Patents by Inventor Frank Corbin, III
Frank Corbin, III has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20100042038Abstract: Method and apparatus for separating plasma from blood in a membrane separator and further separator the separated plasma into desired plasma proteins in a plasma separator fluidly connected to the membrane separator to receive the separated plasma.Type: ApplicationFiled: April 24, 2009Publication date: February 18, 2010Applicant: CaridianBCT, Inc.Inventors: Steven Gage URDAHL, Frank CORBIN, III, Thomas J. FELT
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Patent number: 7582049Abstract: A centrifugal fluid separation system is disclosed for centrifugally separating a composite fluid into components thereof. This centrifugal separation system includes at least a centrifugal rotor which has a composite fluid containment area, a fluid flow channel/tubing and at least one separated component collection area defined therein. A composite fluid to be separated is delivered to the fluid containment area where under centrifugal forces the composite fluid is separated into components and then from which a component travels through an outlet channel to a respective separated component fluids flowing therethrough. A centrally disposed pump is also provided to move the separated component(s) to the collection area(s). Optical sensing of the interface of the separated fluid components may be used with a clamp to stop flow. A disposable bag and tubing system is also disclosed for use with reusable rotor devices.Type: GrantFiled: February 8, 2006Date of Patent: September 1, 2009Assignee: CaridianBCT, Inc.Inventors: Dennis J. Hlavinka, William G Palsulich, Thomas J. Felt, Frank Corbin, III
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Publication number: 20090127206Abstract: A method used in connection with processing of blood components, wherein blood products are then filtered via a filter rotating along with a centrifuge rotor and the sensed pressure may be used in connection with controlling the pumping of the blood products and/or in connection with determining the location of an interface associated with the blood products.Type: ApplicationFiled: January 26, 2009Publication date: May 21, 2009Applicant: CARIDIANBCT, INC.Inventors: Niclas HOGBERG, Emanuel HALLGREN, Peter PIHLSTEDT, Brian M. HOLMES, Lars PERSSON, Lars STRANDBERG, Geert VAN WAEG, Frank CORBIN, III
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Patent number: 7497944Abstract: A system and method are used in connection with processing of blood components. The processing of blood components may involve centrifugal separation and/or filtering of the blood components. In some examples, at least some blood components are centrifugally separated in a chamber and then filtered via a filter rotating along with a centrifuge rotor, wherein the filter is located closer than the chamber to an axis of rotation of the rotor. The filter may include a porous filtration medium configured to filter leukocytes, platelets, and/or red blood cells. Some examples include a pressure sensor sensing pressure of pumped blood components. The sensed pressure may be used in connection with controlling the pumping of the blood products and/or in connection with determining the location of an interface associated with the blood products. Other uses of the sensed pressure are also possible.Type: GrantFiled: March 27, 2007Date of Patent: March 3, 2009Assignee: CaridianBCT, Inc.Inventors: Niclas Högberg, Emanuel Hällgren, Peter Pihlstedt, Brian M. Holmes, Lars Persson, Lars Strandberg, Geert Van Waeg, Frank Corbin, III
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Patent number: 7279107Abstract: A system and method are used in connection with processing of blood components. The processing of blood components may involve centrifugal separation and/or filtering of the blood components. In some examples, at least some blood components are centrifugally separated in a chamber and then filtered via a filter rotating along with a centrifuge rotor, wherein the filter is located closer than the chamber to an axis of rotation of the rotor. The filter may include a porous filtration medium configured to filter leukocytes, platelets, and/or red blood cells. Some examples include a pressure sensor sensing pressure of pumped blood components. The sensed pressure may be used in connection with controlling the pumping of the blood products and/or in connection with determining the location of an interface associated with the blood products. Other uses of the sensed pressure are also possible.Type: GrantFiled: April 16, 2003Date of Patent: October 9, 2007Assignee: Gambro, Inc.Inventors: Niclas Högberg, Emanuel Hällgren, Peter Pihlstedt, Brian M. Holmes, Lars Persson, Lars Strandberg, Geert Van Waeg, Frank Corbin, III
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Patent number: 7072769Abstract: A blood component collection system with manipulation and optimization capabilities. In one embodiment, process parameters are derived from an input/configured predetermined blood component yield and which is based upon the maximization of at least one process parameter. Thereafter, the blood component collection procedure is performed with these derived process control parameters. In another embodiment, process parameters are derived from an input total procedure time from a maximized value for at least one of the other process control parameters so as to maximize blood component yield in this fixed time. Thereafter, the blood component collection procedure is performed with these derived parameters.Type: GrantFiled: March 1, 2001Date of Patent: July 4, 2006Assignee: Gambro, Inc.Inventors: Peter Fletcher-Haynes, William Sweat, Richard Judy, Scott Butzke, Kim Pemberton, Frank Corbin, III, Robert W. Langley, Steven Gage Urdahl, Christopher Fletcher
