Patents by Inventor Frederic Andre
Frederic Andre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11967588Abstract: Various embodiments include combined lens and safety enclosure apparatuses and methods for forming the apparatuses. In one example a combined lens and safety enclosure apparatus for a light-emitting diode (LED) module is disclosed. The enclosure apparatus includes at least one plastic-material-based optical-lens element mounted over a plurality of LED elements, where a distance between the optical-lens element and any portion of any one of the plurality of LED elements is spaced away from each other by at least 0.8 mm. A driver-on-board (DoB) subsystem, including an electronic circuit configured to provide power to the plurality of LED elements, has a plastic-material-based optical enclosure mounted over the DoB subsystem. A distance between the optical enclosure and any portion of any of the electronic circuit is spaced away from optical enclosure by at least 0.8 mm. Other devices and methods are described.Type: GrantFiled: December 15, 2020Date of Patent: April 23, 2024Assignee: Lumileds LLCInventors: Frederic Stephane Diana, Charles André Schrama
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Patent number: 11940144Abstract: A luminaire can include a curved light guide plate including a first receiving surface, an emitting surface, a major surface opposing the emitting surface, second and third receiving surfaces, the first receiving surface extending in a first dimension between the major surface and the emitting surface and extending in a second dimension between the second and third receiving surfaces, the first receiving surface, emitting surface, and major surface including a positive, non-zero radius of curvature (R) and the second and third receiving surfaces generally planar, and a plurality of LEDs positioned to emit light into one or more of the first: receiving surface, second receiving surface, third receiving surface, or a fourth receiving surface, the fourth receiving surface opposing the first receiving surface.Type: GrantFiled: May 22, 2023Date of Patent: March 26, 2024Assignee: Lumileds LLCInventors: Frederic Stephane Diana, Mehdi Aas, Charles André Schrama
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Patent number: 11718588Abstract: The present invention discloses compounds according to Formula I: Wherein R1, R2, R3a, R3b, and Cy are as defined herein. The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory conditions, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis by administering a compound of the invention.Type: GrantFiled: January 5, 2021Date of Patent: August 8, 2023Assignee: GALAPAGOS NVInventors: Franck Laurent Brebion, Luke Jonathan Alvey, David Amantini, Frédéric André De Ceuninck, Pierre Marc Marie Joseph Deprez, Romain Luc Marie Gosmini, Hélène Marie Jary, Christophe Peixoto, Iuliana Ecaterina Pop-Botez, Marie Laurence Claire Varin
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Publication number: 20220357314Abstract: The present invention is directed to a method for identifying a gene that regulates clostridial neurotoxin activity, the method comprising: a. providing a sample of human neuronal cells expressing a polypeptide that comprises a C-terminal detectable label, wherein the polypeptide is cleavable by a clostridial neurotoxin; b. altering expression of a target gene of the cells; c. contacting the cells with the clostridial neurotoxin; d. measuring an amount of C-terminal detectable label, thereby quantifying clostridial neurotoxin activity; and e. identifying the target gene as a regulator of clostridial neurotoxin activity when the quantified clostridial neurotoxin activity is different to the quantified clostridial neurotoxin activity when expression of the target gene is unaltered; or f.Type: ApplicationFiled: September 27, 2019Publication date: November 10, 2022Inventors: Keith FOSTER, Matthew BEARD, Jeremy Changyu YEO, Frederic Andre Jean BARD, Pei Ling Felicia TAY
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Publication number: 20220246381Abstract: A travelling-wave tube comprising a helix joined by posts to a vacuum chamber, each post made of electrically insulating material being covered by an electrically conductive material, of electrical conductivity comprised between 1000 and 100000 S·m?1, over a portion of the post extending from the end of the post joined to the helix to the end of the post joined to the vacuum chamber and corresponding to a height comprised between 10% and 50% of the post.Type: ApplicationFiled: January 24, 2022Publication date: August 4, 2022Inventor: Frédéric ANDRE
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Publication number: 20210309614Abstract: The present invention discloses compounds according to Formula I: Wherein R1, R2, R3a, R3b, and Cy are as defined herein. The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory conditions, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis by administering a compound of the invention.Type: ApplicationFiled: January 5, 2021Publication date: October 7, 2021Inventors: Franck Laurent BREBION, Luke Jonathan ALVEY, David AMANTINI, Frédéric André DE CEUNINCK, Pierre Marc Marie Joseph DEPREZ, Romain Luc Marie GOSMINI, Hélène Marie JARY, Christophe PEIXOTO, Iuliana Ecaterina POP-BOTEZ, Marie Laurence Claire VARIN
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Patent number: 10941117Abstract: The present invention discloses compounds according to Formula I: Wherein R1, R2, R3a, R3b, and Cy are as defined herein. The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory conditions, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis by administering a compound of the invention.Type: GrantFiled: October 15, 2019Date of Patent: March 9, 2021Assignees: GALAPAGOS NV, LES LABORATORIES SERVIERInventors: Franck Laurent Brebion, Luke Jonathan Alvey, David Amantini, Frédéric André De Ceuninck, Pierre Marc Marie Joseph Deprez, Romain Luc Marie Gosmini, Hélène Marie Jary, Christophe Peixoto, Iuliana Ecaterina Pop-Botez, Marie Laurence Claire Varin
