Patents by Inventor Francine Wincott

Francine Wincott has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis, deprotection, analysis & purification of RNA & ribozymes
    Publication number: 20060223990
    Abstract: Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form.
    Type: Application
    Filed: September 9, 2005
    Publication date: October 5, 2006
    Inventors: Nassim Usman, Francine Wincott, David Sweedler, Leonid Beigelman, Lech Dudycz, Susan Grimm, Anthony DiRenzo, Danuta Tracz
  • Synthesis, deprotection, analysis and purification of RNA and ribozymes
    Patent number: 7041817
    Abstract: Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form.
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: May 9, 2006
    Assignee: Sirna Therapeutics, Inc.
    Inventors: Nassim Usman, Francine Wincott, David Sweedler, Leonid Beigelman, Lech W. Dudycz, Susan Grimm, Anthony DiRenzo, Danuta Tracz
  • Sequencing of modified nucleic acid molecules
    Publication number: 20060019298
    Abstract: Modified nucleic acids are used for many purposes in research, diagnostic, and treatment protocols. However, direct sequencing of such molecules is generally considered to require special conditions. Methods of making a cDNA using a modified nucleic acid molecule and sequencing methods of sequencing a modified nucleic acid molecule are described.
    Type: Application
    Filed: July 19, 2005
    Publication date: January 26, 2006
    Inventors: David Shima, Pericles Calias, Gregory Robinson, Yin-Shan Ng, Francine Wincott, Corinna Krinos
  • 5'-and 3'-capped aptamers and uses therefor
    Publication number: 20050096290
    Abstract: The invention provides compositions and methods for the treating disease using aptamers having 5?-5? and 3?-3? inverted nucleotide capped ends. In particular, the invention provides 5?-5? and 3?-3? capped anti-VEGF aptamers for the treatment of neovascularization-related diseases and disorders including age-related macular degeneration.
    Type: Application
    Filed: August 6, 2004
    Publication date: May 5, 2005
    Inventors: Anthony Adamis, David Shima, Francine Wincott, Perry Calias
  • Enzymatic nucleic acids containing 5'-and/or 3'-cap structures
    Publication number: 20050074760
    Abstract: An enzymatic nucleic acid molecule comprising a 5?- and/or a 3?-cap structure, wherein said structure is not a 5?-5?-linked inverted nucleotide or a 3?-3?-linked inverted nucleotide.
    Type: Application
    Filed: May 6, 2003
    Publication date: April 7, 2005
    Inventors: Jasenka Matulic-Adamic, Leonid Beigelman, Alexander Karpeisky, Thale Jarvis, Nassim Usman, Anthony DiRenzo, Francine Wincott
  • Non-nucleotide containing RNA
    Patent number: 6849726
    Abstract: The present invention relates to RNA molecules containing one or more non-nucleotide mimetics.
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: February 1, 2005
    Assignee: Sirna Therapeutics, Inc.
    Inventors: Nassim Usman, Francine Wincott, Jasenka Matulic-Adamic, Leonid Beigelman, Alex Karpeisky
  • Synthesis, deprotection, analysis and purification of RNA and ribozymes
    Patent number: 6649751
    Abstract: Provided is a method for purification and synthesis of RNA molecules that have at least one chemical modification.
    Type: Grant
    Filed: May 28, 2002
    Date of Patent: November 18, 2003
    Assignee: Sirna Therapeutics, Inc.
    Inventors: Nassim Usman, Francine Wincott, David Sweedler, Leonid Beigelman, Lech W. Dudycz, Susan Grimm, Anthony DiRenzo, Danuta Tracz
  • SYNTHESIS, DEPROTECTION, ANALYSIS AND PURIFICATION OF RNA AND RIBOZYMES
    Publication number: 20030166917
    Abstract: Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form.
    Type: Application
    Filed: May 28, 2002
    Publication date: September 4, 2003
    Inventors: Nassim Usman, Francine Wincott, David Sweedler, Leonid Beigelman, Lech W. Dudycz, Susan Grimm, Anthony DiRenzo, Danuta Tracz
  • Non-nucleotide containing enzymatic nucleic acid
    Publication number: 20030165969
    Abstract: Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule.
    Type: Application
    Filed: March 17, 2003
    Publication date: September 4, 2003
    Applicant: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Francine Wincott, Jasenka Matulic-Adamic, Leonid Beigelman, Alexander Karpeisky
  • Enzymatic nucleic acids containing 5?-and or 3?-cap structures
    Patent number: 6586238
    Abstract: An enzymatic nucleic acid molecule comprising a 5′- and/or a 3′-cap structure, wherein said structure is not a 5′-5′-linked inverted nucleotide or a 3′-3′-linked inverted nucleotide.
