Patents by Inventor Fuk-Wah Sum

Fuk-Wah Sum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of cytosolic phospholipase A2
    Patent number: 6797708
    Abstract: This invention provides substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes, and for the medical treatment, prevention and inhibition of pain and inflammation.
    Type: Grant
    Filed: November 22, 2002
    Date of Patent: September 28, 2004
    Assignee: Wyeth
    Inventors: John C. McKew, Steven Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
  • N-(4-sulfonylaryl)cyclylamine-2-hydroxyethylamines as beta-3 adrenergic receptor agonists
    Patent number: 6743787
    Abstract: This invention provides compounds of Formula I having the structure wherein R1, R2, R3, R4, W, X, and Y are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.
    Type: Grant
    Filed: July 25, 2002
    Date of Patent: June 1, 2004
    Assignee: Wyeth
    Inventors: Fuk-Wah Sum, Michael Sotirios Malamas
  • Process for making an aldehyde
    Publication number: 20040082785
    Abstract: A process for making an aromatic aldehyde in which a sulfoxide is reacted with a dihalogenated aromatic compound in the absence of an effective amount of an activating reagent. The aldehyde may then be used to make other compounds, such as a compound that acts as a cPLA inhibitor.
    Type: Application
    Filed: November 26, 2003
    Publication date: April 29, 2004
    Applicant: Wyeth
    Inventors: John C. McKew, Steven Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark, Wei Li
  • Bicyclic 5-alkylidene-penems as beta lactamases inhibitors
    Publication number: 20040077622
    Abstract: The present invention provides a compound of formula 1, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.
    Type: Application
    Filed: May 1, 2003
    Publication date: April 22, 2004
    Applicant: Wyeth
    Inventors: Aranapakam Mudumbai Venkatesan, Tarek Suhayl Mansour, Takao Abe, Itsuki Yamamura, Tsuyoshi Takasaki, Atul Agarwal, Osvaldo dos Santos, Fuk-Wah Sum, Yang-I Lin
  • Tricyclic 6-alkylidene-penems as beta-lactamase inhibitors
    Publication number: 20040043978
    Abstract: The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.
    Type: Application
    Filed: May 1, 2003
    Publication date: March 4, 2004
    Applicant: Wyeth
    Inventors: Aranapakam Mudumbai Venkatesan, Tarek Suhayl Mansour, Takao Abe, Ado Mihira, Atul Agarwal, Hideki Ushirogochi, Yansong Gu, Satoshi Tamai, Fuk-Wah Sum
  • Cyclylamine sulfonamides as &bgr;3-adrenergic receptor agonists
    Patent number: 6649603
    Abstract: This invention provides compounds of Formula I having the structure wherein R1, R2, R3, W, X, and Z are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.
    Type: Grant
    Filed: September 5, 2002
    Date of Patent: November 18, 2003
    Assignee: Wyeth
    Inventor: Fuk-Wah Sum
  • N-benzhydryl indole compounds
    Patent number: 6635771
    Abstract: Compounds of the formula in which R, R′, R7-R11, X, n1 and n3 are as defined herein. These compounds are useful as intermediates for preparing pharmaceutical compounds having pharmacological activity as chemical inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes.
