Abstract: The present invention concerns antigen binding proteins specifically binding melanoma associated antigen A (MAGE-A) protein-derived antigens. The invention in particular provides antigen binding proteins which specifically bind to the MAGE-A antigenic peptide comprising or consisting of SEQ ID NO: 1 in a complex with a major histocombatibility (MHC) protein. The antigen binding proteins of the invention contain, in particular, the complementary determining regions (CDRs) of novel engineered T cell receptors (TCRs) that specifically bind to said MAGE-A peptide/MHC complex. The antigen binding proteins of the invention are of use for the diagnosis, treatment and prevention of MAGE-A expressing cancerous diseases. Further provided are nucleic acids encoding the antigen binding proteins of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins of the invention.

Abstract: The present invention concerns antigen binding proteins directed against PRAME protein-derived antigens. The invention in particular provides antigen binding proteins which are specific for the tumor expressed antigen PRAME, wherein the tumor antigen comprises or consists of SEQ ID NO: 50 and is in a complex with a major histocompatibility complex (MHC) protein. The antigen binding proteins of the invention contain, in particular, the complementary determining regions (CDRs) of novel engineered T cell receptors (TCRs) that specifically bind to said PRAME peptide. The antigen binding proteins of the invention are for use in the diagnosis, treatment and prevention of PRAME expressing cancerous diseases. Further provided are nucleic acids encoding the antigen binding proteins of the invention, vectors comprising said nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins of the invention.

Abstract: Disclosed are systems, methods, and devices for generating a visualization of a deep reinforcement learning (DRL) process. State data is received, reflective of states of an environment explored by an DRL agent, each state corresponding to a time step. For each given state, saliency metrics are calculated by processing the state data, each metric measuring saliency of a feature at the time step corresponding to the given state. A graphical visualization is generated, having at least two dimensions in which: each feature of the environment is graphically represented along a first axis; and each time step is represented along a second axis; and a plurality of graphical markers representing corresponding saliency metrics, each graphical marker having a size commensurate with the magnitude of the particular saliency metric represented, and a location along the first and second axes corresponding to the feature and time step for the particular saliency metric.

Abstract: In a method, dynamic pressure oscillations in the intake tract or outlet tract of a respective internal combustion engine are measured during normal operation, and from these measured oscillations, a corresponding pressure oscillation signal is generated. A crankshaft phase angle signal is determined at the same time. From the pressure oscillation signal, an actual value of at least one characteristic of at least one selected signal frequency of the measured pressure oscillations in relation to the crankshaft phase angle signal is determined, and the current trimming of the intake tract is determined on the basis of the determined actual value, taking into consideration reference values of the corresponding characteristic of the respectively identical signal frequency for different trimmings of the intake tract.

Abstract: A method for checking the function of a pressure sensor in the air intake tract or gas outlet tract of an internal combustion engine and to an engine control unit for carrying out the method and based on measuring dynamic pressure oscillations of the intake air or the exhaust gas by the relevant pressure sensor and, on the basis of the pressure oscillation signal obtained, respectively determining with the aid of a discrete Fourier transformation for a number of selected signal frequencies in each case a value of a specific operating characteristic of the internal combustion engine and deviation values of the values determined for the different signal frequencies from one another. Depending on whether deviation values determined fall below or exceed a predetermined limit value, the satisfactory function of the pressure sensor is confirmed, or a malfunction of the pressure sensor is diagnosed.

Abstract: An electronic reader may operate in a normal mode. The reader may evaluate criteria to determine whether to continue operating in the normal mode or operate in a secure mode. The secure mode may include deactivating functionality in the reader. Deactivating functionality may include at least one of disabling a credential reading functionality, disabling a credential processing functionality, and disabling a credential communicating functionality.

Abstract: Various embodiments include a method for detecting deviations occurring in the valve drive of an internal combustion engine comprising: measuring dynamic pressure oscillations of intake air in an air intake tract of respective internal combustion engine during operation; calculating an inlet valve stroke phase difference and/or an outlet valve stroke phase difference based on the measured dynamic pressure oscillation; calculating a valve stroke phase deviation value with respect to a valve stroke phase reference value based on the calculated phase difference; and calculating a first valve drive deviation value based on the valve stroke phase deviation value.

Abstract: In the method according to example embodiments, dynamic pressure oscillations in the inlet tract of the respective internal combustion engine are measured during normal operation, and from these a corresponding pressure oscillation signal is generated. A crankshaft phase angle signal is acquired at the same time. The pressure oscillation signal is used to determine an actual value of at least one characteristic of at least one selected signal frequency of the measured pressure oscillations in relation to the crankshaft phase angle signal, and the current compression ratio is determined on the basis of the determined actual value and using reference values of the corresponding characteristic of the respective same signal frequency for different compression ratios.

Abstract: Disclosed are systems, methods, and devices for generating a visualization of a deep reinforcement learning (DRL) process. State data is received, reflective of states of an environment explored by an DRL agent, each state corresponding to a time step. For each given state, saliency metrics are calculated by processing the state data, each metric measuring saliency of a feature at the time step corresponding to the given state. A graphical visualization is generated, having at least two dimensions in which: each feature of the environment is graphically represented along a first axis; and each time step is represented along a second axis; and a plurality of graphical markers representing corresponding saliency metrics, each graphical marker having a size commensurate with the magnitude of the particular saliency metric represented, and a location along the first and second axes corresponding to the feature and time step for the particular saliency metric.

