Patents by Inventor Fumio Itoh
Fumio Itoh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8492378Abstract: For the purpose of providing a GSK-3? inhibitor containing an oxadiazole compound or a salt thereof or a prodrug thereof useful as an agent for the prophylaxis or treatment of a GSK-3?-related pathology or disease, the present invention provides a GSK-3? inhibitor containing a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof or a prodrug thereof.Type: GrantFiled: August 2, 2007Date of Patent: July 23, 2013Assignee: Takeda Pharmaceutical Company LimitedInventors: Fumio Itoh, Jun Kunitomo, Hiromi Kobayashi, Eiji Kimura, Morihisa Saitoh, Tomohiro Kawamoto, Hiroki Iwashita, Katsuhito Murase
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Publication number: 20100130737Abstract: The present invention provides a GPR receptor function regulator comprising the compound represented by the formula: [wherein ring A is an optionally substituted isocyclic or heterocyclic ring, P is a bond or spacer, ring D is an optionally substituted monocyclic aromatic ring which may be condensed with a 5- to 7-membered ring, V is a bond or the group represented by the formula —CR14?CR15— or —N?CR16— (wherein R14, R15 and R16 each represents a hydrogen atom or optionally substituted hydrocarbon group), Q is a bond or spacer, and W is a carboxyl or a group biologically equivalent to a carboxyl] or its salt or a prodrug thereof.Type: ApplicationFiled: February 17, 2006Publication date: May 27, 2010Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Fumio Itoh, Eiji Kimura, Yumi Imai, Masaaki Mori, Yoshio Aramaki, Yasuhisa Kohara, Tsukasa Sugo, Yoji Hayase, Hiromi Kobayashi, Kazuhiro Ogi
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Publication number: 20100068702Abstract: The invention relates to a sample containing a gastric mucosa lavage fluid collected from a subject who has received a gastric mucus removal treatment and a method for detecting a disease-related marker using the same. By using the sample of the invention, the disease-related marker can be detected conveniently, less invasively, highly sensitively and highly accurately.Type: ApplicationFiled: May 15, 2007Publication date: March 18, 2010Applicants: Sapporo Medical University, St. Marianna University, School of MedicineInventors: Yoshiyuki Watanabe, Yoshiyuki Watanabe, Minoru Toyota, Kohzoh Imai, Yasuhisa Shinomura, Fumio Itoh, Takashi Tokino
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Publication number: 20100069381Abstract: For the purpose of providing a GSK-3? inhibitor containing an oxadiazole compound or a salt thereof or a prodrug thereof useful as an agent for the prophylaxis or treatment of a GSK-3?-related pathology or disease, the present invention provides a GSK-3? inhibitor containing a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof or a prodrug thereof.Type: ApplicationFiled: August 2, 2007Publication date: March 18, 2010Inventor: Fumio Itoh
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Patent number: 7625887Abstract: It is intended to provide a TGR5 receptor agonist containing a fused ring compound represented by the following general formula, its salt or a prodrug thereof: (1) wherein ring A represents an optionally substituted aromatic ring; and the ring B? represents a 5- to 8-membered ring having one or more substituents; which is useful in treating various diseases.Type: GrantFiled: January 27, 2004Date of Patent: December 1, 2009Assignee: Takeda Pharmaceutical Company LimitedInventors: Fumio Itoh, Shuji Hinuma, Naoyuki Kanzaki, Yuji Kawamata, Taisuke Tawaraishi, Yuji Ishichi, Mariko Hirohashi
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Publication number: 20090239839Abstract: An agent for modulating the function of an RFRP receptor, characterized by containing either a compound represented by the formula (I) [wherein ring A represents an optionally substituted aromatic ring; ring B represents an optionally substituted benzene ring; X represents oxygen, S(O)n (n is an integer of 0 to 2), or NR3 (R3 represents hydrogen, an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group); and R1 and R2 each represents hydrogen, an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group] or a salt of the compound.Type: ApplicationFiled: February 24, 2009Publication date: September 24, 2009Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Fumio ITOH, Shuji Hinuma, Naoyuki Kanzaki, Hiroshi Mabuchi, Hiromi Yoshida, Hirokazu Matsumoto, Takeshi Wakabayashi
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Patent number: 7402595Abstract: A JNK inhibitor containing a compound having an isoquinolinone skeleton or a salt thereof, such as a compound represented by the formula wherein ring A and ring B are each an optionally substituted benzene ring, X is —O—, —N?, —NR3— or —CHR3—, R2 is an acyl group, an optionally esterified or thioesterified carboxyl group, an optionally substituted carbamoyl group or an optionally substituted amino group and the like, a broken line shows a single bond or a double bond, and R1 is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group and the like, and the like.Type: GrantFiled: February 12, 2003Date of Patent: July 22, 2008Assignee: Takeda Pharmaceutical Company LimitedInventors: Fumio Itoh, Hiroyuki Kimura, Hideki Igata, Tomohiro Kawamoto, Mitsuru Sasaki, Shuji Kitamura
