Abstract: A closed, gravity-fed burette for intravenous (IV) fluid delivery and flush system supporting multiple input combinations for simplicity and standardization. Able to handle both hazardous and non-hazardous drugs, this system may incorporate plastic and elastomeric materials that are resistant to the effects of antineoplastic materials in conjunction with a hazardous air filter module while still integration compatible with electronic peristaltic pumps for finer control of flow rate and when the IV infusion recipient's physical position is not compatible with a gravity-fed flow. The buoyant-activated shuttle valve enables the AutoStart function providing steady flush of the IV line to the patient for optimized vein patency from the Primary IV fluid feed. This Primary line works in conjunction with a Secondary IV fluid feed and a needleless connector Drug Port for multiple feed and flush conditions directed by way of a monoblock design supporting combinations of rotary, toggle, and check valves.

Abstract: A process and sensor system with particular control of polarization of the interrogating light beams useful for determining a concentration of a targeted molecule M (such as glucose) within a given time period in a liquid sampling matrix through use of a Direct Infrared Laser Absorption Spectroscopy Technique.

Abstract: Antibodies that bind to ?v?8 are provided.

Abstract: Provided herein are engineered lipid-bound vesicles for cytosolic delivery of an exogenous secreted, cell surface receptor-binding signaling molecule. Also provided herein are methods of making and using the engineered lipid-bound vesicles, and devices comprising the lipid-bound vesicles.

Abstract: A controller and a distal sensor module are used to emit optical emissions to a liquid sample being tested in a human body and detect desired optical data which the controller uses to electronically calculate a concentration measurement of a targeted analyte (e.g., glucose). The distal sensor module is held in place by a retention mechanism while a clamping system applies clamping pressure to the liquid sample during a test period to maintain a specified sample height of the liquid sample. An optical cable is intermediate the controller and the distal sensor module and is pluggably connected to the controller. Continuous monitoring of the analyte is possible without disconnecting the controller from the optical cable or the distal sensor module from the patient while clamping pressure on the test sample is reduced outside of the test period.

Abstract: An absorption spectroscopy process uses a single radiation beam with two or more pulsed beams (including at least a signal beam and a reference beam) that are passed into a liquid sample to a variable effective depth and then reflected out of the liquid sample where it is detected and processed to obtain a value over a preselected time. As values are determined for multiple effective depths, a sampling dataset is obtained which is used to calculate a concentration level of a targeted particle in the liquid sample by use of calibration dataset obtained from use of known samples.

Abstract: Disclosed here is a method for making a three-dimensional micro-architected aerogel, comprising: (a) curing a reaction mixture comprising a co-sol-gel material (e.g., graphene oxide (GO)) and at least one catalyst to obtain a crosslinked co-sol-gel (e.g., GO hydrogel); (b) providing a photoresin comprising a solvent, a photoinitiator, a crosslinkable polymer precursor, and a dispersion of the crosslinked co-sol-gel (e.g., GO hydrogel); (c) curing the photoresin using projection microstereolithography layer-by-layer to produce a wet gel having a pre-designed three-dimensional structure; (d) drying the wet gel to produce a dry gel; and (e) pyrolyzing the dry gel to produce a three-dimensional micro-architected aerogel (e.g., graphene aerogel). Also disclosed is a photoresin for projection microstereolithography, comprising a solvent, a photoinitiator, a crosslinkable polymer precursor, and a dispersion of a crosslinked co-sol-gel.

Abstract: Disclosed here is a method for making an architected three-dimensional aerogel, comprising providing a photoresin comprising a solvent, a photoinitiator, a crosslinkable polymer precursor, and a precursor for graphene, metal oxide or metal chalcogenide; curing the photoresin using projection microstereolithography layer-by-layer to produce a wet gel having a pre-designed three dimensional structure; drying the wet gel to produce a dry gel; and pyrolyzing the dry gel to produce an architected three-dimensional aerogel. Also disclosure is a photoresin for projection microstereolithography, comprising a solvent, a photoinitiator, a crosslinkable polymer precursor, and graphene oxide.

