Patents by Inventor Florencio Zaragoza Dorwald

Florencio Zaragoza Dorwald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted 3,3-diamino-2-propenenitriles, their preparation and use
    Patent number: 6362205
    Abstract: Described are substituted cyanoenamines of formula I wherein Z, R1, R2 and R3 are defined in the description, compositions thereof and methods for preparing these compounds. These compounds are useful in the treatment of diseases of the central nervous system, the cardiovascular system, the pulmonary system, the gastrointestinal system and the endocrinologic system.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: March 26, 2002
    Assignee: Novo Nordisk A/S
    Inventors: John Bondo Hansen, Tina Moller Tagmose, John Patrick Mogensen, Florencio Zaragoza Dorwald, Anker Steen Jorgensen
  • Substituted 3,3-diamino-2-propenenitriles, their preparation and use
    Publication number: 20010056188
    Abstract: Disclosed are substituted cyanoenamines, compositions containing these compounds, and methods for preparing these compounds. These compounds are useful in the treatment of diseases of the central nervous system, the cardiovascular system, the pulmonary system, the gastrointestinal system and the endocrinologic system.
    Type: Application
    Filed: March 16, 2001
    Publication date: December 27, 2001
    Inventors: John Bondo Hansen, Tina Moller Tagmose, John Patrick Mogensen, Florencio Zaragoza Dorwald, Anker Steen Jorgensen
  • Imidazo heterocyclic compounds
    Publication number: 20010049385
    Abstract: A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.
    Type: Application
    Filed: March 16, 2001
    Publication date: December 6, 2001
    Inventors: Knud Erik Andersen, Florencio Zaragoza Dorwald, Bernd Peschke
  • Substituted 3,3-diamino-2-propenenitriles, their preparation and use
    Publication number: 20010025111
    Abstract: Substituted cyanoenamines of the general formula I 1
    Type: Application
    Filed: May 3, 2001
    Publication date: September 27, 2001
    Inventors: John Bondo Hansen, Tina Moller Tagmose, John Patrick Mogensen, Florencio Zaragoza Dorwald, Anker Steen Jorgensen
  • Solid phase and combinatorial synthesis of substituted 2-methylene-2, 3-dihydrothiazoles and of arrays of substituted 2-methylene-2, 3-dihydrothiazoles
    Patent number: 5847150
    Abstract: A solid phase method for the synthesis of a plurality of differently substituted 2-methylenethiazoles with a wide variety of side-chain substituents as compounds of potential therapeutic interest. The 2-methylenethiazoles are prepared by acylation of a substrate-bound primary or secondary amine with cyanoacetic acid and reaction of the resulting cyanoacetamide with an isothiocyanate in the presence of a base. Alkylation with an appropriate alkyl halide under acidic conditions yields differently substituted, support-bound 2-methylene-2,3-dihydrothiazoles. These may be screened on the substrate or cleaved from the substrate and then screened in solution. The efficient synthesis of a wide variety of 2-methylenethiazoles using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse thiazole-based libraries.
    Type: Grant
    Filed: April 16, 1997
    Date of Patent: December 8, 1998
    Assignee: Novo Nordisk A/S
    Inventor: Florencio Zaragoza Dorwald