Patents by Inventor Fumiaki Koizumi
Fumiaki Koizumi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11371982Abstract: The purpose of the present invention is to provide a method for accurately predicting a cancer patient prognosis based on a count of desired cells for which expression of a leukocyte marker and an epithelial marker is hardly exhibited by detecting those cells. Provided is a method for diagnosing an overall survival prognosis for a patient suffering from cancer, the method including: a step of obtaining a concentrated solution containing desired cells by pre-treating a biological sample obtained from the patient; a step of optically detecting the concentrated cells; and a step of detecting the desired cells from the detected image, wherein an association is made with the overall survival prognosis diagnosis by counting the detected desired cells, and wherein the desired cells are cells confirmed by the existence of a cell nucleus and in which expression of a leukocyte marker and an epithelial marker is hardly exhibited.Type: GrantFiled: January 19, 2017Date of Patent: June 28, 2022Assignees: TOSOH CORPORATION, TOKYO METROPOLITAN GOVERNMENTInventors: Yasuyuki Akiyama, Atsushi Morimoto, Toru Futami, Fumiaki Koizumi, Takeshi Sawada
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Patent number: 11280792Abstract: The object of the present invention is to provide an evaluation method capable of accurately determining a metastasis of cancer, the stage of cancer progression, or the malignancy of cancer.Type: GrantFiled: September 6, 2018Date of Patent: March 22, 2022Assignees: ON-CHIP BIOTECHNOLOGIES CO., LTD., SHIZUOKA PREFECTUREInventors: Kazuo Takeda, Namiko Yamashita, Yuu Fujimura, Kaori Nishio, Yasuhiro Koh, Masaru Watanabe, Fumiaki Koizumi, Yuri Uehara
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Patent number: 10684905Abstract: A disk device includes; a sensor that, when a driver that records and reads data in the disk device is in a non-operation state, detects an influence on the disk device; a determination circuit that determines based on a detection result of the sensor whether the detection result satisfies a condition leading to a failure of the disk device; and a transmitter that transmits information relating to a fact that the detection result satisfies the condition, to another device.Type: GrantFiled: March 16, 2018Date of Patent: June 16, 2020Assignee: NEC CORPORATIONInventor: Fumiaki Koizumi
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Publication number: 20190025282Abstract: The purpose of the present invention is to provide a method for accurately predicting a cancer patient prognosis based on a count of desired cells for which expression of a leukocyte marker and an epithelial marker is hardly exhibited by detecting those cells. Provided is a method for diagnosing an overall survival prognosis for a patient suffering from cancer, the method including: a step of obtaining a concentrated solution containing desired cells by pre-treating a biological sample obtained from the patient; a step of optically detecting the concentrated cells; and a step of detecting the desired cells from the detected image, wherein an association is made with the overall survival prognosis diagnosis by counting the detected desired cells, and wherein the desired cells are cells confirmed by the existence of a cell nucleus and in which expression of a leukocyte marker and an epithelial marker is hardly exhibited.Type: ApplicationFiled: January 19, 2017Publication date: January 24, 2019Applicants: TOSOH CORPORATION, TOKYO METROPOLITAN GOVERNMENTInventors: Yasuyuki AKIYAMA, Atsushi MORIMOTO, Toru FUTAMI, Fumiaki KOIZUMI, Takeshi SAWADA
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Publication number: 20190011450Abstract: The object of the present invention is to provide an evaluation method capable of accurately determining a metastasis of cancer, the stage of cancer progression, or the malignancy of cancer.Type: ApplicationFiled: September 6, 2018Publication date: January 10, 2019Applicants: ON-CHIP BIOTECHNOLOGIES CO., LTD., SHIZUOKA PREFECTUREInventors: Kazuo TAKEDA, Namiko YAMASHITA, Yuu FUJIMURA, Kaori NISHIO, Yasuhiro KOH, Masaru WATANABE, Fumiaki KOIZUMI, Yuri UEHARA
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Publication number: 20180276066Abstract: A disk device includes; a sensor that, when a driver that records and reads data in the disk device is in a non-operation state, detects an influence on the disk device; a determination circuit that determines based on a detection result of the sensor whether the detection result satisfies a condition leading to a failure of the disk device; and a transmitter that transmits information relating to a fact that the detection result satisfies the condition, to another device.Type: ApplicationFiled: March 16, 2018Publication date: September 27, 2018Applicant: NEC CorporationInventor: Fumiaki KOIZUMI
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Patent number: 8981402Abstract: Disclosed are a white LED lighting device and an optical lens used in it. The white LED lighting device comprises a white LED and an optical lens. The white LED includes: a LED chip which emits blue light; and a fluorescent material which is excited by emission light of the LED chip and converts a wavelength into fluorescence of a complementary color of blue. The optical lens is formed with a scattering light guide which is given uniform scattering power in terms of a volume. The scattering light guide includes scattering particles for the scattering efficiency in a short wavelength range of light to be higher than that in a long wavelength range of light.Type: GrantFiled: January 4, 2011Date of Patent: March 17, 2015Assignees: Nittoh Kogaku K.K.Inventors: Yoshinori Shinohara, Fumiaki Koizumi
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Publication number: 20150064722Abstract: The object of the present invention is to provide an evaluation method capable of accurately determining a metastasis of cancer, the stage of cancer progression, or the malignancy of cancer.Type: ApplicationFiled: March 28, 2013Publication date: March 5, 2015Applicants: SHIZUOKA PREFECTURE, ON-CHIP BIOTECHNOLOGIES CO., LTD.Inventors: Kazuo Takeda, Namiko Yamashita, Yuu Fujimura, Kaori Nishio, Yasuhiro Koh, Masaru Watanabe, Fumiaki Koizumi, Yuri Uehara