Abstract: A vacuum interrupter has a toroidal portion at one or both ends that achieves higher dielectric levels and hence higher interruption levels.

Abstract: A therapeutic delivery system uses an engineered extracellular vesicle-albumin hybrid carrier for curcumin, which is embedded in dissolvable microneedle arrays. The co-encapsulation of curcumin with albumin in extracellular vesicles extends curcumin's stability. The incorporation of therapeutic loaded carrier into microneedle arrays does not alter its cell uptake properties or bioactivity. Moreover, the bioactivity of therapeutic loaded carrier can be preserved for at least one year when encapsulated in microneedle arrays and stored under room temperature storage conditions. The microneedle arrays of the delivery system are fabricated using molding and casting processes. The extracellular vesicle carrier can be loaded using sonication.

Abstract: Antibodies that bind to ?v?8 are provided.

Abstract: Increased precision for liquid absorption spectroscopy, especially for in vivo samples of human analytes, is obtained by varying the signal or signal and interference central wavelengths when the temperature of the sample site varies beyond a selected threshold used for determining standardized signal or signal and interference central wavelengths. The amount of variance for a central wavelength of the signal beam which includes 1,150 nm is approximately 2 nm or less.

Abstract: Disclosed here is a method for producing a graphene macro-assembly (GMA)-fullerene composite, comprising providing a mixture of graphene oxide and water, adding a hydroxylated fullerene to the mixture, and forming a gel of the hydroxylated fullerene and the mixture. Also described are a GMA-fullerene composite produced, an electrode comprising the GMA-fullerene composite, and a supercapacitor comprising the electrode.

Abstract: A mold for encapsulating an electrical component. The mold includes an encapsulation chamber and an air inlet. The encapsulation chamber is defined by a housing, an open top, and a solid bottom. The housing includes a solid outer wall, a permeable inner wall, and an air chamber between the solid outer wall and the inner wall. The air inlet is configured to introduce a gas into the air chamber. The encapsulation chamber is sized and shaped to receive the electrical component while leaving a gap for the introduction of encapsulant around the electrical component. The encapsulant may be silicone rubber. To remove an encapsulated electrical component, pressurized air may be introduced through the air inlet into the air chamber, passing through the permeable inner wall, separating the outer surface of the encapsulant from the housing, and allowing the combination casting to be removed from the mold.

Abstract: A vacuum interrupter has a toroidal portion at one or both ends that achieves higher dielectric levels and hence higher interruption levels.

Abstract: An advanced manufactured electrochemical reactor to convert air (N2+O2) to nitric acid (HNO3) and ammonia (NH3). The electrochemical reactor platform can be tailored via advanced manufacturing to improve activity, selectivity, energy efficiency and stability of the reactions.

Abstract: Antibodies that bind to ???8 are provided.

Abstract: A system and method used to fabricate an implant from cartilage, where the implant can be used in reconstructive surgery. The system includes a thermoregulation device capable of maintaining a desired temperature range during milling operations. The milling machine is controlled by instructions generated from a digital model of the implant. The digital model can be a stock model or a custom model created from medical scans.

Abstract: Disclosed are effective methods for activating, washing, specifically extracting and purifying cannabinoids from Cannabis plant tissues using heat activation, washing impurities away with a polar solvent, optionally modified with an organic acid, base, surfactant or inorganic salt, extracting the activated non-polar cannabinoids with a potable selective solvent such as ethanol. The extracted active ingredients may be purified by chromatography and detected and quantified by mass spectrometry with external or isotopic or otherwise labelled standards.

Abstract: A method of immobilizing extracellular vesicles in an extracellular matrix material provides for improved extracellular vesicle retention in vitro and in vivo. Extracellular matrix materials, such as collagen, are functionalized with chemicals that are complimentary to ligands disposed on the surface of the extracellular vesicle. In one example embodiment, collagen is functionalized with dibenzocyclooctyne and the extracellular vesicle is functionalized with an azide tag. The extracellular vesicle is immobilized within the collagen through a click reaction involving the dibenzocyclooctyne and the azide tag.