device, a pressure device and a measuring instrument. The casing has a containing space for disposing a plurality of nano-particles. An internal wall surface of the casing has active self-cleaning function. The pressure control device controls the pressure status of the containing space. The active self-clean function is that nano-particles adhered to the internal surface wall are removed into the containing space. The nano-particles then are pumped by the air extracting device from the containing space. The measuring instrument then detects the status of an object affected by the nano-particles after the object is delivered into the containing space.

Abstract: An ultrasound scanner is equipped with one or more fuzzy control units that can perform adaptive system parameter optimization anywhere in the system. In one embodiment, an ultrasound system comprises a plurality of ultrasound image generating subsystems configured to generate an ultrasound image, the plurality of ultrasound image generating subsystems including a transmitter subsystem, a receiver subsystem, and an image processing subsystem; and a fuzzy logic controller communicatively coupled with at least one of the plurality of ultrasound imaging generating subsystems.

Abstract: An ultrasound scanner is equipped with one or more fuzzy control units that can perform adaptive system parameter optimization anywhere in the system. In one embodiment, an ultrasound system comprises a plurality of ultrasound image generating subsystems configured to generate an ultrasound image, the plurality of ultrasound image generating subsystems including a transmitter subsystem, a receiver subsystem, and an image processing subsystem; and a fuzzy logic controller communicatively coupled with at least one of the plurality of ultrasound imaging generating subsystems.

Abstract: A nano-particle containing apparatus, a nano-particle detection system and a method are disclosed. The nano-particle containing apparatus includes a casing, an air extracting device, a pressure device and a measuring instrument. The casing has a containing space for disposing a plurality of nano-particles. An internal wall surface of the casing has active self-cleaning function. The pressure control device controls the pressure status of the containing space. The active self-clean function is that nano-particles adhered to the internal surface wall are removed into the containing space. The nano-particles then are pumped by the air extracting device from the containing space. The measuring instrument then detects the status of an object affected by the nano-particles after the object is delivered into the containing space.

Abstract: Selected substituted piperazine compounds are effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving activation of the melanocortin receptor. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Abstract: Selected substituted piperazine compounds of Formula I are effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving activation of the melanocortin receptor. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.