Abstract: Methods and compositions are provided for treating a vascular abnormality.

Abstract: The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.

Abstract: Methods and systems of managing workloads and resources for tenants structured as a hierarchical tenant queue defining a resource distribution policy. The tenants are modified and the system responds with dynamic adjustments to the hierarchical tenant queue and workload distribution. A rule-based workload management engine defines rules for actions for the workload to respond to the dynamic update.

Abstract: Methods and systems of managing a resource in a distributed resource management system can include: receiving a resource request including data identifying at least one requested resource attribute; identifying one or more candidate resources from a plurality of resources by performing element-wise operations on one or more resource attribute element sets corresponding to the at least one requested resource attribute, each resource attribute element set comprising an element for each of the plurality of resources, each element representing a resource attribute for a respective resource of the plurality of resources; and scheduling a workload associated with the resource request for execution based on the one or more identified candidate resources.

Abstract: The present invention provides a nanocarrier having an interior and an exterior, the nanocarrier comprising at least one conjugate, wherein each conjugate includes a polyethylene glycol (PEG) polymer. Each conjugate also includes at least two amphiphilic compounds having both a hydrophilic face and a hydrophobic face. In addition, each conjugate includes an oligomer, wherein at least 2 of the amphiphilic compounds are covalently attached to the oligomer which is covalently attached to the PEG. The nanocarrier is such that each conjugate self-assembles in an aqueous solvent to form the nanocarrier such that a hydrophobic pocket is formed in the interior of the nanocarrier by the orientation of the hydrophobic face of each amphiphilic compound towards each other, and wherein the PEG of each conjugate self-assembles on the exterior of the nanocarrier.

Abstract: Embodiments of the present invention provide systems and methods for allocating multiple resources. In one embodiment, a configured resource plan is used to construct a hierarchical tree. The system then identifies a set of unowned resources from the configured resource plan and sends the set of unowned resource to a share pool. The share pool is either a global or local pool and can be accessed by one or more consumers. In response to changes in workload demands, a set of unused resources are lent to a global or local pool.

Abstract: In a distributed computing network, requests for allocation of resources to tenant workloads and messages identifying resource availability are received and aggregated. Resources are allocated to the workloads in accordance with a distribution policy defining values for resource entitlements of the tenants. The values include pre-emption quantities. In response to determining that a quantity of resources allocated for workloads of a first tenant is less than the tenant's pre-emption quantity, processing of another workload from a second tenant is interrupted to re-allocate resources from the second tenant's workload to the first tenant's workload.

Abstract: Embodiments of the present invention provide systems and methods for allocating multiple resources. In one embodiment, a configured resource plan is used to construct a hierarchical tree. The system then identifies a set of unowned resources from the configured resource plan and sends the set of unowned resource to a share pool. The share pool is either a global or local pool and can be accessed by one or more consumers. In response to changes in workload demands, a set of unused resources are lent to a global or local pool.

Abstract: Problem determination in an enterprise computer system in a distributed environment is provided. Information is obtained regarding the enterprise applications, and high-level information is presented to a user, with one or more prompts provided to the user for more detailed information. In response to a request from a user for more detailed information about the application, more detailed information is provided to the user. Several levels of more detailed information about applications, including information as to individual threads, is available. The method also includes the steps of receiving instructions from an administrator to establish an account for a user, associating one or more servers with the account, and providing access to the corresponding user only to the associated servers. In the method, searches may be conducted for strings and requests, and identified strings and requests may be sorted by a variety of criteria.

Abstract: A single workload scheduler schedules sessions and tasks having a tree structure to resources, wherein the single workload scheduler has scheduling control of the resources and the tasks of the parent-child workload sessions and tasks. The single workload scheduler receives a request to schedule a child session created by a scheduled parent task that when executed results in a child task; the scheduled parent task is dependent on a result of the child task. The single workload scheduler receives a message from the scheduled parent task yielding a resource based on the resource not being used by the scheduled parent task, schedules tasks to backfill the resource, and returns the resource yielded by the scheduled parent task to the scheduled parent task based on receiving a resume request from the scheduled parent task or determining dependencies of the scheduled parent task have been met.