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Publication number: 20140080132Abstract: A method for predicting ADCC activity in a subject, the method comprising the steps of: (a) preparing a biological sample from the subject, said sample including a leukocyte, (b) bringing a portion of the biological sample and an antibody into contact with each other, (c) detecting expression of at least one marker of ADCC activity selected from the group consisting of tumor necrosis factor super family 15, chemokine CXCL3, and interleukin 6 in the leukocyte in (i) the portion of the sample brought into contact with the antibody and in (ii) another portion of the sample not brought into contact with the antibody, (d) comparing an expression level in portion (i) with the expression level in portion (ii); and (e) predicting presence of the cytotoxic activity when the expression level in portion (i) is higher than the expression level in portion (ii)Type: ApplicationFiled: September 16, 2013Publication date: March 20, 2014Inventors: Kazuhiko Obara, Hiroshi Izutsu, Masato Mitsuhashi, Fumiaki Koizumi, Kenji Tamura, Mayu Yunokawa, Yasuo Kodera, Fumiko Taguchi
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Patent number: 8579472Abstract: The present invention provides an illumination lens which suppresses a change of an illuminance distribution following a change of an arrangement position of a light source with respect to the illumination lens. A reflection surface and emission surface of the illumination lens are configured to refract and emit, in the emission surface, second illumination light and third illumination light with refracting power of different signs. By changing an illuminance distribution of third illumination light to cancel the change of an illuminance distribution of the second illumination light when a light source is moved, it is possible to suppress the change of the illuminance distribution small even when the light source is moved back and forth.Type: GrantFiled: October 25, 2011Date of Patent: November 12, 2013Assignee: Nittoh Kogaku K.K.Inventor: Fumiaki Koizumi
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Publication number: 20130085081Abstract: Disclosed are a method of detecting the presence or absence of a single nucleotide polymorphism of a gene, for prediction of the risk of developing drug-induced lung injury, or for improving a therapeutic method, and a kit for carrying out the detection method. The detection method is characterized by comparing an ABCB1 gene in a biological sample with a wild-type ABCB1 gene to detect the presence or absence of a single nucleotide polymorphism in the ABCB1 gene in the biological sample, in particular, by determining the nucleotide at position 3751 of the CDS of the ABCB1 gene. The kit comprises an oligonucleotide probe which specifically binds to a single nucleotide polymorphism in an ABCB1 gene under selective binding conditions, or an oligonucleotide primer which amplifies a nucleic acid sequence comprising a single nucleotide polymorphism in an ABCB1 gene.Type: ApplicationFiled: June 8, 2011Publication date: April 4, 2013Applicants: National Cancer Center, Kinki University, Mitsubishi Chemical Medience CorporationInventors: Fumiaki Koizumi, Shintaro Kanda, Tomohide Tamura, Koichi Goto, Masaru Sekijima, Akira Ohide, Kazuto Nishio
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Publication number: 20120286314Abstract: Disclosed are a white LED lighting device and an optical lens used in it. The white LED lighting device comprises a white LED and an optical lens. The white LED includes: a LED chip which emits blue light: and a fluorescent material which is excited by emission light of the LED chip and converts a wavelength into fluorescence of a complementary color of blue. The optical lens is formed with a scattering light guide which is given uniform scattering power in terms of a volume. The scattering light guide includes scattering particles for the scattering efficiency in a short wavelength range of light to be higher than that in a long wavelength range of light.Type: ApplicationFiled: January 4, 2011Publication date: November 15, 2012Applicants: NITTOH KOGAKU K.K.Inventors: Yoshinori Shinohara, Fumiaki Koizumi
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Publication number: 20120113653Abstract: The present invention provides an illumination lens which suppresses a change of an illuminance distribution following a change of an arrangement position of a light source with respect to the illumination lens. A reflection surface and emission surface of the illumination lens are configured to refract and emit, in the emission surface, second illumination light and third illumination light with refracting power of different signs. By changing an illuminance distribution of third illumination light to cancel the change of an illuminance distribution of the second illumination light when a light source is moved, it is possible to suppress the change of the illuminance distribution small even when the light source is moved back and forth.Type: ApplicationFiled: October 25, 2011Publication date: May 10, 2012Applicant: NITTOH KOGAKU K.K.Inventor: Fumiaki KOIZUMI
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Patent number: 6972903Abstract: A vision assisting apparatus includes a casing for forming an inversely U-shaped optical path, a light entry, provided at one end of the optical path, through which light enters, a light exit, provided at another end of the optical path, through which light exits in an opposite direction to the light entry, an optical system for processing an image entered via the light entry by using the optical pass and outputting a processed image via the light exit, and attaching structure for attaching the casing to a wearer so that the light exit is positioned close to an eye of the wearer. By forming the inversely U-shaped optical path with the casing, it is possible to provide a sufficiently long optical path in a compact form.Type: GrantFiled: April 12, 2002Date of Patent: December 6, 2005Assignees: Nittoh Kogaku K.K.Inventors: Hideo Hara, Kazunaga Shimizu, Fumiaki Koizumi, Yasuhiro Sakai
