Patents by Inventor Francis P. Miller

Francis P. Miller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS COMPRISING AN ANTI-CTLA4 MONOCLONAL ANTIBODY WITH REDUCED HOST CELL PROTEINS AND INCREASED POLYSORBATE-80 STABILITY
    Publication number: 20240115701
    Abstract: Provided herein are methods of separating host cell lipases from a production protein in chromatographic processes and methods of improving polysorbate-80 stability in a production protein formulation by separating host cell lipases from the production protein using chromatographic processes. Also provided herein are compositions comprising antibodies or antigen binding fragments thereof that bind to cytotoxic T lymphocyte associated antigen 4 (CTLA4). In another aspect, such compositions further comprise a reduced level of host cell proteins and/or increased level of polysorbate-80 (PS-80) stability.
    Type: Application
    Filed: September 18, 2020
    Publication date: April 11, 2024
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Rebecca A. Chmielowski, Francis K. Insaidoo, Justin B. Miller, David J. Roush, Darshini Shah, John P. Welsh
  • Method of treating drug abuse
    Patent number: 5500433
    Abstract: The present invention is directed to a new class of piperidinyl medicinal agents which are useful for treating drug abuse.
    Type: Grant
    Filed: January 10, 1995
    Date of Patent: March 19, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Richard C. Dage, John E. Koerner, Tung Li, Francis P. Miller, Thaddeus R. Nieduzak, Mark W. Dudley, . Christopher J. Schmidt, Robert A. Frank
  • 5-aryl-3H-1,2,4-triazol-3-ones and their use in the treatment of neurodegenerative disorders
    Patent number: 5436252
    Abstract: This invention relates to neuroprotective 5-aryl-3H-1,2,4-triazol-3-ones and to their use in the treatment of neurodegenerative disorders such as cerebral ischemia, stroke, Alzheimer's disease, Parkinson's disease, and Huntington's disease.
    Type: Grant
    Filed: March 15, 1990
    Date of Patent: July 25, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Stephen M. Sorensen, John M. Kane, Francis P. Miller
  • Antithrombotic compounds
    Patent number: 5292752
    Abstract: The present invention is directed to a new class of piperidinyl medicinal agents which are useful as antithrombotic agents and as serotonin 5HT.sub.2 antagonists.
    Type: Grant
    Filed: March 5, 1992
    Date of Patent: March 8, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Richard C. Dage, John E. Koerner, Tung Li, Francis P. Miller, Thaddeus R. Nieduzak
  • 3-aryl-5-alkylthio-4H-1,2,4-triazoles
    Patent number: 5260450
    Abstract: This invention relates to novel sulfone and sulfoxide derivatives of 3-aryl-5-alkylthio-4H-1,2,4-triazoles and to the use of 3-aryl-5-alkylthio-, alkylsulfinyl- and alkylsulfonyl-4H-1,2,4-triazoles in the treatment of patients suffering from convulsant seizures.
    Type: Grant
    Filed: August 11, 1992
    Date of Patent: November 9, 1993
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: John M. Kane, Francis P. Miller
  • Method of using 1,4-disubstituted piperidinyl compounds in the treatment of coronary vasospasons and variant angina
    Patent number: 5166211
    Abstract: The present invention pertains to a new class of compounds which can be characterized as 1,4-disubstituted piperidinyl compounds useful as antiarrhythmics, analgesics, and serotonin 5HT.sub.2 antagonists.
    Type: Grant
    Filed: December 16, 1991
    Date of Patent: November 24, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Richard C. Dage, John E. Koerner, Tung Li, Francis P. Miller
  • Use of 1,4-disubstituted-piperidinyl compounds for analgesia and muscle relaxation
    Patent number: 5162342
    Abstract: The present invention relates to 1,4-disubstituted-piperidinyl compounds that have utility as analgesics and as muscle relaxants.
    Type: Grant
    Filed: July 3, 1991
    Date of Patent: November 10, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert A. Carr, Francis P. Miller, Thaddeus R. Nieduzak, Stephen M. Sorensen
  • 3-aryl-5-alkylthio-4H-1,2,4-traizoles for treatment of hyperreflexia due to spinal trauma
    Patent number: 5158968
    Abstract: This invention relates to the use of 3-aryl-5-alkylthio-4H-1,2,4-triazoles and the corresponding alkylsulfinyl- and alkylsulfonyl-4H-1,2,4-triazoles in the treatment of patients suffering from chronic hyperreflexia due to spinal trauma.
    Type: Grant
    Filed: October 4, 1991
    Date of Patent: October 27, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: John H. Kehne, John M. Kane, Francis P. Miller
  • 3-aryl-5-alkylthio-4H-1,2,4-triazoles
    Patent number: 5143933
    Abstract: This invention relates to novel sulfone and sulfoxide derivatives of 3-aryl-5-alkylthio-4H-1,2,4-triazoles and to the use of 3-aryl-5-alkylthio-, alkylsulfinyl- and alkylsulfonyl-4H-1,2,4-triazoles in the treatment of patients suffering from convulsant seizures.
