Patents by Inventor Frank I. Carroll
Frank I. Carroll has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9512105Abstract: Provided are compounds represented by the formula: where R, Y3, R1, R2, R3, R4, R6, G, R7, E1, E2, A, B, W, X, Y and Z are as defined herein.Type: GrantFiled: December 10, 2012Date of Patent: December 6, 2016Assignee: RESEARCH TRIANGLE INSTITUTEInventors: Frank I. Carroll, James B. Thomas, Hernan A. Navarro, S. Wayne Mascarella, Scott P. Runyon, Chunyang Jin, Chad M. Kormos
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Publication number: 20160095854Abstract: Provided are opioid receptor antagonists represented by the formula (I): where R, Y3, R1, R2, R3, R4 and R5 are as defined herein.Type: ApplicationFiled: December 14, 2015Publication date: April 7, 2016Applicant: RESEARCH TRIANGLE INSTITUTEInventors: Frank I. CARROLL, Juan P. CUEVA, James B. THOMAS, S. Wayne MASCARELLA, Scott P. RUNYON
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Patent number: 9273027Abstract: Provided are opioid receptor antagonists represented by the formula (I) where R, Y3, R1, R2, R3, R4 and R5 are as defined herein.Type: GrantFiled: October 12, 2010Date of Patent: March 1, 2016Assignee: RESEARCH TRIANGLE INSTITUTEInventors: Frank I. Carroll, Juan P. Cueva, James B. Thomas, S. Wayne Mascarella, Scott P. Runyon
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Publication number: 20150005315Abstract: Provided are compounds represented by the formula: where R, Y3, R1, R2, R3, R4, R6, G, R7, E1, E2, A, B, W, X, Y and Z are as defined herein.Type: ApplicationFiled: December 10, 2012Publication date: January 1, 2015Applicant: RESEARCH TRIANGLE INSTITUTEInventors: Frank I. Carroll, James B. Thomas, Hernan A. Navarro, S. Wayne Mascarella, Scott P. Runyon, Chunyang Jin, Chad M. Kormos
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Publication number: 20120295919Abstract: Provided are opioid receptor antagonists represented by the formula (I) where R, Y3, R1, R2, R3, R4 and R5 are as defined herein.Type: ApplicationFiled: October 12, 2010Publication date: November 22, 2012Applicant: RESEARCH TRIANGLE INSTITUTEInventors: Frank I. Carroll, Juan P. Cueva, James B. Thomas, S. Wayne Mascarella, Scott P. Runyon
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Publication number: 20080153870Abstract: A class of binding ligands for cocaine receptors and other receptors in the brain. Specifically, a novel family of compounds shows high binding specificity and activity, and, in a radiolabeled form, can be used to bind to these receptors, for biochemical assays and imaging techniques. Such imaging is useful for determining effective doses of new drug candidates in human populations. In addition, the high specificity, slow onset and long duration of the action of these compounds at the receptors makes them particularly well suited for therapeutic uses, for example as substitute medication for psychostimulant abuse. Some of these compounds may be useful in treating Parkinson's Disease or depression, by virtue of their inhibitory properties at monoamine transporters.Type: ApplicationFiled: September 28, 2007Publication date: June 26, 2008Applicant: Research Triangle InstituteInventors: Michael J. KUHAR, Frank I. CARROLL, John W. BOJA, Anita H. LEWIN, Philip ABRAHAM
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Patent number: 7291737Abstract: A class of binding ligands for cocaine receptors and other receptors in the brain. Specifically, a novel family of compounds shows high binding specificity and activity, and, in a radiolabeled form, can be used to bind to these receptors, for biochemical assays and imaging techniques. Such imaging is useful for determining effective doses of new drug candidates in human populations. In addition, the high specificity, slow onset and long duration of the action of these compounds at the receptors makes them particularly well suited for therapeutic uses, for example as substitute medication for psychostimulant abuse. Some of these compounds may be useful in treating Parkinson's Disease or depression, by virtue of their inhibitory properties at monoamine transporters.Type: GrantFiled: November 12, 2004Date of Patent: November 6, 2007Assignee: Research Triangle InstituteInventors: Michael J. Kuhar, Frank I. Carroll, John W. Boja, Anita H. Lewin, Philip Abraham
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Patent number: 7189737Abstract: A class of binding ligands for cocaine receptors and other receptors in the brain. Specifically, a novel family of compounds shows high binding specificity and activity, and, in a radiolabeled form, can be used to bind to these receptors, for biochemical assays and imaging techniques. Such imaging is useful for determining effective doses of new drug candidates in human populations. In addition, the high specificity, slow onset and long duration of the action of these compounds at the receptors makes them particularly well suited for therapeutic uses, for example as substitute medication for psychostimulant abuse. Some of these compounds may be useful in treating Parkinson's Disease or depression, by virtue of their inhibitory properties at monoamine transporters.Type: GrantFiled: October 25, 2002Date of Patent: March 13, 2007Assignee: Research Triangle InstituteInventors: Michael J. Kuhar, Frank I. Carroll, John W. Boja, Anita H. Lewin, Philip Abraham
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Patent number: 6900228Abstract: The present application relates to novel opioid receptor antagonists and agonists, methods of making these compounds, and methods of use thereof.Type: GrantFiled: March 9, 1999Date of Patent: May 31, 2005Assignee: Research Triangle InstituteInventors: Frank I. Carroll, James B. Thomas, S. Wayne Mascarella
