Abstract: The invention provides for a microstructured nozzle (1) for a device (100) for the generation of an inhalable aerosol of a medically active fluid (2), the microstructured nozzle having a main filter (21), an inlet (3) for unfiltered fluid and an outlet (4) for filtered fluid, the inlet and the outlet defining a direction of flow (X) of the fluid from the inlet to the outlet, the nozzle comprising a substantially flat base plate (5) and a cover plate (6) which may be attached thereto; a main filter area (20) comprising the main filter (21); a filtrate outlet area (30) arranged between the main filter and the outlet in the direction of flow; and a fluid distribution area (40) arranged between the inlet and the main filter area in the direction of flow, wherein in the fluid distribution area is disposed a secondary structure (41) which comprises a plurality of pillar-shaped built-in elements (42) extending from the base plate and/or the cover plate transversely to the flow direction.

Abstract: The invention relates to a valve, in particular for a device for administering a liquid medicament, with a valve body (1) which has an interior (2) for receiving a liquid (20), wherein the valve body (1) has a liquid inlet (3) and an opposite liquid outlet (4) which both open into the interior (2), wherein the interior (2) accommodates a large number of micro channels (5) which extend in connection direction (x) between the liquid inlet (3) and the liquid outlet (4). A corresponding device for administering a liquid medicament is also described.

Abstract: The invention provides for device for clamping a fluidic component which is subjected to a fluctuating fluid pressure, said fluidic component having a downstream end, an opposite upstream end and an outer contour, said device comprising a holder, an elastomeric shaped part and a mating part, wherein the elastomeric shaped part comprises at least one compensating surface, and wherein the at least one compensating surface in the assembled state does not contact the mating part or the at least one projection of the mating part.

Abstract: An inhalation device for providing a particularly high pressure for nebulization. The inhalation device can include a housing, a reservoir, a pumping unit adapted to receive the delivery of mechanical energy to the pumping unit, and a nozzle. The pumping unit can also include a hollow cylindrical part and a piston, the cylindrical part having an interior space with a defined first cross section configured to receive an upstream end portion of the piston, wherein the cylindrical part and the piston are linearly moveable relative to one another such as to form a pumping chamber having a variable volume.

Abstract: The device (1) for wetting the eye (2) with a liquid (F) comprises a reservoir (3) for storage of the liquid (F), a dispensing device (4) which is feedable from said reservoir (3) and which is orientable to the eye (2), and a triggering device (5) which activates same. The device (1) comprises a means for sensing (6) of a suitable position of the dispensing device (4) in relation to the eye (2) for wetting. The method for wetting the eye (2) with a liquid (F) comprises the step of continuously detecting the position of a dispensing device (4) designed to withdraw a liquid (F) from a reservoir (3) and to use it for wetting the eye (2). A means for sensing (6) transmits a signal when a suitable position of the dispensing device (4) in relation to the eye (2) for wetting has been sensed.

Abstract: A valve for an inhalation device for generation of an aerosol of a medically active liquid may include: a housing, inside this housing a reservoir for storing medically active liquid, downstream from this reservoir a pumping unit for generation of a pressure connected to a means for the delivery of mechanical energy to said pumping unit, and downstream said pumping unit a nozzle; wherein the pumping unit includes a hollow cylindrical part and a piston, the cylindrical part having an interior space configured to receive an end portion of said piston, wherein said cylindrical part and said piston are linearly moveable relative to one another such as to form a pumping chamber having a variable volume.

Abstract: An inhalation device for medically active liquids for generation of an aerosol comprises a housing, inside this housing a reservoir for storing a liquid, a pumping device with a pumping chamber for generation of a pressure inside said pumping chamber, wherein the pumping chamber is fluidically connected with the reservoir via a check valve which blocks in direction of the reservoir, a riser pipe which can be received with at least one reservoir-facing, interior end in said pumping chamber, and a nozzle which is connected liquid-tight to an exterior end of the riser pipe, wherein the interior volume of the pumping chamber is changeable by means of relative motion to the riser pipe, and wherein the riser pipe is immobile and firmly attached to the housing or to the nozzle, and the pumping chamber is moveable relative to the housing or to the nozzle.

Abstract: The invention provides a microfluidic device (1), specifically a nozzle for an inhalation device, comprising at least two microfluidic structures (2A, 2A?), each of said structures (2A, 2A?) is located at a front end (1B) of the microfluidic device; characterized in that the microfluidic device (1) is made at least in part from a mono-crystalline material and wherein said front end (1B) of the microfluidic device (1) and the microfluidic structures (2A, 2A?) are aligned with the crystal orientation line and methods producing said devices and uses thereof.

