Patents by Inventor Florencio Zaragoza Dorwald

Florencio Zaragoza Dorwald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Extended Glp-1 Compounds
    Publication number: 20080207507
    Abstract: Protracted GLP-1 compounds and therapeutic uses thereof.
    Type: Application
    Filed: March 20, 2006
    Publication date: August 28, 2008
    Applicant: Novo Nordisk A/S
    Inventors: Jesper Lau, Florencio Zaragoza Dorwald, Lauge Schaffer, Thomas Kruse Hansen
  • Growth Hormone Conjugates
    Publication number: 20080182783
    Abstract: Compounds of formula (I) wherein GH represent a radical derived from a growth hormone compound by removal of one hydrogen atom from the N-terminal amino group; X represents oxygen or two hydrogen atoms; Z represents a bond, alkylene, arylene, heteroarylene, —CH2—O—(CH2)1-10—, —CH2—O—(C6H4)—, or combinations thereof; and Y represents a radical selected from are provided together with methods for making said compounds. The compounds are useful in therapy.
    Type: Application
    Filed: October 18, 2005
    Publication date: July 31, 2008
    Applicant: Novo Nordisk A/S
    Inventors: Florencio Zaragoza Dörwald, Lars Fogh Iversen, Nils Langeland Johansen
  • Substituted piperazines and diazepanes
    Publication number: 20080113968
    Abstract: A novel class of substituted piperazines and diazepanes, pharmaceutical compositions comprising them and use thereof in the treatment of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.
    Type: Application
    Filed: April 10, 2007
    Publication date: May 15, 2008
    Applicant: Novo Nordisk A/S
    Inventors: Florencio Zaragoza Dorwald, Knud Erik Andersen, Jan Lindy Sorensen
  • Method for the Preparation of Oxime, Thiazolidine, Dithiane, Dithiolane, or Hydrazone Linked Analogues of Growth Hormone
    Publication number: 20080076700
    Abstract: A method for the production of conjugated growth hormone is provided, wherein a GH derived aldehyde or ketone is reacted with an alkoxyamine, hydrazine or 2-aminothiol compound at acid pH in the presence of a dipolar solvent.
    Type: Application
    Filed: October 18, 2005
    Publication date: March 27, 2008
    Applicant: Novo Nordisk A/S
    Inventors: Florencio Zaragoza Dorwald, Christine Bruun Schiodt
  • Substituted piperazines and diazepanes
    Patent number: 7208497
    Abstract: A novel class of substituted piperazines and diazepanes, pharmaceutical compositions comprising them and use thereof in the treatment of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.
    Type: Grant
    Filed: June 27, 2002
    Date of Patent: April 24, 2007
    Assignee: Novo Nordisk A/S
    Inventors: Florencio Zaragoza Dorwald, Knud Erik Andersen, Jan Lindy Sørensen
  • Substituted piperidines
    Patent number: 7064135
    Abstract: A novel class of substituted piperidines, pharmaceutical compositions comprising them and use thereof in the treatment of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.
    Type: Grant
    Filed: October 9, 2002
    Date of Patent: June 20, 2006
    Assignee: Novo Nordisk Inc.
    Inventor: Florencio Zaragoza Dörwald
  • Substituted imidazoles, their preparation and use
    Patent number: 6908926
    Abstract: Disclosed is a novel class of substituted imidazole compounds, pharmaceutical compositions containing them and uses of these compounds in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, these compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial. These imidazoles compounds have the formula I wherein R1, R2, R3, R4, R5, R6, A, X, Y and Z are as defined in the specification.
    Type: Grant
    Filed: April 12, 2000
    Date of Patent: June 21, 2005
    Assignee: Novo Nordisk A/S
    Inventors: Florencio Zaragoza Dörwald, Knud Erik Andersen, Tine Krogh Jørgensen, Bernd Peschke, Birgitte Schjellerup Wulff, Ingrid Pettersson, Klaus Rudolf, Dirk Stenkamp, Rudolf Hurnaus, Stephan Georg Müller, Bernd Krist
  • Substituted piperidines
    Publication number: 20040248938
    Abstract: A novel class of substituted piperidines, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.
    Type: Application
    Filed: July 15, 2004
    Publication date: December 9, 2004
    Inventor: Florencio Zaragoza Dorwald
  • Imidazole compounds
    Patent number: 6756384
    Abstract: A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.
    Type: Grant
    Filed: July 23, 2002
    Date of Patent: June 29, 2004
    Assignees: Novo Nordisk A/S, Boehringer Ingelheim International GmbH
    Inventors: Knud Erik Andersen, Florencio Zaragoza Dorwald, Bernd Peschke, Ulla Grove Sidelmann, Klaus Rudolf, Dirk Stenkamp, Rudolf Hurnaus, Stephan Georg Muller, Bernd Krist, Birgitte Eriksen
  • Substituted piperazines and diazepanes
    Publication number: 20040019039
    Abstract: A novel class of substituted piperazines and diazepanes, pharmaceutical compositions comprising them and use thereof in the treatment of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.
