Patents by Inventor Frank W. Moser

Frank W. Moser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of substituted morphinan-6-ones and salts and intermediates thereof
    Patent number: 8115002
    Abstract: The present invention is directed to processes for the synthesis of morphinan-6-ones and salts, intermediates, and analogs thereof.
    Type: Grant
    Filed: September 6, 2007
    Date of Patent: February 14, 2012
    Assignee: Mallinckrodt LLC
    Inventors: Peter X. Wang, Frank W. Moser, Gary L. Cantrell, Christopher W. Grote
  • Synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs
    Patent number: 8067597
    Abstract: Novel methods of synthesis of known and novel 14-hydroxyl opiates through 1-halothebaine and derivatives are described.
    Type: Grant
    Filed: May 22, 2006
    Date of Patent: November 29, 2011
    Assignee: Mallinckrodt LLC
    Inventors: Peter X. Wang, Frank W. Moser, Gary L. Cantrell, Daniel P. Magparangalan, Jian Bao
  • Process for the preparation of 3-hydroxymorphinan derivatives
    Patent number: 7999105
    Abstract: Processes are described for the synthesis of 3-hydroxymorphinan derivatives by hydrolysis of side products from the O-demethylation of 3-methoxymorphinan derivatives.
    Type: Grant
    Filed: February 18, 2009
    Date of Patent: August 16, 2011
    Assignee: Mallinckrodt Inc.
    Inventors: Peter X. Wang, Tao Jiang, Gary L. Cantrell, David W. Berberich, Frank W. Moser, Jian Bao
  • Process for the preparation of 6-alpha-hydroxy-N-alkylated opiates
    Patent number: 7985858
    Abstract: The present invention is directed to the conversion of a 6-keto morphinan to a 6-alpha-hydroxy morphinan in the presence of a ruthenium, rhodium, or iridium asymmetric catalyst and a hydrogen source.
    Type: Grant
    Filed: May 2, 2008
    Date of Patent: July 26, 2011
    Assignee: Mallinckrodt Inc.
    Inventors: Christopher W. Grote, Peter X. Wang, Tao Jiang, Gary L. Cantrell, Frank W. Moser, Catherine E. Thomasson
  • One-Pot Preparation of Hexahydroisoquinolines from Amides
    Publication number: 20110071299
    Abstract: The present invention provides an efficient process for the preparation of hexahydroisoquinolines from amides. In particular, the invention provides a good yielding, one-pot process for the synthesis of hexahydroisoquinolines.
    Type: Application
    Filed: September 24, 2010
    Publication date: March 24, 2011
    Applicant: Mallinckrodt Inc.
    Inventors: Christopher W. Grote, Frank W. Moser, Peter X. Wang, Gary L. Cantrell, David W. Berberich
  • One-Pot Preparation of Hexahydroisoquinolines from Dihydroisoquinolines
    Publication number: 20110071300
    Abstract: The present invention provides an efficient process for the preparation of hexahydroisoquinolines from dihydroisoquinolines. In particular, the invention provides a good yielding, one-pot process for the synthesis of hexahydroisoquinolines.
    Type: Application
    Filed: September 24, 2010
    Publication date: March 24, 2011
    Applicant: Mallinckrodt Inc.
    Inventors: Christopher W. Grote, Frank W. Moser, Peter X. Wang, Gary L. Cantrell, David W. Berberich
  • 3-Oxy-Hydromorphone Derivatives
    Publication number: 20110015398
    Abstract: The present invention provides 3-oxy-hydromorphone derivatives, and in particular, 3-ester, 3-carbonate, and 3-sulfonate derivatives of hydromorphone.
    Type: Application
    Filed: July 9, 2010
    Publication date: January 20, 2011
    Applicant: Mallinckrodt Inc.
