Abstract: A new class of alkylsulfonyl-substituted thiazolide compounds is described. These compounds show strong activity against hepatitis virus.

Abstract: A new class of haloalkyl heteroaryl benzamides is described. These compounds show strong activity against hepatitis viruses.

Abstract: A new class of haloalkyl heteroaryl benzamides is described. These compounds show strong activity against hepatitis viruses.

Abstract: A new class of alkylsulfinyl thiazolides is described. These compounds show strong activity against hepatitis viruses.

Abstract: The present disclosure relates to methods for treating viral hepatitis, compounds useful in the treatment of viral hepatitis, and pharmaceutical compositions comprising such compounds. In one embodiment, pharmaceutical compositions comprising nitazoxanide, tizoxanide, or derivatives and/or mixtures thereof are provided, as well as methods of treating hepatitis C using such compositions.

Abstract: Solid dosage formulations of nitazoxanide or a nitazoxanide analogue are provided that comprise a controlled release portion and an immediate release portion. The pharmaceutical composition is typically in the form of a bilayer solid oral dosage form comprising (a) a first layer comprising a first quantity of nitazoxanide or analogue thereof in a controlled release formulation; and (b) a second layer comprising a second quantity of nitazoxanide or analogue thereof in an immediate release formulation. Method of using the formulations in the treatment of hepatitis C are also provided.

Abstract: The present disclosure relates to methods for treating viral hepatitis, compounds useful in the treatment of viral hepatitis, and pharmaceutical compositions comprising such compounds. In one embodiment, pharmaceutical compositions comprising nitazoxanide, tizoxanide, or derivatives and/or mixtures thereof are provided, as well as methods of treating hepatitis C using such compositions.

Abstract: A method and an apparatus for filtering motion vector fields provided by a motion estimator apparatus are disclosed. The method includes receiving an input image, determining a motion vector field associated with the input image, determining a local segmentation image, forming a lattice map to identify periodic structures, using the local segmentation image and the lattice map to obtain an image segment pixel count and an image/motion segment pixel count, and using the segment pixel count and the image/motion segment pixel count to provide a filtered motion vector field. Some embodiments further include a motion estimation apparatus including an image delay apparatus, a lattice detector to find lattice structures in the input and delayed images, a histogram generator and a histogram analyzer to provide a set of horizontal and vertical search masks, a motion vector estimator to provide a motion vector field, and a motion vector filter as provided herein.

Abstract: An image interpolator for high-definition images is presented that utilizes a two or more level hierarchical decomposition for complexity reduction. At the lowest level, after a block-based motion estimator, a pixel-based motion vector selector and a motion vector-based halo reducer, an occlusion-based adaptive motion field interpolator provides preliminary motion vectors for higher resolution level. At the high resolution level, a new motion estimation refining based on the double consideration of eventual occlusion region and motion vector precision refines the preliminary motion vectors, and again a motion vector-based halo reduction re-corrects the refined motion vectors. A new motion compensated image interpolator with controllable features for multiple interpolated images is presented. A versatile post-processing configuration for remaining artifacts may also be included.

Abstract: Solid dosage formulations of nitazoxanide or a nitazoxanide analogue are provided that comprise a controlled release portion and an immediate release portion. The pharmaceutical composition is typically in the form of a bilayer solid oral dosage form comprising (a) a first layer comprising a first quantity of nitazoxanide or analogue thereof in a controlled release formulation; and (b) a second layer comprising a second quantity of nitazoxanide or analogue thereof in an immediate release formulation. Method of using the formulations in the treatment of hepatitis C are also provided.

Abstract: The invention provides for the use of pharmaceutical compositions comprising a thiazolide in the stimulation of the immune system in a subject in need thereof, thereby preventing and/or treating viral diseases, cancer and diseases caused by intracellular protozoan infections

Abstract: A system and method for estimating random noise in an image frame or a sequence of image frames are presented. In some embodiments, the method includes performing Global Noise Estimation by comparing current and past filtered frames; converting global noise estimates into local noise estimates using estimated noise parameters based on current input image's local mean intensity; and providing local noise estimates to an adapted generic spatio-temporal filter. A parameter-based noise model is applied in the noise calculation.

Abstract: A method and apparatus for estimating motion of a pixel block in a first frame, the method including searching a first area in a second frame to identify a first matching block that corresponds to the pixel block, the first matching block including a first error value that is a minimum of at least one error criteria between the pixel block and the first matching block, calculating a first motion vector associated with the first matching block. The method further including searching a second area in the second frame to identify a second matching block that corresponds to the pixel block, the second matching block including a second error value that is a minimum of the at least one error criteria between the pixel block and the second matching block, calculating a second motion vector associated with the second matching block and selecting a final motion vector between the first and second motion vectors based on the first and second error value.

Abstract: A new class of alkylsulfonyl-substituted thiazolide compounds is described. These compounds show strong activity against hepatitis virus.

Abstract: A new class of salicylanilides is described. These compounds show strong activity against hepatitis viruses.

Abstract: A new class of alkylsulfinyl thiazolides is described. These compounds show strong activity against hepatitis viruses.

Abstract: A new class of alkylsulfonyl-substituted thiazolide compounds is described. These compounds show strong activity against hepatitis virus.

Abstract: The invention relates to an injector for injecting fuel into combustion chambers. According to the invention, a valve piston of a control valve is provided with low pressure on both faces thereof. The valve piston is arranged in a valve chamber hydraulically connected to a control chamber and is guided inside a sleeve received in the valve chamber. The valve chamber contains a spring supported on one end against the sleeve and on the other end on the valve piston such that the spring presses the valve piston onto a valve seat and the sleeve onto an opposing bottom surface. The valve piston diameter inside the sleeve corresponds to the effective valve piston diameter at the valve seat.

Abstract: An image interpolator for high-definition images is presented that utilizes a two or more level hierarchical decomposition for complexity reduction. At the lowest level, after a block-based motion estimator, a pixel-based motion vector selector and a motion vector-based halo reducer, an occlusion-based adaptive motion field interpolator provides preliminary motion vectors for higher resolution level. At the high resolution level, a new motion estimation refining based on the double consideration of eventual occlusion region and motion vector precision refines the preliminary motion vectors, and again a motion vector-based halo reduction re-corrects the refined motion vectors. A new motion compensated image interpolator with controllable features for multiple interpolated images is presented. A versatile post-processing configuration for remaining artifacts may also be included.

Abstract: A method and an apparatus for filtering motion vector fields provided by a motion estimator apparatus are disclosed. The method includes receiving an input image, determining a motion vector field associated with the input image, determining a local segmentation image, forming a lattice map to identify periodic structures, using the local segmentation image and the lattice map to obtain an image segment pixel count and an image/motion segment pixel count, and using the segment pixel count and the image/motion segment pixel count to provide a filtered motion vector field. Some embodiments further include a motion estimation apparatus including an image delay apparatus, a lattice detector to find lattice structures in the input and delayed images, a histogram generator and a histogram analyzer to provide a set of horizontal and vertical search masks, a motion vector estimator to provide a motion vector field, and a motion vector filter as provided herein.