Patents by Inventor Francis S. Collins

Francis S. Collins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gene therapy vector for cystic fibrosis
    Patent number: 5240846
    Abstract: The present invention comprises gene therapy for treating cystic fibrosis(CF). Delivery and expression of a single copy of a normal CFTR gene leads to stable correction of the Cl channel regulation defect present in CF epithelial cells. The present invention includes recombinant viral and plasmid vectors, alternative CFTR gene delivery strategies, and transduced CF cells and cell lines carrying a recombinant gene for functional CFTR. CF epithelial complementation through transduction of the present invention also provides an assay for determining the validity of other putative CF mutations.
    Type: Grant
    Filed: September 18, 1990
    Date of Patent: August 31, 1993
    Assignee: The Regents of the University of Michigan
    Inventors: Francis S. Collins, James M. Wilson