Abstract: The present invention relates to methods and compositions for inducing an immune response in a subject, wherein the subject is administered an effective amount of at least one heat shock protein in combination with one or more defined target antigens. These methods and compositions may be used in the treatment of infectious diseases and cancers.

Abstract: The present invention relates to methods and compositions for inducing an immune response in a subject, wherein the subject is administered an effective amount of at least one heat shock protein in combination with one or more defined target antigens. These methods and compositions may be used in the treatment of infectious diseases and cancers.

Abstract: The present invention relates to methods and compositions for inducing an immune response in a subject, wherein the subject is administered an effective amount of at least one heat shock protein in combination with one or more defined target antigens. These methods and compositions may be used in the treatment of infectious diseases and cancers.

Abstract: The present invention relates to methods and compositions for inducing an immune response in a subject, wherein the subject is administered an effective amount of at least one heat shock protein in combination with one or more defined target antigens. These methods and compositions may be used in the treatment of infectious diseases and cancers.

Abstract: The present invention relates to methods and compositions for inducing an immune response in a subject, wherein the subject is administered an effective amount of at least one heat shock protein in combination with one or more defined target antigens. These methods and compositions may be used in the treatment of infectious diseases and cancers.

Abstract: The present invention relates to methods and compositions for inducing an immune response in a subject, wherein the subject is administered an effective amount of at least one heat shock protein in combination with one or more defined target antigens. These methods and compositions may be used in the treatment of infectious diseases and cancers.

Abstract: Methods and compositions are provided for modulating the immune response to an antigen based upon the finding that the cell surface protein CD40 is a mammalian heat shock protein (hsp) receptor. Cell surface CD40 mediates the binding, cell signaling, and uptake of hsp and particularly hsp with antigen bound thereto. Methods are provided for modulating hsp-antigen uptake and an immune response to the antigen by altering CD40 expression, as well as utilizing CD40-binding fragments of mammalian hsp and muteins thereof for targeting antigens to CD40-expressing cells. Screening methods for agonists and antagonists of the CD40-hsp interaction are also provided.

Abstract: The present invention relates to methods and compositions for inducing an immune response in a subject, wherein the subject is administered an effective amount of at least one heat shock protein in combination with one or more defined target antigens. These methods and compositions may be used in the treatment of infectious diseases and cancers.

Abstract: The present invention relates to methods and compositions for inducing an immune response in a subject, wherein the subject is administered an effective amount of a heat shock protein complexed to a hybrid antigen comprising an antigenic domain and a heat shock protein-binding domain. These methods and compositions may be used in the treatment of infectious diseases and cancers.

Abstract: The present invention relates to methods and compositions for inducing an immune response in a subject, wherein the subject is administered an effective amount of a heat shock protein complexed to a hybrid antigen comprising an antigenic domain and a heat shock protein-binding domain. These methods and compositions may be used in the treatment of infectious diseases and cancers.

Abstract: The invention relates to a method for producing large-surface markings such as patterns, images, text, company logos, signs or decorative markings. A marking head (5) that is positioned on a mobile device (1), preferably a vehicle, is moved along the surface to be marked with one or more e nozzles (6). Electronic control means (8) control the nozzles (6) of the marking head in accordance with the actual position of the mobile device (1), according to the model to be reproduced. This enables oversized markings to be produced, for example on areas of ground or other suitable surfaces, especially for advertising purposes.

Abstract: A process for the production of aromatic amines by catalylic hydrogenation.

Abstract: A refilling cartridge is provided for refilling a jet printer cartridge with ink. The refilling cartridge includes a housing for a foil pouch refilling chamber and a hollow needle projecting from the housing. A rubber elastic sealing element is provided at a free end of the needle to be selectively penetrated by the needed. The sealing element is secured by a movable retaining element that shields the hollow needed and is movable in a lengthwise direction of the hollow needle to selectively expose the free end of the hollow needle. A spring element holds the retaining element in a position where the sealing element seals the open end of the needle and releasable locking elements are provided for the retaining element.

Abstract: The mechanisms and components required for chaperonin-dependent folding of proteins has been elucidated using the groEL and groES proteins of E. coli to reconstitute enzymatic activity of two monomeric enzymes, dihydrofolate reductase (DHFR) and rhodanese following dilution from denaturant. The essential elements for properly folding any protein are Mg-ATP (provided in the preferred embodiment as 5 mM Mg acetate and 1 mM ATP), groEL or hsp60, and groES or eukaryotic equivalent. These can be provided in purified form or as a semi-purified cell extract. The groES eukaryotic equivalent, encoded by a gene which does not hybridize to the groES gene, can be isolated using the same technique as was described to isolate Hsp60: isolation of a temperature sensitive lethal yeast mutant (petite at permissive temperature) defective in folding and assembly of imported proteolytically processed human ornithine transcarbamylase (OTC).

Abstract: Denatured recombinant fusion proteins are correctly folded in the presence of a heat shock protein which acts according to the functional principle of the bacterial GroEL or of the equivalent mitochondrial component Hsp60, and of ATP. After cleaving off the foreign sequence, biologically and medically interesting proteins are obtained in the correct conformation.

Abstract: The mold continuous casting of metals includes a stationary base frame; a support plate within the base frame, the support plate including first and second opposed sides; a metallic shaping wall mounted on the support plate and having a longitudinal axis in the direction of casting; a carrier plate attached to the base frame; a plurality of spring elements each having two ends and being uniformly distributed over and fastened at one end thereof to the first side of the support plate, the other ends of the spring elements being fastened to the carrier plate, the first side of the support plate facing away from the shaping wall, the spring elements extending in a direction transverse to the direction of casting and having a stiffness which is substantially less in the direction of casting than in the two directions transverse thereto.

Abstract: A novel carrier which is stable and effective over long cycle times (6.times.10.sup.6 prints), has an iron oxide coating of the formula (FeO).sub.x.Fe.sub.2 O.sub.3 where x=0.1-1 and is obtained by treating steel cores (or balls) with defined small amounts of sulfuric acid of defined concentration, partial oxidation of the cores thus treated and drying at 60.degree.-150.degree. C. at .ltoreq.100 mbar.

Abstract: Carriers for a two-component dry developer are based on a ferrite or iron-containing core which carries a metal oxide layer consisting of reaction products deposited in the gas phase.The carriers according to the invention have abrasion-resistant metal oxide layers which permit electrostatic charging in both directions. By adjusting the thickness of the metal oxide layer, the electrical conductivity can be altered.

Abstract: Colored single-component toners essentially consist of a magnetic pigment, a binder based on an organic polymer and/or a wax, a dye or colored pigment homogeneously distributed in the binder, and other assistants, the magnetic pigment being iron powder which has a spherical or elliptical shape.

Abstract: A diesel fuel filter, which is arranged in a conduit between a fuel tank and a fuel injection pump, comprises a housing accommodating a filter element and a cover non-releasably connected to the housing. A temperature-responsive switching device for switching fuel overflow quantities from the pump to the tank as well as a ventilation device are positioned in a chamber formed by a protruding formation of the cover and a flat plate connected to the housing. A plate shaped pressure control valve, which opens into a contaminated side of the filter element, connects that side to the chamber.