Abstract: This invention relates generally to inhibitors of trypsin-like serine protease enzymes, especially factor Xa or thrombin, pharmaceutical compositions containing the same, and methods of using the same as anticoagulant agents for treatment and prevention of thromboembolic disorders.

Abstract: A system and method for transparently transmitting aural signals across a wide area network (WAN). The system of present invention is connected to one or more of a private branch exchange, a key telephone system, a telephone, a facsimile machine, and a modem, for example. In the case of voice transmission, a user places a telephone call using the same procedure that is used when placing a telephone call over a conventional public switched network. The aural signals are translated into a format that is compatible with the local area network (LAN) and the translated signals are transmitted to a router or a switch that connects the LAN to the WAN. The data is transmitted across the WAN to a router or switch coupled to a second LAN. The data is then sent to a destination central site unit or PC which translates the signal into a format that is compatible with the telephone system connected thereto.

Abstract: Fermentation of Nocardia sp. ATCC-202099 in the presence of a halogen- or hydroxy-substituted tryptophan precursor yields a novel corresponding halogen- or hydroxy-substituted nocathiacin compound which has broad spectrum antibiotic activity against Gram-positive bacteria and has in vivo efficacy in animals.

Abstract: A case sealer for overlap flap type boxes wherein the major flaps extend greater than ½ the width of the carton. The case sealer uses a folding shoe for folding the inner major flap and then holding the inner major flap and a trailing minor flap in folded position until a plough folds a leading minor flap and the overlies the inner major flap and at least the leading minor flap at least until the outer major flap traps the trailing and leading flaps and thus the inner major flap in folded position.

Abstract: Novel thiazolyl peptide antibiotic compounds, including nocathiacin I, II and III, are disclosed. Also, novel microorganism ATCC-202099 is disclosed.

Abstract: The invention relates to libraries of synthetic test compound attached to separate phase synthesis supports. In particular, the invention relates to libraries of synthetic test compound attached to separate phase synthesis supports that also contain coding molecules that encode the structure of the synthetic test compound. The molecules may be polymers or multiple nonpolymeric molecules. Each of the solid phase synthesis support beads contains a single type of synthetic test compound. The synthetic test compound can have backbone structures with linkages such as amide, urea, carbamate (i.e., urethane), ester, amino, sulfide, disulfide, or carbon--carbon, such as alkane and alkene, or any combination thereof. Examples of subunits suited for the different linkage chemistries are provided.

Abstract: Novel nucleic acid molecules encoding proteins involved in the synthesis and assembly of O-antigen in P. aeruginosa; and novel proteins encoded by the nucleic acid molecules are described. Methods are disclosed for detecting P. aeruginosa in a sample by determining the presence of the proteins or a nucleic acid molecule encoding the proteins in the sample.

Abstract: A method and apparatus employing a memory management system that can be used with applications requiring a large contiguous block of memory, such as video decompression techniques (e.g., MPEG 2 decoding). The system operates with a computer and the computer's operating system to request and employ approximately 500 4-kilobyte pages in two or more noncontiguous blocks of the main memory to construct a contiguous 2-megabyte block of memory. The system can employ, on a single chip, a direct memory access engine, a microcontroller, a small block of optional memory, and a video decoder circuit. The microcontroller retains the blocks of multiple pages of the main memory, and the page descriptors of these blocks, so as to lock down these blocks of memory and prohibit the operating system or other applications from using them. The microcontroller requests the page descriptors for each of the blocks, and programs a lookup table or memory mapping system in the on-chip memory to form a contiguous block of memory.

Abstract: A system and method for extending the time period at which a facsimile response signal can be received before a time-out occurs without altering the underlying transmission protocol. The disclosed system and method determines a response time before which a response signal must be received by a transmitting facsimile station in order to avoid a time-out event. Before the response time arrives, the disclosed system and method generates and transmits a delay signal to the transmitting facsimile station which does not substantively interfere with ongoing communications. Instead, the delay signal causes the transmitting facsimile station to tickle an internal time-out counter which results in an extension of the response signal delay tolerance. Delay signal frames can be transmitted repeatedly to accommodate any desired time-out period.

Abstract: A system and method for transmitting aural signals across a wide area network (WAN) from a local phone coupled to a computer, e.g., a PC-phone, to a remote phone coupled to a KTS, PBX, or PSTN, for example. This capability is provided by the gateway unit of the present invention. The system of the present invention is quickly installed in a server or a personal computer coupled to a local area network. The system is connected to one or more of a PSTN, a private branch exchange, a key telephone system, a telephone, a facsimile machine, and a modem. In the case of voice transmission, a gateway unit translates received telephony signal into a format that is compatible with the telephone system or equipment connected thereto. The present invention can provide a voice quality that approaches, equals, or exceeds the voice quality of conventional telephone switched networks.

