Abstract: The invention provides compounds of the formula: R1 is OR11, or NR5R5?; R2 is H or F; R5 is H, OH, C1-C6 alkyl, OH, C(?O)R6, O(C?O)R6 or O(C?O)OR6; R5? is H or C1-C6 alkyl; R6 is C1-C6 alkyl or C3-C7 cycloalkyl; R13 is H, phenyl, pyridyl, benzyl, indolyl or naphthyl wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl is optionally substituted with 1, 2 or 3 R22; and the other variables are as defined in the claims, which are of use in the treatment of cancer, and related aspects.

Abstract: A genetically modified Saccharomyces cerevisiae including an active fermentation pathway producing 3-HP expresses an exogenous gene expressing the aminotransferase YhxA from Bacillus cereus AH1272 catalysing a transamination reaction between beta-alanine and pyruvate to produce malonate semialdehyde. The yeast may also express a 3-hydroxyisobutyrate dehydrogenase (HIBADH) and a 3-hydroxypropanoate dehydrogenase (3-HPDH) and aspartate 1-decarboxylase. Additionally the yeast may express pyruvate carboxylase and aspartate aminotransferase.

Abstract: A system for monitoring and documenting the installation of at least one rock reinforcement bolt in a tunnel or a mine, wherein bolt installation related information is stored and related to the identity of the bolt is distinguished by means (S1, S2, S3, 4) for registering of at least one bolt installation related parameter and means for storing the corresponding installation parameter data in a related memory (M), and means (S4, 4) for registering the installation position and means for storing the corresponding installation position data in a related memory (M). The invention also concerns a method.

Abstract: A device for rock bolting with an adapter device (10) for connection of a drilling machine (3) to a self drilling rock bolt (7), in which the adapter device has an adapter element (14) which is sealingly surrounded by a swivel sleeve (13) for connection to one or more external source for flushing medium (8) and bolt grouting medium (9), and in which the adapter element has a thread for connecting to a corresponding thread on the rock bolt (7), and an integral connection portion for connection to the drilling machine (3).

Abstract: A device (5) for installing a pressure fluid expandable rock bolt (4) of the kind having a tubular expansion portion and a fitting portion, said device at a distal portion having chuck means for gripping the fitting portion and for establishing a sealed connection between a fluid source and the inlet, said device extending essentially in an axial direction. The device includes at a proximal portion a holder portion (11) that is adapted to be fitted to a drill string engagement element (27) of a rock drilling machine. The invention also concerns a method and a rig.

Abstract: A device (5) for installing a pressure fluid expandable rock bolt (4) of the kind having a tubular expansion portion and a fitting portion, said device at a distal portion having chuck means for gripping the fitting portion and for establishing a sealed connection between a fluid source and the inlet, said device extending essentially in an axial direction. The device includes at a proximal portion a holder portion (11) that is adapted to be fitted to a drill string engagement element (27) of a rock drilling machine. The invention also concerns a method and a rig.

Abstract: In a method and a device for installing, in a rock wall or roof, a self-drilling expandable rock bolt (2) having a drill bit portion (5), an expansion portion (9) and a connecting portion (10), in a rock breaking step, the self-drilling rock bolt (2) is provided with a rock breaking movement and flushing fluid for producing a bore hole, and in an expansion step, pressurized expansion fluid is introduced into the expansion portion (9) in order to expand it so as to be fixed to the inside of the bore hole. Expansion fluid is introduced by means of a swiveling device (6) so that the rock bolt (2) is free to move during the rock breaking step, and be tightened against the rock bolt (2) in the expansion step in such a way that a sealed channel for expansion fluid is established between an expansion fluid source and the expansion portion (9). The invention also concerns a self-drilling rock bolt.

Abstract: A system for monitoring and documenting the installation of at least one rock reinforcement bolt in a tunnel or a mine, wherein bolt installation related information is stored and related to the identity of the bolt is distinguished by means (S1, S2, S3, 4) for registering of at least one bolt installation related parameter and means for storing the corresponding installation parameter data in a related memory (M), and means (S4, 4) for registering the installation position and means for storing the corresponding installation position data in a related memory (M). The invention also concerns a method.

Abstract: The present invention is related to a method for manual installation of rock bolts expandable by means of a pressure media comprising manual coupling of a pressure source to a rock bolt to be expanded. The method comprises the steps of an operator starting a sequence whereby the rock bolt is pressurized to a predetermined pressure, and it being ensured that the predetermined pressure is kept for a predetermined period of time. The present invention is also related to such a control system, and an apparatus comprising such a control system.

