Patents by Inventor Fernando Albericio

Fernando Albericio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200255478
    Abstract: The invention relates to peptidic compounds, which peptidic compounds are compounds of formula (I)?, or a pharmaceutically acceptable salt, or solvate, or N-oxide, or stereoisomer thereof: wherein R1; R2; s; t; u; Aa78 and G1 are as defined herein. The peptidic compounds are useful in activating the Nrf2 pathway.
    Type: Application
    Filed: August 8, 2018
    Publication date: August 13, 2020
    Inventors: Carlos PUIG DURAN, Fernando ALBERICIO PALOMERA, Miriam GONGORA BENITEZ, Marta PARADIS BAS, Laia MIRET CASALS, Ivan RAMOS TOMILLERO, Stephen FIACCO, Andrew DAVIS, Stefan GESCHWINDNER, Omar BRUN CUBERO, Carlos HERAS PANIAGUA, Nuria TRALLERO CANELA
  • Publication number: 20200024306
    Abstract: The invention discloses a method for the preparation of a peptide by liquid phase coupling of two fragments, an N-terminal fragment and a C-terminal fragment of the desired peptide, wherein the C-terminal fragment is protected on its C-terminal COOH by a psWang linker; the method is demonstrated with liraglutide wherein the C-terminal fragment carries the Palmitoyl-Glu-OtBu residue on the Lys.
    Type: Application
    Filed: January 20, 2017
    Publication date: January 23, 2020
    Inventors: Luciano Forni, Daniel Carbajo Lopez, Fernando Albericio Palomera
  • Patent number: 10407389
    Abstract: The invention discloses a method for the preparation of N-omega-(1,2-dimethylindole-3-sulfonyl)-L-arginine and its derivatives using L-ornithine.
    Type: Grant
    Filed: October 9, 2016
    Date of Patent: September 10, 2019
    Assignee: POLYPEPTIDE LABORATORIES HOLDING (PPL) AB
    Inventors: Deyong Tan, Joanna Dai, Matthieu Giraud, Fernando Albericio Palomera
  • Publication number: 20190241517
    Abstract: The invention discloses a method for the preparation of N-omega-(1,2-dimethylindole-3-sulfonyl)-L-arginine and its derivatives using L-ornithine.
    Type: Application
    Filed: October 9, 2016
    Publication date: August 8, 2019
    Inventors: Deyong Tan, Joanna Dai, Matthieu Giraud, Fernando Albericio Palomera
  • Patent number: 9932368
    Abstract: The present invention relates to a compound of formula (I) (R1-Arg-Gly-Asp-Gly-Ala-Asn-Pro-Asn-Ala-Ala-Gly-R2), formula II (R5-Arg-Gly-Asp-Gly-Pro-Gln-Gly-Pro-Gln-R6), or formula III (R9-Trp-Arg-Phe-Gln-Trp-Gln-Phe-Glu-Gln-R10), and to compositions comprising a compound of formulas I, II or III, as well as the use of said compounds and/or said compositions in the cosmetic treatment of skin and/or hair, and to the use thereof for inducing the formation of collagen.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: April 3, 2018
    Assignee: INFINITEC ACTIVOS S.L.
    Inventors: Fernando Albericio Palomera, Gerardo Alexis Acosta Crespo
  • Patent number: 9744247
    Abstract: The invention relates to conjugates in which a sterol is functionalized by an ether bond with a water-soluble polymer to which a guiding ligand is bound. These conjugates improve the physico-chemical and delivery properties of their carrying vesicles, making these more stable, homogeneous and effective. A method for their preparation, a pharmaceutical composition containing said liposomes, and their therapeutic use are described as well.
    Type: Grant
    Filed: June 28, 2013
    Date of Patent: August 29, 2017
    Assignees: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC), FUNDACIÓ PARC CIENTÍFIC DE BARCELONA, CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED, FUNDACIÓ INSTITUT DE RECERCA BIOMÈDICA (IRB BARCELONA), UNIVERSITAT DE BARCELONA, FUNDACIÓ HOSPITAL UNIVERSITARI VALL D'HEBRON—INSTITUT DE RECERCA, UNIVERSITAT AUTÒNOMA DE BARCELONA
    Inventors: Leonor Ventosa Rull, Jaume Veciana Miró, Ingrid Cabrera Puig, Elisa Elizondo Saez De Vicuña, Marta Melgarejo Diaz, Miriam Royo Expósito, Fernando Albericio Palomera, Daniel Pulido Martinez, Santiago Sala Vergés, Jose Luis Corchero Nieto, Simón Schwartz Navarro, Ibane Abasolo Olaortua, Antonio Pedro Villaverde Corrales
  • Publication number: 20160185819
    Abstract: The present invention relates to a compound of formula (I) and to compositions comprising said compound, as well as the use of said compound and/or said compositions in the cosmetic treatment of skin and/or hair, and to the use thereof for inducing the formation of collagen.
