Patents by Inventor Francois Binette

Francois Binette has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10603408
    Abstract: A biocompatible tissue repair implant or scaffold device is provided for use in repairing a variety of tissue injuries, particularly injuries to cartilage, ligaments, tendons, and nerves. The repair procedures may be conducted with implants that contain a biological component that assists in healing or tissue repair. The biocompatible tissue repair implants include a biocompatible scaffold and particles of living tissue, such that the tissue and the scaffold become associated. The particles of living tissue contain one or more viable cells that can migrate from the tissue and populate the scaffold.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: March 31, 2020
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Francois Binette, Julia Hwang, Sridevi Dhanaraj, Anna Gosiewska
  • Publication number: 20200085882
    Abstract: Described herein are compositions and methods for treating retinal diseases or disorders using RPE cells.
    Type: Application
    Filed: March 16, 2018
    Publication date: March 19, 2020
    Applicant: Lineage Cell Therapeutics, Inc.
    Inventors: Oscar Cuzzani, Francois Binette, Gary Hogge
  • Patent number: 10583220
    Abstract: A biocompatible, bioresorbable tissue repair implant or scaffold device is provided for use in repairing a variety of cartilage tissue injuries, and particularly for resurfacing and/or repairing damaged or diseased cartilage. The repair procedures may be conducted with tissue repair implants that contain a biological component that assists in delaying or arresting the progression of degenerative joint diseases and in enhancing tissue healing or repair. The biocompatible, bioresorbable tissue repair implants include a scaffold and particles of viable tissue derived from cartilage tissue, such that the tissue and the scaffold become associated. The particles of living tissue contain one or more viable cells that can migrate from the tissue and populate the scaffold.
    Type: Grant
    Filed: August 11, 2003
    Date of Patent: March 10, 2020
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Francois Binette, Ed Yiling Lu
  • Publication number: 20180325958
    Abstract: Disclosed herein are compositions comprising cell-derived preparations and/or bioactive substances derived therefrom, in combination with biological carriers. Methods for making the aforementioned compositions, and methods for their use in stimulating osteogenesis and chondrogenesis in subjects in need thereof, are also disclosed.
    Type: Application
    Filed: December 7, 2017
    Publication date: November 15, 2018
    Inventors: Francois Binette, Brent Atkinson, David Larocca
  • Publication number: 20180135018
    Abstract: Aspects of the present invention include methods and compositions related to the production and use of embryonic progenitor cell types useful in the generation of cartilage, bone, choroid plexus, tendon, lipasin-secreting adipocytes, and other differentiated cell types useful in research and therapy.
    Type: Application
    Filed: June 12, 2017
    Publication date: May 17, 2018
    Inventors: Michael West, Karen Chapman, Hal Sternberg, Francois Binette
  • Publication number: 20180099009
    Abstract: A delivery system and method suitable for delivering a fluid to an interior of a bone and for removing fluid including bodily material from the interior of the bone. The delivery system includes a proximal portion graspable by a user and in fluid communication with a source of negative pressure and a delivery fluid. A delivery cannula has a length sufficient to extend from the proximal portion to a distal tip insertable into the interior of the bone to deliver the delivery fluid into the bone. A removal cannula has a length sufficient to extend from the proximal portion to a distal tip insertable into the interior of the bone to withdraw fluid including bodily material from the bone.
    Type: Application
    Filed: March 15, 2016
    Publication date: April 12, 2018
    Inventors: Francois BINETTE, Lawrence A. SHIMP
  • Patent number: 9827111
    Abstract: A small diameter delivery device capable of delivering a tissue loaded scaffold arthroscopically to a tissue defect or injury site without reducing the pressure at the injury site is provided. The scaffold delivery device of the present invention comprises a plunger system that includes two main components: an insertion tube and an insertion rod. The insertion tube has a flared proximal end for holding a tissue scaffold prior to delivery. An elongate, hollow body extends from the flared proximal end to a distal end of the insertion tube, and defines a passageway that extends through the body for delivery of the tissue scaffold. The insertion rod has an elongate body that extends into a handle at a proximal end and a tip at a distal end. The insertion rod is configured to be removably disposed within the insertion tube for sliding along the passageway to effect delivery of the tissue scaffold through the insertion tube.