Abstract: The inhalation device for medically active liquids (F) for generation of an aerosol comprises a housing (1), a reservoir (2), a pumping device with a pumping chamber (3), and a nozzle (6), wherein the interior volume of the pumping chamber (3) is changeable by means of linear relative motion of the pumping chamber to the riser pipe (5). Said linear relative motion can be effected by a relative rotation of a rotatable part (1A) which is part of, or connected to, the housing (1) with respect to a second part (1B) of said housing (1), in that said relative rotation can be transferred by means of a gear mechanism into said relative translational motion. A means for the storage of potential energy (7) is provided which is chargeable by means of said relative rotation, and wherein said energy is releasable to said pumping device when released by activation of a release means.

Abstract: The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to an improved seal construction for an inhalation device having a nebulizing nozzle and a piston which moves relative to a pumping chamber in order to generate pumping pressure and to an inhalation device comprising such seal.

Abstract: The invention relates to the field of inhalation methods and inhalation devices for liquids. In particular, the invention relates to an inhalation method using an inhalation device adapted to separately eject at least two liquid compositions each having different properties, and to a method for the generation of an aerosol of at least two medicinal formulations by means of such inhalation device.

Abstract: The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to an inhalation device having improved flow characteristics.

Abstract: The invention relates to the field of nozzles for inhalation devices for liquids. In particular, the invention relates to a nebulizing nozzle for an inhalation device, suitable for the generation of an aerosol of a medically active liquid, and to inhalation devices comprising such nozzle. Such nozzle (1) for an inhalation device for medically active liquids (F, F1, F2) for generation of an aerosol has a main axis (Z) and at least three ejection channels (1A, 1B, 1C, 1D) adapted to eject liquid (F, F1, F2) along respective ejection trajectories, wherein at least two collision points (X1, X2) are provided at which at least two of said ejection trajectories intersect with one another, and/or wherein further, all ejection angles (A, A1, A2) at which the individual trajectories leave the nozzle (1) are identical, or at least one of said ejection angles (A, A1, A2) differs from the other ejection angles (A, A1, A2).

Abstract: The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to a liquid emission mechanism for an inhalation device, as well as a method of emitting a liquid from an inhalation device.

Abstract: The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to a nebulizing nozzle to be used in such an inhalation device, as well as a method for fabrication of such a nozzle. A nozzle for an inhalation device for nebulizing a liquid into a respirable aerosol has a nozzle body (1) which has a front end (1B) and which comprises at least two ejection channels (2, 2?), each channel (2, 2?) having an channel exit (2A, 2A?), wherein the ejection channels (2, 2?) are arranged such as to eject liquid along respective ejection trajectories which intersect with one another at a collision point. The nozzle is characterized in that at least one recess (3) is provided at the front end (1B) in which the channel exits (2A, 2A?) are positioned.

Abstract: The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to a nebulizing nozzle to be used in such an inhalation device, as well as a method for fabrication of such a nozzle. A nozzle for an inhalation device for nebulizing a liquid into a respirable aerosol has a nozzle body (1) which has a front end (1B) and which comprises at least two ejection channels (2, 2?), each channel (2, 2?) having an channel exit (2A, 2A?), wherein the ejection channels (2, 2?) are arranged such as to eject liquid along respective ejection trajectories which intersect with one another at a collision point. The nozzle is characterized in that at least one recess (3) is provided at the front end (1B) in which the channel exits (2A, 2A?) are positioned.

Abstract: The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to a fixture for a nebulizing nozzle to be used in such an inhalation device. A nozzle fixing assembly (1) for an inhalation device, comprising an elastically deformable seal element (2), having a continuous opening (3) capable of receiving a nozzle body (4), said seal element (2) and said nozzle body (4) each having a high pressure side (2A, 4A) and an outlet side (2B, 4B); and a pressure element (5) with a high pressure side (5A), said side being arranged to face the high pressure side (2A) of the seal element (2); wherein (i) the high pressure side (2A) of the seal element (2) is substantially flat, and (ii) the high pressure side (5A) of the pressure element (5) is chamfered in a way that, in the assembled state, the distance between these high pressure sides (2A, 5A) is higher in a central region (C) than in a peripheral region (P).

Abstract: An inhalation device including a housing; a reservoir for storing a liquid; a pumping unit including a riser pipe; a hollow cylindrical part having an interior space and being linearly moveable on the riser pipe, the pumping chamber fluidically connected with the reservoir; a nozzle connected liquid-tight to a downstream end portion of the riser pipe; wherein the linear relative motion can be effected by a relative rotation around a rotational axis of a rotatable part with respect to a counterpart converting the relative rotation into the linear relative motion by a gear mechanism comprising at least one cam surface having a first section and a second section, a spring for the storage of potential energy, wherein the cam surface has, between the first section and the second section, a third section of constant height upon which no linear relative motion occurs while the counterpart slides along it.

Abstract: The invention relates to the field of inhalation methods and inhalation devices for liquids. In particular, the invention relates to an inhalation method using an inhalation device having a nebulizing nozzle, and to a method for the generation of an aerosol of an aqueous formulation comprising pirfenidone by means of such inhalation device.

Abstract: The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to an inhalation device having a nebulizing nozzle, and to a method for the generation of an aerosol of a medically active liquid by means of such inhalation device.