Abstract: The present invention generally relates to pH-dependent mutant interleukin-2 polypeptides that exhibit reduced IL-2 receptor binding at neutral pH and retained IL-2 receptor binding at reduced pH. In addition, the invention relates to immunoconjugates comprising said pH-dependent mutant IL-2 polypeptides, polynucleotide molecules encoding the pH-dependent mutant IL-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the pH-dependent mutant IL-2 polypeptides or immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.

Abstract: The present invention relates to a method for obtaining monoclonal human antibodies directed against an infectious pathogen, monoclonal human antibodies or binding fragments thereof which are directed against an infectious pathogen as obtained by the method of the invention, a pharmaceutical composition comprising such monoclonal human antibodies, a kit comprising such antibodies, and the monoclonal antibodies or binding fragments thereof and the pharmaceutical composition and the kit for use as a medicament and in the treatment or prevention of a disease caused by the infectious pathogen.

Abstract: A combined bypass filter element module is disclosed. The combined bypass filter element module includes at least one filter slot for receiving at least one filter element that can be arranged in the at least one filter slot. A bypass flap device is arranged in a flow direction in parallel with the at least one filter slot.

Abstract: A method for operating an air-conditioning system that carries out an air quality testing cycle is disclosed. The air quality testing cycle includes: Step A: testing if the current pollutant concentration is below a predetermined first pollutant limit value; Step B: in the event that it is determined in the Step A that the current pollutant concentration is below the first pollutant limit value, testing if the bypass device is completely open or if the current flow rate of the blower device corresponds to a current air volume demand of the air-conditioning system; Step D: in the event that it is determined in the Step B that the bypass device is not completely opened or that the current flow rate does not correspond to the current air volume demand, testing current pollutant concentration is below a predetermined second pollutant limit value that is smaller than the first pollutant limit value.

Abstract: An HVAC unit for a motor vehicle is disclosed. The HVAC unit includes a housing, a sensor device through which air is flowable and an air duct arrangement through which air is flowable. The sensor device is attached to the housing and airflow-connected to the air duct arrangement at an interface. The interface is provided by two connecting pieces of the sensor device aligned in a Z-direction and two receptacles of the air duct arrangement corresponding with the two connecting pieces. The two connecting pieces are disposed on the sensor device and the two receptacles of the air duct arrangement are disposed in the housing. The respective connecting piece engages in the respective receptacle at the interface and is airtight-connected to the respective receptacle.

Abstract: An air duct system for conducting air within an HVAC equipment of a motor vehicle may include a housing of the HVAC equipment, a sensor through which air is flowable, and at least one air duct connected to the sensor in an air-conducting manner. The housing may include (i) a first housing part with a first connecting surface and (ii) a second housing part with a second connecting surface. The first housing part and the second housing part may abut one another and may be fixedly connected to each other via the first and second connecting surface. The at least one air duct may be formed, at least in regions, between the first and second connecting surface. The at least one air duct may have at least one constriction point at which a cross-section of the at least one air duct is reduced.

Abstract: A system and a corresponding method for assisting selective hearing are provided. The system includes a detector for detecting an audio source signal portion of one or more audio sources by using at least two received microphone signals of a hearing environment. In addition, the system includes a position determiner for allocating position information to each of the one or more audio sources. In addition, the system includes an audio type classifier for assigning an audio source signal type to the audio source signal portion of each of the one or more audio sources. In addition, the system includes a signal portion modifier for varying the audio source signal portion of at least one audio source of the one or more audio sources depending on the audio signal type of the audio source signal portion of the at least one audio source so as to obtain a modified audio signal portion of the at least one audio source. In addition, the system includes a signal generator.

Abstract: The present invention relates to a fluid line system (10) for guiding fluid, in particular for a motor vehicle. The fluid line system (10) comprises a sensor device (20) for capturing sensor parameters and a housing (30), which has two or more housing parts (40, 60). Each housing part (40, 60) has a mounting surface area (50, 70) for arranging a further housing part (40, 60). The housing (30) further has a groove arrangement (80), which comprises at least one groove recess (90), which is arranged on a mounting surface area (50, 70), wherein a groove recess (90) has a groove opening (95), which opens out to the respective mounting surface area (50, 70). In any case, the groove opening (95) is closed by in a fluid-tight manner means of the mounting surface area (50, 70) of at least one further housing part (40, 60).

Abstract: The present invention relates to antibodies or antigen-binding fragments thereof against SARS-related coronavirus, a pharmaceutical composition comprising such antibodies or antigen-binding fragments thereof, a kit comprising such antibodies or antigen-binding fragments thereof. The present invention also relates to the antibodies or antigen-binding fragments thereof, the pharmaceutical composition, and the kit, for use as a medicament, and in the treatment or prevention of a disease caused by SARS-related coronavirus.