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Publication number: 20040179261Abstract: The vision assisting apparatus of the present invention includes a casing for forming an inversely U-shaped optical path, a light entry, provided at one end of the optical path, through which light enters, a light exit, provided at another end of the optical path, through which light exits in an opposite direction to the light entry, an optical system for processing an image entered via the light entry by using the optical pass and outputting a processed image via the light exit, and means for attaching the casing to a wearer so that the light exit is positioned close to an eye of the wearer. By forming the inversely U-shaped optical path with the casing, it is possible to provide a sufficiently long optical path in a compact form.Type: ApplicationFiled: April 26, 2004Publication date: September 16, 2004Inventors: Hideo Hara, Kazunaga Shimizu, Fumiaki Koizumi, Yasuhiro Sakai
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Patent number: 6678538Abstract: The remaining level of a battery 9 is detected, and when the remaining level is lower than a specified value, supply of power is stopped to other circuits except necessary circuits 5, 7, 10 that need electric power for reading out a telephone number from a telephone number memory 13 and displaying the read out telephone number. Only the telephone directory function is remaining, and if the battery is spend and the portable telephone can not be used, at least a worst case of impossibility of any operation can be avoided. The specified value is a voltage level at which it is usually difficult to transmit and receive. The necessary circuits include the telephone number memory 13 and the display unit 7 for displaying the telephone number. It is further preferred to display it is impossible to transmit and receive, and possible to display the telephone number.Type: GrantFiled: July 13, 2000Date of Patent: January 13, 2004Assignee: NEC CorporationInventor: Fumiaki Koizumi
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Patent number: 6678372Abstract: A telephone terminal is connected to a line network and has an individual terminal number. The telephone terminal comprises a clock section for measuring date and hour. A memory section is for memorizing a call telephone number as a communication telephone number on call. The memory section is for memorizing a reception telephone number as the communication telephone number on reception. The memory section further memorizes communication information in correspondence to the communication telephone number. The communication information and the communication telephone number are displayed on a display section. A control section controls the memory section to make the memory section memorize the communication information in correspondence to the communication telephone number. The control section controls the display section to make the display section display the communication telephone number and the communication information.Type: GrantFiled: June 25, 1999Date of Patent: January 13, 2004Assignee: NEC CorporationInventor: Fumiaki Koizumi
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Patent number: 6504868Abstract: Since a conventional adaptive equalizer handles an update quantity control parameter &mgr; as a fixed value, the update quantity control parameter &mgr; is not optimized adaptively to variation of a channel state and the BER characteristic is deteriorated.Type: GrantFiled: March 11, 1999Date of Patent: January 7, 2003Assignee: NEC CorporationInventor: Fumiaki Koizumi
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Patent number: 6240145Abstract: In outputting the decision results of decoding of a received signal by the maximum likelihood serial estimation using Viterbi algorithm, a channel estimation section estimates the channel state. The magnitude and delay quantity of delay wave contained in the received signal are determined, by a control section for the number of states, from the channel state estimated by the channel estimation section to determine the necessary number of states in Viterbi decoding, and decoding is controlled by the number of states. A viterbi decoder carries out the decoding according to the control based on the number of states determined by the control section for the number of states. By virtue of this constitution, when the transmission quality of the channel is good, the quantity of computation in the Viterbi decoder is reduced to reduce the power consumption and, at the same time, the quantity of the computation is minimized to realize high speed processing.Type: GrantFiled: June 5, 1998Date of Patent: May 29, 2001Assignee: NEC CorporationInventor: Fumiaki Koizumi
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Patent number: 5995562Abstract: In a maximum-likelihood decoder, a reliability information of decoded data corresponding to a maximum-likelihood path is generated by using state codes previously assigned to the trellis states, respectively. After a survivor path is selected for each of the trellis states according to Viterbi algorithm, the survivor path is stored, and then a maximum-likelihood path is selected from the survivor paths stored. Based on at least two state codes each corresponding to a different trellis state, a reliability value is generated as the reliability information. Since the assigned state codes are used to generate the reliability information, the reliability criterion of decoded data is kept substantially at constant even when the conditions of input signals are changed, resulting in improved reliability of decoded data.Type: GrantFiled: October 24, 1996Date of Patent: November 30, 1999Assignee: NEC CorporationInventor: Fumiaki Koizumi