    Type: Application
    Filed: July 31, 2014
    Publication date: June 30, 2016
    Inventors: Fernando ALBERICIO PALOMERA, Gerardoª Alexis ACOSTA CRESPO
  • Publication number: 20150190530
    Abstract: The invention relates to conjugates in which a sterol is functionalized by an ether bond with a water-soluble polymer to which a guiding ligand is bound. These conjugates improve the physico-chemical and delivery properties of their carrying vesicles, making these more stable, homogeneous and effective. A method for their preparation, a pharmaceutical composition containing said liposomes, and their therapeutic use are described as well.
    Type: Application
    Filed: June 28, 2013
    Publication date: July 9, 2015
    Applicants: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC), FUNDACIÓ PRIVADA PARC CIENTÍFIC DE BARCELONA, CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED EN BIONG- ENIERÍA, BIOMATERIALES Y NANOMEDICINA (CIBER-BBN), FUNDACIÓ PRIVADA INSTITUT DE RECERCA BIOMÈDICA, UNIVERSITAT DE BARCELONA, FUNDACIÓ HOSPITAL UNIVERSITARI VALL D'HEBRON- INSTITUT DE RECERCA, UNIVERSITAT AUTÒNOMA DE BARCELONA
    Inventors: Leonor Ventosa Rull, Jaume Veciana Miró, Ingrid Cabrera Puig, Elisa Elizondo Saez De Vicuña, Marta Melgarejo Diaz, Miriam Royo Expósito, Fernando Albericio Palomera, Daniel Pulido Martinez, Santiago Sala Vergés, Jose Luis Corchero Nieto, Simón Schwartz Navarro, Ibane Abasolo Olaortua, Antonio Pedro Villaverde Corrales
  • Publication number: 20140343227
    Abstract: The invention relates to a method for homogeneous solution phase peptide synthesis (HSPPS) of a N-terminal peptide fragment PEP-N and a C-terminal peptide fragment C-PEP, with C-PEP carrying a specific diketopiperazine (DKP) comprising C-terminal protecting group, which contains a handle group HG, with HG being connected to the C-terminus of the peptide fragmcnt; thereby this specific DKP comprising C-terminal protecting group can be selectively cleaved from the peptide as a conventionally used C-terminal protecting group. By the use of this DKP and HG comprising C-terminal protecting group, certain process steps in convergent peptide synthesis based on a combination of HSPPS and solid phase peptide synthesis (SPPS) can be avoided.
    Type: Application
    Filed: June 20, 2014
    Publication date: November 20, 2014
    Inventors: Fernando Albericio, Michèle Cristau, Matthieu Giraud, Miriam Gongora Benitez, Judit Tulla-Puche
  • Patent number: 8802819
    Abstract: The invention relates to a method for homogeneous solution phase peptide synthesis (HSPPS) of a N-terminal peptide fragment PEP-N and a C-terminal peptide fragment C-PEP, with C-PEP carrying a specific diketopiperazine (DKP) comprising C-terminal protecting group, which contains a handle group HG, with HG being connected to the C-terminus of the peptide fragment; thereby this specific DKP comprising C-terminal protecting group can be selectively cleaved from the peptide as a conventionally used C-terminal protecting group. By the use of this DKP and HG comprising C-terminal protecting group, certain process steps in convergent peptide synthesis based on a combination of HSPPS and solid phase peptide synthesis (SPPS) can be avoided.
    Type: Grant
    Filed: October 20, 2011
    Date of Patent: August 12, 2014
    Assignee: Lonza Ltd.
    Inventors: Fernando Albericio, Michèle Cristau, Matthieu Giraud, Miriam Gongora Benitez, Judit Tulla-Puche
  • Patent number: 8748388
    Abstract: Antitumoral compounds of Formula I, and pharmaceutically acceptable salts, derivatives, tautomers, prodrugs or stereoisomers thereof useful as antitumour agents.
    Type: Grant
    Filed: December 10, 2008
    Date of Patent: June 10, 2014
    Assignee: Pharma Mar, S.A.
