Abstract: Provided herein are compounds of Formula (I), their pharmaceutically acceptable salts, and their pharmaceutical compositions: wherein R1, R2, R3a, R3b, R4, R5, and A are defined in the present disclosure. The compounds are potent inhibitors of the main protease (Mpro) of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), and they are useful in treating or preventing COVID-19 in a subject.

Abstract: Provided herein are compounds of Formula (I), their pharmaceutically acceptable salts, and their pharmaceutical compositions: wherein R1, R2, R3a, R3b, R4, R5, and A are defined in the present disclosure. The compounds are potent inhibitors of the main protease (Mpro) of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), and they are useful in treating or preventing COVID-19 in a subject.

Abstract: Provided herein are compounds of Formula (I), their pharmaceutically acceptable salts, and their pharmaceutical compositions: wherein R1, R2, R3a, R3b, R4, R5, and A are defined in the present disclosure. The compounds are potent inhibitors of the main protease (Mpro) of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), and they are useful in treating or preventing COVID-19 in a subject.

Abstract: Provided herein are compounds of Formula (I), their pharmaceutically acceptable salts, and their pharmaceutical compositions: wherein R1, R2, R3a, R3b, R4, R5, and A are defined in the present disclosure. The compounds are potent inhibitors of the main protease (Mpro) of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), and they are useful in treating or preventing COVID-19 in a subject.

Abstract: An improved multi-stage broadband directional coupler with at least one line junction between two successive coupling sections has a) a change in the line thickness (LD) and/or b) a change in the line width (LB) and/or c) a change in the coupling distance (KA) between the adjacent coupling sections of the two coupling lines. An electrically conductive cover connected to the coupler housing is provided adjacent to the at least one line junction.

Abstract: A high-frequency filter consists of a housing, which includes resonators, each of which has at least one dielectric. The n resonators are arranged along a central axis. The n resonators are isolated from one another by at least n?1 isolation devices. The n?1 isolation devices have coupling openings, through which a coupling is established at a right angle to or with one component predominantly at a right angle to the H field. A first signal line terminal is inserted into the first resonator chamber through a first opening in the housing and is in contact with the respective dielectric there. In addition or alternatively, a second signal line terminal is inserted into the nth resonator chamber through a second opening in the housing and is in contact with the respective dielectric there.

Abstract: An improved multi-stage broadband directional coupler with at least one line junction between two successive coupling sections has a) a change in the line thickness (LD) and/or b) a change in the line width (LB) and/or c) a change in the coupling distance (KA) between the adjacent coupling sections of the two coupling lines. An electrically conductive cover connected to the coupler housing is provided adjacent to the at least one line junction.

Abstract: A high-frequency filter consists of a housing, which includes resonators, each of which has at least one dielectric. The n resonators are arranged along a central axis. The n resonators are isolated from one another by at least n?1 isolation devices. The n?1 isolation devices have coupling openings, through which a coupling is established at a right angle to or with one component predominantly at a right angle to the H field. A first signal line terminal is inserted into the first resonator chamber through a first opening in the housing and is in contact with the respective dielectric there. In addition or alternatively, a second signal line terminal is inserted into the nth resonator chamber through a second opening in the housing and is in contact with the respective dielectric there.

Abstract: A multiplex filter has at least n filter chambers which are surrounded by a housing and/or at least one insert positioned in the housing. A metal dividing device is constructed in each of the n filter chambers, dividing each filter chamber into m resonator chambers, wherein m?2. The resonator chambers are coupled perpendicular to the H fields and/or parallel to the central axis or with a component essentially perpendicular to the H fields and/or parallel to the central axis. A common connection is guided into the first filter chamber via a first opening in the housing, and is coupled in the same to the m resonators of the m resonator chambers. As a result of the fact that the coupling is established perpendicular to the H field, the resonator can have a very compact construction.

Abstract: A method for operating an internal combustion engine is disclosed, in which method test injections are carried out in order to adapt, during the operation of the internal combustion engine, the injection parameters used for the control of the injection processes. For this purpose, during the test injections, an electric machine which is coupled to the internal combustion engine generates negative torque impulses in a manner synchronized with the positive torque impulses generated by the test injections, which negative torque impulses counteract the torque impulses generated by the test injections. In this way, rotational speed oscillations generated by the test injections are eliminated. Also described is an internal combustion engine of said type.

