Abstract: A method, computer program product, and system for optimizing service pools supporting resource sharing and enforcing SLAs, to minimize service restart. A computer processor determines a first resource to be idle, wherein a service instance continues to occupy the first resource that is idle. The processor adds the first resource to a resource pool, wherein the service instance continues to occupy the first resource as a global standby service instance on the first resource. The processor receives a request for a resource, wherein the request for the resource includes a global name associated with a service that corresponds to the global standby service instance, and the processor allocates, from the resource pool, the first resource having the global standby service instance, based on the request for the resource that includes the global name associated with the service corresponding to the global standby service instance.

Abstract: The present invention provides a nanocarrier having an interior and an exterior, the nanocarrier comprising at least one conjugate, wherein each conjugate includes a polyethylene glycol (PEG) polymer. Each conjugate also includes at least two amphiphilic compounds having both a hydrophilic face and a hydrophobic face. In addition, each conjugate includes an oligomer, wherein at least 2 of the amphiphilic compounds are covalently attached to the oligomer which is covalently attached to the PEG. The nanocarrier is such that each conjugate self-assembles in an aqueous solvent to form the nanocarrier such that a hydrophobic pocket is formed in the interior of the nanocarrier by the orientation of the hydrophobic face of each amphiphilic compound towards each other, and wherein the PEG of each conjugate self-assembles on the exterior of the nanocarrier.

Abstract: The present application describes lactam-containing compounds and derivatives thereof of Formula I: P4—P-M-M4??I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.

Abstract: The present invention provides compounds and pharmaceutical compositions of a peptidomimetic ligand, e.g. LLP2A, conjugated with a bisphosphonate drug, e.g. Alendronate. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of osteoporosis and for the promotion of bone growth due to their specificity for the ?4?1 integrin on mesenchymal stem cells and for the surface of bone.

Abstract: The present invention is directed to bladder cancer specific ligand peptides, comprising the amino acid sequence X1DGRX5GF (SEQ ID NO:1), and methods of their use, e.g., for imaging detection for diagnosis of bladder, tumor localization to guide transurethral resection of bladder cancer, imaging detection of bladder cancer for follow-up after the initial treatment that can replace or complement costly cystoscopy, imaging detection of metastatic bladder cancer, and targeted therapy for superficial and metastatic bladder cancer.

Abstract: The present invention provides compounds of Formula (I): Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are antagonists of P2Y1 receptor which may be used medicaments.

Abstract: A method, computer program product, and system for optimizing service pools supporting resource sharing and enforcing SLAs, to minimize service restart. A computer processor determines a first resource to be idle, wherein a service instance continues to occupy the first resource that is idle. The processor adds the first resource to a resource pool, wherein the service instance continues to occupy the first resource as a global standby service instance on the first resource. The processor receives a request for a resource, wherein the request for the resource includes a global name associated with a service that corresponds to the global standby service instance, and the processor allocates, from the resource pool, the first resource having the global standby service instance, based on the request for the resource that includes the global name associated with the service corresponding to the global standby service instance.

Abstract: A one-bead-one-compound (OBOC) assay technique and associated components and kits are disclosed herein. With the described assay, target macromolecules that are bound to compound beads, and the compounds can be identified and separated without labeling the compounds.

Abstract: The present invention provides kits and methods for detecting peptides that change of the fluorescence of dyes upon binding to the dye. In addition, the invention provides methods for identifying said peptides.

Abstract: Embodiments of the present invention provide systems and methods for allocating multiple resources. In one embodiment, a configured resource plan is used to construct a hierarchical tree. The system then identifies a set of unowned resources from the configured resource plan and sends the set of unowned resource to a share pool. The share pool is either a global or local pool and can be accessed by one or more consumers. In response to changes in workload demands, a set of unused resources are lent to a global or local pool.