    Type: Grant
    Filed: February 13, 2014
    Date of Patent: November 28, 2017
    Assignee: DEPUY MITEK, LLC
    Inventors: Keith M. Orr, Eric Hyman, Francois Binette, Ian D. McRury, Steve Lepke, Ash Perkins, Julia Hwang
  • Patent number: 9616104
    Abstract: Effective methods of treating a spinal disorder or osteoarthritis associated with a proinflammatory agent in a patient in need of such treatment, the method comprising administering an effective amount of DN-TNF (e.g., XPro®-1595) to a target tissue site at or near the spine or osteoarthritic joint to reduce pain and/or inflammation.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: April 11, 2017
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: Francois Binette
  • Publication number: 20170049931
    Abstract: A biocompatible tissue repair implant or scaffold device is provided for use in repairing a variety of tissue injuries, particularly injuries to cartilage, ligaments, tendons, and nerves. The repair procedures may be conducted with implants that contain a biological component that assists in healing or tissue repair. The biocompatible tissue repair implants include a biocompatible scaffold and particles of living tissue, such that the tissue and the scaffold become associated. The particles of living tissue contain one or more viable cells that can migrate from the tissue and populate the scaffold.
    Type: Application
    Filed: October 31, 2016
    Publication date: February 23, 2017
    Inventors: Francois Binette, Julia Hwang, Sridevi Dhanaraj, Anna Gosiewska
  • Patent number: 9511171
    Abstract: A biocompatible tissue repair implant or scaffold device is provided for use in repairing a variety of tissue injuries, particularly injuries to cartilage, ligaments, tendons, and nerves. The repair procedures may be conducted with implants that contain a biological component that assists in healing or tissue repair. The biocompatible tissue repair implants include a biocompatible scaffold and particles of living tissue, such that the tissue and the scaffold become associated. The particles of living tissue contain one or more viable cells that can migrate from the tissue and populate the scaffold.
    Type: Grant
    Filed: November 22, 2010
    Date of Patent: December 6, 2016
    Assignee: DEPUY MITEK, LLC
    Inventors: Francois Binette, Julia Hwang, Sridevi Dhanaraj, Anna Gosiewska
  • Publication number: 20150283211
    Abstract: Effective methods of treating a spinal disorder or osteoarthritis associated with a proinflammatory agent in a patient in need of such treatment, the method comprising administering an effective amount of DN-TNF (e.g., XPro®-1595) to a target tissue site at or near the spine or osteoarthritic joint to reduce pain and/or inflammation.
    Type: Application
    Filed: June 19, 2015
    Publication date: October 8, 2015
    Inventor: Francois Binette
  • Patent number: 9125888
    Abstract: Systems and methods for modifying the environment of target cell using genetically altered chondrocytes are provided. The genetically engineered chondrocytes can be used to express a therapeutic agent in a subject, including in an environment typically associated with chondrocytes and in an environment not typically associated with chondrocytes.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: September 8, 2015
    Assignee: DEPUY MITEK, LLC
    Inventors: Brooks J. Story, M. E. Liesbeth Brown, Francois Binette
  • Patent number: 9060978
    Abstract: Effective methods of treating a spinal disorder or osteoarthritis associated with a proinflammatory agent in a patient in need of such treatment, the method comprising administering an effective amount of DN-TNF (e.g., XPro®-1595) to a target tissue site at or near the spine or osteoarthritic joint to reduce pain and/or inflammation.
    Type: Grant
    Filed: October 24, 2011
    Date of Patent: June 23, 2015
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: Francois Binette
  • Publication number: 20140178988
    Abstract: Aspects of the present invention include methods and compositions related to the production and use of embryonic progenitor cell types useful in the generation of cartilage, bone, choroid plexus, tendon, lipasin-secreting adipocytes, and other differentiated cell types useful in research and therapy.
    Type: Application
    Filed: October 8, 2013
    Publication date: June 26, 2014
    Inventors: Michael West, Karen Chapman, Hal Sternberg, Francois Binette
  • Publication number: 20140163695
    Abstract: A small diameter delivery device capable of delivering a tissue loaded scaffold arthroscopically to a tissue defect or injury site without reducing the pressure at the injury site is provided. The scaffold delivery device of the present invention comprises a plunger system that includes two main components: an insertion tube and an insertion rod. The insertion tube has a flared proximal end for holding a tissue scaffold prior to delivery. An elongate, hollow body extends from the flared proximal end to a distal end of the insertion tube, and defines a passageway that extends through the body for delivery of the tissue scaffold. The insertion rod has an elongate body that extends into a handle at a proximal end and a tip at a distal end. The insertion rod is configured to be removably disposed within the insertion tube for sliding along the passageway to effect delivery of the tissue scaffold through the insertion tube.
