Patents by Inventor For S. Lam

For S. Lam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROARYL COMPOUNDS AS P2Y1 RECEPTOR INHIBITORS
    Publication number: 20100093689
    Abstract: The present invention provides novel heteroaryl compounds and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.
    Type: Application
    Filed: November 17, 2009
    Publication date: April 15, 2010
    Inventors: James C. Sutton, Zulan Pi, Rejean Ruel, Alexandre L'Heureux, Carl Thibeault, Patrick Y.S. Lam
  • Urea antagonists of P2Yreceptor useful in the treatment of thrombotic conditions
    Patent number: 7674828
    Abstract: The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.
    Type: Grant
    Filed: May 8, 2008
    Date of Patent: March 9, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Hannguang J. Chao, Huji Tuerdi, Timothy F. Herpin, Jacques Y. Roberge, Yalei Liu, Michael R. Lawrence, Robert P. Rehfuss, Charles G. Clark, Jennifer X. Qiao, Timur Gungor, Patrick Y. S. Lam, Tammy C. Wang, Rejean Ruel, Alexandre L'Heureux, Carl Thibeault, Gilles Bouthillier, Dora M. Schnur
  • Dual action inlet door and method for use thereof
    Patent number: 7665694
    Abstract: An inlet door assembly and method for reducing noise from an auxiliary power unit (APU) contained within an aircraft housing is provided. The inlet assembly includes an inlet duct, an actuator, and a door. The inlet duct is configured to extend from the auxiliary power unit to the aircraft housing and has a sidewall that defines a flow passage through which APU noise propagates. The actuator is disposed at least partially within the inlet duct. The door coupled to the actuator. The actuator is also configured to selectively rotate the door between at least a first position, in which at least a portion of the door deflects APU noise in a first direction, and a second position, in which at least a portion of the door deflects the APU noise in a second direction.
    Type: Grant
    Filed: March 27, 2007
    Date of Patent: February 23, 2010
    Assignee: Honeywell International Inc.
    Inventors: Jeffrey M. Hein, Nicholas A. Williams, Yogendra Y. Sheoran, Cecilia S. Lam, Ora Morency Cowans, Benjamen Kurt Higuera, Andrew Stephen Peduchi, Ravisha Pramod Sellahewa, Daniel Brown
  • Chemical Antibodies for Immunotherapy and Imaging
    Publication number: 20100021379
    Abstract: The present invention provides antibody conjugates comprising a targeting agent covalently attached to an antibody or fragment thereof. The antibody conjugates of the present invention are particularly useful for imaging a tumor, organ, or tissue and for treating diseases and disorders such as cancer, inflammatory diseases, autoimmune diseases, infectious diseases, and neurological disorders. Kits containing the antibody conjugates described herein find utility in a wide range of applications including, for example, in vivo imaging and immunotherapy.
    Type: Application
    Filed: June 28, 2007
    Publication date: January 28, 2010
    Applicant: The Regents of the University of California
    Inventors: Kit S. Lam, Pappanaicken R. Kumaresan, Amanda Enstrom, Ruiwu Liu
  • Methods of oligosaccharide profiling for the detection of cancer
    Patent number: 7651847
    Abstract: The present invention provides methods for identifying oligosaccharides specific to cancer and methods for determining a strain of cancer in an individual. The present invention also provides methods for diagnosing cancer or a stage of cancer in an individual by detecting the presence or absence of specific cancer markers and methods for treating cancer by administering antibodies directed to such markers. In addition, the present invention provides cancer markers comprising O-linked oligosaccharides and kits for diagnosing or treating cancer.
    Type: Grant
    Filed: June 20, 2005
    Date of Patent: January 26, 2010
    Assignee: The Regents of the University of California
    Inventors: Carlito B. Lebrilla, Hyun Joo An, Kit S. Lam, Suzanne Miyamoto
  • Heteroaryl compounds as P2Yreceptor inhibitors
    Patent number: 7645778
    Abstract: The present invention provides novel heteroaryl compounds and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.