Abstract: The invention is directed to an expandable stent for implantation in a body lumen, such as an artery. The stent consists of a plurality of radially expandable cylindrical elements generally aligned on a common longitudinal stent axis and interconnected by one or more interconnecting members placed so as to limit longitudinal contraction during radial expansion. The individual radially expandable cylindrical elements are formed in an irregular serpentine pattern designed to expand evenly under radial stress, and maximize the overall radial expansion ratio.

Abstract: The invention relates to libraries of synthetic test compound attached to separate phase synthesis supports that also contain coding molecules that encode the structure of the synthetic test compound. The molecules may be polymers or multiple nonpolymeric molecules. The synthetic test compound can have backbone structures with linkages such as amide, urea, carbamate (i.e., urethane), ester, amino, sulfide, disulfide, or carbon-carbon, such as alkane and alkene, or any combination thereof. Examples of subunits suited for the different linkage chemistries are provided. The synthetic test compound can also be molecular scaffolds, such as derivatives of monocyclic of bicyclic carbohydrates, steroids, sugars, heterocyclic structures, polyaromatic structures, or other structures capable of acting as a scaffolding. Examples of suitable molecular scaffolds are provided.

Abstract: A system and method for extending the time period at which a response signal can be received before a time-out occurs without altering the length of the time-out period defined in any transmission protocol, ensuring that the two faxes communicate using one of a predefined, e.g., standard, set of transmission protocols, and/or ensuring that the two faxes communicate using one of a predefined set of signal modulation techniques. The present invention receives signals transmitted from a local fax and transmits these signals to a remote fax. Similarly, the present invention receives signals transmitted from the remote fax and transmits these signals to the local fax.

Abstract: A radiopaque marker associated with a stent which is adapted to be implanted into a patient's body lumen to maintain the patency thereof and a convenient and accurate method for affixing the radiopaque marker to the stent. The radiopaque marker defining an acceptable profile and capable of facilitating, under fluoroscopy, the identification of the position, diameter and length of a stent without obscuring the lesion being repaired and without impeding the deformation of an expandable stent.

Abstract: The invention is directed to an expandable stent for implantation in a body lumen, such as an artery. The stent consists of a plurality of radially expandable cylindrical elements generally aligned on a common longitudinal stent axis and interconnected by one or more interconnecting members placed so as to limit longitudinal contraction during radial expansion. The individual radially expandable cylindrical elements are formed in an irregular serpentine pattern designed to expand evenly under radial stress, and maximize the overall radial expansion ratio.

Abstract: The present invention is directed to linkers based on ester bond linkages, especially iminodiacetic acid ester bond linkages, for use in solid phase peptide synthesis. In particular, the invention is directed to cleavable linkers that can release peptide from the solid phase support under relatively mild conditions by formation of a diketopiperazine or other cyclic structure, such that the cyclic structure remains on the solid phase support, and, in a second cleavage, under more stringent conditions of high pH. The invention is further directed to solid phase supports prepared with multiple cleavable linkers, including a linker that is cleaved by formation of a cyclic product. One such second linker is an ester of hydroxymethylbenzoic acid, or esters formed by carboxy groups of aspartic or glutamic acid.

Abstract: The invention is directed to an expandable stent for implantation in a body lumen, such as an artery. The stent consists of a plurality of radially expandable cylindrical elements generally aligned on a common longitudinal stent axis and interconnected by one or more interconnecting members placed so as to limit longitudinal contraction during radial expansion. The individual radially expandable cylindrical elements are formed in general serpentine pattern designed to expand evenly under radial stress, and maximize the overall radial expansion ratio.

Abstract: The instant invention provides a library of bio-oligomers of defined size and known composition, in which the library contains all of the possible sequences of the bio-oligomers, and a method of synthesis thereof. The bio-oligomers of the library may be peptides, nucleic acids, or a combination of the foregoing. The instant invention also provides methods to identify bio-oligomers from a library that demonstrate desired characteristics such as binding, bioactivity and catalytic activity. Thus the instant invention provides a unique and powerful method to identify a useful bio-oligomer sequences from a library more quickly than current state-of-the-art technology allows. Effector molecules for use in treatment or diagnosis of disease are also provided.

Abstract: A calling station sends to a called station a call request package including the address of the called station and the information digitizing rate of the calling station. The packet may also include the address of the calling station. The called station selects the lower of the information digitizing rates of the calling and called stations or the information digitizing rates of both stations if such rates are the same. The called station sends to the calling station a call request response package including the selected information digitizing rate. The call request response packet may include the addresses of the calling and called stations. The calling station selects the lower of the information digitizing rates of the calling and called stations or the information digitizing rates of both stations if both rates are the same. The information digitizing rates of the calling and called stations may be the voice digitizing rates of both stations.

Abstract: Addition of certain tryptophan analogs to the culture medium during fermentation of a rebeccamycin-producing strain of Saccharothrix aerocolonigenes results in production of new rebeccamycin analogs having advantageous antitumor properties.