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Publication number: 20040146518Abstract: The present application relates to novel opioid receptor antagonists and agonists, methods of making these compounds, and methods of use thereof.Type: ApplicationFiled: December 23, 2003Publication date: July 29, 2004Applicant: Research Triangle InstituteInventors: Frank I. Carroll, James B. Thomas, S. Wayne Mascarella
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Patent number: 6706880Abstract: The invention relates to novel compounds which show high affinity for cocaine receptors in the brain, particularly dopamine and serotonin transporter sites. The compounds may be used as imaging or pharmaceutical agents, in the diagnosis and treatment of drug addiction, depression, anorexia and neurodegenerative diseases or in determining the doses of therapeutic agents that occupy significant numbers of receptors.Type: GrantFiled: September 20, 2001Date of Patent: March 16, 2004Assignee: Research Triangle InstituteInventors: Frank I. Carroll, Michael J. Kuhar, John W. Boja, Anita H. Lewin, Philip Abraham
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Publication number: 20030203934Abstract: A class of binding ligands for cocaine receptors and other receptors in the brain. Specifically, a novel family of compounds shows high binding specificity and activity, and, in a radiolabeled form, can be used to bind to these receptors, for biochemical assays and imaging techniques. Such imaging is useful for determining effective doses of new drug candidates in human populations. In addition, the high specificity, slow onset and long duration of the action of these compounds at the receptors makes them particularly well suited for therapeutic uses, for example as substitute medication for psychostimulant abuse. Some of these compounds may be useful in treating Parkinson's Disease or depression, by virtue of their inhibitory properties at monoamine transporters.Type: ApplicationFiled: October 25, 2002Publication date: October 30, 2003Applicant: Research Triangle InstituteInventors: Michael J. Kuhar, Frank I. Carroll, John W. Boja, Anita H. Lewin, Philip Abraham
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Publication number: 20030158415Abstract: The present invention relates to a class of nitrogen-containing heterocyclic compounds which bind to opioid receptors. The inventive compounds can be used to treat a variety of disease states which involve the opioid receptors.Type: ApplicationFiled: October 9, 2002Publication date: August 21, 2003Applicant: Research Triangle InstituteInventors: Frank I. Carroll, James B. Thomas, S. Wayne Mascarella
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Patent number: 6593348Abstract: The present application relates to novel opioid receptor antagonists and agonists, methods of making these compounds, and methods of use thereof.Type: GrantFiled: March 19, 2002Date of Patent: July 15, 2003Assignee: Research Triangle InstituteInventors: Frank I. Carroll, James B. Thomas, S. Wayne Mascarella
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Patent number: 6552032Abstract: The present application relates to novel opioid receptor antagonists and agonists, methods of making these compounds, and methods of use thereof.Type: GrantFiled: March 19, 2002Date of Patent: April 22, 2003Assignee: Research Triangle InstituteInventors: Frank I. Carroll, James B. Thomas, S. Wayne Mascarella
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Patent number: 6531481Abstract: The present application relates to novel opioid receptor antagonists and agonists, methods of making these compounds, and methods of use thereof.Type: GrantFiled: March 19, 2002Date of Patent: March 11, 2003Assignee: Research Triangle InstituteInventors: Frank I. Carroll, James B. Thomas, S. Wayne Mascarella
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Patent number: 6531483Abstract: The invention relates to novel compounds which show high affinity for cocaine receptors in the brain, particularly dopamine and serotonin transporter sites. The compounds may be used as imaging or pharmaceutical agents, in the diagnosis and treatment of drug addiction, depression, anorexia and neurodegenerative diseases.Type: GrantFiled: September 4, 1996Date of Patent: March 11, 2003Assignee: Research Triangle InstituteInventors: Michael J. Kuhar, Frank I. Carroll, John W. Boja, Anita H. Lewin, Philip Abraham
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Publication number: 20030023090Abstract: The invention relates to novel compounds which show high affinity for cocaine receptors in the brain, particularly dopamine and serotonin transporter sites. The compounds may be used as imaging or pharmaceutical agents, in the diagnosis and treatment of drug addiction, depression, anorexia and neurodegenerative diseases.Type: ApplicationFiled: September 20, 2001Publication date: January 30, 2003Applicant: RESEARCH TRIANGLE INSTITUTEInventors: Frank I. Carroll, Michael J. Kuhar, John W. Boja, Anita H. Lewin, Philip Abraham
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Publication number: 20020193602Abstract: The present application relates to novel opioid receptor antagonists and agonists, methods of making these compounds, and methods of use thereof.Type: ApplicationFiled: March 19, 2002Publication date: December 19, 2002Applicant: Research Triangle InstituteInventors: Frank I. Carroll, James B. Thomas, S. Wayne Mascarella
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Publication number: 20020169324Abstract: The present application relates to novel opioid receptor antagonists and agonists, methods of making these compounds, and methods of use thereof.Type: ApplicationFiled: March 19, 2002Publication date: November 14, 2002Applicant: Research Triangle InstituteInventors: Frank I. Carroll, James B. Thomas, S. Wayne Mascarella