    Type: Grant
    Filed: January 17, 2006
    Date of Patent: January 12, 2010
    Assignee: Bristol-Myers Squibb COmpany
    Inventors: James C. Sutton, Zulan Pi, Rejean Ruel, Alexandre L'Heureux, Carl Thibault, Patrick Y. S. Lam
  • Enhanced spell checking utilizing a social network
    Publication number: 20090254817
    Abstract: A computer-implemented method of enhancing spell check. The method can include receiving from each of a plurality of clients at least one custom term and at least one class identifier that is associated with the custom term. The custom terms and the associated class identifiers can be processed to provide an electronic dictionary that includes a plurality of shared terms. Each of the shared terms can be associated with at least one of the class identifiers to which the shared term corresponds. Each of the custom terms can correspond to at least one of the shared terms. At least one of the shared terms can be output to at least one of the plurality of clients.
    Type: Application
    Filed: April 3, 2008
    Publication date: October 8, 2009
    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Marc Dreyfus, Derek S. Lam, Asima Silva, Robert C. Weir
  • SYSTEM AND METHOD FOR DETERMINING RFID TAG PLACEMENT
    Publication number: 20090231142
    Abstract: In systems and methods for determining the placement of radio-frequency identification (RFID) tags, a tag reader communicates with one or more RFID tags at different locations of a target object. The tag reader determines which of the different locations is a preferable location for placing an RFID tag by detecting the transmission power level or other value required to communicate with the RFID tag at each of the different locations.
    Type: Application
    Filed: March 11, 2008
    Publication date: September 17, 2009
    Inventors: Pavel Nikitin, Venkata Kodukula, John Bleichner, For S. Lam
  • Alpha-4 beta-1 integrin ligands for imaging and therapy
    Patent number: 7576175
    Abstract: The present invention provides ?4?1 integrin ligands that display high binding affinity, specificity, and stability. The ligands comprise a peptide having n independently selected amino acids, wherein at least one amino acid is an unnatural amino acid or a D-amino acid, and wherein n is an integer of from 3 to 20. Methods are provided for administering the ligands for treating cancer, inflammatory diseases, and autoimmune diseases. Also provided are methods for administering the ligands for imaging a tumor, organ, or tissue in a subject.
    Type: Grant
    Filed: May 26, 2005
    Date of Patent: August 18, 2009
    Assignee: The Regents of the University of California
    Inventors: Kit S. Lam, Ruiwu Liu, Li Peng
  • COMPACT FLEXIBLE HIGH GAIN ANTENNA FOR HANDHELD RFID READER
    Publication number: 20090174557
    Abstract: A compact flexible high gain antenna is disclosed which includes a co-planar array of at least three substantially parallel main conducting antenna elements, a reflector, a driven element, and a director. Each of these elements may be terminated on the ends by a stub element, and the reflector and the director may include an intermediate meander element. Stub elements capacitively load the antenna, while meander elements inductively load the antenna, and the loading affects the resonant frequency of the antenna. The conducting antenna elements may be affixed to a flexible dielectric substrate and may be bent or curved into different compact shapes, suitable for fitting manufacturing form factors for a handheld RFID reader. The antenna has a high directional gain which results in a longer operating range.
    Type: Application
    Filed: January 3, 2008
    Publication date: July 9, 2009
    Inventors: Pavel Nikitin, KVS Rao, For S. Lam, Steven Schatz, Jerry Johnson
  • LACTAM-CONTAINING COMPOUNDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS
    Publication number: 20090176758
    Abstract: The present application describes lactam-containing compounds and derivatives thereof of Formula I: P4—P-M-M4??I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
    Type: Application
    Filed: March 10, 2009
    Publication date: July 9, 2009
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Donald J.P. Pinto, Mimi L. Quan, Michael J. Orwat, Yun-Long Li, Wei Han, Jennifer X. Qiao, Patrick Y.S. Lam, Stephanie L. Koch
  • Meeting Scheduling to Minimize Inconvenience of Meeting Participants
    Publication number: 20090132329
    Abstract: A computer-implemented method of automatically scheduling meetings can include determining that no timeslot is available for scheduling a proposed meeting involving a plurality of participants and selecting a plurality of candidate times for the proposed meeting. An inconvenience metric for each participant of the proposed meeting can be calculated. A schedule misfit metric for each of the plurality of candidate times can be calculated, at least in part, according to the inconvenience metric for each participant. A time for the proposed meeting can be selected from the candidate times according to the schedule misfit metric. The proposed meeting can be scheduled for the selected time.
