Patents by Inventor Frank Ruebsam

Frank Ruebsam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUBSTITUTED SPIROCYCLIC INHIBITORS OF AUTOTAXIN
    Publication number: 20190225611
    Abstract: The present invention relates to compounds according to Formula 1 and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.
    Type: Application
    Filed: April 12, 2019
    Publication date: July 25, 2019
    Inventors: Lee BABISS, Matthew CLARK, Anthony D. KEEFE, Mark J. MULVIHILL, Haihong NI, Louis RENZETTI, Frank RUEBSAM, Ce WANG, Zhifeng XIE, Ying ZHANG
  • Substituted spirocyclic inhibitors of autotaxin
    Patent number: 10233182
    Abstract: The present invention relates to compounds according to Formula I and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.
    Type: Grant
    Filed: February 14, 2018
    Date of Patent: March 19, 2019
    Assignee: X-Rx, Inc.
    Inventors: Lee Babiss, Matthew Clark, Anthony D. Keefe, Mark J. Mulvihill, Haihong Ni, Louis Renzetti, Frank Ruebsam, Ce Wang, Zhifeng Xie, Ying Zhang
  • SUBSTITUTED SPIROCYCLIC INHIBITORS OF AUTOTAXIN
    Publication number: 20180282332
    Abstract: The present invention relates to compounds according to Formula I and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.
    Type: Application
    Filed: February 14, 2018
    Publication date: October 4, 2018
    Inventors: Lee BABISS, Matthew CLARK, Anthony D. KEEFE, Mark J. MULVIHILL, Haihong NI, Louis RENZETTI, Frank RUEBSAM, Ce WANG, Zhifeng XIE, Ying ZHANG
  • Substituted spirocyclic inhibitors of autotaxin
    Patent number: 10011601
    Abstract: The present invention relates to compounds according to Formula 1 and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: July 3, 2018
    Assignee: X-Rx, Inc.
    Inventors: Lee Babiss, Matthew Clark, Anthony D. Keefe, Mark J. Mulvihill, Haihong Ni, Louis Renzetti, Frank Ruebsam, Ce Wang, Zhifeng Xie, Ying Zhang
  • SUBSTITUTED SPIROCYCLIC INHIBITORS OF AUTOTAXIN
    Publication number: 20170166568
    Abstract: The present invention relates to compounds according to Formula 1 and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.
    Type: Application
    Filed: April 3, 2015
    Publication date: June 15, 2017
    Applicant: X-Rx, Inc.
    Inventors: Lee Babiss, Matthew Clark, Anthony D. Keefe, Mark J. Mulvihill, Haihong Ni, Louis Renzetti, Frank Ruebsam, Ce Wang, Zhifeng Xie, Ying Zhang
  • SUBSTITUTED N-(2-(AMINO)-2OXOETHYL)BENZAMIDE INHIBITORS OF AUTOTAXIN AND THEIR PREPARATION AND USE IN THE TREATMENT OF LPA-DEPENDENT OR LPA-MEDIATED DISEASES
    Publication number: 20170037007
    Abstract: The present invention relates to compounds according to Formula I and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.
    Type: Application
    Filed: April 21, 2015
    Publication date: February 9, 2017
    Inventors: Frank Ruebsam, Ce Wang, Haihong Ni, Mark J. Mulvihill, Lee Babiss, Louis Renzetti, Ying Zhang
  • METHOD OF INHIBITING HEPATITUS C VIRUS BY COMBINATION OF A 5,6-DIHYDRO-1H-PYRIDIN-2-ONE AND ONE OR MORE ADDITIONAL ANTIVIRAL COMPOUNDS
    Publication number: 20140066396
    Abstract: The invention is directed to a method of treating infections by hepatitis C virus by administering N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.02,7]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1?6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide and one or more additional antiviral compounds or pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: November 8, 2013
    Publication date: March 6, 2014
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Peter S. Dragovich, Peggy A. Thompson, Frank Ruebsam
  • 5,6-DIHYDRO-1H-PYRIDIN-2-ONE COMPOUNDS
    Publication number: 20140031346
    Abstract: The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of Formula I wherein X is CR3, and A is and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Application
    Filed: September 30, 2013
    Publication date: January 30, 2014
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Chinh V. Tran, Frank Ruebsam, Douglas E. Murphy, Peter Dragovich
  • 5,6-D hydro-1H-pyridin-2-one compounds
    Patent number: 8546602
    Abstract: The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of Formula I wherein X is N, and A is and compounds used to synthesize the compounds of Formula I.
    Type: Grant
    Filed: August 6, 2012
    Date of Patent: October 1, 2013
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Chinh V. Tran, Frank Ruebsam, Douglas E. Murphy, Peter Dragovich, Yuefen Zhou, Lijian Chen, David Kucera, Fritz Blatter, Martin Viertelhaus
  • 5,6-DIHYDRO-1H-PYRIDIN-2-ONE COMPOUNDS
    Publication number: 20120302744
    Abstract: The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of Formula I wherein X is N, and A is and compounds used to synthesize the compounds of Formula I.