    Inventors: Gary L. Cantrell, Robert E. Halvachs, Frank W. Moser, David W. Berberich, Peter X. Wang
  • Remove Amination of 6-Keto Normorphinans by Catalytic Hydrogen Transfer
    Publication number: 20100317861
    Abstract: The present invention provides processes for the stereoselective synthesis of 6-alpha-amino morphinans. In particular, the invention provides processes for the reductive amination of 6-keto normorphinans by catalytic transfer hydrogenation.
    Type: Application
    Filed: June 10, 2010
    Publication date: December 16, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Christopher W. Grote, Gary L. Cantrell, Joseph P. McClurg, Catherine E. Thomasson, Frank W. Moser
  • Preparation of 6-Alpha-Amino N-Substituted Morphinans by Catalytic Hydrogen Transfer
    Publication number: 20100317683
    Abstract: The present invention provides processes for the stereoselective synthesis of 6-alpha-amino N-substituted morphinans. In particular, the invention provides processes for the reductive amination of 6-keto N-substituted morphinans by catalytic hydrogen transfer.
    Type: Application
    Filed: June 10, 2010
    Publication date: December 16, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Christopher W. Grote, Gary L. Cantrell, Joseph P. McClurg, Catherine E. Thomasson, Frank W. Moser
  • Processes for preparing morphinans and intermediates thereof
    Patent number: 7838677
    Abstract: The present invention is directed to processes for the synthesis of morphinans. In particular, a process for cyclizing a ?,?-bicyclic ketone compound to form a nordihydrothebainone product using the Grewe cyclization reaction is improved by forming a reaction mixture comprising a ?,?-bicyclic ketone compound, a cyclizing acid and a water scavenging cyclization additive. In one embodiment, the Grewe transformation occurs in the presence of an acid anhydride as the cyclization additive. Further, the present invention is directed to processes for converting ?,?-bicyclic ketone compounds (e.g., by-products of the Grewe cyclization reaction) to ?,?-bicyclic ketone compounds, wherein the ?,?-bicyclic ketone compounds may be recovered to further undergo Grewe cyclization and form the nordihydrothebainone product.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: November 23, 2010
    Assignee: Mallinckrodt Inc
    Inventors: Peter Xianqi Wang, Frank W. Moser, Gary L. Cantrell, Jian Bao
  • Opiate intermediates and methods of synthesis
    Patent number: 7834184
    Abstract: Novel opiate intermediate compositions and methods of synthesis that include changing the substitution pattern on the aromatic ring of the pre-Grewe intermediate are provided. The intermediates are morphinane derivatives of formula (10), wherein X is a F or Cl and R is selected from the group consisting of an H, alkyl, aryl, acyl, formyl, COR?, CONHR?, COOR, Bn(benzyl), alkyl(methyl), and sulfonamide SO2CH2COPh.
    Type: Grant
    Filed: October 21, 2005
    Date of Patent: November 16, 2010
    Assignee: Mallinckrodt Inc.
    Inventors: Peter Xianqi Wang, Frank W. Moser, Gary L. Cantrell, Daniel P. Magparangalan
  • Process for the Preparation of 6-Alpha-Hydroxy-N-Alkylated Opiates
    Publication number: 20100113788
    Abstract: The present invention is directed to the preparation of 6-keto morphinans.
    Type: Application
    Filed: December 3, 2009
    Publication date: May 6, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Christopher W. Grote, Peter X. Wang, Tao Jiang, Gary L. Cantrell, Frank W. Moser, Catherine E. Thomasson
  • Process for the Preparation of 6-Alpha-Hydroxy-N-Alkylated Opiates
    Publication number: 20100081818
    Abstract: The present invention is directed to the preparation of 6-hydroxy morphinans having formula (II) or N-alkylated 6-hydroxy morphinans having formula (III).
    Type: Application
    Filed: December 3, 2009
    Publication date: April 1, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Christopher W. Grote, Peter X. Wang, Tao Jiang, Gary L. Cantrell, Frank W. Moser, Catherine E. Thomasson
  • Berberine compounds and processes for the preparation of berberine compounds
    Publication number: 20100081821
    Abstract: The invention is directed to berberine compounds and processes for the preparation of berberine compounds through an intramolecular Bischler-Napieralski cyclization.