Abstract: In a method, dynamic pressure oscillations in the intake tract or outlet tract of a respective internal combustion engine are measured during normal operation, and from these measured oscillations, a corresponding pressure oscillation signal is generated. A crankshaft phase angle signal is determined at the same time. From the pressure oscillation signal, an actual value of at least one characteristic of at least one selected signal frequency of the measured pressure oscillations in relation to the crankshaft phase angle signal is determined, and the current trimming of the intake tract is determined on the basis of the determined actual value, taking into consideration reference values of the corresponding characteristic of the respectively identical signal frequency for different trimmings of the intake tract.

Abstract: In the method according to example embodiments, dynamic pressure oscillations in the inlet tract of the respective internal combustion engine are measured during normal operation, and from these a corresponding pressure oscillation signal is generated. A crankshaft phase angle signal is acquired at the same time. The pressure oscillation signal is used to determine an actual value of at least one characteristic of at least one selected signal frequency of the measured pressure oscillations in relation to the crankshaft phase angle signal, and the current compression ratio is determined on the basis of the determined actual value and using reference values of the corresponding characteristic of the respective same signal frequency for different compression ratios.

Abstract: A method for checking the function of a pressure sensor in the air intake tract or gas outlet tract of an internal combustion engine and to an engine control unit for carrying out the method and based on measuring dynamic pressure oscillations of the intake air or the exhaust gas by the relevant pressure sensor and, on the basis of the pressure oscillation signal obtained, respectively determining with the aid of a discrete Fourier transformation for a number of selected signal frequencies in each case a value of a specific operating characteristic of the internal combustion engine and deviation values of the values determined for the different signal frequencies from one another. Depending on whether deviation values determined fall below or exceed a predetermined limit value, the satisfactory function of the pressure sensor is confirmed, or a malfunction of the pressure sensor is diagnosed.

Abstract: Various embodiments include a method for operating an internal combustion engine wherein the compression is variably adjusted comprising: checking a sensor signal indicative of a compression of the engine; checking the plausibility of the signal by: ascertaining a series of corresponding values of the signal and values of the actuating variable; determining a mathematical relationship between the signal and the variable based on the series; determining a deviation between the relationship and a predetermined characteristic relationship; and determining the signal is plausible when the determined deviation is lower than a predetermined threshold value; and if the determined deviation is higher than the predetermined threshold value, adjusting operation of the internal combustion engine.

Abstract: A system including a reader device and a mobile device having a user credential. The reader device includes an ultrasonic transmitter configured to transmit an identifier, and a wireless transceiver configured to receive information from and transmit information to the mobile device. The identifier is configured to be received by a microphone of the mobile device. The mobile device may determine a position of the mobile device based on the identifier.

Abstract: Various embodiments include a method for detecting deviations occurring in the valve drive of an internal combustion engine comprising: measuring dynamic pressure oscillations of intake air in an air intake tract of respective internal combustion engine during operation; calculating an inlet valve stroke phase difference and/or an outlet valve stroke phase difference based on the measured dynamic pressure oscillation; calculating a valve stroke phase deviation value with respect to a valve stroke phase reference value based on the calculated phase difference; and calculating a first valve drive deviation value based on the valve stroke phase deviation value.

Abstract: A system including a reader device and a mobile device having a user credential. The reader device includes an ultrasonic transmitter configured to transmit an identifier, and a wireless transceiver configured to receive information from and transmit information to the mobile device. The identifier is configured to be received by a microphone of the mobile device. The mobile device may determine a position of the mobile device based on the identifier.

Abstract: Various embodiments include a method for operating an internal combustion engine wherein the compression is variably adjusted comprising: checking a sensor signal indicative of a compression of the engine; checking the plausibility of the signal by: ascertaining a series of corresponding values of the signal and values of the actuating variable; determining a mathematical relationship between the signal and the variable based on the series; determining a deviation between the relationship and a predetermined characteristic relationship; and determining the signal is plausible when the determined deviation is lower than a predetermined threshold value; and if the determined deviation is higher than the predetermined threshold value, adjusting operation of the internal combustion engine.

Abstract: An electronic reader may operate in a normal mode. The reader may evaluate criteria to determine whether to continue operating in the normal mode or operate in a secure mode. The secure mode may include deactivating functionality in the reader. Deactivating functionality may include at least one of disabling a credential reading functionality, disabling a credential processing functionality, and disabling a credential communicating functionality.

Abstract: A data processing system (1) is programmed with an interface (2) for capturing events which arise, and a process engine (3) for automatically monitoring captured events to identify completion of steps, each comprising a plurality of events linked by dependency relationships; and to identify completion of processes, each comprising a plurality of steps linked by dependency relationships. Software functions (5) execute in response to output of the process engine (3). The process engine (3) processes events to recognize a plurality of potential steps, but terminates other potential steps when completion of a step is determined. The process engine (3) processes steps to recognize a plurality of potential processes, but terminates other potential process when completion of a process is determined. The dependency relationships include Boolean AND operators and Boolean OR operators. There is a discrete start event for each step and a discrete start step for each process.

Abstract: A data processing system (1) is programmed with an interface (2) for capturing events which arise, and a process engine (3) for automatically monitoring captured events to identify completion of steps, each comprising a plurality of events linked by dependency relationships; and to identify completion of processes, each comprising a plurality of steps linked by dependency relationships. Software functions (5) execute in response to output of the process engine (3). The process engine (3) processes events to recognize a plurality of potential steps, but terminates other potential steps when completion of a step is determined. The process engine (3) processes steps to recognize a plurality of potential processes, but terminates other potential process when completion of a process is determined. The dependency relationships include Boolean AND operators and Boolean OR operators. There is a discrete start event for each step and a discrete start step for each process.