    Type: Application
    Filed: February 13, 2014
    Publication date: June 12, 2014
    Applicant: DePuy Mitek, LLC
    Inventors: Keith M. Orr, Eric Hyman, Francois Binette, Ian D. McRury, Steve Lepke, Ash Perkins, Julia Hwang
  • Patent number: 8691259
    Abstract: A biocompatible tissue repair stimulating implant or “scaffold” device is used to repair tissue injuries, particularly injuries to ligaments, tendons, and nerves. Such implants are especially useful in methods that involve surgical procedures to repair injuries to ligament, tendon, and nerve tissue in the hand and foot. The repair procedures may be conducted with implants that contain a biological component that assists in healing or tissue repair.
    Type: Grant
    Filed: November 16, 2005
    Date of Patent: April 8, 2014
    Assignee: DePuy Mitek, LLC
    Inventors: Steven M. Bowman, Izi Bruker, Alireza Rezania, Mora Carolynne Melican, Francois Binette, Julia Hwang
  • Publication number: 20140081209
    Abstract: Devices and methods for delivering a therapeutic agent produced via a genetically-altered chondrocyte are provided. More specifically, the device includes a housing which defines a cell chamber configured to retain a large volume of chondrocytes while selectively releasing therapeutic agents produced via these entrapped cells. In an exemplary embodiment, the cell chamber can be configured such that a portion of cells can be positioned at least about 1.5 mm from an external wall of the device (i.e., about 1.5 mm away from an external nutrient supply). For example, the cell chamber can have a tubular configuration having a length and a diameter wherein each of these dimensions is at least about 3 mm (thereby the central core to the chamber is at least about 1.5 mm from the outer wall of the device).
    Type: Application
    Filed: November 21, 2013
    Publication date: March 20, 2014
    Applicant: DePuy Mitek, LLC
    Inventors: Brooks J. Story, Francois Binette, M.E. Liesbeth Brown
  • Patent number: 8673021
    Abstract: A small diameter delivery device capable of delivering a tissue loaded scaffold arthroscopically to a tissue defect or injury site without reducing the pressure at the injury site is provided. The scaffold delivery device of the present invention comprises a plunger system that includes two main components: an insertion tube and an insertion rod. The insertion tube has a flared proximal end for holding a tissue scaffold prior to delivery. An elongate, hollow body extends from the flared proximal end to a distal end of the insertion tube, and defines a passageway that extends through the body for delivery of the tissue scaffold. The insertion rod has an elongate body that extends into a handle at a proximal end and a tip at a distal end. The insertion rod is configured to be removably disposed within the insertion tube for sliding along the passageway to effect delivery of the tissue scaffold through the insertion tube.
    Type: Grant
    Filed: November 26, 2003
    Date of Patent: March 18, 2014
    Assignee: DePuy Mitek, LLC
    Inventors: Keith M. Orr, Eric Hyman, Francois Binette, Ian D. Mcrury, Steve Lepke, Ash Perkins, Julia Hwang
  • Patent number: 8592201
    Abstract: Devices and methods for delivering a therapeutic agent produced via a genetically-altered chondrocyte are provided. More specifically, the device includes a housing which defines a cell chamber configured to retain a large volume of chondrocytes while selectively releasing therapeutic agents produced via these entrapped cells. In an exemplary embodiment, the cell chamber can be configured such that a portion of cells can be positioned at least about 1.5 mm from an external wall of the device (i.e., about 1.5 mm away from an external nutrient supply). For example, the cell chamber can have a tubular configuration having a length and a diameter wherein each of these dimensions is at least about 3 mm (thereby the central core to the chamber is at least about 1.5 mm from the outer wall of the device).
    Type: Grant
    Filed: August 6, 2012
    Date of Patent: November 26, 2013
    Inventors: Brooks J. Story, Francois Binette, M. E. Liesbeth Brown
  • Patent number: 8562542
    Abstract: A biological tissue collection device is provided having a housing with a fluid-retaining inner chamber adapted to retain a bioimplantable, fluid permeable tissue scaffold. The scaffold is preferably retained in the housing in such a way that the scaffold separates the fluid-retaining inner chamber into a first chamber and a second chamber. The collection device further includes a driver mechanism coupled to the housing and effective to create a force within the housing to displace fluid disposed within the second chamber to the first chamber. As the fluid is displaced, any biological tissue deposited on the tissue scaffold is dispersed within the fluid. Removal of the force enables the fluid to return to the second chamber and thereby deposit the tissue onto the tissue scaffold. In an exemplary embodiment, the tissue is deposited evenly onto the tissue scaffold.
    Type: Grant
    Filed: July 15, 2010
    Date of Patent: October 22, 2013
    Assignee: DePuy Mitek, LLC
    Inventors: Francois Binette, Julia Hwang, Keith M. Orr, Steve Lepke, Eric Hyman, Ashley Perkins