    Inventors: Judit Tulla-Puche, Eleonora Marcucci, Núria Bayó-Puxan, Fernando Albericio, Maria del Carmen Cuevas Marchante
  • Publication number: 20140094567
    Abstract: The invention relates to a method for homogeneous solution phase peptide synthesis (HSPPS) of a N-terminal peptide fragment PEP-N and a C-terminal peptide fragment C-PEP, with C-PEP carrying a specific diketopiperazine (DKP) comprising C-terminal protecting group, which contains a handle group HG, with HG being connected to the C-terminus of the peptide fragment; thereby this specific DKP comprising C-terminal protecting group can be selectively cleaved from the peptide as a conventionally used C-terminal protecting group. By the use of this DKP and HG comprising C-terminal protecting group, certain process steps in convergent peptide synthesis based on a combination of HSPPS and solid phase peptide synthesis (SPPS) can be avoided.
    Type: Application
    Filed: October 20, 2011
    Publication date: April 3, 2014
    Applicant: LONZA LTD
    Inventors: Fernando Albericio, Michèle Cristau, Matthieu Giraud, Miriam Gongora Benitez, Judit Tulla-Puche
  • Patent number: 8680126
    Abstract: Compounds of formula (I) or their pharmaceutically acceptable salts, or their stereoisomers or mixtures of stereoisomers, where: R1 is selected from the group consisting of: phenyl, and phenyl mono-, di-, or tri-substituted by a radical independently selected from the group consisting of F, Cl, Br, I, (C1-C6)-alkyl, COO—(C1-C6)-alkyl, and (C1-C6)-alkoxy; and R2 is a radical selected from the same group as R1, further including a phenyl substituted in 4-position by a radical independently selected from the group consisting of —O(CH2)CONH(CH2)3CH3 and OCH2COOC(CH3)3, a biphenyl-4-yl, thiazol-2-yl, and a thiazol-2-yl mono- or di-substituted by a radical selected from F and phenyl; inhibit cell proliferation of tumor cells independently of p53 protein and may also induce apoptosis in several tumor cells independently of p53 protein, being useful for the treatment of several types of cancer.
    Type: Grant
    Filed: August 29, 2011
    Date of Patent: March 25, 2014
    Assignees: Universitat de Barcelona, Fundacio Privada Institut d'Inbestigacio Biomedica de Bell Vitge, Fundacio Privada Institute de Recerca Biomedica de Barcelona, Fundacio Privada Parc Cientific de Barcelona
    Inventors: Joan Gil Santano, Rodolfo Lavilla Grifols, Fernando Albericio Palomera, Alba Pérez Perarnau, Sara Preciado Gallego, Diana Ma González Gironès, Daniel Iglesias Serret, Rosario Ramón Albalate
  • Patent number: 8524898
    Abstract: Novel iminium-type coupling agents containing proton acceptors in their iminium moiety, which can be used beneficially as coupling agents in various chemical polypeptide and/or polynucleotide syntheses, and are particularly useful as yield enhancing and racemization suppressing coupling agents for use in peptide syntheses, are disclosed. Further disclosed are a process of preparing such iminium-type coupling agents and their use in the preparation of polypeptides and/or polynucleotides.
    Type: Grant
    Filed: May 15, 2008
    Date of Patent: September 3, 2013
    Assignee: Luxembourg Bio Technologies Ltd.
    Inventors: Fernando Albericio, Ayman El-Faham, Yoav Luxembourg, Ariel Ewenson
  • Publication number: 20130190367
    Abstract: Compounds of formula (I) or their pharmaceutically acceptable salts, or their stereoisomers or mixtures of stereoisomers, where: R1 is selected from the group consisting of: phenyl, and phenyl mono-, di-, or tri-substituted by a radical independently selected from the group consisting of F, Cl, Br, I, (C1-C6)-alkyl, COO-(C1-C6)-alkyl, and (C1-C6)-alkoxy; and R2 is a radical selected from the same group as R1, further including a phenyl substituted in 4-position by a radical independently selected from the group consisting of —O(CH2)CONH(CH2)3CH3 and OCH2COOC(CH3)3, a biphenyl-4-yl, thiazol-2-yl, and a thiazol-2-yl mono- or di-substituted by a radical selected from F and phenyl; inhibit cell proliferation of tumor cells independently of p53 protein and may also induce apoptosis in several tumor cells independently of p53 protein, being useful for the treatment of several types of cancer.
