Patents by Inventor Frank Johns

Frank Johns has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ROTARY DRUM FILTERING APPARATUS
    Publication number: 20170014740
    Abstract: A drum structure, for a rotary drum filtering apparatus, comprising: a generally annular supporting drum, and a plurality of rib elements carried by the supporting drum longitudinally extending along the circumference of the drum generally in the longitudinal direction of the drum. A duplex stainless steel cover plate extends between two rib elements. A single supporting element supports the cover plate extending between each pair of two rib elements.
    Type: Application
    Filed: July 15, 2015
    Publication date: January 19, 2017
    Inventors: Frank John Merchel, III, Michael Alan Tardie, Robert Carl Short
  • Kappa opioid receptor effectors and uses thereof
    Patent number: 9540375
    Abstract: The present invention is a selective kappa opioid receptor effector, or a pharmaceutically acceptable salt thereof, useful for treating ethanol use disorder withdrawal, anxiety and/or depression, schizophrenia, mania or post-traumatic stress disorder.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: January 10, 2017
    Assignees: University of Kansas, The Scripps Research Institute
    Inventors: Jeffrey Aube, Laura Bohn, Thomas Edward Prisinzano, Frank John Schoenen, Kevin J. Frankowski
  • Substrates and methods for collection, stabilization and elution of biomolecules
    Patent number: 9480966
    Abstract: A solid substrate for the extraction, stabilization, and storage of proteins is provided. The substrate includes: a polysaccharide, such as melezitose under a substantially dry state. The substrate is configured to extract proteins from a sample and stabilize the extracted proteins in a dry format under ambient conditions for a prolonged period of time. Methods for collecting and recovering the proteins stored in the dry solid substrate are also described.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: November 1, 2016
    Assignee: General Electric Company
    Inventors: Ernest William Kovacs, Erik Leeming Kvam, Bing Li, Frank John Mondello
  • HCV helicase inhibitors and methods of use thereof
    Patent number: 9464064
    Abstract: The present invention discloses thioflavine S and primuline derivatives which inhibit hepatitis C virus helicase and protease activity. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are useful as antiviral agents. The present invention further relates to pharmaceutical compositions containing the aforementioned compounds and methods of treating an HCV infection.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: October 11, 2016
    Assignees: University of Kansas, UWM Research Foundation, Inc.
    Inventors: Jeffrey Aube, Brian Scott Jonathan Blagg, Kevin John Frankowski, David Norman Frick, Kelin Li, Frank John Schoenen
  • Salicylic acid derivatives useful as glucocerebrosidase activators
    Patent number: 9464035
    Abstract: Compounds of Formula (I) and the pharmaceutically acceptable salts thereof are disclosed. The variables. R1-R13, m, n, o, and p are disclosed herein. The compounds are useful for treating Gaucher disease and inhibiting the onset of Gaucher disease symptoms in a patient having a GBA gene mutation and for treating Parkinson's disease. Pharmaceutical compositions containing compounds of Formula (I) and methods of treatment comprising administering compounds of Formula (I) are also disclosed.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: October 11, 2016
    Assignees: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE UNIVERSITY OF KANSAS
    Inventors: Juan Jose Marugan, Wei Zheng, Samarjit Patnaik, Noel Southall, Ellen Sidransky, Ehud Goldin, Wendy Westbroek, Elma Aflaki, Steven Andrew Rogers, Frank John Schoenen
  • Emergency evacuation systems door restraint lanyard for aircraft
    Patent number: 9457911
    Abstract: Evacuation slide systems including a slide pack comprising a packboard coupled to an aircraft door, a girt bar coupled to an aircraft floor when the aircraft door is armed, and a restraint coupled to the packboard and the girt bar are detailed. The restraint controls a speed at which the aircraft door opens when the aircraft door is armed until the aircraft door has traveled beyond a predetermined distance.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: October 4, 2016
    Assignee: Air Cruisers Company
    Inventor: Frank John Brown
  • METHOD AND SYSTEM FOR DETERMINING THE PROGNOSIS OF A PATIENT SUFFERING FROM PULMONARY EMBOLISM
    Publication number: 20160260210
    Abstract: A system for determining the prognosis of a patient suffering from pulmonary embolism is provided. The system may include at least one computer system configure to receive patient specific data regarding his pulmonary embolism status. The at least one computer system may be further configured to create a model of the patient's heart, with at least information of the two ventricles, and to determine the ratio of sizes of the ventricles. The system will then report such ratio to the clinician or report a risk index of clinical outcome for such patient.