Abstract: Method and device for rock bolting, wherein a tubular bolt (2) with closed cross-section is inserted and expanded for anchoring inside a bore hole (12), wherein the tubular bolt is expanded to contact in the inner portion of the bore hole, a tension element (3, 7, 8, 9) which is arranged in the outer portion of the bore hole with an inner part (7) attached to the tubular bolt (2) is pre-stressed and a settable medium is injected into the outer portion of the bore hole (14) between (27) the tension element and the wall of the bore hole and is allowed to set.

Abstract: A method for providing a rock bolt (2) for rock bolting, wherein a rock bolt (2) having a tubular bolt portion (4) with a closed cross section is inserted and expanded for bearing contact in a bore hole (3) in a rock structure (1). The length of the tubular bolt portion (4) is determined such that maximum frictional force at pulling inside a bore hole (3) of a rock bolt with a tubular bolt portion with this length is below a predetermined maximum value. The invention also concerns a rock bolt.

Abstract: The present invention is related to a rock bolt (7), expandable by means of a pressure media, for insertion into a borehole. The expandable bolt (7) comprises a connection unit (8) with means (11) for detachable interaction with an expansion means (10) for expansion of the rock bolt (7), as well as with a suspension element (16). The connection unit is designed with such external dimensions so that it may be inserted into the bore-hole. The invention also relates to such a rock bolting system.

Abstract: In a method and a device for installing, in a rock wall or roof, a self-drilling expandable rock bolt (2) having a drill bit portion (5), an expansion portion (9) and a connecting portion (10), in a rock breaking step, the self-drilling rock bolt (2) is provided with a rock breaking movement and flushing fluid for producing a bore hole, and in an expansion step, pressurized expansion fluid is introduced into the expansion portion (9) in order to expand it so as to be fixed to the inside of the bore hole. Expansion fluid is introduced by means of a swiveling device (6) so that the rock bolt (2) is free to move during the rock breaking step, and be tightened against the rock bolt (2) in the expansion step in such a way that a sealed channel for expansion fluid is established between an expansion fluid source and the expansion portion (9). The invention also concerns a self-drilling rock bolt.

Abstract: The present invention is related to a method for manual installation of rock bolts expandable by means of a pressure media comprising manual coupling of a pressure source to a rock bolt to be expanded. The method comprises the steps of an operator starting a sequence whereby the rock bolt is pressurized to a predetermined pressure, and it being ensured that the predetermined pressure is kept for a predetermined period of time. The present invention is also related to such a control system, and an apparatus comprising such a control system.

Abstract: The present invention is related to a rock bolt (7), expandable by means of a pressure media, for insertion into a borehole. The expandable bolt (7) comprises a connection unit (8) with means (11) for detachable interaction with an expansion means (10) for expansion of the rock bolt (7), as well as with a suspension element (16). The connection unit is designed with such external dimensions so that it may be inserted into the bore-hole. The invention also relates to such a rock bolting system.

Abstract: Device for rock bolting with an adapter device (10) for connection of a drilling machine (3) to a self drilling rock bolt (7), said adapter device including an adapter element (14) which is sealingly surrounded by a swivel sleeve (13) for connection to (one) external (source) sources for flushing medium (8) and bolt grouting medium (9), wherein the adapter element includes a thread for connecting to a corresponding thread on the rock bolt (7), and an integral connection portion for connection to the drilling machine (3). The invention also concerns a device for automatized rock bolting and a method for rock bolting.

Abstract: Method and device for rock bolting, wherein a tubular bolt (2) with closed cross-section is inserted and expanded for anchoring inside a bore hole (12), wherein the tubular bolt is expanded to contact in the inner portion of the bore hole, a tension element (3, 7, 8, 9) which is arranged in the outer portion of the bore hole with an inner part (7) attached to the tubular bolt (2) is pre-stressed and a settable medium is injected into the outer portion of the bore hole (14) between (27) the tension element and the wall of the bore hole and is allowed to set.

Abstract: Coupling sleeve for connecting a threaded rock bolt (1) to an impact rock drilling machine (2) comprising a first part (3) provided with an internal thread (4) for connection of the rock bolt (1) and a second part (5) provided with an internal thread (6) for connection of the rock drilling machine (2), whereby the second part (5) comprises a transversely to a longitudinal axis (9) on the coupling sleeve arranged locking device (7) which cooperates with a region (8) on the rock drilling machine (2) for preventing that the coupling sleeve and the rock drilling machine (2) are separated.

Abstract: A method for therapeutic or prophylactic control of Acquired Immunodeficiency Syndrome (AIDS) in which an effective dose of phosphonoformic acid or a therapeutically-acceptable salt thereof is administered to a patent.

Abstract: The present invention relates to a method of inhibiting the activity of the HIV virus in a human comprising administering to the human an effective dose of phosphonoformic acid or a therapeutically effective salt thereof.