    Type: Application
    Filed: August 29, 2011
    Publication date: July 25, 2013
    Applicants: UNIVERSITAT DE BARCELONA, FUNDACIO PRIVADA INSTITUT DE RECERCA BIOMEDICA DE BARCELONA, FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE, FUNDACIO PRIVADA PARC CIENTÍFIC DE BARCELONA
    Inventors: Joan Gil Santano, Rodolfo Lavilla Grífols, Fernando Albericio Palomera, Alba Pérez Perarnau, Sara Preciado Gallego, Diana Mª González Gironès, Daniel Iglesias Serret, Rosario Ramón Albalate
  • Patent number: 8431720
    Abstract: The invention relates to indolesulfonyl halogenides which are useful for the protection of organic compounds comprising at least one guanidino moiety and/or at least one amino group. The invention further relates to a process for their preparation and their use as protecting reagents. The invention also relates to the process for the protecting reaction and to the protected compounds thereof.
    Type: Grant
    Filed: May 5, 2009
    Date of Patent: April 30, 2013
    Assignee: Lonza Ltd.
    Inventors: Matthieu Giraud, Fernando Albericio, Albert Isidro Liobet, Mercedes Alvarez Domingo
  • Publication number: 20120196915
    Abstract: The present invention relates to a new series of 1,2-diphenylpyrroles of formula (I) or their pharmaceutically acceptable salts, or their pharmaceutically acceptable solvates, having antitumor activity, wherein R1 and R2 are individually selected from the group consisting of halogen, optionally substituted O(C1-C4)alkyl and optionally substituted (C1-C4)alkyl; and R3 is selected from the group consisting of H, (C1-C4)alkyl, CONH2 and (C?NH)NH2. It also relates to a process for preparing them, to pharmaceutical compositions containing them, and to their use for the treatment of cancer, in particular lung carcinoma, colorectal carcinoma, breast carcinoma and/or prostate carcinoma.
    Type: Application
    Filed: July 28, 2010
    Publication date: August 2, 2012
    Applicant: ARGON PHARMA, S.L.
    Inventors: Ramon Mangues Bafalluy, Isolda Casanova Rigalt, Fernando Albericio Palomera, Mercedes Álvarez, Svetlana Savina
  • Publication number: 20110207674
    Abstract: Antitumoral compounds of Formula I, and pharmaceutically acceptable salts, derivatives, tautomers, prodrugs or stereoisomers thereof useful as antitumour agents.
    Type: Application
    Filed: December 10, 2008
    Publication date: August 25, 2011
    Applicant: PHARMA MAR, S.A.
    Inventors: Judit TULLA-PUCHE, Eleonora MARCUCCI, Núria BAYÓ-PUXAN, Fernando ALBERICIO, María del Carmen CUEVAS MARCHANTE
  • Publication number: 20110060125
    Abstract: The invention relates to indolesulfonyl halogenides which are useful for the protection of organic compounds comprising at least one guanidino moiety and/or at least one amino group. The invention further relates to a process for their preparation and their use as protecting reagents. The invention also relates to the process for the protecting reaction and to the protected compounds thereof.
    Type: Application
    Filed: May 5, 2009
    Publication date: March 10, 2011
    Inventors: Matthieu Giraud, Fernando Albericio, Albert Isidro Llobet, Mercedes Alvarez Domingo
  • Publication number: 20110046349
    Abstract: Exenatide, a polypeptide having the 39 amino acid sequence H-1His-Gly-Glu-Gly-5Thr-Phe-Thr-Ser-Asp-10Leu-Ser- Lys-Gln-Met-15Glu-Glu-Glu--Ala-Val-20Arg-Leu-Phe- Ile-Glu-25Trp-Leu-Lys-Asn-Gly-30Gly-Pro-Ser-Ser- Gly-35Ala--Pro-Pro-Pro-Ser-NH2, respectively its 44-mer analogue H-1His-Gly-Glu-Gly-5Thr-Phe-Thr-Ser-Asp-10Leu-Ser- Lys-Gln-Met-15Glu-Glu-Glu--Ala-Val-20Arg-Leu-Phe- Ile-Glu-25Trp-Leu-Lys-Asn-Gly-30Gly-Pro-Ser-Ser- Gly-35Ala--Pro-Pro-Ser-Lys-40Lys-Lys-Lys-Lys-Lys- NH2 is prepared via a convergent four-fragment synthesis strategy from the fragments comprising the amino acid positions 1-10, 11-21, 22-29 and 30-39, respectively 30-44.
    Type: Application
    Filed: July 14, 2010
    Publication date: February 24, 2011
    Inventors: Matthieu Giraud, Anne-Sophie Droz, Stéphane Varray, El Djouhar Rekai, Marie-Hèléne Brichard, Daniel Latassa, Christine Devijver, Pascal Gilles, Jeanne-Marie Cauvin, Fernando Albericio, Marta Paradis Bas