    Type: Application
    Filed: November 27, 2014
    Publication date: September 8, 2016
    Inventors: Germán SERRANO GONZÁLEZ, Daniel CARRETERO JIMÉNEZ, Frank JOHN RYBICKI, María J. LEDESMA CARBAYO, Sara LÓPEZ RODRÍGUEZ, Raúl ESTÉPAR SAN JOSÉ
  • KAPPA OPIOID RECEPTOR EFFECTORS AND USES THEREOF
    Publication number: 20160257685
    Abstract: The present invention is a selective kappa opioid receptor effector, or a pharmaceutically acceptable salt thereof, useful for treating ethanol use disorder withdrawal, anxiety and/or depression, schizophrenia, mania or post-traumatic stress disorder.
    Type: Application
    Filed: May 17, 2016
    Publication date: September 8, 2016
    Inventors: Jeffrey Aube, Laura Bohn, Thomas Edward Prisinzano, Frank John Schoenen, Kevin J. Frankowski
  • Adjustable zero fret and method of use on a stringed instrument
    Patent number: 9412345
    Abstract: An apparatus and method of varying the tonal aspects of a string instrument such as an acoustic or electric guitar is disclosed. The apparatus and method employing a unique zero fret assembly. The zero fret assembly includes an upper portion and a lower portion. The lower portion is configured to connect with a fret board, headstock or body of an instrument. The upper portion is configured to engage the lower portion. The upper portion is also configured to receive and support an instrument's strings. The upper portion is selectively movable relative to the lower portion by an operator to change the tonal nature of the instrument.
    Type: Grant
    Filed: January 11, 2016
    Date of Patent: August 9, 2016
    Assignee: Gibson Brands, Inc.
    Inventors: Frank Johns, George Mathews, John Steve Frensley
  • Adjustable Zero Fret and Method of Use on a Stringed Instrument
    Publication number: 20160196807
    Abstract: An apparatus and method of varying the tonal aspects of a string instrument such as an acoustic or electric guitar is disclosed. The apparatus and method employing a unique zero fret assembly. The zero fret assembly includes an upper portion and a lower portion. The lower portion is configured to connect with a fret board, headstock or body of an instrument. The upper portion is configured to engage the lower portion. The upper portion is also configured to receive and support an instrument's strings. The upper portion is selectively movable relative to the lower portion by an operator to change the tonal nature of the instrument.
    Type: Application
    Filed: January 11, 2016
    Publication date: July 7, 2016
    Inventors: Frank Johns, George Mathews, John Steve Frensley
  • POROUS MEMBRANES WITH A POLYMER GRAFTING, METHODS AND USES THEREOF
    Publication number: 20160146802
    Abstract: A device comprising a modified porous membrane is provided. The modified porous membrane comprises a polymer coating grafted to a porous membrane. The device is used for analyte detection from a biological sample using an immunoassay. The device comprises a sample application zone at one end of the device for applying a biological sample comprising a target analyte; and a detection zone present at another end of the device, downstream of the sample application zone for detecting the target analyte, wherein the detection zone comprises one or more first biomolecules immobilized on a modified porous membrane having a structure of Formula (I).
    Type: Application
    Filed: November 20, 2014
    Publication date: May 26, 2016
    Inventors: Bing Li, Brian Christopher Bales, David Roger Moore, Jason Michael Nichols, Cathryn Ellen Olsen, William Christopher Alberts, Frank John Mondello
  • POROUS MEMBRANES WITH A POLYMER GRAFTING, METHODS AND USES THEREOF
    Publication number: 20160146795
    Abstract: A modified porous membrane comprising a polymer coating grafted to a porous membrane is described. A method for analyte detection from a biological sample using an immunoassay is also provided using the modified membrane, wherein the method comprises a) providing a modified porous membrane having the structure of Formula (I), b) incubating the modified porous membrane with a first biomolecule, wherein the first biomolecule binds to the modified porous membrane to form a first biomolecule bound modified porous membrane; and c) adding a biological sample comprising at least an analyte to the first biomolecule bound modified porous membrane for analyte detection by binding the analyte to the first biomolecule bound to the modified porous membrane.
    Type: Application
    Filed: November 20, 2014
    Publication date: May 26, 2016
    Inventors: Bing Li, Brian Christopher Bales, David Roger Moore, Jason Michael Nichols, Cathryn Ellen Olsen, William Christopher Alberts, Frank John Mondello
  • Kappa opioid receptor effectors and uses thereof
    Patent number: 9345703
    Abstract: The present invention is a selective kappa opioid receptor effector, or a pharmaceutically acceptable salt thereof, useful for treating ethanol use disorder withdrawal, anxiety and/or depression, schizophrenia, mania or post-traumatic stress disorder.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: May 24, 2016
    Assignees: University of Kansas, The Scripps Research Institute
    Inventors: Jeffrey Aube, Laura Bohn, Thomas Edward Prisinzano, Frank John Schoenen, Kevin John Frankowski
  • INHIBITORS OF THE MITF MOLECULAR PATHWAY
    Publication number: 20160130222
    Abstract: Provided herein are compounds of the formula (IV) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful as MITF inhibitors, MITF pathway inhibitors and for the treatment of cancer.
