Patents by Inventor Frank W. Moser

Frank W. Moser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted berbines and processes for their synthesis
    Patent number: 9856251
    Abstract: The present invention provides processes for the synthesis of substituted berbine compounds. Also provided are intermediates used in the synthesis of substituted berbine compounds.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: January 2, 2018
    Assignee: Mallinckrodt LLC
    Inventors: Peter X. Wang, Frank W. Moser, Gary L. Cantrell, Christopher W. Grote
  • SUBSTITUTED BERBINES AND PROCESSES FOR THEIR SYNTHESIS
    Publication number: 20160347747
    Abstract: The present invention provides processes for the synthesis of substituted berbine compounds. Also provided are intermediates used in the synthesis of substituted berbine compounds.
    Type: Application
    Filed: August 12, 2016
    Publication date: December 1, 2016
    Inventors: Peter X. Wang, Frank W. Moser, Gary L. Cantrell, Christopher W. Grote
  • Substituted berbines and processes for their synthesis
    Patent number: 9458109
    Abstract: The present invention provides processes for the synthesis of substituted berbine compounds. Also provided are intermediates used in the synthesis of substituted berbine compounds.
    Type: Grant
    Filed: September 2, 2009
    Date of Patent: October 4, 2016
    Assignee: Mallinckrodt LLC
    Inventors: Peter X. Wang, Frank W. Moser, Gary L. Cantrell, Christopher W. Grote
  • One-pot preparation of hexahydroisoquinolines from amides
    Patent number: 8921561
    Abstract: The present invention provides an efficient process for the preparation of hexahydroisoquinolines from amides. In particular, the invention provides a good yielding, one-pot process for the synthesis of hexahydroisoquinolines.
    Type: Grant
    Filed: January 25, 2013
    Date of Patent: December 30, 2014
    Assignee: Mallinckrodt LLC
    Inventors: Christopher W. Grote, Frank W. Moser, Peter X. Wang, Gary L. Cantrell, David W. Berberich
  • 3-oxy-hydromorphone derivatives
    Patent number: 8623888
    Abstract: The present invention provides 3-oxy-hydromorphone derivatives, and in particular, 3-ester, 3-carbonate, and 3-sulfonate derivatives of hydromorphone.
    Type: Grant
    Filed: July 9, 2010
    Date of Patent: January 7, 2014
    Assignee: Mallinckrodt LLC
    Inventors: Gary L. Cantrell, Robert E. Halvachs, Frank W. Moser, David W. Berberich, Peter X. Wang
  • Process for the preparation of 6-alpha-hydroxy-N-alkylated opiates
    Patent number: 8524904
    Abstract: The present invention is directed to the preparation of 6-hydroxy morphinans having formula (II) or N-alkylated 6-hydroxy morphinans having formula (III).
    Type: Grant
    Filed: December 3, 2009
    Date of Patent: September 3, 2013
    Assignee: Mallinckrodt LLC
    Inventors: Christopher W. Grote, Peter X. Wang, Tao Jiang, Gary L. Cantrell, Frank W. Moser, Catherine E. Thomasson
  • Preparation of 6-alpha-amino N-substituted morphinans by catalytic hydrogen transfer
    Patent number: 8519133
    Abstract: The present invention provides processes for the stereoselective synthesis of 6-alpha-amino N-substituted morphinans. In particular, the invention provides processes for the reductive amination of 6-keto N-substituted morphinans by catalytic hydrogen transfer.
    Type: Grant
    Filed: June 10, 2010
    Date of Patent: August 27, 2013
    Assignee: Mallinckrodt LLC
    Inventors: Christopher W. Grote, Gary L. Cantrell, Joseph P. McClurg, Catherine E. Thomasson, Frank W. Moser
  • Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer
    Patent number: 8471023
    Abstract: The present invention provides processes for the stereoselective synthesis of 6-alpha-amino morphinans. In particular, the invention provides processes for the reductive amination of 6-keto normorphinans by catalytic transfer hydrogenation.