Abstract: An air-conditioning system of a motor vehicle to air-condition a vehicle interior may include a channel system through which air is flowable and an outside-air channel configured to let outside air into the channel system. The air-conditioning system may also include a system conveying device separating a suction area from a pressure area and a system filter device separating a raw area from a pure area. The system filter device may include a filter housing and a filter material. The air-conditioning system may additionally include a system outlet to let air into the vehicle interior and a sensor device, including a sensor housing, in which at least one analysis channel is arranged, through which air, a characteristic of which is measured, is flowable. The sensor device may also include at least one sensor inlet and at least one sensor outlet to let air in and out of the sensor device.

Abstract: The present invention relates to a fluid line system (10) for guiding fluid, in particular for a motor vehicle. The fluid line system (10) comprises a sensor device (20) for capturing sensor parameters and a housing (30), which has two or more housing parts (40, 60). Each housing part (40, 60) has a mounting surface area (50, 70) for arranging a further housing part (40, 60). The housing (30) further has a groove arrangement (80), which comprises at least one groove recess (90), which is arranged on a mounting surface area (50, 70), wherein a groove recess (90) has a groove opening (95), which opens out to the respective mounting surface area (50, 70). In any case, the groove opening (95) is closed by in a fluid-tight manner means of the mounting surface area (50, 70) of at least one further housing part (40, 60).

Abstract: An integral hook arrangement for hanging accessories in a vehicle interior, has at least one hook element and an integral hook base. The integral hook base is designed as a single piece with the or each hook element and is connected pivotably via at least one live hinge such that the or each hook element can pivot from a folded-in stowed position into a folded-out operating position with an opening angle. The integral hook arrangement here has a stop element, wherein a removable abutment and/or engagement is or can be formed between the integral hook base and the or each hook element in order to limit the opening angle in the folded-out operating position.

Abstract: An integral hook arrangement for hanging accessories in a vehicle interior, has at least one hook element and an integral hook base. The integral hook base is designed as a single piece with the or each hook element and is connected pivotably via at least one live hinge such that the or each hook element can pivot from a folded-in stowed position into a folded-out operating position with an opening angle. The integral hook arrangement here has a stop element, wherein a removable abutment and/or engagement is or can be formed between the integral hook base and the or each hook element in order to limit the opening angle in the folded-out operating position.

Abstract: A fastening clip for fastening coverings to body parts of a motor vehicle is provided. The fastening clip comprises a one-piece plastic part with a fastening foot for pressing into an opening provided in the respective body part, a supporting shaft adjoining the fastening foot and intended for receiving the covering by laterally pushing on a holding part provided on the covering, and a holding plate seated on the outer end of the supporting shaft. In order to improve and facilitate mounting, elastic ribs are provided on the periphery of the supporting shaft.

Abstract: An air-conditioning system of a motor vehicle to air-condition a vehicle interior may include a channel system through which air is flowable and an outside-air channel configured to let outside air into the channel system. The air-conditioning system may also include a system conveying device separating a suction area from a pressure area and a system filter device separating a raw area from a pure area. The system filter device may include a filter housing and a filter material. The air-conditioning system may additionally include a system outlet to let air into the vehicle interior and a sensor device, including a sensor housing, in which at least one analysis channel is arranged, through which air, a characteristic of which is measured, is flowable. The sensor device may also include at least one sensor inlet and at least one sensor outlet to let air in and out of the sensor device.

Abstract: An air filter element with a filter cover and a filter body, whereby the filter body is connected to the filter cover with a water drainage duct, whereby the filter cover has a first side and a second side opposite to the first side, whereby the filter body is connected to the first side and the water drainage duct is connected to the second side.

Abstract: An assembly for an air conditioning system may include an air filter for filtering drawn-in fresh air. The air filter may be arranged in a fresh air path and may separate a raw side from a clean side of the fresh air path. A water path for discharging water separated from the fresh air may be disposed at the raw side of the air filter. The water path may include a water filter for filtering the separated water. The water filter may separate a raw side from a clean side of the water path.

Abstract: An air filter element with a filter cover and a filter body, whereby the filter body is connected to the filter cover with a water drainage duct, whereby the filter cover has a first side and a second side opposite to the first side, whereby the filter body is connected to the first side and the water drainage duct is connected to the second side.

Abstract: A fastening clip for fastening coverings to body parts of a motor vehicle is provided. The fastening clip comprises a one-piece plastic part with a fastening foot for pressing into an opening provided in the respective body part, a supporting shaft adjoining the fastening foot and intended for receiving the covering by laterally pushing on a holding part provided on the covering, and a holding plate seated on the outer end of the supporting shaft. In order to improve and facilitate mounting, elastic ribs are provided on the periphery of the supporting shaft.

Abstract: An assembly for an air conditioning system may include an air filter for filtering drawn-in fresh air. The air filter may be arranged in a fresh air path and may separate a raw side from a clean side of the fresh air path. A water path for discharging water separated from the fresh air may be disposed at the raw side of the air filter. The water path may include a water filter for filtering the separated water. The water filter may separate a raw side from a clean side of the water path.