Patents by Inventor Fuk-Wah Sum

Fuk-Wah Sum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted 1,3-benzodioxoles
    Patent number: 5914339
    Abstract: The present invention provides new compounds having anti-diabetic and/or antihyperglycemia and/or anti-obesity activity, as well as pharmaceutical compositions and methods of treatment utilizing the compounds and processes for making the compounds, the compounds having the formula (II): ##STR1## wherein: R.sub.1 and R.sub.6 are independently hydrogen, C.sub.1 to C.sub.6 alkyl, trifluoromethyl, cyano, C.sub.1 to C.sub.6 alkoxy, or halogen;R.sub.2 is hydrogen or C.sub.1 to C.sub.6 trialkylsilyl;R.sub.3 is hydrogen or C.sub.1 to C.sub.6 alkoxycarbonyl;or R.sub.2 and R.sub.3 are joined to form a ring: ##STR2## wherein R' is hydrogen, C.sub.1 to C.sub.6 alkyl, or aryl; R.sub.4 and R.sub.5 are independently hydrogen or C.sub.1 to C.sub.6 alkyl;R.sub.7 and R.sub.8 are independently OR.sub.9 or NR.sub.10 R.sub.11 ;R.sub.9 is hydrogen, C.sub.1 to C.sub.12 alkyl, C.sub.1 to C.sub.12 cycloalkyl, C.sub.1 to C.sub.12 silylalkyl, aryl, arylalkyl, alkoxyalkyl, heteroaryl, --CHR.sub.12 COOR.sub.13, --CHR.sub.12 C(O)R.sub.
    Type: Grant
    Filed: May 9, 1997
    Date of Patent: June 22, 1999
    Assignee: American Home Products Corporation
    Inventors: Fuk-Wah Sum, Adam M. Gilbert, George T. Grosu, Michael S. Malamas, Aranapakam M. Venkatesan, Gerardo D. Francisco
  • Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
    Patent number: 5889001
    Abstract: Tricyclic diazepines of the formula: ##STR1## wherein A, B, D, E, F, Y and Z are defined in the specification which compounds have vasopressin and oxytocin antagonist activity.
    Type: Grant
    Filed: June 13, 1997
    Date of Patent: March 30, 1999
    Assignee: American Cyanamid Company
    Inventors: Jay Donald Albright, Marvin Fred Reich, Fuk-Wah Sum, Efren Guillermo Delos Santos
  • Tricyclic benzazepine vasopressin antagonists
    Patent number: 5869483
    Abstract: Tricyclic compounds of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V.sub.1 and/or V.sub.2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and processes for preparing such compounds.
    Type: Grant
    Filed: April 24, 1996
    Date of Patent: February 9, 1999
    Assignee: American Cyanamid Company
    Inventors: Jay Donald Albright, Fuk-Wah Sum
  • Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
    Patent number: 5854237
    Abstract: Tricyclic diazepines of the formula: ##STR1## wherein A, B, D, E, F, Y and Z are defined in the specification which compounds have vasopressin and oxytocin antagonist activity.
    Type: Grant
    Filed: June 17, 1997
    Date of Patent: December 29, 1998
    Assignee: American Cyanamid Company
    Inventors: Jay Donald Albright, Marvin Fred Reich, Fuk-Wah Sum, Efren Guillermo Delos Santos
  • Tricyclic benzazepine vasopressin antagonists
    Patent number: 5843952
    Abstract: Tricyclic compounds of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V.sub.1 and/or V.sub.2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and processes for preparing such compounds.
    Type: Grant
    Filed: July 8, 1997
    Date of Patent: December 1, 1998
    Assignee: American Cyanamid Company
    Inventors: Jay Donald Albright, Fuk-Wah Sum
  • Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
    Patent number: 5843944
    Abstract: Tricyclic diazepines of the formula: ##STR1## wherein A, B, D, E, F, Y and Z are defined in the specification which compounds have vasopressin and oxytocin antagonist activity.
    Type: Grant
    Filed: July 11, 1997
    Date of Patent: December 1, 1998
    Assignee: American Cyanamid Company
    Inventors: Jay Donald Albright, Marvin Fred Reich, Fuk-Wah Sum, Efren Guillermo Delos Santos
  • Tricyclic benzazepine vasopressin antagonists
    Patent number: 5786353
    Abstract: Tricyclic compounds of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V.sub.1 and/or V.sub.2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and processes for preparing such compounds.
    Type: Grant
    Filed: July 11, 1997
    Date of Patent: July 28, 1998
    Assignee: American Cyanamid Company
    Inventors: Jay Donald Albright, Marvin Fred Reich, Fuk-Wah Sum, Xuemei Du
  • Tricyclic benzazepine vasopressin antagonists
    Patent number: 5753648
    Abstract: Tricyclic compound of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V.sub.1 and/or V.sub.2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and process for preparing such compounds.
    Type: Grant
    Filed: June 27, 1996
    Date of Patent: May 19, 1998
    Assignee: American Cyanamid Company
    Inventors: Jay Donald Albright, Aranapakam M. Venkatesan, John P. Dusza, Fuk-Wah Sum
  • Tricyclic benzazepine vasopressin antagonists
    Patent number: 5739128
    Abstract: Tricyclic compounds of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V.sub.1 and/or V.sub.2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and processes for preparing such compounds.