    Type: Grant
    Filed: June 10, 2010
    Date of Patent: June 25, 2013
    Assignee: Mallinckrodt LLC
    Inventors: Christopher W. Grote, Gary L. Cantrell, Joseph P. McClurg, Catherine E. Thomasson, Frank W. Moser
  • Preparation of amides from an acid and amine for intermediates in the synthesis of morphinans
    Patent number: 8461384
    Abstract: The present invention is directed to processes for the synthesis of morphinans. In particular, a process for coupling a carboxylic acid compound with an amine compound to form an amide product that can then be isolated or the crude amide product can be cyclized to form a 3,4-dihydroisoquinoline. In one embodiment, the carboxylic acid contains a phenol moiety protected with a labile protecting group. The protected phenol reduces reaction times, simplifies work-up of the product, and reduces the amount of cyclizing agent, POCl3 that is necessary to form the 3,4-dihydroisoquinoline.
    Type: Grant
    Filed: June 10, 2009
    Date of Patent: June 11, 2013
    Assignee: Mallinckrodt LLC
    Inventors: Peter X. Wang, Frank W. Moser, Christopher W. Grote, Gary L. Cantrell
  • One-Pot Preparation of Hexahydroisoquinolines from Amides
    Publication number: 20130137874
    Abstract: The present invention provides an efficient process for the preparation of hexahydroisoquinolines from amides. In particular, the invention provides a good yielding, one-pot process for the synthesis of hexahydroisoquinolines.
    Type: Application
    Filed: January 25, 2013
    Publication date: May 30, 2013
    Applicant: Mallinckrodt LLC
    Inventors: Christopher W. Grote, Frank W. Moser, Peter X. Wang, Gary L. Cantrell, David W. Berberich
  • Preparation of 3,4-dihydroisoquinolines from an acid and an amine
    Patent number: 8445682
    Abstract: The present invention is directed to processes for the synthesis of morphinans. In particular, a process for coupling a carboxylic acid compound with an amine compound to form an amide product that can then be isolated or the crude amide product can be cyclized to form a 3,4-dihydroisoquinoline. In one embodiment, the carboxylic acid contains a phenol moiety protected with a labile protecting group. The protected phenol reduces reaction times, simplifies work-up of the product, and reduces the amount of cyclizing agent, POCl3 that is necessary to form the 3,4-dihydroisoquinoline.
    Type: Grant
    Filed: December 10, 2007
    Date of Patent: May 21, 2013
    Assignee: Mallinckrodt LLC
    Inventors: Christopher W. Grote, Peter X. Wang, Frank W. Moser, Gary L. Cantrell
  • One-pot preparation of hexahydroisoquinolines from amides
    Patent number: 8431705
    Abstract: The present invention provides an efficient process for the preparation of hexahydroisoquinolines from amides. In particular, the invention provides a good yielding, one-pot process for the synthesis of hexahydroisoquinolines.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: April 30, 2013
    Assignee: Mallinckrodt LLC
    Inventors: Christopher W. Grote, Frank W. Moser, Peter X. Wang, Gary L. Cantrell, David W. Berberich
  • One-pot preparation of hexahydroisoquinolines from dihydroisoquinolines
    Patent number: 8415474
    Abstract: The present invention provides an efficient process for the preparation of hexahydroisoquinolines from dihydroisoquinolines. In particular, the invention provides a good yielding, one-pot process for the synthesis of hexahydroisoquinolines.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: April 9, 2013
    Assignee: Mallinckrodt LLC
    Inventors: Christopher W. Grote, Frank W. Moser, Peter X. Wang, Gary L. Cantrell, David W. Berberich
  • Process for the preparation of 6-alpha-hydroxy-N-alkylated opiates
    Patent number: 8273888
    Abstract: The present invention is directed to the preparation of 6-keto morphinans.
