Abstract: The invention relates to monoclonal and/or monovalent antibodies that bind CD47. The invention relates to monoclonal and/or monovalent antibodies that bind CD19. The invention also relates to novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, where one of the binding sites is specific for CD47. The invention also relates to novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, where one of the binding sites is specific for CD19.

Abstract: The invention relates to monoclonal and/or monovalent antibodies that bind CD47. The invention relates to monoclonal and/or monovalent antibodies that bind CD19. The invention also relates to novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, where one of the binding sites is specific for CD47. The invention also relates to novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, where one of the binding sites is specific for CD19.

Abstract: A wiper fluid container including a fluid dispensing opening and an opening of a connecting member. The fluid dispensing opening is equipped with a connector that works with another connector in order to ensure fluid communication between those openings, where one connector can move from a first closed position of the container to a second open position thereby freeing that opening.

Abstract: The invention relates to antigen-binding proteins or antibodies having heterodimers of heavy chains, i.e., two immunoglobulin heavy chains that differ by at least one or two amino acid(s) that allows for isolation of the antigen-binding protein based on a differential affinity of an immunoglobulin heavy chain and a modified/mutated immunoglobulin heavy chain toward an affinity reagent. The invention also relates antigen-binding proteins, including bispecific antibodies, having IgG CH1 regions with different affinities with respect to affinity reagent(s) that allows rapid isolation by differential binding of the IgG regions to the affinity reagent(s).

Abstract: The invention concerns a rear view system (1) of a motor vehicle comprising:—an optical image capturing sensor (3),—a protective support (5) comprising a transparent and flat protective screen (7), the optical sensor (3) being installed on the protective support (5) in such a way as to point through said protective screen (7), and—a scraper blade (9) for cleaning the protective screen (7) disposed on the face of the protective screen (7) opposite that of the optical sensor (3) side, characterised in that it further comprises an electromagnetic actuation device (11) for actuating said scraper blade (9) in translation on the protective screen (7).

Abstract: The invention relates to antigen-binding proteins or antibodies having heterodimers of heavy chains, i.e., two immunoglobulin heavy chains that differ by at least one or two amino acid(s) that allows for isolation of the antigen-binding protein based on a differential affinity of an immunoglobulin heavy chain and a modified/mutated immunoglobulin heavy chain toward an affinity reagent. The invention also relates antigen-binding proteins, including bispecific antibodies, having IgG CH1 regions with different affinities with respect to affinity reagent(s) that allows rapid isolation by differential binding of the IgG regions to the affinity reagent(s).

Abstract: According to the invention, the device for recording images (1) of a road scene for a motor vehicle comprises at least one camera (2) defining an optical axis, a protective element (4) for protecting the camera and cleaning means (8) for cleaning this screen. The protective element surrounds the camera and is mounted movable in rotation about said camera, comprising at least two separate portions each capable of assuming an image capturing position (16; 116) opposite the camera under the effect of the rotation. At least one of the separate portions is a light-transparent screen (18; 118) for being disposed in the image capturing position when the camera is operating, and the cleaning means (8) are disposed on the passage of the movable protective element in order to clean the transparent screen.

Abstract: A cleaning device for cleaning a lens of a motor vehicle camera is disclosed. The lens is designed to capture images along a longitudinal optical axis, and includes a cleaning head arranged in a fixed position with respect to the camera so that part of the head, that bears cleaning means, is arranged along the optical axis behind the lens. The cleaning device is applicable to the cleaning of reversing cameras positioned at the rear of the vehicle and oriented in such a way as to capture images of a road scene extending to the rear of the vehicle.

Abstract: Disclosed are antibodies that specifically bind Toll-like Receptor 4 (TLR-4), and to methods of using the anti-TLR4 antibodies as therapeutics and diagnostic agents.

Abstract: This invention provides fully human monoclonal antibodies that recognize IL-17F and/or the heterodimeric IL-17A/IL-17F complex, but do not recognize IL-17A. The invention further provides methods of using such monoclonal antibodies as a therapeutic, diagnostic, and prophylactic.

Abstract: Disclosed are antibodies that specifically bind Toll-like Receptor 4 (TLR-4), and to methods of using the anti-TLR4 antibodies as therapeutics and diagnostic agents.