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Patent number: 7033512Abstract: A centrifugal fluid separation system is disclosed for centrifugally separating a composite fluid into components thereof. This centrifugal separation system includes at least a centrifugal rotor which has a composite fluid containment area, a fluid flow channel/tubing and at least one separated component collection area defined therein. A composite fluid to be separated is delivered to the fluid containment area where under centrifugal forces the composite fluid is separated into components and then from which a component travels through an outlet channel to a respective separated component fluids flowing therethrough. A centrally disposed pump is also provided to move the separated component(s) to the collection area(s). Optical sensing of the interface of the separated fluid components may be used with a clamp to stop flow. A disposable bag and tubing system is also disclosed for use with reusable rotor devices.Type: GrantFiled: April 14, 2003Date of Patent: April 25, 2006Assignee: Gambro, IncInventors: Dennis J. Hlavinka, William G. Palsulich, Thomas J. Felt, Frank Corbin, III
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Patent number: 6994790Abstract: A method is disclosed for collecting and processing whole blood. Whole blood is collected at several remote donor sites and transported to a central blood-processing center, where information regarding demand for blood products is used to direct processing of whole blood into blood products. Whole blood is initially collected in collection bags unattached to satellite bags instead of commonly used multiple bag sets. When the determination is made at the blood processing center as to which blood products are to be made, the appropriate satellite bags and/or other system components are sterile docked to the blood-collection bag and the whole blood is processed. The use of blood-collection bags initially unattached to satellite bags eliminates waste and simplifies the transportation and processing of whole blood. Also disclosed are blood collection systems that remove leukocytes and collect whole blood into blood-collection bags unattached to satellite bags.Type: GrantFiled: February 3, 2003Date of Patent: February 7, 2006Assignee: Gambro, Inc.Inventors: Frank Corbin, III, Steven Gage Urdahl
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Patent number: 6726671Abstract: A cell storage maintenance and monitoring system includes a blood product storage container, such as a flexible bag, and a microporous membrane which may be attached to an inner wall of the blood storage container to form a contained space between the inner wall and the membrane. The membrane includes a plurality of pores, preferably filled with an erodible substance responsive to a selected characteristic of the blood product.Type: GrantFiled: October 4, 2001Date of Patent: April 27, 2004Assignee: Gambro, Inc.Inventors: Larry Joe Dumont, Frank Corbin, III
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Patent number: 6315767Abstract: A cell storage maintenance and monitoring system includes a blood product storage container, such as a flexible bag, and a microporous membrane which may be attached to an inner wall of the blood storage container to form a contained space between the inner wall and the membrane. The membrane includes a plurality of pores, preferably filled with an erodible substance responsive to a characteristic of the blood product, such as pH. When the pH value drops to a predetermined level, the substance begins to erode, causing the pores to enlarge, and allowing a portion of the blood product to pass through the pores into the contained space, where it can be visibly detected. The contained space may contain a chemical indicator or buffers and nutrients, which are released into the blood product when the pores begin to open. In another embodiment, the microporous membrane may be in the form of a pod or capsule which may be attached to the wall or allowed to free-float within the contents of the storage container.Type: GrantFiled: August 19, 1998Date of Patent: November 13, 2001Assignee: Gambro, Inc.Inventors: Larry Joe Dumont, Frank Corbin, III
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Patent number: 6277337Abstract: Methods and apparatuses are provided for inactivation of microorganisms in fluids or on surfaces. Preferably the fluids contain blood or blood products and comprise biologically active proteins. Preferred methods include the steps of adding an effective, non-toxic amount of an endogenous photosensitizer to a fluid and exposing the fluid to photoradiation sufficient to activate the endogenous photosensitizer whereby microorganisms are inactivated. Other fluids, including juices, water and the like, may also be decontaminated by these methods as may surfaces of foods, animal carcasses, wounds, food preparation surfaces and bathing and washing vessel surfaces. Alloxazines and K- and L-vitamins are among the preferred photosensitizers. Systems and apparatuses for flow-through and batch processes are also provided for decontamination of such fluids using photosensitizers.Type: GrantFiled: July 20, 1999Date of Patent: August 21, 2001Assignee: Gambro, Inc.Inventors: Raymond Paul Goodrich, Jr., Dennis Hlavinka, Frank Corbin, III, Edward C. Wood, Jr.
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Patent number: 6258577Abstract: Methods and apparatuses are provided for inactivation of microorganisms in a fluid containing blood or blood products and comprising biologically active proteins. The method includes the steps of adding an effective, non-toxic amount of an endogenous photosensitizer to the fluid; exposing the fluid to photoradiation sufficient to activate the endogenous photosensitizer; and allowing the activated endogenous photosensitizer to interfere with nucleic acid present in microorganisms in the fluid so that the microorganisms are inactivated. Isoalloxazines and K- and L-vitamins are among the preferred photosensitizers.Type: GrantFiled: July 21, 1998Date of Patent: July 10, 2001Assignee: Gambro, Inc.Inventors: Raymond Paul Goodrich, Jr., Frank Corbin, III, Edward C. Wood, Jr.