    Type: Application
    Filed: November 20, 2007
    Publication date: May 21, 2009
    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Derek S. Lam, Asima Silva, Ping Wang, Robert C. Weir, Andrew L. Schirmer, Tolga Oral
  • Processing Electronic Messages According to Sender Classification
    Publication number: 20090106370
    Abstract: A computer-implemented method of sorting electronic messages can include identifying at least one recipient of an electronic message and retrieving a classification scheme of the recipient. An identifier can be included within the electronic message. The identifier can specify a tag selected from the classification scheme of the recipient. The electronic message, including the identifier specifying the selected tag, can be sent.
    Type: Application
    Filed: October 19, 2007
    Publication date: April 23, 2009
    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Marc Dreyfus, Derek S. Lam, Michael Muller, Asima Silva, Ping Wang, Robert C. Weir
  • Detection of Missing Recipients in Electronic Messages
    Publication number: 20090100183
    Abstract: A computer-implemented method of identifying a missing recipient of an electronic message can include identifying at least one user specified as a recipient of an electronic message and accessing a data store comprising measures of correlation between a plurality of users, wherein the plurality of users comprises the recipient of the electronic message. One or more users not designated as a recipient of the electronic message and having a measure of correlation, with at least one recipient of the electronic message, that exceeds a predetermined threshold can be identified as a potential missing recipient of the electronic message. An indication that a recipient may have been excluded from the electronic message can be output.
    Type: Application
    Filed: October 14, 2007
    Publication date: April 16, 2009
    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Derek S. Lam, Asima Silva, Ping Wang, Robert C. Weir
  • SYSTEM AND COMPUTER PROGRAM FOR MONITORING PERFORMANCE OF APPLICATIONS IN A DISTRIBUTED ENVIRONMENT
    Publication number: 20090070462
    Abstract: A system and computer program for monitoring the performance of applications running on a server in a distributed computing environment includes prompting the user to select information for monitoring, monitoring application performance in accordance with the selected information, and making the monitored performance information available to the user.
    Type: Application
    Filed: September 22, 2008
    Publication date: March 12, 2009
    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: James C. CHONG, Joseph L. CHAN, Tushar M. PATEL, Jean Jacques HELER, Chi Hong SO, Arthur TSANG, Robert S. LAM, Raymond CHOW, Jerome D. BANKS, Christopher M. ZYCHOWSKI, Henry TANG
  • DUAL ACTION INLET DOOR AND METHOD FOR USE THEREOF
    Publication number: 20090065297
    Abstract: An inlet door assembly and method for reducing noise from an auxiliary power unit (APU) contained within an aircraft housing is provided. The inlet assembly includes an inlet duct, an actuator, and a door. The inlet duct is configured to extend from the auxiliary power unit to the aircraft housing and has a sidewall that defines a flow passage through which APU noise propagates. The actuator is disposed at least partially within the inlet duct. The door coupled to the actuator. The actuator is also configured to selectively rotate the door between at least a first position, in which at least a portion of the door deflects APU noise in a first direction, and a second position, in which at least a portion of the door deflects the APU noise in a second direction.
    Type: Application
    Filed: March 27, 2007
    Publication date: March 12, 2009
    Applicant: HONEYWELL INTERNATIONAL, INC.