Abstract: The invention relates to a wiper fluid container (18), comprising a fluid dispensing opening (22) equipped with first connecting means (24) configured to cooperate with second connecting means (26) for an opening of a member such as a pump (16) or reservoir in order to ensure fluid communication between those openings, characterized in that said first connecting means comprise a movable element (24) able to move from a first position closing of the opening of the container to a second position freeing that opening, said first means being configured to cooperate with the aforementioned second means to cause the movable member to move from the first position to the second position.

Abstract: A Cleaning device (1) for cleaning a lens (8) of a motor vehicle camera (2) which lens is designed to capture images along a longitudinal optical axis, comprises a cleaning head (4) arranged in a fixed position with respect to the camera (2) and having an annular overall shape, of axis coincident with the axis of the lens. The cleaning head (4) comprises an internal annular wall (16) being arranged along the optical axis behind the lens and bearing cleaning means (20, 36) oriented towards the lens. The internal annular wall (16) of the head (4) is equipped with a plurality of nozzles (32) via which a cleaning liquid is able to exit bound for the lens (8). The invention is particularly applicable to the cleaning of reversing cameras positioned at the rear of the vehicle and oriented in such a way as to capture images of a road scene extending to the rear of the vehicle.

Abstract: A leaf spring for a wiper blade of a vehicle window in a motor car is disclosed. The leaf spring includes at least one flexible leaf, the spring having an elongate shape and including, at a first longitudinal extremity, linking means to at least one stiffening joint of the wiper blade. The leaf spring includes or carries, at a second longitudinal extremity, a tubular member designed to receive a shaft of a driver of the wiper blade.

Abstract: The invention relates to an actuation device for a driving arm (2) of a wiper (3), in particular for a motor vehicle, said device comprising: a body (10) hinged to rotate about a pivot axis and capable of receiving the arm (2), and a means (14) for locking the arm (2) on the body (10), said locking means (14) being hinged with the body (10). The invention also relates to a system for wiping a window of a vehicle, comprising said device.

Abstract: The invention relates to a window-wiping system, in particular for a motor vehicle, said wiping system comprising a wiper (3) and an arm (2) for driving the wiper (3). The wiper comprises a wiping blade (4) and one or more spines (6) for stiffening the wiping blade (4). The aforementioned arm (2) extends from one end of the spine(s) (6), known as the proximal end, and it is designed to apply the wiper (3) against the window.

Abstract: The invention provides heterodimer bispecific antigen-binding molecules that include a first polypeptide that does not include an IgG CH1 domain and a second polypeptide having an immunoglobulin constant region where there is at least one mutation in the IgG CH3 domain that abolishes the ability of the second polypeptide to bind CH3-specific affinity media such that the first and second polypeptides have different affinities with respect to CH1 and CH3 specific affinity reagents that allows rapid isolation by differential binding of the first and second polypeptides to these affinity reagents. The invention also provides bispecific antibodies that have IgG CH1 and CH3 regions with different affinities with respect to affinity reagents that allows rapid isolation by differential binding of the IgG regions to these affinity reagents. The invention also concerns bispecific antibodies which are heterodimers of heavy chains, i.e.

Abstract: The invention relates to monoclonal and/or monovalent antibodies that bind CD47. The invention relates to monoclonal and/or monovalent antibodies that bind CD19. The invention also relates to novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, where one of the binding sites is specific for CD47. The invention also relates to novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, where one of the binding sites is specific for CD19.

Abstract: The invention relates to antigen-binding proteins or antibodies having heterodimers of heavy chains, i.e., two immunoglobulin heavy chains that differ by at least one or two amino acid(s) that allows for isolation of the antigen-binding protein based on a differential affinity of an immunoglobulin heavy chain and a modified/mutated immunoglobulin heavy chain toward an affinity reagent. The invention also relates antigen-binding proteins, including bispecific antibodies, having IgG CH1 regions with different affinities with respect to affinity reagent(s) that allows rapid isolation by differential binding of the IgG regions to the affinity reagent(s).

Abstract: This invention provides fully human monoclonal antibodies that recognize IL-17F and/or the heterodimeric IL-17A/IL-17F complex, but do not recognize IL-17A. The invention further provides methods of using such monoclonal antibodies as a therapeutic, diagnostic, and prophylactic.