    Type: Grant
    Filed: October 4, 1991
    Date of Patent: September 1, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: John M. Kane, Francis P. Miller
  • N-aralkyl piperidine derivatives useful as antithrombolytic agents
    Patent number: 5093341
    Abstract: The present invention is directed to a new class of compounds useful as antiarrhythmics, analgesics and serotonin 5HT.sub.2 antagonists, which compounds have the following formula: ##STR1## wherein; Y is represented by H, CO(CH.sub.2).sub.n CH.sub.3 in which n is an integer from 0-3, or SO.sub.2 (CH.sub.2).sub.n CH.sub.3 in which n is an integer from 0--3; X is represented CO, CHOH, or C.dbd.N--O--A, wherein A is represented by hydrogen or a C.sub.1-4 alkyl; R is either selected from the group consisting of halogens, lower alkyl groups, lower alkoxy groups, and hydrogen or R is a divalent substituent and is represented by a 3,4-methylenedioxy or a 3,4-ethylenedioxy substituent; m is an integer from 1-5; and the pharmaceutically acceptable acid addition salts thereof.
    Type: Grant
    Filed: August 26, 1988
    Date of Patent: March 3, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Albert A. Carr, John E. Koerner, Richard C. Dage, Tung Li, Francis P. Miller
  • Anti-psychotic piperidylbenzimidazole compounds
    Patent number: 5064840
    Abstract: The present invention is directed to a new class of therapeutic agent which are useful as anti-psychotic agents and as analgesics.
    Type: Grant
    Filed: April 10, 1990
    Date of Patent: November 12, 1991
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: Albert A. Carr, Francis P. Miller, John M. Kane
  • 1,4-disubstituted-piperidinyl compounds as pain relievers
    Patent number: 5064838
    Abstract: The present invention relates to 1,4-disubstituted-piperidinyl compounds that have utility as analgesics and as muscle relaxants.
    Type: Grant
    Filed: December 7, 1988
    Date of Patent: November 12, 1991
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: Albert A. Carr, Francis P. Miller, Thaddeus R. Nieduzak, Stephen M. Sorensen
  • Medicament compositions derived from quinolizine and quinolizinone and methods of use thereof
    Patent number: 5011846
    Abstract: The present invention is directed to the use of esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and hexahydro-8-hydroxy-2,6-methano-2H-quinolizines in the manufacture of a medicament for the treatment of anxiety, psychosis, glaucoma and for the stimulation of gastric motility.
    Type: Grant
    Filed: May 16, 1990
    Date of Patent: April 30, 1991
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Maurice W. Gittos, Francis P. Miller, Stephen M. Sorensen, John R. Fozard, Paul Moser, Michael G. Palfreyman, Hsien Cheng
  • 3-aryl-5-alkylthio-4H-1,2,4-triazoles
    Patent number: 4981863
    Abstract: This invention relates to derivatives of 3-aryl-5-alkylthio-4H-1,2,4-triazoles, to their pharmacological properties and to their use as muscle relaxants, spasmolytics, anticonvulsants and anxiolytics.
    Type: Grant
    Filed: January 10, 1990
    Date of Patent: January 1, 1991
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: John M. Kane, Francis P. Miller
  • 4-benzyl-5-phenyl-2,4-dihydro-3H-1,2,4-triazol-3-ones and their use as anticonvulsants
    Patent number: 4966909
    Abstract: The invention relates to 4-benzyl-5-phenyl-1,2,4-dihydro-3H-1,2,4-triazol-3-ones and to their use as anticonvulsants for treatment of seizure disorders.
    Type: Grant
    Filed: December 20, 1989
    Date of Patent: October 30, 1990
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: John M. Kane, Francis P. Miller
  • 5-heterocyclic-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants
    Patent number: 4952593
    Abstract: This invention relates to novel 5-R.sub.n -(Het)-2,4-di alkyl-3H-1,2,4-triazole-3-thiones, to the intermediates and processes for their preparation, and to their use as antidepressants.
    Type: Grant
    Filed: July 23, 1987
    Date of Patent: August 28, 1990
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: John M. Kane, Francis P. Miller
  • 5-phenyl-3H-1,2,4-triazol-3-ones and their use as anticonvulsants
    Patent number: 4946856
    Abstract: This invention relates to 5-phenyl-3H-1,2,4-triazol-3-ones and to their use as anticonvulsants for treatment of seizure disorders.
    Type: Grant
    Filed: March 1, 1989
    Date of Patent: August 7, 1990
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: John M. Kane, Francis P. Miller
  • Antiepileptic pyrazolopyridines
    Patent number: 4916140
    Abstract: The disclosure pertains to certain pyrazolopyridincarboxylates which are calcium channel blockers and possess anticonvulsant properties. By virtue of this activity, the compounds are useful in the treatment of epilepsy.
    Type: Grant
    Filed: September 28, 1988
    Date of Patent: April 10, 1990
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Michael G. Palfreyman, Francis P. Miller, Anis Mir
  • 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones useful as antidepressants
    Patent number: 4912095
    Abstract: This invention relates to novel 5-(R.sub.n -phenyl)-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and to their use as antidepressants.
    Type: Grant
    Filed: February 8, 1989
    Date of Patent: March 27, 1990
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: John M. Kane, Francis P. Miller
  • 3-aryl-5-alkylthio-4H-1,2,4-triazoles
    Patent number: 4900743
    Abstract: This invention relates to derivatives of 3-aryl-5-alkylthio-4H-1,2,4-triazoles, to their pharmacological properties and to their use as muscle relaxants, spasmolytics, anticonvulsants and anxiolytics.
    Type: Grant
    Filed: December 4, 1987
    Date of Patent: February 13, 1990
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: John M. Kane, Francis P. Miller