    Type: Grant
    Filed: December 3, 2009
    Date of Patent: September 25, 2012
    Assignee: Mallinckrodt LLC
    Inventors: Christopher W. Grote, Peter X. Wang, Tao Jiang, Gary L. Cantrell, Frank W. Moser, Catherine E. Thomasson
  • Process and compounds for the production of (+)opiates
    Patent number: 8252808
    Abstract: The invention generally provides processes and intermediate compounds useful for the production of (+)-opiates. Non-limiting examples of (+) opiates that may be derived from one or more compounds of the invention include (+)-noroxymorphone, (+)-naltrexone, (+)-naloxone, (+)-N-cyclopropylmethylnorhydrocodone, (+)-N-cycloproylmethylnorhydromorphone, (+)-N-allylnorhydrocodone, (+)-N-allylnorhydromorphone, (+)-noroxycodone, (+)-naltrexol, (+)-naloxol, and (+)-3-O-methyl-naltrexone.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: August 28, 2012
    Assignee: Mallinckrodt LLC
    Inventors: Peter X. Wang, Tao Jiang, Gary L. Cantrell, David W. Berberich, Bobby N. Trawick, Todd Osiek, Subo Liao, Frank W. Moser, Joseph P. McClurg
  • Preparation of tetrahydroisoquinolines from dihydroisoquinolines
    Patent number: 8242277
    Abstract: The present invention is directed to processes for the synthesis of morphinans. In particular, a process for the asymmetric reduction of an imine moiety in a 3,4-dihydroisoquinoline to produce a tetrahydroisoquinoline, followed by a Birch reduction to produce a hexahydroisoquinoline. In various embodiments, the 3,4-dihydroisoquinoline contains a phenol moiety protected with a labile protecting group. In other embodiments, the imine reduction reaction mixture contains silver tetrafluoroborate.
    Type: Grant
    Filed: December 10, 2007
    Date of Patent: August 14, 2012
    Assignee: Mallinckrodt LLC
    Inventors: Gary L. Cantrell, Dan P. Magparangalan, Frank W. Moser, Jian Bao, Christopher W. Grote, Peter X. Wang
  • Preparation of 3,4-dihydroisoquinolines in the synthesis of morphinans
    Patent number: 8232400
    Abstract: The present invention is directed to processes for the synthesis of morphinans. In particular, a process for coupling a carboxylic acid compound with an amine compound to form an amide product that can then be isolated or the crude amide product can be cyclized to form a 3,4-dihydroisoquinoline. In one embodiment, the carboxylic acid contains a phenol moiety protected with a labile protecting group. The protected phenol reduces reaction times, simplifies work-up of the product, and reduces the amount of cyclizing agent, POCl3 that is necessary to form the 3,4-dihydroisoquinoline.
    Type: Grant
    Filed: June 10, 2009
    Date of Patent: July 31, 2012
    Assignee: Mallinckrodt LLC
    Inventors: Peter X. Wang, Frank W. Moser, Christopher W. Grote, Gary L. Cantrell
  • Process for the preparation of hexahydroisoquinolines from 1,2,3,4-tetrahydroisoquinolines
    Patent number: 8227611
    Abstract: The present invention is directed to processes for the synthesis of morphinans. In particular, a process for the asymmetric reduction of an imine moiety in a 3,4-dihydroisoquinoline to produce a tetrahydroisoquinoline, followed by a Birch reduction to produce a hexahydroisoquinoline. In various embodiments, the 3,4-dihydroisoquinoline contains a phenol moiety protected with a labile protecting group. In other embodiments, the imine reduction reaction mixture contains silver tetrafluoroborate.
    Type: Grant
    Filed: June 10, 2009
    Date of Patent: July 24, 2012
    Assignee: Mallinckrodt LLC
    Inventors: Gary L. Cantrell, Dan P. Magparangalan, Frank W. Moser, Jian Bao, Christopher W. Grote, Peter X. Wang
  • Berberine compounds and processes for the preparation of berberine compounds
    Patent number: 8163912
    Abstract: The invention is directed to berberine compounds and processes for the preparation of berberine compounds through an intramolecular Bischler-Napieralski cyclization.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: April 24, 2012
    Assignee: Mallinckrodt LLC
    Inventors: Christopher W. Grote, Frank W. Moser, John E. Johnson
  • Processes and compounds for the preparation of normorphinans
    Patent number: 8148528
    Abstract: The invention generally provides processes and intermediate compounds useful for the production of normorphinans and derivatives of normorphinans.
    Type: Grant
    Filed: May 21, 2009
    Date of Patent: April 3, 2012
    Assignee: Mallinckrodt LLC
    Inventors: Peter X. Wang, Frank W. Moser, Gary L. Cantrell, Tao Jiang, Robert E. Halvachs, Christopher W. Grote