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Publication number: 20080021069Abstract: The present invention relates to a GPR40 receptor function regulator comprising a fused imidazole compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof or a prodrug thereof. The GPR40 receptor function regulator is useful as an agent for the prophylaxis or treatment of obesity, hyperinsulinemia, type 2 diabetes and the like.Type: ApplicationFiled: October 7, 2005Publication date: January 24, 2008Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Fumio Itoh, Satoshi Sasaka, Junichi Miyazaki, Nobuhiro Suzuki
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Publication number: 20070129348Abstract: An agent for modulating the function of an RFRP receptor, characterized by containing either a compound represented by the formula (I) [wherein ring A represents an optionally substituted aromatic ring; ring B represents an optionally substituted benzene ring; X represents oxygen, S(O)n (n is an integer of 0 to 2), or NR3 (R3 represents hydrogen, an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group); and R1 and R2 each represents hydrogen, an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group] or a salt of the compound.Type: ApplicationFiled: April 15, 2004Publication date: June 7, 2007Inventors: Fumio Itoh, Shuji Hinuma, Naoyuki Kanzaki, Hiroshi Mabuchi, Hiromi Yoshida, Hirokazu Matsumoto, Takeshi Wakabayashi
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Publication number: 20070117840Abstract: A compound represented by the formula (I): wherein ring A represents an aromatic ring; X represents a bond, oxygen, NR4 (R4 represents hydrogen, a hydrocarbon group, or a heterocyclic group), or alkylene; R1 represents a hydrocarbon group, or a heterocyclic group; R2 represents —COYR5 (Y represents a bond, alkylene, oxygen, sulfur, or NR6 (R6 represents hydrogen, a hydrocarbon group, or a heterocyclic group), and R5 represents a hydrocarbon group, or a heterocyclic group), a hydrocarbon group, or a heterocyclic group; and R3 represents a hydrocarbon group, a heterocyclic group, optionally substituted hydroxy, optionally substituted amino, or —S(O)nR7 (R7 represents a hydrocarbon group, or a heterocyclic group, and n is 0 to 2), a salt of the compound, or a prodrug or either is useful as an agent for modulating the function of an RFRP receptor.Type: ApplicationFiled: March 16, 2004Publication date: May 24, 2007Inventors: Fumio Itoh, Shuji Hinuma, Naoyuki Kanzaki, Yoshihiro Banno, Hiromi Yoshida, Hirokazu Matsumoto
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Patent number: 7109200Abstract: Novel carbamate derivatives which are useful as drugs because of inhibiting activated blood coagulation factor X and thus exerting an anticoagulant effect. Compounds represented by the formula: wherein R1 represents a group represented by the formula: (wherein Y1 represents CH?CH, etc.), which may be substituted, etc.; the ring A represents an oxo-substituted nitrogen-containing heterocyclic ring which may be further substituted; R2 represents a hydrogen atom, optionally substituted C1-4 alkyl, etc.; R3 represents optionally substituted C1-4 alkyl, etc.; and Z represents an optionally substituted nitrogen containing heterocyclic group, etc., or salts thereof.Type: GrantFiled: November 8, 2001Date of Patent: September 19, 2006Assignee: Takeda Pharmaceutical Company LimitedInventors: Fumio Itoh, Hiroshi Banno, Masaki Kawamura, Shuji Kitamura
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Publication number: 20060199795Abstract: The present invention provides a TGR5 receptor agonist comprising a fused ring compound represented by the formula wherein ring A is an optionally substituted aromatic ring; and ring B? is a 5- to 8-membered ring having one or more substituents or a salt thereof or a prodrug thereof, which is useful for the treatment of various diseases.Type: ApplicationFiled: January 27, 2004Publication date: September 7, 2006Inventors: Fumio Itoh, Shuji Hinuma, Naoyuki Kanzaki, Takashi Miki, Yuji Kawamata, Satoru Oi, Taisuke Tawaraishi, Yuji Ishichi, Mariko Hirohashi
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Publication number: 20050194671Abstract: A high frequency semiconductor device including: at least two high frequency semiconductor chips each having an output electrode pad and a circuit; a frame having a die bond area in which the high frequency semiconductor chips are mounted; a plurality of leads which electrically connect the circuits of the respective high frequency semiconductor chips to an external device; and a plurality of output terminal connection wires connected between the output electrode pads of the respective chips and the corresponding leads, wherein the high frequency semiconductor chips are disposed in the die bond area with the output electrode pad of one of the high frequency semiconductor chips being spaced at least a first predetermined distance from the output electrode pad of the other high frequency semiconductor chip, and wherein the output terminal connection wire connected to the output electrode pad of the one high frequency semiconductor chip is spaced at least a second predetermined distance from the output terminalType: ApplicationFiled: February 28, 2005Publication date: September 8, 2005Applicant: Sharp Kabushiki KaishaInventors: Kouken Yoshikawa, Fumio Itoh