Abstract: A support disc for supporting high frequency (HF) components, in particular in HF coaxial cables or coaxial plug-in connections, having a support body with a longitudinal bore, additionally having at least one cross-sectional bore.

Abstract: An auditory user interactive interface to an application program being installed in the computer controlled system. A routine in an object, in an application program being installed in the computer controlled system for providing an auditory user interface to the program in combination with auditory means for offering the user of the computer controlled system the auditory user interface during installation of said application program, and responsive to the selection of the auditory interface provides the auditory user interface during said installation of the application program.

Abstract: An optical communication system for generating and transmitting a modulated optical signal in which light emitted by a light source is modulated by an optical modulator in accordance with an input electrical signal. A bias signal generator applies a bias electrical signal to bias the optical modulator at a bias angle away from quadrature. The bias signal generator monitors the input electrical signal and adjusts the applied bias electrical signal in dependence on the input electrical signal. The system further includes a receiver which may include an equalizer coupled to the photodetector of the receiver.

Abstract: An auditory user interactive interface to an application program being installed in the computer controlled system. A routine in an object, in an application program being installed in the computer controlled system for providing an auditory user interface to the program in combination with auditory means for offering the user of the computer controlled system the auditory user interface during installation of said application program, and responsive to the selection of the auditory interface provides the auditory user interface during said installation of the application program.

Abstract: A connecting device for connecting a high-frequency (HF) cable, in particular a coaxial cable, to an HF interface, in particular a coaxial plug-in connector or hollow conductor, wherein the connecting device has a sleeve, which is formed at a first axial end for plugging with a connection part of the HF interface and at a second end axially opposite the first end for connecting to the HF cable, wherein a surface of the sleeve, which faces the connection part of the HF interface in the plugged state of the sleeve and the connection part of the HF interface, is provided with at least one first groove in the axial direction, wherein at least one cylindrical pin is provided for engaging in at least one first groove.

Abstract: In a control device and a method for regulating a combustion process in an internal combustion engine, fuel is injected into the internal combustion engine for combustion, wherein exhaust gas is returned in an intake channel, wherein a combustion point of the combustion is detected, wherein the detected point of time is compared to a target value, wherein depending on the comparison result the injection is changed in order to move the combustion toward the target value, wherein part of the change of the injection is translated into an adaptation value for regulating the exhaust gas return in order to move the combustion in the direction of the target value.

Abstract: An auditory user interactive interface to an application program being installed in the computer controlled system. A routine in an object, in an application program being installed in the computer controlled system for providing an auditory user interface to the program in combination with auditory means for offering the user of the computer controlled system the auditory user interface during installation of said application program, and responsive to the selection of the auditory interface provides the auditory user interface during said installation of the application program.

Abstract: A method for operating an internal combustion engine is disclosed, in which method test injections are carried out in order to adapt, during the operation of the internal combustion engine, the injection parameters used for the control of the injection processes. For this purpose, during the test injections, an electric machine which is coupled to the internal combustion engine generates negative torque impulses in a manner synchronized with the positive torque impulses generated by the test injections, which negative torque impulses counteract the torque impulses generated by the test injections. In this way, rotational speed oscillations generated by the test injections are eliminated. Also described is an internal combustion engine of said type.

Abstract: The invention relates to a stripeline for high-frequency signals, having a signal conductor and at least one earth conductor, both being disposed on a substrate made from an electrically insulating material. According to the invention at least one hole is made in the substrate, wherein said hole is at least partially filled with an electrically conducting material, wherein an electrically conducting connection is made from at least one earth conductor to the electrically conducting material.

Abstract: A calibration adapter with coaxial connector for connecting to a complementary coaxial connector of a device to be calibrated, where the coaxial connector has an inner conductor part, an outer conductor part arranged coaxially thereto, and a male termination. The calibration adapter has a drum where at least two calibration standards are arranged, the drum is rotatably arranged on a pin connected centrally to a first cap such that a longitudinal axis of the pin is flush with a longitudinal axis of the first cap. The coaxial connector with a second termination opposite the male termination, is connected eccentrically to the longitudinal axis of the first cap, and the at least two calibration standards are arranged in the drum such that by the rotation of the drum relative to the first cap, the second termination can be optionally connected to one of the calibration standards.