Abstract: The present disclosure provides methods for treating hematological malignancies and Ewings sarcoma using menin inhibitors. Compositions for use in these methods are also provided.

Abstract: Composite anode materials and methods of making same, the anode materials including capsules including graphene, reduced graphene oxide, graphene oxide, or a combination thereof, and particles of an active material disposed inside of the capsules. The particles may each include a core and a buffer layer surrounding the core. The core may include crystalline silicon, and the buffer layer may include a silicon oxide, a lithium silicate, carbon, or a combination thereof.

Abstract: A system for updating a hypercube includes an interface and a processor. The interface is configured to receive an indication to update a cell of the hypercube. The processor is configured to determine a primary dimension value associated with the cell; determine a group of dependencies based at least in part on the primary dimension value, wherein a dependency of the group of dependencies comprises one or more primary dimension values and a pattern; for the dependency of the group of dependencies, determine a set of source locations based at least in part on the one or more primary dimension values and the pattern; and mark the set of source locations as invalid.

Abstract: A system for updating a hypercube includes an interface and a processor. The interface is configured to receive an indication to update a cell of the hypercube. The processor is configured to determine a primary dimension value associated with the cell; determine a group of dependencies based at least in part on the primary dimension value, wherein a dependency of the group of dependencies comprises one or more primary dimension values and a pattern; for the dependency of the group of dependencies, determine a set of source locations based at least in part on the one or more primary dimension values and the pattern; and mark the set of source locations as invalid.

Abstract: A system for determining access for a hypercube includes an interface configured to receive a request for access from a user to data in a location in a hypercube; receive a tree structure with subcubes of the hypercube arranged in a hierarchical structure; and receive a user permission list, wherein an element of the user permission list comprises a permission, a root node, and a set of pruned nodes. The system also includes a processor configured to determine a user permission associated with the data in the location of the hypercube using the user permission list; and provide an indication of the user permission.

Abstract: A system for updating a hypercube includes an interface and a processor. The interface is configured to receive an indication to update a cell of the hypercube. The processor is configured to determine a primary dimension value associated with the cell; determine a group of dependencies based at least in part on the primary dimension value, wherein a dependency of the group of dependencies comprises one or more primary dimension values and a pattern; for the dependency of the group of dependencies, determine a set of source locations based at least in part on the one or more primary dimension values and the pattern; and mark the set of source locations as invalid.

Abstract: A system for updating a hypercube includes an interface and a processor. The interface is configured to receive an indication to update a cell of the hypercube. The processor is configured to determine a primary dimension value associated with the cell; determine a group of dependencies based at least in part on the primary dimension value, wherein a dependency of the group of dependencies comprises one or more primary dimension values and a pattern; for the dependency of the group of dependencies, determine a set of source locations based at least in part on the one or more primary dimension values and the pattern; and mark the set of source locations as invalid.

Abstract: An electrochemically active material including composite particles that each include a graphene-based material shell surrounding nanoparticles of a core material. The composite particles may include a BET surface area of less than about 75 m2/g. The electrochemically active material may be formed into an electrode incorporated within a lithium ion electrochemical cell.

Abstract: A system for caching includes an interface to receive a portion of a hypercube to evaluate. The hypercube includes cells with a set of the cells having a formula. The system includes a processor to determine term(s) in the formula for each cell of the set of cells; remove from consideration a time dimension and/or a primary dimension for the term(s) in the formula for each cell of the set of cells; determine a set of distinct terms using the term(s); determine whether a total number of terms in the set of cells is larger than a number of distinct terms in the set of distinct terms; and in response to determining that the total number of terms in the set of cells is larger than the number of distinct terms in the set of distinct terms, indicate to cache the set of distinct terms during evaluation.

Abstract: A negative electrode of a lithium ion electrochemical cell, the negative electrode including an active electrode material that includes a first component and a second component. The first component may include graphene, silicon, or a combination thereof. The second component may include silicon. The active electrode material may include particles in which the second component is encapsulated by the first component. The negative electrode may have an internal porosity of between 40 to 60 percent.

Abstract: Composite anode materials and methods of making same, the anode materials including capsules including graphene, reduced graphene oxide, graphene oxide, or a combination thereof, and particles of an active material disposed inside of the capsules. The particles may each include a core and a buffer layer surrounding the core. The core may include crystalline silicon, and the buffer layer may include a silicon oxide, a lithium silicate, carbon, or a combination thereof.

Abstract: A composite anode material including an active material including a core of silicon, silicon oxide, or combination thereof encased within a buffer layer including a polymeric material, and a shell encapsulating the active material. The shell may include graphene, graphene oxide, partially reduced graphene oxide, or combinations thereof.

Abstract: Composite anode materials and methods of making same, the anode materials including capsules including graphene, reduced graphene oxide, graphene oxide, or a combination thereof, and particles of an active material disposed inside of the capsules. The particles may each include a core and a buffer layer surrounding the core. The core may include crystalline silicon, and the buffer layer may include a silicon oxide, a lithium silicate, carbon, or a combination thereof.

Abstract: The present application relates to composite particles for a negative electrode of an electrochemical cell, an anode including the composite particles, methods of forming the same. The composite particles each include: a capsule including crumpled sheets of a graphene material; a core encapsulated in the capsule, the core including an electrochemically active material; and carbon nanotubes (CNTs) disposed in capsule, the core, or both the capsule and the core.

Abstract: A composite anode material including an active material including a core of silicon, silicon oxide, or combination thereof encased within a buffer layer including a polymeric material, and a shell encapsulating the active material. The shell may include graphene, graphene oxide, partially reduced graphene oxide, or combinations thereof.

Abstract: Composite anode materials and methods of making same, the anode materials including capsules including graphene, reduced graphene oxide, graphene oxide, or a combination thereof, and particles of an active material disposed inside of the capsules. The particles may each include a core and a buffer layer surrounding the core. The core may include crystalline silicon, and the buffer layer may include a silicon oxide, a lithium silicate, carbon, or a combination thereof.

Abstract: One example includes a battery case sealed to retain electrolyte, an electrode disposed in the battery case, the electrode comprising a current collector formed of a framework defining open areas disposed along three axes (“framework”), the framework electrically conductive, with active material disposed in the open areas; a conductor electrically coupled to the electrode and sealingly extending through the battery case to a terminal disposed on an exterior of the battery case, a further electrode disposed in the battery case, a separator disposed between the electrode and the further electrode and a further terminal disposed on the exterior of the battery case and in electrical communication with the further electrode, with the terminal and the further terminal electrically isolated from one another.

Abstract: A bipolar battery, a manufacturing method thereof and a vehicle comprising the bipolar battery. The bipolar battery comprises a case comprising a first half case and a second half case; at least one bipolar plate with periphery sealed and sandwiched between the first half case and the second half case; and at least two electrical cores located at opposite two sides of the bipolar plate, respectively. With using the case made of flexible packaging material and sealing the peripheries of the bipolar plate collector and the case by sticking, it is easy to assemble and maintain the bipolar battery.

Abstract: A negative electrode of a lithium ion electrochemical cell, the negative electrode including an active electrode material that includes a first component and a second component. The first component may include graphene, silicon, or a combination thereof. The second component may include silicon. The active electrode material may include particles in which the second component is encapsulated by the first component. The negative electrode may have an internal porosity of between 40 to 60 percent.

Abstract: An electrochemically active material including composite particles that each include a graphene-based material shell surrounding nanoparticles of a core material. The composite particles may include a BET surface area of less than about 75 m2/g. The electrochemically active material may be formed into an electrode incorporated within a lithium ion electrochemical cell.