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Patent number: 6231537Abstract: An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.Type: GrantFiled: January 21, 1998Date of Patent: May 15, 2001Assignee: Gambro, Inc.Inventors: Brian M. Holmes, Jeffrey J. Blakeslee, Marlene Adele Bainbridge, Frank Corbin, III
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Patent number: 6179801Abstract: An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.Type: GrantFiled: January 21, 1998Date of Patent: January 30, 2001Assignee: Gambro, Inc.Inventors: Brian M. Holmes, Jeffrey J. Blakeslee, Marlene Adele Bainbridge, Frank Corbin, III
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Patent number: 5910252Abstract: Blood from a patient is treated extracorporeally by any selected one of a plurality of predetermined treatments. Each of the treatments involves the flow of blood from the patient into a primary chamber of a filtration unit, past a semipermeable membrane located in the filtration unit which separates the primary chamber from a secondary chamber of the filtration unit, out the filtration unit and back to the patient. A replacement fluid is selectively and controllably added to the blood, as required for the selected treatment. A secondary fluid is controllably and selectively introduced into the secondary chamber of the filtration unit for controllably collecting material passing across the semipermeable membrane from the blood or for supplying material to pass across the semipermeable membrane into the blood as required for the selected treatment. Materials are removed from the secondary chamber and collected in accordance with the selected treatment.Type: GrantFiled: February 12, 1993Date of Patent: June 8, 1999Assignee: COBE Laboratories, Inc.Inventors: Lori A. Truitt, Frank Corbin, III, Donn D. Lobdell, Douglas P. Miller, Keith Manica, George J. Eilers, Steven H. Johnson, Lawrence L. Leppert
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Patent number: 5762805Abstract: Blood from a patient is treated extracorporeally by any selected one of a plurality of predetermined treatments. Each of the treatments involves the flow of blood from the patient into a primary chamber of a filtration unit, past a semipermeable membrane located in the filtration unit which separates the primary chamber from a secondary chamber of the filtration unit, out the filtration unit and back to the patient. A replacement fluid is selectively and controllably added to the blood, as required for the selected treatment. A secondary fluid is controllably and selectively introduced into the secondary chamber of the filtration unit for controllably collecting material passing across the semipermeable membrane from the blood or for supplying material to pass across the semipermeable membrane into the blood as required for the selected treatment. Materials are removed from the secondary chamber and collected in accordance with the selected treatment.Type: GrantFiled: June 7, 1995Date of Patent: June 9, 1998Assignee: COBE Laboratories, Inc.Inventors: Lori A. Truitt, Frank Corbin, III, Donn D. Lobdell, Douglas P. Miller, Keith Manica, George J. Eilers, Steven H. Johnson, Lawrence L. Leppert
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Patent number: 5738644Abstract: An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.Type: GrantFiled: June 7, 1995Date of Patent: April 14, 1998Assignee: Cobe Laboratories, Inc.Inventors: Brian M. Holmes, Jeffrey J. Blakeslee, Marlene Adele Bainbridge, Frank Corbin, III
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Patent number: 5520218Abstract: A tubing set includes at least one fluid conveying tube. The fluid conveying tube has a predetermined outside diameter, and is formed of a material adapted to be dielectrically heated at a sealing location. The insulating sleeve has an inside dimension at least as large as the outside diameter of the fluid conveying tube. The tubular insulating sleeve is positioned in a substantially coaxial relationship with the fluid conveying tube at the sealing location, and has a wall with thickness which insulates the fluid conveying tube to permit sealing the fluid conveying tube, and forming a thin, easily tearable web, by the application of the radio frequency dielectric heating.Type: GrantFiled: June 9, 1994Date of Patent: May 28, 1996Assignee: Cobe Laboratories, Inc.Inventors: Dennis J. Hlavinka, Frank Corbin, III, Robert L. White
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Patent number: 5345070Abstract: An insulating sleeve retains heat in the plastic of a flexible plastic medical tube when the plastic of the medical tube is dielectrically heated by a radio frequency tubing sealer. The heat retained by the insulating sleeve permits additional melting of the plastic of the medical tube after a seal has been formed. The additional melting results in forming an easily tearable web between the segments of the medical tube in the same operation as the sealing operation. The medical tube is selectively sealed without forming the easily tearable web by using the radio frequency tubing sealer without the insulating sleeve.Type: GrantFiled: February 23, 1993Date of Patent: September 6, 1994Assignee: COBE Laboratories, Inc.Inventors: Dennis J. Hlavinka, Frank Corbin, III, Robert L. White
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Patent number: 4246121Abstract: A fluid flow transfer device having a pleated membrane bonded at its tips to the interior of a housing and a method of making the same wherein a fluid manifold is provided by forming a channel portion in the housing interior, applying a gasket material around the channel portion, and placing the membrane tips against the adhesive to provide a formed-in-place gasket prior to potting of the membrane tips to the housing interior with a potting material.Type: GrantFiled: November 17, 1978Date of Patent: January 20, 1981Assignee: Cobe Laboratories, Inc.Inventors: Frank Corbin, III, Dennis J. Hlavinka