    Type: Application
    Filed: June 10, 2014
    Publication date: May 12, 2016
    Inventors: Patrick FALOON, Warren S. WEINER, Robert A. SMITH, Frank John SCHOENEN, David E. FISHER, Rizwan HAQ
  • PINNED FLY RING FOR ROTARY DRUM WASHER AND METHOD OF MANUFACTURE
    Publication number: 20160051914
    Abstract: Disclosed is a fly ring adapted to be used in a rotary drum filtering apparatus, and a method of forming such a fly ring. The fly ring comprises a plurality of ring segments, each ring segment being laser cut. Each ring segment has a first end which overlaps a second end of an adjacent ring segment, forming a lapped joint. Each ring segment first and second end has at least two spaced apart through holes, the through holes of the first end being aligned with the through holes of the second end. A custom fastener extends through the first end and second end aligned through holes.
    Type: Application
    Filed: August 20, 2015
    Publication date: February 25, 2016
    Inventors: Joel Kimmett Clement, Michael Alan Tardie, Frank John Merchel, III
  • SYSTEM AND METHOD OF GROUPING AND EXTRACTING INFORMATION FROM DATA CORPORA
    Publication number: 20150363384
    Abstract: A system for annotating words of a data corpus based upon their particular concept and their corresponding grammatical sense with Conceptual Numerical Identifiers (CNIs) from a Conceptual Dictionary, pairing the words based on conceptual inter-relating network (CIRN) rules, and determining if a selected plurality of paired words are grammatically, syntactically, and linguistically correct by matching CNIs from each pair of words.
    Type: Application
    Filed: April 3, 2015
    Publication date: December 17, 2015
    Inventors: FRANK JOHN WILLIAMS, WALTER EDWARD WILLIAMS
  • CEPHALOSPORIN DERIVATIVES AND METHODS OF USE
    Publication number: 20150322087
    Abstract: This invention provides cephalosporin derivatives for killing or inhibiting the spread of microorganisms such as non-replicating Mycobacterium tuberculosis and in the treatment of infectious disease.
    Type: Application
    Filed: November 4, 2013
    Publication date: November 12, 2015
    Inventors: Jeffrey Aube, Carl Nathan, Robert Smith, Ben S. Gold, Paul Hanson, Chunjing Liu, Lester Allen Mitscher, Maneesh Pingle, Frank John Schoenen
  • INTEGRAL SAMPLE IDENTIFICATION THROUGHOUT A WORKFLOW PROCESS
    Publication number: 20150285714
    Abstract: Provided are devices and methods for sample collection and processing. A tubular body has a chamber closed at a first end by a thin penetrable barrier and open at a second end opposite the first end. The tubular body further includes a partition that divides the chamber into two adjacent compartments, wherein a first compartment of the two adjacent compartments has the partition facing opposite the open end of the chamber and a second compartment of the two adjacent compartments has the partition facing opposite the closed end of the chamber. The partition has one or more holes to allow passage of fluid from the first compartment into the second compartment. A tracking identification may be permanently affixed to the first end of the tubular body.
    Type: Application
    Filed: April 6, 2015
    Publication date: October 8, 2015
    Inventors: Pamela J. Longenbach, Moon Chul Jung, Frank John Marszalkowski, JR., Geoff Gerhardt
  • APPARATUS AND METHOD FOR ANALYTE EXTRACTION
    Publication number: 20150266019
    Abstract: Described is a matrix spot processing device comprising a tubular apparatus. An absorbent media is located either separate from, or attached to, the tubular apparatus. A sample is spotted on the absorbent media. A reservoir is in the tubular apparatus. A first region of the reservoir is constructed and arranged to have an extraction solvent. A second region of the reservoir, which may or may not be the same as the first region, is constructed and arranged to receive an extract generated from an interaction between the extraction solvent and the spotted sample at the absorbent media.
    Type: Application
    Filed: September 25, 2013
    Publication date: September 24, 2015
    Inventors: Pamela J. Longenbach, Moon Chul Jung, Frank John Marszalkowski, JR.
  • Adjustable Zero Fret and Method of Use on a Stringed Instrument
    Publication number: 20150248875
    Abstract: An apparatus and method of varying the tonal aspects of a string instrument such as an acoustic or electric guitar is disclosed. The apparatus and method employing a unique zero fret assembly. The zero fret assembly includes an upper portion and a lower portion. The lower portion is configured to connect with a fret board, headstock or body of an instrument. The upper portion is configured to engage the lower portion. The upper portion is also configured to receive and support an instrument's strings. The upper portion is selectively movable relative to the lower portion by an operator to change the tonal nature of the instrument.
    Type: Application
    Filed: May 18, 2015
    Publication date: September 3, 2015
    Inventors: Frank Johns, George Mathews, John Steve Frensley