Abstract: Systems, methods, and compositions for targeting polynucleotides. More particularly, the disclosure provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting nucleic acid-guided nuclease and at least one targeting nucleic acid component like a guide RNA.

Abstract: A display panel and a display device are provided, the display panel include a substrate, an EL display unit group and a filter layer. The EL display unit group is disposed on one side of the substrate, the EL display units includes a plurality of EL display units for emitting light of different colors; the filter layer is disposed on a light emitting side of the EL display unit, the filter layer includes a plurality of filters allowing lights of different colors to pass through, a light emitted from the EL display unit has a color same as a color of a light allowed to pass through the filter disposed on the light emitting side of the EL display unit.

Abstract: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.

Abstract: Compositions, systems and methods for targeted gene modification, insertion and perturbation of gene transcripts and nucleic acid editing are provided. In particular, helitron-mediated gene targeting systems and methods of their use are detailed and provided herein.

Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in prokaryotic and eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity.

Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a SIN CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing SIN CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.

Abstract: Described herein are engineered retroviral delivery vesicle generation compositions, systems, and methods to deliver a cargo to a cell. The engineered compositions, systems, and method include one or more polynucleotides encoding one or more elements for forming a delivery vesicle and optionally one or more cargos.

Abstract: A method for event identification including receiving event information pertaining to events occurring with respect to a computing environment, each event having a measurement metric; evaluating by a probability function the measurement metric for each event to determine when the measurement metric is above a predetermined probability threshold or below a probability threshold wherein above a probability threshold or below a probability threshold is classified as alarm data; processing the alarm data through a decision tree to determine based on historical data when the alarm data is significant or when the alarm data is not significant and to reduce the number of alarm data to a predetermined number of significant alarm data; and displaying the predetermined number of significant alarm data to a user.

Abstract: The present disclosure relates to a display substrate and a method for manufacturing the same. The display substrate includes: a substrate; a first electrode located on the substrate; and a conductive convex located on the first electrode. A dimension of a cross section of the conductive convex along a plane parallel to the substrate is negatively correlated to a distance from the cross section to a surface of the first electrode.

Abstract: This disclosure relates to a see-through display device, including: a collimated light source assembly, configured to form collimated light and control a light emitting direction; a first light extraction layer, configured to extract, in a collimated manner, the light ray transmitted inside the light guide plate through a light extraction outlet; an extinction layer and a second light extraction layer, wherein the extinction layer includes a light guide region and a light absorption region which are arranged alternately, and the second light extraction layer includes multiple light extraction inlets; a reflecting layer, arranged on a side, close to the light guide plate, of the second light extraction layer and configured to reflect the collimated light extracted from the light extraction outlet to the light guide plate; and a liquid crystal dimming layer. This disclosure further relates to a manufacturing method of the see-through display device.

Abstract: A projection mechanism and glasses are disclosed. The projection mechanism comprises an arc-shaped guide rail, a mounting bracket and a projection assembly. The mounting bracket is slidably arranged on the arc-shaped guide rail. The mounting bracket is provided with a through hole. The projection assembly is inserted in the through hole. The arc-shaped guide rail and the mounting bracket are respectively used to connect the rim and the temples. The mounting bracket can be located at a first position or a second position of the arc-shaped guide rail. When the mounting bracket is located at the first position of the arc-shaped guide rail, a light source output end of the projection assembly faces toward the rim. When the mounting bracket is located at the second position of the arc-shaped guide rail, the projection assembly is far away from the rim.

Abstract: Embodiments disclosed herein provide methods for identifying new CRISPR loci and effectors, as well as different CRISPR loci combinations found in various organisms. Class-II CRISPR systems contain single-gene effectors that have been engineered for transformative biological discovery and biomedical applications. Discovery of additional single-gene or multi-component CRISPR effectors may enhance existing CRISPR applications, such as precision genome engineering. Comprehensive characterization of CRISPR-loci may identify novel functional roles of CRISPR loci enabling new tools for biomedicine and biological discovery. CRISPR loci have enormous feature complexity, but classification of CRISPR loci has been focused on a small fraction of highly abundant features. Increased genome sequencing has enhanced the sampling of this feature complexity.

Abstract: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.

Abstract: Described herein are systems, methods, and compositions capable of targeting nucleic acids. Describe in certain exemplary embodiments herein are a class of small Cas proteins (Type II-D Cas proteins) and systems thereof. Also described in certain exemplary embodiments herein are methods of modifying target sequences using the class of small Cas proteins (Type II-D Cas proteins) and systems thereof described herein.

Abstract: The present disclosure belongs to the field of display technology, and provides an optical module, a manufacturing method thereof, and a display device. The optical module includes: a substrate; a barrier structure arranged on the substrate; a black matrix arranged within the barrier structure, an orthogonal projection of the black matrix onto the substrate not going beyond a region surrounded by the barrier structure; and optical lenses arranged on a side of the black matrix away from the substrate. An orthogonal projection of a gap between adjacent optical lenses onto the substrate falls into the black matrix.

Abstract: A liquid crystal display, including a transparent region, a light shielding region, and a display region. The liquid crystal display includes a liquid crystal box, a lower polarizer, and a backlight module that are sequentially disposed in a stacked manner. A part of the liquid crystal box is located in the transparent region and is configured to allow visible light to pass through, a part of the liquid crystal box is located in the light shielding region and is configured to shield visible light, and a part of the liquid crystal box is located in the display region and is configured to display an image.

Abstract: This application discloses example data sending methods and apparatuses, and an example FlexE switching system. In one example, when slice packets received include a SOP flag and an EOP flag of a same data packet, immediately data packet slices is restored in the slice packets to a FlexE data stream and the FlexE data stream is sent, or the data packet slices are restored in the slice packets to the FlexE data stream and the FlexE data stream is sent when a latency is greater than or equal to a first present duration. When the slice packets received include the SOP flag but do not include the EOP flag of a data packet, the data packet slices are restored in the slice packets and the FlexE data stream is sent when the latency reaches a second preset duration. The first preset duration is less than the second preset duration.