Abstract: The present invention provides compounds and pharmaceutical compositions of a peptidomimetic ligand, e.g. LLP2A, conjugated with a bisphosphonate drug, e.g. Alendronate. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of osteoporosis and for the promotion of bone growth due to their specificity for the ?4?1 integrin on mesenchymal stem cells and for the surface of bone.

Abstract: The present invention is directed to bladder cancer specific ligand peptides, comprising the amino acid sequence X1DGRX5GF (SEQ ID NO: 1), and methods of their use, e.g., for imaging detection for diagnosis of bladder, tumor localization to guide transurethral resection of bladder cancer, imaging detection of bladder cancer for follow-up after the initial treatment that can replace or complement costly cystoscopy, imaging detection of metastatic bladder cancer, and targeted therapy for superficial and metastatic bladder cancer.

Abstract: A method, system, and computer program include receiving a request string, and mapping the received request string to a distinguishable request string and a collapsible request string. The received request string may be in the form of a JSP, a servlet, and remote Enterprise Java Bean calls. A user may be prompted to create rules for mapping of a received request string to a distinguishable request string and a collapsible request string.

Abstract: A system for managing a distributed service may include one or more compute nodes, with each compute node having one or more computer processors and a memory. The system may additionally include: a set of software services, the set of software services including the distributed service; a configuration manager to store configuration information about the distributed service, including a criteria for transitioning the distributed service from a first execution state to an initialization state, the criteria associating the execution first state with a second execution state of a first service of the set of software services; a set of measuring agents to obtain execution information from the set of software services; an execution system configured to: determine, based on the execution information, whether the criteria is satisfied; and transition, in response to determining that the criteria is satisfied, the distributed service from the first execution state to the initialization state.

Abstract: A computer processor allocates a service instance to a first resource of a resource pool, in which the service instance corresponds to performing a first task and for the service instance to continue to occupy the first resource subsequent to task completion, and determines the first resource to be idle. The first resource is returned to a resource pool, with the service instance occupying the first resource as a global standby service instance of a first service. In response to a request of a resource to perform a task from a second application, in which the request for the resource includes a global name associated with the first service of the global standby service instance, occupying the first resource returned to the resource pool, allocating from the resource pool, the first resource occupied by the global standby service instance, based on the global name associated with the first service.

Abstract: A single workload scheduler schedules sessions and tasks having a tree structure to resources, wherein the single workload scheduler has scheduling control of the resources and the tasks of the parent-child workload sessions and tasks. The single workload scheduler receives a request to schedule a child session created by a scheduled parent task that when executed results in a child task; the scheduled parent task is dependent on a result of the child task. The single workload scheduler receives a message from the scheduled parent task yielding a resource based on the resource not being used by the scheduled parent task, schedules tasks to backfill the resource, and returns the resource yielded by the scheduled parent task to the scheduled parent task based on receiving a resume request from the scheduled parent task or determining dependencies of the scheduled parent task have been met.

Abstract: The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula PEG-L-D-(R)n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a poly(ethylene glycol) polymer; each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Cell free methods of making the nanodiscs are also provided.

Abstract: The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.

Abstract: A method for order prioritization includes calculating a cycle time for a product order of a plurality of product orders using an artificial neural network, determining a first order priority of the product order based on a priority index using an analytic hierarchy process, determining a second order priority of the product order based on event based simulation model, and determining a shipping date for the product order based on the second order priority. The artificial neural network calculates the cycle time based upon product order type and a plurality of component counts. The analytic hierarchy process determines a first order priority based upon a plurality of product order attributes. The simulation model determines a second order priority and completion time based upon the first order priority, product model, product type, a plurality of component counts, manufacturing capacity and inventory data, and production time data for historical product orders.

Abstract: Methods and systems of managing a resource in a distributed resource management system can include: monitoring, by at least one processor, utilization of the resource being used by at least one workload; and performing an enforcement action on a particular workload of the at least one workload when a utilization condition is met, and when the particular workload has a current resource utilization exceeding its associated resource allocation limit.