Abstract: Embodiments of the present invention provide systems and methods for allocating multiple resources. In one embodiment, a configured resource plan is used to construct a hierarchical tree. The system then identifies a set of unowned resources from the configured resource plan and sends the set of unowned resource to a share pool. The share pool is either a global or local pool and can be accessed by one or more consumers. In response to changes in workload demands, a set of unused resources are lent to a global or local pool.

Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are antagonists of P2Y1 receptor and may be used as medicaments in the treatment and/or prophylaxis of thromboembolic disorders.

Abstract: The present invention provides methods of treating a subject having a primary inflammatory disease or disorder comprising administering to the subject a composition comprising a conjugate of an LLP2A peptidomimetic ligand and a bisphosphonate drug, wherein the composition comprising the LLP2A-bisphosphonate conjugate enhances the delivery of mesenchymal stem cells to a site of inflammation. Methods of enhancing an anti-inflammatory or immunomodulatory property of mesenchymal stem cells, comprising administering to a subject in need thereof the mesenchymal stem cells and a composition comprising a conjugate of an LLP2A peptidomimetic ligand and a bisphosphonate drug, are also provided.

Abstract: A single workload scheduler schedules sessions and tasks having a tree structure to resources, wherein the single workload scheduler has scheduling control of the resources and the tasks of the parent-child workload sessions and tasks. The single workload scheduler receives a request to schedule a child session created by a scheduled parent task that when executed results in a child task; the scheduled parent task is dependent on a result of the child task. The single workload scheduler receives a message from the scheduled parent task yielding a resource based on the resource not being used by the scheduled parent task, schedules tasks to backfill the resource, and returns the resource yielded by the scheduled parent task to the scheduled parent task based on receiving a resume request from the scheduled parent task or determining dependencies of the scheduled parent task have been met.

Abstract: The present invention provides a cell adhesion matrix having poly(vinyl alcohol) chains crosslinked via carboxy phenyl boronic acid crosslinkers. The cell adhesion matrix can also include a molecular recognition element bound to the poly(vinyl alcohol) chains via a carboxy phenyl boronic acid group, as well as including cells. The present invention also provides a method for making and de-gelling the cell adhesion matrix.

Abstract: The present invention provides compounds and pharmaceutical compositions of a peptidomimetic ligand, e.g. LLP2A, conjugated with a bisphosphonate drug, e.g. Alendronate. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of osteoporosis and for the promotion of bone growth due to their specificity for the ?4?1 integrin on mesenchymal stem cells and for the surface of bone.

Abstract: The present invention is drawn to cyclic RGD peptides linked via a disulfide bond, where the terminal cysteines are preferably in the D configuration. These peptides target ?v?3 integrin on tumor cells and neovasculatures and function as targeting agents for tumor diagnostic imaging and therapy. Compared with the commonly used RGD ligands, compounds of the present invention have improved targeting efficacy and lower nonspecific binding to normal organs. Moreover, the compounds of the present invention can be functionalized to conjugate imaging payload without decreasing binding strength.

Abstract: A single workload scheduler schedules sessions and tasks having a tree structure to resources, wherein the single workload scheduler has scheduling control of the resources and the tasks of the parent-child workload sessions and tasks. The single workload scheduler receives a request to schedule a child session created by a scheduled parent task that when executed results in a child task; the scheduled parent task is dependent on a result of the child task. The single workload scheduler receives a message from the scheduled parent task yielding a resource based on the resource not being used by the scheduled parent task, schedules tasks to backfill the resource, and returns the resource yielded by the scheduled parent task to the scheduled parent task based on receiving a resume request from the scheduled parent task or determining dependencies of the scheduled parent task have been met.

Abstract: The present invention provides compounds of Formula (I): Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are antagonists of P2Y1 receptor which may be used medicaments.

Abstract: The present invention provides compounds and pharmaceutical compositions of a peptidomimetic ligand, e.g. LLP2A, conjugated with a bisphosphonate drug, e.g. Alendronate. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of osteoporosis and for the promotion of bone growth due to their specificity for the ?4?1 integrin on mesenchymal stem cells and for the surface of bone.