    Type: Grant
    Filed: November 22, 2002
    Date of Patent: October 21, 2003
    Assignee: Wyeth
    Inventors: John C. McKew, Steven Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
  • Methods for treating arthritic disorders
    Publication number: 20030166649
    Abstract: This invention provides methods for treating in mammals arthritic or rheumatic disorders using substituted indole compounds of the general formula: 1
    Type: Application
    Filed: November 22, 2002
    Publication date: September 4, 2003
    Applicant: Wyeth
    Inventors: John C. McKew, Steve Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
  • N-BENZHYDRYL INDOLE COMPOUNDS
    Publication number: 20030158405
    Abstract: Compounds of the formula 1
    Type: Application
    Filed: November 22, 2002
    Publication date: August 21, 2003
    Applicant: Wyeth
    Inventors: John C. McKew, Steve Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
  • Methods for treating asthmatic conditions
    Publication number: 20030149029
    Abstract: This invention provides methods for treating in mammals asthma and asthmatic conditions using substituted indole compounds of the general formula: 1
    Type: Application
    Filed: November 22, 2002
    Publication date: August 7, 2003
    Applicant: Wyeth
    Inventors: John C. McKew, Steve Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
  • Cyclic amine phenyl beta-3 adrenergic receptor agonists
    Publication number: 20030144326
    Abstract: This invention provides compounds of Formula I having the structure 1
    Type: Application
    Filed: December 27, 2002
    Publication date: July 31, 2003
    Applicant: Wyeth
    Inventors: Baihua Hu, Fuk-Wah Sum, Michael Sotirios Malamas
  • Inhibitors of cytosolic phospholipase A2
    Publication number: 20030144282
    Abstract: This invention provides substituted indole compounds of the general formula: 1
    Type: Application
    Filed: November 22, 2002
    Publication date: July 31, 2003
    Applicant: Wyeth
    Inventors: John C. McKew, Steve Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
  • Cyclic amine phenyl beta-3 adrenergic receptor agonists
    Patent number: 6525202
    Abstract: This invention provides compounds of Formula I having the structure wherein, R1, R2, R3, R4, R5, T, T1, T2, and X are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: February 25, 2003
    Assignee: Wyeth
    Inventors: Baihua Hu, Fuk-Wah Sum, Michael S. Malamas
  • Cyclylamine sulfonamides as beta-3 adrenergic receptor agonists
    Publication number: 20030027797
    Abstract: This invention provides compounds of Formula I having the structure 1
    Type: Application
    Filed: September 5, 2002
    Publication date: February 6, 2003
    Applicant: Wyeth
    Inventors: Fuk-Wah Sum, Baihua Hu
  • N-(4-sulfonylaryl)cyclylamine-2-hydroxyethylamines as beta-3 adrenergic receptor agonists
    Publication number: 20030027795
    Abstract: This invention provides compounds of Formula I having the structure 1
    Type: Application
    Filed: July 25, 2002
    Publication date: February 6, 2003
    Applicant: Wyeth
    Inventors: Fuk-Wah Sum, Michael Sotirios Malamas
  • Cyclamine sulfonamides as &bgr;-3 adrenergic receptor agonists
    Patent number: 6498170
    Abstract: This invention provides compounds of Formula I having the structure wherein R1, R2, R3, W, X, and Z are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: December 24, 2002
    Assignee: Wyeth
    Inventors: Fuk-Wah Sum, Baihua Hu
  • N-(4-sulfonylaryl)Cyclylamine 2-hydroxyethylamines as beta-3 adrenergic receptor agonists
    Patent number: 6444685
    Abstract: This invention provides compounds of Formula I having the structure wherein R1, R2, R3, R4, W, X, and Y are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: September 3, 2002
    Assignee: Wyeth
    Inventors: Fuk-Wah Sum, Michael Sotirios Malamas
  • Cyclic amine phenyl beta-3 adrenergic receptor agonists
    Publication number: 20020028835
    Abstract: This invention provides compounds of Formula I having the structure 1
    Type: Application
    Filed: July 12, 2001
    Publication date: March 7, 2002
    Inventors: Baihua Hu, Fuk-Wah Sum, Michael S Malamas
  • N-(4-sulfonylaryl)Cyclylamine 2-hydroxyethylamines as beta-3 adrenergic receptor agonists
    Publication number: 20020028797
    Abstract: This invention provides compounds of Formula I having the structure 1
    Type: Application
    Filed: July 12, 2001
    Publication date: March 7, 2002
    Applicant: American Home Products Corporation
    Inventors: Fuk-Wah Sum, Michael S. Malamas
  • Cyclamine sulfonamides as beta-3 adrenergic receptor agonists
    Publication number: 20020022605
    Abstract: This invention provides compounds of Formula I having the structure 1
    Type: Application
    Filed: July 12, 2001
    Publication date: February 21, 2002
    Applicant: American Home Products Corporation
    Inventors: Fuk-Wah Sum, Baihua Hu