Patents by Inventor Frank Ruebsam

Frank Ruebsam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oxime glucokinase activators
    Patent number: 7902248
    Abstract: Disclosed herein are pyrazole glucokinase activators of the formula (I): that are useful for the treatment of metabolic diseases and disorders.
    Type: Grant
    Filed: December 6, 2007
    Date of Patent: March 8, 2011
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Steven Joseph Berthel, Robert Francis Kester, Douglas Eric Murphy, Thomas Jay Prins, Frank Ruebsam, Chinh Viet Tran, Dionisios Vourloumis
  • Pyrro[1,2-]pyridazinone intermediates
    Patent number: 7842838
    Abstract: The invention is directed to pyrro[1,2-b]pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Grant
    Filed: August 21, 2009
    Date of Patent: November 30, 2010
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Stephen E. Webber, Frank Ruebsam, Martin Tran, Peter Dragovich, Liansheng Li, Douglas Eric Murphy, David Kucera, Zhongxiang Sun, Chinh Viet Tran
  • 4-hydroxy-5,6-dihydro-1-pyridin-2-one compounds
    Patent number: 7834009
    Abstract: The invention is directed to 4-hydroxy-5,6-dihydro-1H-pyridin-2-one compounds of Formula I and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus: wherein R6 is X is N, Ring A is a 5- or 6-membered aryl, optionally substituted by 1-3 R8 moieties, n is 2, and R1-R6 and R8 are defined herein.
    Type: Grant
    Filed: August 27, 2007
    Date of Patent: November 16, 2010
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: David Ellis, Liansheng Li, Chinh V. Tran, Frank Ruebsam, Yuefen Zhou
  • 5,6-DIHYDRO-1H-PYRIDIN-2-ONE COMPOUNDS
    Publication number: 20100119481
    Abstract: The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Application
    Filed: October 9, 2009
    Publication date: May 13, 2010
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Frank Ruebsam, Chinh V. Tran, Douglas E. Murphy, Peggy A. Thompson, Peter Dragovich, Stephen E. Webber
  • 5,6-DIHYDRO-1H-PYRIDIN-2-ONE COMPOUNDS
    Publication number: 20100034773
    Abstract: The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Application
    Filed: April 2, 2008
    Publication date: February 11, 2010
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Chinh V. Tran, Frank Ruebsam, Douglas E. Murphy, Peter Dragovich, Yuefen Zhou, Lijian Chen, David Kucera, Fritz Blatter, Martin Viertelhaus
  • PYRRO[1,2-b]PYRIDAZINONE COMPOUNDS
    Publication number: 20090312570
    Abstract: The invention is directed to pyrro[1,2-b]pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Application
    Filed: August 21, 2009
    Publication date: December 17, 2009
    Applicant: Anadys Pharmaceuticals, Inc
    Inventors: Stephen E. Webber, Frank Ruebsam, Martin Tran, Peter Dragovich, Liansheng Li, Douglas E. Murphy, David Kucera, Zhongxiang Sun, Chinh V. Tran
  • [1,2,4]THIADIAZINE 1,1-DIOXIDE COMPOUNDS
    Publication number: 20090306057
    Abstract: The invention is directed to [1,2,4]thiadiazine 1,1-dioxide compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Application
    Filed: June 9, 2009
    Publication date: December 10, 2009
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Frank Ruebsam, Peter Dragovich, Stephen E. Webber, Douglas E. Murphy, Chinh V. Tran
  • 5,6-dihydro-1-pyridin-2-one compounds
    Patent number: 7582626
    Abstract: The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of Formula I and pharmaceutical compositions containing such compounds that are useful in treating hepatitis C virus infections: wherein Z is X is N or CR9; Y is —(CR4R5)n—; n is 2, 3, 4, or 5; and R1 through R9 are defined herein.
    Type: Grant
    Filed: December 12, 2007
    Date of Patent: September 1, 2009
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Chinh V. Tran, Frank Ruebsam, Yuefen Zhou, Peter Dragovich, Alan X. Xiang
  • Pyrro[1,2-]pyridazinone compounds
    Patent number: 7582754
    Abstract: The invention is directed to pyrro[1,2-b]pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Grant
    Filed: November 6, 2008
    Date of Patent: September 1, 2009
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Stephen E. Webber, Frank Ruebsam, Martin Tran, Peter Dragovich, Liansheng Li, Douglas Eric Murphy, David Kucera, Zhongxiang Sun, Chinh Viet Tran
  • 5,6-DIHYDRO-1H-PYRIDIN-2-ONE COMPOUNDS
    Publication number: 20090111798
    Abstract: The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Application
    Filed: December 12, 2007
    Publication date: April 30, 2009
    Inventors: Chinh V. Tran, Frank Ruebsam, Yuefen Zhou, Peter Dragovich, Alan X. Xiang
  • PYRRO[1,2-b]PYRIDAZINONE COMPOUNDS
    Publication number: 20090105473
    Abstract: The invention is directed to pyrro[1,2-b]pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Application
    Filed: November 6, 2008
    Publication date: April 23, 2009
    Applicant: ANADYS PHARMACEUTICALS, INC.