    Inventors: Jeffrey M. Hein, Nicholas A. Williams, Yogendra Y. Sheoran, Cecilia S. Lam, Ora Morency Cowans, Benjamen Kurt Higuera, Andrew Stephen Peduchi, Ravisha Pramod Sellahewa, Daniel Brown
  • METHOD, SYSTEM, AND COMPUTER PROGRAM FOR MONITORING PERFORMANCE OF APPLICATIONS IN A DISTRIBUTED ENVIRONMENT
    Publication number: 20090019441
    Abstract: A method, system, and computer program include receiving a request string, and mapping the received request string to a distinguishable request string and a collapsible request string. The received request string may be in the form of a JSP, a servlet, and remote Enterprise Java Bean calls. A user may be prompted to create rules for mapping of a received request string to a distinguishable request string and a collapsible request string.
    Type: Application
    Filed: September 23, 2008
    Publication date: January 15, 2009
    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: James C. CHONG, Joseph L. CHAN, Tushar M. PATEL, Jean Jacques HELER, Chi Hong SO, Arthur TSANG, Robert S. LAM, Raymond CHOW, Jerome D. BANKS, Christopher M. ZYCHOWSKI, Henry TANG
  • Dual action inlet door and method for use thereof
    Patent number: 7461814
    Abstract: An inlet door assembly and method for reducing noise from an auxiliary power unit (APU) contained within an aircraft housing is provided. The inlet assembly includes an inlet duct, an actuator, and a door. The inlet duct is configured to extend from the auxiliary power unit to the aircraft housing and has a sidewall that defines a flow passage through which APU noise propagates. The actuator is disposed at least partially within the inlet duct. The door coupled to the actuator. The actuator is also configured to selectively rotate the door between at least a first position, in which at least a portion of the door deflects APU noise in a first direction, and a second position, in which at least a portion of the door deflects the APU noise in a second direction.
    Type: Grant
    Filed: December 8, 2005
    Date of Patent: December 9, 2008
    Assignee: Honeywell International Inc.
    Inventors: Jeffrey M. Hein, Nicholas A. Williams, Yogendra Y. Sheoran, Cecilia S. Lam, Ora Morency Cowans, Benjamen Kurt Higuera, Andrew Stephen Peduchi, Ravisha Pramod Sellahewa, Daniel Brown
  • Digital hidden data transport (DHDT)
    Patent number: 7460667
    Abstract: A system for embedding auxiliary digital information into a primary digital signal to form a composite digital signal. Auxiliary data bits modulate a pseudo-random (e.g., PN) sequence to provide an auxiliary data sequence used to modify the Least Perceptually Significant Bits (LPSBs) of successive multi-bit samples of the primary signal. In a cross-term compensation embodiment, a correlation between the PN sequence and the sample bits is determined, and compared to the auxiliary data bits to determine whether there is a desired correspondence. The LPSBs in the samples are toggled, if necessary, to provide the desired correspondence. The selection of LPSBs to modify accounts for a desired noise level of the auxiliary data in the primary signal. LPSBs may be modified based on a sparse PN sequence to achieve the desired noise level and conceal the presence of the auxiliary data.
    Type: Grant
    Filed: May 26, 2004
    Date of Patent: December 2, 2008
    Assignee: Verance Corporation
    Inventors: Chong U. Lee, Katherine S. Lam, Julien J. Nicolas, Edward Atrero
  • UREA ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS
    Publication number: 20080280905
    Abstract: The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.
    Type: Application
    Filed: May 8, 2008
    Publication date: November 13, 2008
    Applicant: Bristol Myers Squibb Company
    Inventors: Hannguang J. Chao, Huji Tuerdi, Timothy F. Herpin, Jaques Yves Roberge, Yalei Liu, R. Michael Lawrence, Robert P. Rehfuss, Charles G. Clark, Jennifer X. Qiao, Timur Gungor, Patrick Y. S. Lam, Tammy Wang, Rejean Ruel, Alexandre L'Heureux, Carl Thibeault, Gilles Bouthillier, Dora M. Schnur