    Type: Grant
    Filed: October 15, 1999
    Date of Patent: July 1, 2003
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Jasenka Matulic-Adamic, Leonid Beigelman, Alexander Karpeisky, Thale Jarvis, Nassim Usman, Anthony DiRenzo, Francine Wincott
  • Synthesis, deprotection, analysis & purification of RNA & ribozymes
    Publication number: 20030088087
    Abstract: Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form.
    Type: Application
    Filed: August 30, 2002
    Publication date: May 8, 2003
    Applicant: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Francine Wincott, David Sweedler, Leonid Beigelman, Lech W. Dudycz, Susan Grimm, Anthony DiRenzo, Danuta Tracz
  • Non-nucleotide containing enzymatic nucleic acid
    Patent number: 6555668
    Abstract: Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule.
    Type: Grant
    Filed: January 8, 2002
    Date of Patent: April 29, 2003
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Francine Wincott, Jasenka Matulic-Adamic, Leonid Beigelman, Alex Karpeisky
  • Non-nucleotide containing enzymatic nucleic acid
    Publication number: 20020193579
    Abstract: Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule.
    Type: Application
    Filed: January 8, 2002
    Publication date: December 19, 2002
    Applicant: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Francine Wincott, Jasenka Matulic-Adamic, Leonid Beigelman, Alex Karpeisky
  • Synthesis, deprotection, analysis and purification of RNA and ribozymes
    Patent number: 6469158
    Abstract: Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form.
    Type: Grant
    Filed: May 2, 1995
    Date of Patent: October 22, 2002
    Assignee: Ribozyme Pharmaceuticals, Incorporated
    Inventors: Nassim Usman, Francine Wincott, David Sweedler, Leonid Beigelman, Lech W. Dudycz, Susan Grimm, Anthony DiRenzo, Danuta Tracz
  • Synthesis, deprotection, analysis and purification for RNA and ribozymes
    Patent number: 6437117
    Abstract: Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form.
    Type: Grant
    Filed: July 27, 1999
    Date of Patent: August 20, 2002
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Francine Wincott, David Sweedler, Leonid Beigelman, Lech W. Dudycz, Susan Grimm, Anthony DiRenzo, Danuta Tracz
  • Non-nucleotide containing nucleic acid
    Patent number: 6362323
    Abstract: Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule.
    Type: Grant
    Filed: July 31, 2000
    Date of Patent: March 26, 2002
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Francine Wincott, Jasenka Matulic-Adamic, Leonid Beigelman, Alex Karpeisky
  • Synthesis, deprotection, analysis and purification of RNA and ribozymes
    Patent number: 6353098
    Abstract: A process for deprotecting RNA alkylsilyl groups comprising, contacting the groups with a solution of anhydrous triethylamine-hydrogen fluoride (aHF-TEA) in triethylamine and N-methylpyrrolidine at between 60° C.-70° C. for 0.25-24 h.
    Type: Grant
    Filed: June 17, 1998
    Date of Patent: March 5, 2002
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Francine Wincott
  • Non-nucleotide containing enzymatic nucleic acid
    Patent number: 6117657
    Abstract: Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule.
    Type: Grant
    Filed: October 29, 1998
    Date of Patent: September 12, 2000
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Francine Wincott, Jasenka Matulic-Adamic, Leonid Beigelman, Alex Karpeisky
  • Enzymatic nucleic acids containing 5'-and/or 3'-cap structures
    Patent number: 5998203
    Abstract: An enzymatic nucleic acid molecule comprising a 5'- and/or a 3'-cap structure, wherein said structure is not a 5'-5'-linked inverted nucleotide or a 3'-3'-linked inverted nucleotide.
    Type: Grant
    Filed: April 16, 1996
    Date of Patent: December 7, 1999
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Jasenka Matulic-Adamic, Leonid Beigelman, Alexander Karpeisky, Thale Jarvis, Nassim Usman, Anthony DiRenzo, Francine Wincott
  • Non-nucleotide containing enzymatic nucleic acid
    Patent number: 5891683
    Abstract: Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule.
    Type: Grant
    Filed: December 23, 1994
    Date of Patent: April 6, 1999
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Francine Wincott, Jasenka Matulic-Adamic, Leonid Beigelman, Alex Karpeisky