    Inventors: Stephen E. Webber, Frank Ruebsam, Martin Tran, Peter Dragovich, Liansheng Li, Douglas E. Murphy, David Kucera, Zhongxiang Sun, Chinh V. Tran
  • 4-Hydroxy-5,6-dihydro-1H-pyridin-2-one compounds
    Publication number: 20090062263
    Abstract: The invention is directed to 4-hydroxy-5,6-dihydro-1H-pyridin-2-one compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Application
    Filed: August 27, 2007
    Publication date: March 5, 2009
    Inventors: David Ellis, Liansheng Li, Chinh V. Tran, Frank Ruebsam, Yuefen Zhou
  • Pyrro[1,2-b]pyridazinone compounds
    Patent number: 7462611
    Abstract: The invention is directed to pyrro[1,2-b]pyridazinone compounds of Formula I and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus: wherein R4 is selected from Ring A is 5 or 6- membered aryl or heterocyclyl, and the remaining substituents are defined herein.
    Type: Grant
    Filed: June 21, 2007
    Date of Patent: December 9, 2008
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Frank Ruebsam, Martin Tran, Stephen E. Webber, Peter Dragovich, Liansheng Li, Douglas Murphy, David Kucera, Zhongxiang Sun, Chinh Viet Tran
  • Pyridazinone compounds
    Publication number: 20080275032
    Abstract: The invention is directed to pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Application
    Filed: September 11, 2007
    Publication date: November 6, 2008
    Inventors: Yuefen Zhou, Liansheng Li, Stephen E. Webber, Peter Dragovich, Douglas E. Murphy, Chinh V. Tran, Jingjing Zhao, Frank Ruebsam
  • 5,5-DISUBSTITUTED-INDOLIZINONE COMPOUNDS
    Publication number: 20080227774
    Abstract: The invention is directed to 5,5-disubstituted-indolizinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Application
    Filed: March 14, 2008
    Publication date: September 18, 2008
    Inventors: Frank Ruebsam, Peter Dragovich
  • SATURATED FUSED [1,2-b]PYRIDAZINONE COMPOUNDS
    Publication number: 20080214529
    Abstract: The invention is directed to saturated fused [1,2-b]pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Application
    Filed: December 12, 2007
    Publication date: September 4, 2008
    Inventors: Frank Ruebsam, Zhongxiang Sun, Benjamin Ayida, Yuefen Zhou, Alan X. Xiang
  • Oxime glucokinase activators
    Publication number: 20080146625
    Abstract: Disclosed herein are pyrazole glucokinase activators of the formula (I): that are useful for the treatment of metabolic diseases and disorders.
    Type: Application
    Filed: December 6, 2007
    Publication date: June 19, 2008
    Inventors: Steven Joseph Berthel, Robert Francis Kester, Douglas Eric Murphy, Thomas Jay Prins, Frank Ruebsam, Chinh Viet Tran, Dionisios Vourloumis
  • PYRRO[1,2-b]PYRIDAZINONE COMPOUNDS
    Publication number: 20080031852
    Abstract: The invention is directed to pyrro[1,2-b]pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
    Type: Application
    Filed: June 21, 2007
    Publication date: February 7, 2008
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Stephen Webber, Frank Ruebsam, Martin Tran, Peter Dragovich, Liansheng Li, Douglas Murphy, David Kucera, Zhongxiang Sun, Chinh Tran
  • Pyrazole glucokinase activators
    Publication number: 20080021032
    Abstract: Disclosed herein are pyrazole glucokinase activators of the formula (I) useful for the treatment of metabolic diseases and disorders, preferably diabetes mellitus.
    Type: Application
    Filed: July 19, 2007
    Publication date: January 24, 2008
    Inventors: Steven Joseph Berthel, Robert Francis Kester, Douglas Eric Murphy, Thomas Jay Prins, Frank Ruebsam, Ramakanth Sarabu, Chinh Viet Tran, Dionisios Vourloumis