Abstract: Disclosed are a micro-lens structure, a displaying device, and a machining method of the micro-lens structure. The micro-lens structure specifically comprises: micro-lens units distributed in an array, wherein each micro-lens unit comprises at least two micro-lenses made of a photoresist, and the at least two micro-lenses have different arch heights.

Abstract: Described herein are systems, methods, and compositions capable of targeting nucleic acids. Describe in certain exemplary embodiments herein are a class of small Cas proteins (Type II-D Cas proteins) and systems thereof. Also described in certain exemplary embodiments herein are methods of modifying target sequences using the class of small Cas proteins (Type II-D Cas proteins) and systems thereof described herein.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting Cas13b effector protein and at least one targeting nucleic acid component like a guide RNA or crRNA.

Abstract: Embodiments disclosed herein are directed to engineered CRISPR-Cas effector proteins that comprise at least one modification compared to an unmodified CRISPR-Cas effector protein that enhances binding of the CRISPR complex to the binding site and/or alters editing preference as compared to wild type. In certain example embodiments, the CRISPR-Cas effector protein is a Type V effector protein. In certain other example embodiments, the Type V effector protein is Cpf1. Embodiments disclosed herein are directed to viral vectors for delivery of CRISPR-Cas effector proteins, including Cpf1. In certain example embodiments, the vectors are designed so as to allow packaging of the CRISPR-Cas effector protein within a single vector. There is also an increased interest in the design of compact promoters for packing and thus expressing larger transgenes for targeted delivery and tissue-specificity.

Abstract: An ontology management method includes receiving, by a machine-to-machine (M2M) platform, an ontology mapping request sent by a first application entity, where the ontology mapping request carries a first ontology identifier, a second ontology identifier, and mapping method description information, determining, by the M2M platform, a first ontology and a second ontology based on the first ontology identifier and the second ontology identifier, determining, by the M2M platform, a mapping manner based on the mapping method description information, and creating mapping between the first ontology and the second ontology according to the determined mapping manner, and storing, by the M2M platform, the mapping between the first ontology and the second ontology in an ontology mapping resource, and returning an identifier of the ontology mapping resource to the first application entity.

Abstract: The present invention discloses a Cu-containing non-oriented electrical steel plate having high cleanliness, comprising the following chemical elements in percentage by mass: 0<C?0.003%; Si: 0.1-2.0%; Mn: 0.1-0.55%; S: 0-0.004%; Cu: 0.003-0.2%; Al: 0.1-1.0%; and the balance being Fe and inevitable impurities. In addition, the present invention further discloses a continuous annealing process for the Cu-containing non-oriented electrical steel plate having high cleanliness. Moreover, the present invention further discloses a manufacturing method for Cu-containing non-oriented electrical steel plate having high cleanliness, including the steps of: smelting and casting; hot rolling; normalizing; cold rolling; performing the continuous annealing process; and applying an insulation coating to obtain a finished non-oriented electrical steel plate. The Cu-containing non-oriented electrical steel plate having high-cleanliness is high in cleanliness and excellent in magnetic performance.

Abstract: This application provides a BIER multicast traffic statistics collection method, a device, and a system. The method includes: A first network device obtains a first BIER packet. The first network device performs traffic statistics collection on the first BIER packet based on multicast flow information, to obtain a traffic statistics collection result of the first BIER packet, where the multicast flow information is used to identify a multicast flow to which the first BIER packet belongs. The first network device sends the multicast flow information and the traffic statistics collection result of the first BIER packet to a controller.

Abstract: The invention provides for systems, methods, and compositions for targeting and editing nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a DNA-targeting Cpf1 protein, at least one guide molecule, and at least one adenosine deaminase protein or catalytic domain thereof.

Abstract: A heat exchanger having: a first heat exchanger core including a first sub-heat exchanger core and a second sub-heat exchanger core, wherein the first sub-heat exchanger core and the second sub-heat exchanger core includes heat exchange tubes, the heat exchange tubes of the first sub-heat exchanger core and the second sub-heat exchanger core are connected to each other, and orthographic projections of the first sub-heat exchanger core and the second sub-heat exchanger core on a plane where the second sub-heat exchanger core is located at least overlap partially; and a second heat exchanger core including a heat exchange tube, wherein the heat exchange tube of the second heat exchanger core is connected to the heat exchange tubes of the first sub-heat exchanger core and the second sub-heat exchanger core is disclosed.

Abstract: Provided are a display panel and a preparation method thereof, and a display apparatus. The display panel includes a first display region, and the first display region includes multiple sub-display regions and a first light transmittance region located between adjacent sub-display regions. Each first sub-display region of the multiple sub-display regions includes a first light-emitting element and a first filter unit disposed in a first light-emergence direction of the first light-emitting element. Each second sub-display region in the multiple sub-display regions includes a first collimating light extraction element disposed in a second light-emergence direction of the first light-emitting element and a second filter unit disposed in a light-emergence direction of the first collimating light extraction element.

Abstract: The present invention discloses a non-oriented electrical steel plate, comprising the following chemical elements in percentage by mass: 0<C?0.003%; Si: 1.6-3.4%; Mn: 0.1-1.2%; S?0.003%; Al: 0.1-3.0%; Sn: 0.005-0.2%; Ca: 0.0005-0.01%; O?0.003%; N?0.003%; and the balance being Fe and inevitable impurities. In addition, the present invention further discloses a manufacturing method for the above non-oriented electrical steel plate, including the steps of: smelting and casting; hot rolling; intermediate annealing; cold rolling; continuous annealing; and applying an insulation coating to obtain a finished non-oriented electrical steel plate. The non-oriented electrical steel plate is excellent in magnetic property.

Abstract: Systems and methods for rapid diagnostics related to the use of isothermal amplification reagents for detection of microbial species, including coronavirus, and methods of use, are provided.

Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

Abstract: Authentication management by receiving a request to initiate an authentication from a computing device of a user, directing the request to a selected authentication service of a plurality of authentication services, wherein the selected authentication service is determined dynamically based on respective authentication metrics of the plurality of authentication services, receiving authentication information via the selected authentication service, and authenticating the user based on the received authentication information.

Abstract: Systems, methods and compositions for targeting polynucleotides are detailed herein. In particular, engineered DNA-targeting systems comprising IscB polypeptides, novel IscB nucleases and reprogrammable targeting nucleic acid components and methods and application of use are provided.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

Abstract: Systems and methods for targeted gene modification, targeted insertion, perturbation of gene transcripts, and nucleic acid editing. The novel nucleic acid targeting systems can comprise components of one or more transposases, one or more components of a CRISPR-Cas system, and a transposable element.

Abstract: A method for sleep monitoring is provided, including: detecting whether a sleep assistance command is received; lighting up a breathing light at a preset frequency in response to receiving the sleep assistance command; monitoring physical sign information of a user in response to receiving a monitoring command; detecting whether the user enters into a sleep state according to the physical sign information; gradually reducing a brightness of the breathing light within a first preset duration until the breathing light is extinguished in a case where the user enters into the sleep state, and determining sleep quality information of the user according to the physical sign information of the user. The physical sign information includes at least breathing information, which is determined according to at least one of: oronasal airflow information, thoracoabdominal motion information, or pressure sensing information.