Abstract: The present system and method is directed to a solution for dynamically assigning a machine readable code for directing traffic to information online. In an embodiment, the system scans a machine readable code, recognizes an account code associated with the machine readable code, verifies an authorized user associated with the account code, receives instructions to activate the machine readable code, receives instructions to assign the machine readable code to a system user specified landing page, and activates a link from the machine readable code to the user specified landing page upon request from the system user.

Abstract: A golf club head with a sole having a low stiffness compliance zone, which allows the face to deflect downward upon impact with a golf ball, is disclosed herein. The compliance zone comprises a plurality of through openings that are filled with one or more filler pieces comprising a low modulus material, all of which are located within three inches of a face section measured along a front-to-back axis of the golf club head.

Abstract: Methods of manufacturing a golf club head with one or more stiffening members proximate the face, and particularly solid rods or a plate with one or more cutouts, is disclosed herein. One method includes the steps of preparing a wax mold of a golf club head including a plate stiffening member with excess material, casting the golf club head, and machining away the excess material. Another method includes the steps of casting a golf club body, providing a plate stiffening member, providing a face component such as a face cup, tack welding the plate stiffening member and the face component to the golf club body, and welding these parts together.

Abstract: A depth limiter that is configured to couple with a cannula of a surgical access device. The depth limiter includes first and second user contact portions and first and second biasing features. The first biasing feature includes a first resilient portion and a first gripping surface. The second biasing feature includes a second resilient portion and a second gripping surface. The first and second resilient portions are configured to move the respective first and second gripping surfaces from a fixed configuration to a movable configuration when the respective first and second user contact portions are actuated. In the fixed configuration, the first and second gripping surfaces collectively restrict axial movement of the depth limiter by directly contacting the cannula. In the movable configuration, the first and second gripping surfaces extend parallel to a longitudinal axis and allow for axial movement of the depth limiter relative to the cannula.

Abstract: A surgical stapler kit includes a surgical stapler having a body, a shaft, and an end effector. The kit includes a first staple cartridge having a first cartridge body and a first sled, and a second staple cartridge having a second cartridge body and a second sled. When the first staple cartridge is at least partially seated within a cartridge jaw with the first sled in a proximal undisplaced position, a knife drives the first sled distally to deploy staples from the first cartridge body. When the second staple cartridge is at least partially seated within the cartridge jaw with the second sled in a proximal undisplaced position, the knife advances distally into a lockout position before causing any staples to be deployed from the second cartridge body.

Abstract: Disclosed is a method for the synthesis of a therapeutic double-stranded RNA (tdsRNA), comprising: a) synthesizing a first single-stranded RNA (first ssRNA) in a first synthesis reaction with PNPase as the only RNA polymerase; b) synthesizing a second single-stranded RNA (second ssRNA) in a second synthesis reaction with PNPase as the only RNA polymerase; and c) hybridizing the first ssRNA with the second ssRNA to form the tdsRNA; wherein step a) and step b) are performed in any order. Also disclosed is a product produced by the method.

Abstract: A loading unit for use with a surgical stapling instrument is disclosed. The loading unit comprises a shaft and an end effector extending from the shaft. The end effector comprises a first jaw comprising an anvil, and a second jaw. At least one of the first jaw and the second jaw is movable relative to the other to grasp tissue. The second jaw comprises an elongated channel and a staple cartridge insertable into the elongated channel for assembly therewith. The staple cartridge comprises a cartridge pan, and a sled translatable relative to the cartridge pan from a home position along a firing path in a firing motion to deploy staples from the staple cartridge. The loading unit also comprises a sled position-resetting mechanism configured to return the sled to the home position from a predefined range of positions distal to the home position prior to the firing motion.

Abstract: Methods of manufacturing a golf club head comprising one or more stiffening members proximate the face, and particularly solid rods or a plate with one or more cutouts, is disclosed herein. One method comprises the steps of preparing a wax mold of a golf club head including a plate stiffening member with excess material, casting the golf club head, and machining away the excess material. Another method comprises the steps of casting a golf club body, providing a plate stiffening member, providing a face component such as a face cup, tack welding the plate stiffening member and the face component to the golf club body, and welding these parts together.

Abstract: An apparatus includes a first and second elongate member that can releasably couple together to in order to cooperate to clamp and staple tissue, a latch member that can latch the first and second elongate member to clamp tissue, a firing assembly that can sever and staple clamped tissue, and a clamp force measuring assembly. The clamp force measuring assembly can measure a parameter associated with a clamping force imparted on the first and second stapling surfaces while clamping tissue, and process and communicate the measured parameter to be compared with a predetermined limit associated with successful staple formation.