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Publication number: 20050148624Abstract: A JNK inhibitor containing a compound having an isoquinolinone skeleton or a salt thereof, such as a compound represented by the formula wherein ring A and ring B are each an optionally substituted benzene ring, X is —O—, —N?, —NR3— or —CHR3—, R2 is an acyl group, an optionally esterified or thioesterified carboxyl group, an optionally substituted carbamoyl group or an optionally substituted amino group and the like, a broken line shows a single bond or a double bond, and R1 is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group and the like, and the like.Type: ApplicationFiled: February 12, 2003Publication date: July 7, 2005Inventors: Fumio Itoh, Hiroyuki Kimura, Hideki Igata, Tomohiro Kawamoto, Mitsuru Sasaki, Shuji Kitamura
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Patent number: 6723722Abstract: Novel acylhydrazine derivatives exhibiting an inhibitory activity against activated blood coagulation factor X, which are compounds of general formula (I) or salts thereof, wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; R1 and R2 are each hydrogen or optionally substituted hydrocarbyl, or alternatively R1 and R2 or the substituent of X1 and R2 may be united to form an optionally substituted ring; X1 and X2 are each free valency, optionally substituted alkylene, or optionally substituted imino; D is oxygen or sulfur; A is —N(R3)—Y— or —N═Y—, R3 is hydrogen, optionally substituted hydrocarbyl, or acyl; Y is an optionally substituted chain hydrocarbon group or an optionally substituted cyclic group; and Z is (1) optionally substituted amino, (2) optionally substituted imidoyl, or (3) an optionally substituted nitrogenous heterocycle group.Type: GrantFiled: December 18, 2001Date of Patent: April 20, 2004Assignee: Takeda Chemical Industries, Ltd.Inventors: Fumio Itoh, Hiroshi Hosono, Masaki Kawamura, Keiji Kubo
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Publication number: 20040038986Abstract: Novel carbamate derivatives which are useful as drugs because of inhibiting activated blood coagulation factor X and thus exerting an anticoagulant effect.Type: ApplicationFiled: May 6, 2003Publication date: February 26, 2004Inventors: Fumio Itoh, Hiroshi Banno, Masaki Kawamura, Shuji Kitamura
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Patent number: 6680312Abstract: The present invention is to provide a compound or a salt thereof represented by the formula: wherein R1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, the ring A is an optionally substituted divalent nitrogen-containing heterocyclic group, X′ is an optionally substituted alkylene chain, Y is an optionally substituted divalent cyclic group, X is a chemical bond or an optionally substituted alkylene chain, and Z is (1) an optionally substituted amino group, (2) an optionally substituted imidoyl group or (3) an optionally substituted nitrogen-containing heterocyclic group, or a pro-drug thereof, which has activated coagulation factor X inhibitory activity and which are useful as anti-coagulants.Type: GrantFiled: April 24, 2002Date of Patent: January 20, 2004Assignee: Takeda Chemical Industries, Ltd.Inventors: Hiroyuki Tawada, Fumio Itoh, Hiroshi Banno, Zen-ichi Terashita
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Publication number: 20020193382Abstract: The present invention is to provide a compound or a salt thereof represented by the formula: 1Type: ApplicationFiled: April 24, 2002Publication date: December 19, 2002Inventors: Hiroyuki Tawada, Fumio Itoh, Hiroshi Banno, Zen-Ichi Terashita
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Patent number: 6420375Abstract: To provide a novel compound of the formula: [wherein A1 ix a 5 or 6-membered ring which may be substituted by a group not containing a cyclic group, A2 is an aromatic ring which may be substituted, X is a divalent group, Y is a nitrogen atom or a methine group, Z is an ethenylene which may be substituted or ethynylene, R is a heterocyclic group which may be substituted, provided that 3,4-dihydro-6-[3-(1H-imidazol-1-yl)-1-propenyl]-2(1H)-quinolone and 2-[3-[5-ethyl-6-methyl-2-(benzyloxy)-3-pyridyl]-1-propenyl]benzoxazole are excluded.], or a salt thereof which has steroid C17,20-lyase inhibitory activity, and is useful for preventing and treating mammals suffering from, for example, primary cancer of malignant tumor, its metastasis and recurrence thereof.Type: GrantFiled: August 18, 1999Date of Patent: July 16, 2002Assignee: Takeda Chemical Industries, Ltd.Inventors: Tetsuya Aono, Fumio Itoh, Tomohiro Kaku, Masuo Yamaoka
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Patent number: 6403595Abstract: The present invention is to provide a compound or a salt thereof represented by the formula: wherein R1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, the ring A is an optionally substituted divalent nitrogen-containing heterocyclic group, X′ is an optionally substituted alkylene chain, Y is an optionally substituted divalent cyclic group, X is a chemical bond or an optionally substituted alkylene chain, and Z is (1) an optionally substituted amino group, (2) an optionally substituted imidoyl group or (3) an optionally substituted nitrogen-containing heterocyclic group, or a pro-drug thereof, which have activated coagulation factor X inhibitory activity and which are useful as anti-coagulants.Type: GrantFiled: August 3, 2000Date of Patent: June 11, 2002Assignee: Takeda Chemical Industries, Ltd.Inventors: Hiroyuki Tawada, Fumio Itoh, Hiroshi Banno, Zen-ichi Terashita