    Type: Grant
    Filed: April 24, 1996
    Date of Patent: April 14, 1998
    Assignee: American Cyanamid Company
    Inventors: Jay Donald Albright, Marvin Fred Reich, Fuk-Wah Sum, Xuemei Du
  • Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
    Patent number: 5736540
    Abstract: Tricyclic diazepines of the formula: ##STR1## wherein A, B, D, E, F, Y and Z are defined in the specification which compounds have vasopressin and oxytocin antagonist activity.
    Type: Grant
    Filed: May 8, 1996
    Date of Patent: April 7, 1998
    Assignee: American Cyanamid Company
    Inventors: Jay Donald Albright, Marvin Fred Reich, Fuk-Wah Sum, Efren Guillermo Delos Santos
  • Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
    Patent number: 5733905
    Abstract: Tricyclic diazepines of the formula: ##STR1## wherein A, B, D, E, F, Y and Z are defined in the specification which compounds have vasopressin and oxytocin antagonist activity.
    Type: Grant
    Filed: May 8, 1996
    Date of Patent: March 31, 1998
    Assignee: American Cyanamid Company
    Inventors: Jay Donald Albright, Marvin Fred Reich, Fuk-Wah Sum, Efren Guillermo Delos Santos
  • Tricyclic benzazepine vasopressin antagonists
    Patent number: 5700796
    Abstract: Tricyclic compound of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V.sub.1 and/or V.sub.2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and process for preparing such compounds.
    Type: Grant
    Filed: June 27, 1996
    Date of Patent: December 23, 1997
    Assignee: American Cyanamid Company
    Inventors: Jay Donald Albright, Aranapakam M. Venkatesan, John P. Dusza, Fuk-Wah Sum
  • Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
    Patent number: 5624923
    Abstract: Tricyclic diazepines of the formula: ##STR1## wherein A, B, D, E, F, Y and Z are defined in the specification which compounds have vasopressin and oxytocin antagonist activity.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 29, 1997
    Assignee: American Cyanamid Company
    Inventors: Jay D. Albright, Marvin F. Reich, Fuk-Wah Sum, Efren G. Delos Santos
  • Tricyclic benzazepine vasopressin antagonists
    Patent number: 5536718
    Abstract: Tricyclic compound of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V.sub.1 and/or V.sub.2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and process for preparing such compounds.
    Type: Grant
    Filed: January 17, 1995
    Date of Patent: July 16, 1996
    Assignee: American Cyanamid Company
    Inventors: Jay D. Albright, Aranapakam M. Venkatesan, John P. Dusza, Fuk-Wah Sum
  • Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
    Patent number: 5516774
    Abstract: Tricyclic diazepines of the formula: ##STR1## wherein A, B, D, E, F, Y and Z are defined in the specification which compounds have vasopressin and oxytocin antagonist activity.
    Type: Grant
    Filed: June 13, 1994
    Date of Patent: May 14, 1996
    Assignee: American Cyanamid Company
    Inventors: Jay D. Albright, Marvin F. Reich, Fuk-Wah Sum, Efren G. Delos Santos
  • Tricyclic benzazepine vasopressin antagonists
    Patent number: 5512563
    Abstract: Tricyclic compounds of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V.sub.1 and/or V.sub.2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and processes for preparing such compounds.
    Type: Grant
    Filed: June 13, 1994
    Date of Patent: April 30, 1996
    Assignee: American Cyanamid Company
    Inventors: Jay D. Albright, Fuk-Wah Sum, Xuemei Du
  • Renin inhibitors
    Patent number: 5189023
    Abstract: Renin inhibiting compounds of the formula: ##STR1## containing two .alpha.-amino acids or a single .alpha.-amino acid wherein R.sub.1 is a phosphorus containing moiety, W is oxygen or NR.sub.3 and A is a moiety selected from those of the formula: ##STR2## wherein Z is O, S, SO, SO.sub.2 and p is an integer from 1 to 2; and, when W is oxygen, A may also be a moiety of the formula ##STR3## and analogs thereof which compounds inhibit the substrate-cleaving action of renin, pharmaceutical compositions containing these compounds, processes for producing the compounds and methods of treating hypertension which employ the novel renin inhibitors.
    Type: Grant
    Filed: October 22, 1991
    Date of Patent: February 23, 1993
    Assignee: American Cyanamid Company
    Inventors: Jay D. Albright, Fuk-Wah Sum
  • Renin inhibitors
    Patent number: 5106835
    Abstract: The invention is new renin inhibitor dipeptide and tripeptide derivatives of the formula: ##STR1##
    Type: Grant
    Filed: June 22, 1990
    Date of Patent: April 21, 1992
    Assignee: American Cyanamid Company
    Inventors: Jay D. Albright, Fuk-Wah Sum, Charles F. Howell
  • Renin inhibitors
    Patent number: 5104869
    Abstract: Renin inhibiting compounds containing a single .alpha.-amino acid of the formula: ##STR1## and analogs thereof which inhibit the substrate-cleaving acting or renin, pharmaceutical compositions containing these compounds, processes for producing the compounds and methods of treating hypertension which employ the novel renin inhibitors.
    Type: Grant
    Filed: October 25, 1990
    Date of Patent: April 14, 1992
    Assignee: American Cyanamid Company
    Inventors: Jay D. Albright, Charles Frederick, Jeremy I. Levin, Fuk-Wah Sum, Marvin F. Reich