    Type: Application
    Filed: June 27, 2002
    Publication date: January 29, 2004
    Inventors: Florencio Zaragoza Dorwald, Knud Erik Andersen, Jan Lindy Sorensen
  • Aminoazetidine,-pyrrolidine and -piperidine derivatives
    Patent number: 6673829
    Abstract: Novel aminoazetidine, -pyrrolidine, and -piperidine derivatives, use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds, and a method of treatment employing these compounds and compositions. The compounds show a high and selective binding affinity to the histamine H3 receptor indicating histamine H3 receptor antagonistic, inverse agonistic or agonistic activity. As a result, the compounds are useful for the treatment of diseases and disorders related to the histamine H3 receptor.
    Type: Grant
    Filed: September 12, 2002
    Date of Patent: January 6, 2004
    Assignee: Novo Nordisk A/S
    Inventors: Florencio Zaragoza Dorwald, Rolf Hohlweg
  • Novel aryl- and heteroarylpiperazines
    Publication number: 20030236259
    Abstract: Novel aryl- and heteroarylpiperazines, use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds, and a method of treatment employing these compounds and compositions. The compounds show a high and selective binding affinity to the histamine H3 receptor indicating histamine H3 receptor antagonistic, inverse agonistic or agonistic activity. As a result, the compounds are useful for the treatment of diseases and disorders related to the histamine H3 receptor.
    Type: Application
    Filed: March 7, 2003
    Publication date: December 25, 2003
    Inventors: Rolf Hohlweg, Florencio Zaragoza Dorwald, Henrik Stephensen, Ingrid Pettersson, Bernd Peschke
  • Novel substituted piperidines
    Publication number: 20030191112
    Abstract: A novel class of substituted piperidines, pharmaceutical compositions comprising them and use thereof in the treatment of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.
    Type: Application
    Filed: October 9, 2002
    Publication date: October 9, 2003
    Inventor: Florencio Zaragoza Dorwald
  • Substituted piperidines
    Publication number: 20030186963
    Abstract: A novel class of substituted piperidines, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.
    Type: Application
    Filed: September 12, 2002
    Publication date: October 2, 2003
    Inventor: Florencio Zaragoza Dorwald
  • Imidazo heterocyclic compounds
    Patent number: 6610721
    Abstract: A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: August 26, 2003
    Assignee: Novo Nordisk A/S
    Inventors: Knud Erik Andersen, Florencio Zaragoza Dorwald
  • Imidazole compounds
    Publication number: 20030135056
    Abstract: A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.
    Type: Application
    Filed: July 23, 2002
    Publication date: July 17, 2003
    Inventors: Knud Erik Andersen, Florencio Zaragoza Dorwald, Bernd Peschke, Ulla Grove Sidelmann, Klaus Rudolf, Dirk Stenkamp, Rudolf Hurnaus, Stephan Georg Muller, Bernd Krist, Birgitte Eriksen
  • Novel aminoazetidine,-pyrrolidine and -piperidine derivatives
    Publication number: 20030130253
    Abstract: Novel aminoazetidine, -pyrrolidine, and -piperidine derivatives, use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds, and a method of treatment employing these compounds and compositions. The compounds show a high and selective binding affinity to the histamine H3 receptor indicating histamine H3 receptor antagonistic, inverse agonistic or agonistic activity. As a result, the compounds are useful for the treatment of diseases and disorders related to the histamine H3 receptor.
    Type: Application
    Filed: September 12, 2002
    Publication date: July 10, 2003
    Inventors: Florencio Zaragoza Dorwald, Rolf Hohlweg
  • Imidazole compounds
    Patent number: 6437147
    Abstract: A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: August 20, 2002
    Assignees: Novo Nordisk, Boehringer Ingelheim International GmbH
    Inventors: Knud Erik Andersen, Florencio Zaragoza Dorwald, Bernd Peschke, Ulla Grove Sidelmann, Klaus Rudolf, Dirk Stenkamp, Rudolf Hurnaus, Stephan Georg Muller, Bernd Krist, Birgitte Eriksen
  • Substituted imidazoles, their preparation and use
    Patent number: 6417218
    Abstract: A class of substituted imidazole compounds of formula I methods for their preparation, pharmaceutical compositions comprising them and use thereof in the treatment of disorders related to the histamine H3 receptor are disclosed. More particularly, these compounds possess histamine H3 receptor antagonistic activity and are thus useful for the treatment of disorders in which a histamine H3 receptor blockade is beneficial.
    Type: Grant
    Filed: January 18, 2000
    Date of Patent: July 9, 2002
    Assignees: Novo Nordisk A/S, Boehringer Ingelheim International GmbH
    Inventors: Florencio Zaragoza Dorwald, Knud Erik Andersen
  • Substituted 3,3-diamino-2-propenenitriles, their preparation and use
    Patent number: 6365609
    Abstract: Described are substituted cyanoenamines of formula I wherein Z, R1, R2 and R3 are defined in the description, compositions thereof and methods for preparing these compounds. These compounds are useful in the treatment of diseases of the central nervous system, the cardiovascular system, the pulmonary system, the gastrointestinal system and the endocrinologic system.
    Type: Grant
    Filed: September 22, 2000
    Date of Patent: April 2, 2002
    Assignee: Novo Nordisk A/S
    Inventors: John Bondo Hansen, Tina Moller Tagmose, John Patrick Mogensen, Florencio Zaragoza Dorwald, Anker Steen Jorgensen