    Type: Application
    Filed: August 6, 2012
    Publication date: November 29, 2012
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Chinh V. Tran, Frank Ruebsam, Douglas E. Murphy, Peter Dragovich, Yuefen Zhou, Lijian Chen, David Kucera, Fritz Blatter, Martin Viertelhaus
  • 5,6-dihydro-1H-pyridin-2-one compounds
    Patent number: 8236948
    Abstract: The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of Formula I wherein X is N, and A is and compounds used to synthesize the compounds of Formula I.
    Type: Grant
    Filed: January 23, 2012
    Date of Patent: August 7, 2012
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Chinh V. Tran, Frank Ruebsam, Douglas E. Murphy, Peter Dragovich
  • 5,6-DIHYDRO-1H-PYRIDIN-2-ONE COMPOUNDS
    Publication number: 20120130068
    Abstract: The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of Formula I wherein X is N, and A is and compounds used to synthesize the compounds of Formula I.
    Type: Application
    Filed: January 23, 2012
    Publication date: May 24, 2012
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Chinh V. Tran, Frank Ruebsam, Douglas E. Murphy, Peter Dragovich
  • [1,2,4]THIADIAZIN-3-YL ACETIC ACID COMPOUND[[S]] AND METHODS OF MAKING THE ACETIC ACID COMPOUND
    Publication number: 20120116077
    Abstract: The invention is directed to [1,2,4]thiadiazine 1,1-dioxide compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Application
    Filed: January 13, 2012
    Publication date: May 10, 2012
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Frank Ruebsam, Peter Dragovich, Stephen E. Webber, Douglas E. Murphy, Chinh V. Tran
  • 5,6-dihydro-1H-pyridin-2-one compounds
    Patent number: 8129368
    Abstract: The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of formula: wherein R is C1-C6 alkyl or (Aryl)CH2-,and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: March 6, 2012
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Frank Ruebsam, Chinh V Tran, Douglas E. Murphy, Peggy A. Thompson, Peter Dragovich, Stephen E. Webber
  • 5,6-dihydro-1-pyridin-2-one compounds
    Patent number: 8101800
    Abstract: The invention is directed to a 5,6-dihydro-1H-pyridin-2-one compound selected from:
    Type: Grant
    Filed: March 8, 2011
    Date of Patent: January 24, 2012
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Chinh V. Tran, Frank Ruebsam, Douglas E. Murphy, Peter Dragovich, Yuefen Zhou, Lijian Chen, David Kucera, Fritz Blatter, Martin Viertelhaus
  • [1,2,4]thiadiazine 1,1-dioxide compounds
    Patent number: 8097613
    Abstract: The invention is directed to [1,2,4]thiadiazine 1,1-dioxide compounds of formula I wherein A is B is and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Grant
    Filed: June 9, 2009
    Date of Patent: January 17, 2012
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Frank Ruebsam, Peter Dragovich, Stephen E. Webber, Douglas Eric Murphy, Chinh Viet Tran
  • METHOD OF INHIBITING HEPATITUS C VIRUS BY COMBINATION OF A 5,6-DIHYDRO-1H-PYRIDIN-2-ONE AND ONE OR MORE ADDITIONAL ANTIVIRAL COMPOUNDS
    Publication number: 20110229438
    Abstract: The invention is directed to a method of treating infections by hepatitis C virus by administering N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.02,7]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1?6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide and one or more additional antiviral compounds or pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: October 9, 2009
    Publication date: September 22, 2011
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Peter Dragovich, Peggy A. Thompson, Frank Ruebsam
  • 5,6-DIHYDRO-1H-PYRIDIN-2-ONE COMPOUNDS
    Publication number: 20110166344
    Abstract: The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of Formula I wherein X is N, and A is and compounds used to synthesize the compounds of Formula I.
    Type: Application
    Filed: March 8, 2011
    Publication date: July 7, 2011
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Chinh V. Tran, Frank Ruebsam, Douglas E. Murphy, Peter Dragovich, Yuefen Zhou, Lijian Chen, David Kucera, Fritz Blatter, Martin Viertelhaus
  • 5,6-dihydro-1H-pyridin-2-one compounds
    Patent number: 7939524
    Abstract: The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of Formula I wherein X is N, and A is and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Grant
    Filed: April 2, 2008
    Date of Patent: May 10, 2011
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Chinh V. Tran, Frank Ruebsam, Douglas E. Murphy, Peter Dragovich, Yuefen Zhou, Lijian Chen, David Kucera
  • Pyrazole glucokinase activators
    Patent number: 7935699
    Abstract: Disclosed herein are pyrazole glucokinase activators of the formula (I) useful for the treatment of metabolic diseases and disorders, preferably diabetes mellitus.
    Type: Grant
    Filed: July 19, 2007
    Date of Patent: May 3, 2011
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Steven Joseph Berthel, Robert Francis Kester, Douglas Eric Murphy, Thomas Jay Prins, Frank Ruebsam, Ramakanth Sarabu, Chinh Viet Tran, Dionisios Vourloumis