    Type: Application
    Filed: September 29, 2009
    Publication date: April 1, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Christopher W. Grote, Frank W. Moser, John E. Johnson, JR.
  • Preparation of 3,4-Dihydroisoquinolines from an Acid and an Amine
    Publication number: 20100063290
    Abstract: The present invention is directed to processes for the synthesis of morphinans. In particular, a process for coupling a carboxylic acid compound with an amine compound to form an amide product that can then be isolated or the crude amide product can be cyclized to form a 3,4-dihydroisoquinoline. In one embodiment, the carboxylic acid contains a phenol moiety protected with a labile protecting group. The protected phenol reduces reaction times, simplifies work-up of the product, and reduces the amount of cyclizing agent, POCl3 that is necessary to form the 3,4-dihydroisoquinoline.
    Type: Application
    Filed: December 10, 2007
    Publication date: March 11, 2010
    Inventors: Christopher W. Grote, Peter X. Wang, Frank W. Moser, Gary L. Cantrell
  • Substituted Berbines and Processes for their Synthesis
    Publication number: 20100056789
    Abstract: The present invention provides processes for the synthesis of substituted berbine compounds. Also provided are intermediates used in the synthesis of substituted berbine compounds.
    Type: Application
    Filed: September 2, 2009
    Publication date: March 4, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Peter X. Wang, Frank W. Moser, Gary L. Cantrell, Christopher W. Grote
  • Preparation of Substituted Morphinan-6-Ones and Salts and Intermediates Thereof
    Publication number: 20100048906
    Abstract: The present invention is directed to processes for the synthesis of morphinan-6-ones and salts, intermediates, and analogs thereof.
    Type: Application
    Filed: September 6, 2007
    Publication date: February 25, 2010
    Inventors: Peter X. Wang, Frank W. Moser, Gary L. Cantrell, Christopher W. Grote
  • Process for the Preparation of 6-Alpha-Hydroxy-N-Alkylated Opiates
    Publication number: 20100041888
    Abstract: The present invention is directed to the conversion of a 6-keto morphinan to a 6-alpha-hydroxy morphinan in the presence of a ruthenium, rhodium, or iridium asymmetric catalyst and a hydrogen source.
    Type: Application
    Filed: May 2, 2008
    Publication date: February 18, 2010
    Inventors: Christopher W. Grote, Peter X. Wang, Tao Jiang, Gary L. Cantrell, Frank W. Moser, Catherine E. Thomasson
  • Preparation of Hexahydroisoquinolines from Dihydroisoquinolines
    Publication number: 20100022776
    Abstract: The present invention is directed to processes for the synthesis of morphinans. In particular, a process for the asymmetric reduction of an imine moiety in a 3,4-dihydroisoquinoline to produce a tetrahydroisoquinoline, followed by a Birch reduction to produce a hexahydroisoquinoline. In various embodiments, the 3,4-dihydroisoquinoline contains a phenol moiety protected with a labile protecting group. In other embodiments, the imine reduction reaction mixture contains silver tetrafluoroborate.
    Type: Application
    Filed: December 10, 2007
    Publication date: January 28, 2010
    Inventors: Gary L. Cantrell, Dan P. Magparangalan, Frank W. Moser, Jian Bao, Christopher W. Grote, Peter X. Wang
  • Processes and Compounds for the Preparation of Normorphinans
    Publication number: 20090299069
    Abstract: The invention generally provides processes and intermediate compounds useful for the production of normorphinans and derivatives of normorphinans.
    Type: Application
    Filed: May 21, 2009
    Publication date: December 3, 2009
    Applicant: Mallinckrodt Inc.
    Inventors: Peter X. Wang, Frank W. Moser, Gary L. Cantrell, Tao Jiang, Robert E. Halvachs, Christopher W. Grote