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Patent number: 10829478Abstract: The present invention discloses compounds according to Formula I: Wherein R1, R2, R3a, R3b, R6a, R6b, the subscript n and Cy are as defined herein. The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory diseases, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis by administering the compound of the invention.Type: GrantFiled: June 1, 2017Date of Patent: November 10, 2020Assignee: GALAPAGOS NVInventors: Frédéric Gilbert Labéguère, Rama Heng, Frédéric André De Ceuninck, Luke Jonathan Alvey, David Amantini, Franck Laurent Brebion, Pierre Marc Marie Joseph Deprez, Romain Luc Marie Gosmini, Hélène Marie Jary, Christophe Peixoto, Iuliana Ecaterina Pop-Botez, Marie Laurence Claire Varin
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Publication number: 20200216397Abstract: The present invention discloses compounds according to Formula I: Wherein R1, R2, R3a, R3b, and Cy are as defined herein. The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory conditions, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis by administering a compound of the invention.Type: ApplicationFiled: October 15, 2019Publication date: July 9, 2020Inventors: Franck Laurent BREBION, Luke Jonathan ALVEY, David AMANTINI, Frédéric André DE CEUNINCK, Pierre Marc Marie Joseph DEPREZ, Romain Luc Marie GOSMINI, Hélène Marie JARY, Christophe PEIXOTO, Iuliana Ecaterina POP-BOTEZ, Marie Laurence Claire VARIN
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Patent number: 10550100Abstract: The present invention discloses compounds according to Formula I: Wherein R1, R2, R3a, R3b, R6, Cy, and the subscript n are as defined herein. The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory diseases, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis by administering the compound of the invention.Type: GrantFiled: June 1, 2017Date of Patent: February 4, 2020Assignee: GALAPAGOS NVInventors: Frédéric Gilbert Labéguère, Rama Heng, Frédéric André De Ceuninck, Luke Jonathan Alvey, David Amantini, Franck Laurent Brebion, Pierre Marc Marie Joseph Deprez, Romain Luc Marie Gosmini, Hélène Marie Jary, Christophe Peixoto, Iuliana Ecaterina Pop-Botez, Marie Laurence Claire Varin
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Patent number: 10516183Abstract: A cell stack comprising an electrochemical cell, or a plurality of axially arranged electrochemical cells, with an end plate at each end of the stack, each cell comprising an active area surrounded by a peripheral area, wherein the active area comprises the membrane electrode assembly, and the peripheral area includes one or more channels for reactants, and wherein the stack comprises means for applying pressure axially to the active area to contact the membrane and electrodes, and separate means for applying pressure axially to the peripheral area. Further, a method of performing an electrochemical reaction in a cell comprising an active area surrounded by a peripheral area, comprises applying pressure to the active area, and varying the pressure during operation of the cell, wherein the active area includes the membrane electrode assembly and is the area where the cell reaction occurs.Type: GrantFiled: June 15, 2018Date of Patent: December 24, 2019Assignee: ITM POWER (RESEARCH) LIMITEDInventor: Frederic Andre Marchal
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Patent number: 10487060Abstract: The present invention discloses compounds according to Formula I: Wherein R1, R2, R3a, R3b, and Cy are as defined herein. The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory conditions, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis by administering a compound of the invention.Type: GrantFiled: February 14, 2018Date of Patent: November 26, 2019Assignees: GALAPAGOS NV, LES LABORATOIRES SERVIERInventors: Franck Laurent Brebion, Luke Jonathan Alvey, David Amantini, Frédéric André De Ceuninck, Pierre Marc Marie Joseph Deprez, Romain Luc Marie Gosmini, Hélène Marie Jary, Christophe Peixoto, Iuliana Ecaterina Pop-Botez, Marie Laurence Claire Varin
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Publication number: 20190315719Abstract: The present invention discloses compounds according to Formula I: Wherein R1, R2, R3a, R3b, R6a, R6b, the subscript n and Cy are as defined herein. The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory diseases, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis by administering the compound of the invention.Type: ApplicationFiled: June 1, 2017Publication date: October 17, 2019Inventors: Frédéric Gilbert LABÉGUÈRE, Rama HENG, Frédéric André DE CEUNINCK, Luke Jonathan ALVEY, David AMANTINI, Franck Laurent BREBION, Pierre Marc Marie Joseph DEPREZ, Romain Luc Marie GOSMINI, Hélène Marie JARY, Christophe PEIXOTO, Iuliana Ecaterina POP-BOTEZ, Marie Laurence Claire VARIN
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Publication number: 20190300503Abstract: The present invention discloses compounds according to Formula I: Wherein R1, R2, R3a, R3b, R6, Cy, and the subscript n are as defined herein. The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory diseases, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis by administering the compound of the invention.Type: ApplicationFiled: June 1, 2017Publication date: October 3, 2019Inventors: Frédéric Gilbert LABÉGUÈRE, Rama HENG, Frédéric André DE CEUNINCK, Luke Jonathan ALVEY, David AMANTINI, Franck Laurent BREBION, Pierre Marc Marie Joseph DEPREZ, Romain Luc Marie GOSMINI, Hélène Marie JARY, Christophe PEIXOTO, Iuliana Ecaterina POP-BOTEZ, Marie Laurence Claire VARIN
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Patent number: 10364502Abstract: A composite cell plate can include a polymer element laterally mated and interlocked, at a plurality of engagement points, with a resilient metal element. The cell plate can be used in an electrochemical cell. A method of forming a cell plate can include fitting a polymer element to a resilient metal element at a plurality of engagement points, and expanding the polymer of the polymer element such that the polymer element and the resilient metal element engage and interlock at the engagement points.Type: GrantFiled: July 11, 2014Date of Patent: July 30, 2019Assignee: ITM POWER (RESEARCH) LIMITEDInventor: Frederic Andre Marchal
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Publication number: 20190194264Abstract: Described herein are polypeptides comprising a lipoprotein export signal, polypeptide precursors comprising a lipoprotein export signal, nucleic acids encoding said polypeptides or polypeptide precursors, recombinant expression vectors comprising nucleic acids encoding said lipoprotein export signal and/or polypeptides or polypeptide precursors, and 5 recombinant host cells comprising these vectors. The application further provides uses of these polypeptides, polypeptide precursors, nucleic acids, recombinant expression vectors and recombinant host cells.Type: ApplicationFiled: August 11, 2017Publication date: June 27, 2019Applicant: UNIVERSITÉ DE NAMURInventors: Frédéric André Lauber, Francesco Renzi, Guy Richard Comelis
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Publication number: 20190020050Abstract: A cell stack comprising an electrochemical cell, or a plurality of axially arranged electrochemical cells, with an end plate at each end of the stack, each cell comprising an active area surrounded by a peripheral area, wherein the active area comprises the membrane electrode assembly, and the peripheral area includes one or more channels for reactants, and wherein the stack comprises means for applying pressure axially to the active area to contact the membrane and electrodes, and separate means for applying pressure axially to the peripheral area. Further, a method of performing an electrochemical reaction in a cell comprising an active area surrounded by a peripheral area, comprises applying pressure to the active area, and varying the pressure during operation of the cell, wherein the active area includes the membrane electrode assembly and is the area where the cell reaction occurs.Type: ApplicationFiled: June 15, 2018Publication date: January 17, 2019Inventor: Frederic Andre Marchal
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Publication number: 20180258052Abstract: The present invention discloses compounds according to Formula I: Wherein R1, R2, R3a, R3b, and Cy are as defined herein. The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory conditions, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis by administering a compound of the invention.Type: ApplicationFiled: February 14, 2018Publication date: September 13, 2018Inventors: Franck Laurent BREBION, Luke Jonathan ALVEY, David AMANTINI, Frédéric André DE CEUNINCK, Pierre Marc Marie Joseph DEPREZ, Romain Luc Marie GOSMINI, Hélène Marie JARY, Christophe PEIXOTO, Iuliana Ecaterina POP-BOTEZ, Marie Laurence Claire VARIN
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Patent number: 10026987Abstract: A cell stack comprising an electrochemical cell, or a plurality of axially arranged electrochemical cells, with an end plate at each end of the stack, each cell comprising an active area surrounded by a peripheral area, wherein the active area comprises the membrane electrode assembly, and the peripheral area includes one or more channels for reactants, and wherein the stack comprises means for applying pressure axially to the active area to contact the membrane and electrodes, and separate means for applying pressure axially to the peripheral area. Further, a method of performing an electrochemical reaction in a cell comprising an active area surrounded by a peripheral area, comprises applying pressure to the active area, and varying the pressure during operation of the cell, wherein the active area includes the membrane electrode assembly and is the area where the cell reaction occurs.Type: GrantFiled: April 18, 2011Date of Patent: July 17, 2018Assignee: ITM POWER (RESEARCH) LIMITEDInventor: Frederic Andre Marchal
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Publication number: 20180194022Abstract: The invention relates to a manual cutting tool (110), comprising two arms (112) hinged about an axis (X), each arm comprising a first portion (114) to enable said tool to be grasped by a user and a second cutting portion (116), said first and second portions being separated from one another by said axis, the second portions of the arms comprising cutting edges (118) that define a cross-sectional area (A) of an element to be cut, the tool being configured such that a hinge on the arms about said axis brings the cutting edges of the arms together and cuts said element. The invention is characterized in that it further comprises a member (130) for protecting the user, which is made of a transparent material, said member extending substantially in parallel with said cross-sectional area and covering same completely, and being flexible in a plane substantially perpendicular to said cross-sectional area.Type: ApplicationFiled: June 28, 2016Publication date: July 12, 2018Inventors: Mickael Lazaro MARQUES, Frederic Andre DE BIASI