Abstract: A system for stapling tissue is disclosed. The system can include a channel and a compatible staple cartridge comprising a plurality of staples. The channel and the compatible staple cartridge comprise mating or cooperating alignment features for permitting complete insertion of the compatible staple cartridge and for preventing an incompatible staple cartridge from being completely inserted in the channel.

Abstract: A method of creating an anastomosis is provided using a stapling assembly including a body extending distally along a longitudinal axis and a deck member defining a deck surface. The deck surface includes a first array of staple openings comprising a herringbone pattern, and each staple opening of the first array of staple openings has a same size. The method includes positioning an anvil within a first lumen of a patient and positioning the stapling assembly within a second lumen of the patient. The method also includes releasably coupling the anvil with the stapling assembly and compressing tissue of the first and second lumens between the anvil and the deck member. The method further includes actuating a plurality of staple drivers to drive a first plurality of staples distally and parallel to the longitudinal axis from the first array of staple openings into the tissue to define the anastomosis.

Abstract: A loading unit for use with a surgical stapling instrument is disclosed. The loading unit comprises a shaft and an end effector extending from the shaft. The end effector comprises a first jaw that comprising an anvil, and a second jaw. At least one of the first jaw and the second jaw is movable relative to the other to grasp tissue. The second jaw comprises an elongated channel comprising retaining features, and a staple cartridge insertable into the elongated channel for assembly therewith. The staple cartridge comprises a cartridge pan, and a sled translatable relative to the cartridge pan from a first position toward a second position. The retaining features are configured to resist a movement by the sled beyond the first position up to a predetermined force.

Abstract: Provided herein are diagnostic and therapeutic methods for the treatment of cancer using polygenic risk scores (PRSs) for dermatological autoimmune diseases. In particular, the invention provides methods for patient selection and methods of treatment.

Abstract: Disclosed herein are methods for personalized treatment of individual patient tumors. A computer software configured to integrate with a radiation therapy treatment planning system is presented. The computer software is configured to: assign a radiation sensitivity index (RSI) of a subject's tumor based at least in part on expression levels of one or more signature genes in the tumor; calculate a recommended personalized radiation dosage (RxRSI) for the subject based at least in part on a pre-determined genomic adjusted radiation dose (GARD) value and the RSI; and provide, to the radiation therapy treatment planning system, the recommended RxRSI as a radiation therapy dose for a radiation plan.

Abstract: A surgical access device assembly. The assembly includes a cannula having a working channel and a helical tissue engagement feature disposed along an outer surface of the cannula and configured to stabilize the cannula relative to a body cavity wall of a patient. The assembly also includes a depth limiter movably coupled with the cannula. The depth limiter includes a body portion extending about a central axis of the depth limiter and including a protrusion extending radially inwardly relative to the central axis. The body portion is movable angularly relative to the cannula between a fine adjustment configuration and a coarse adjustment configuration. In the fine adjustment configuration the protrusion is configured to selectively threadably engage the helical tissue engagement feature. In the coarse adjustment configuration the protrusion is configured to selectively threadably disengage the helical tissue engagement feature such that the depth limiter is translatable axially along the cannula.

Abstract: Provided herein are diagnostic and therapeutic methods for the treatment of cancer using polygenic risk scores (PRSs) for dermatological autoimmune diseases. In particular, the invention provides methods for patient selection and methods of treatment.

Abstract: An apparatus includes a cartridge body, a deck, an elongate slot, a plurality of pockets, and a plurality of engagement protrusions. The plurality of engagement protrusions extend from the deck and are configured to grip tissue or an adjunct material. The plurality of engagement protrusions include a first engagement protrusion associated with the first pocket. The first engagement protrusion includes a first inwardly facing projection and a first planar surface. The first inwardly facing projection extends inwardly between a first longitudinal end and a first lateral side of the first pocket. The first planar surface extends substantially parallel to the deck. The first planar surface is defined by the first inwardly facing projection. The first planar surface defines a maximum height of the engagement protrusion relative to the deck. The first planar surface has a non-uniform area defined at least in part by the first inwardly facing projection.

Abstract: A surgical stapler kit includes a surgical stapler having a body, a shaft, and an end effector. The kit includes a first staple cartridge having a first cartridge body and a first sled, and a second staple cartridge having a second cartridge body and a second sled. When the first staple cartridge is at least partially seated within a cartridge jaw with the first sled in a proximal undisplaced position, a knife drives the first sled distally to deploy staples from the first cartridge body. When the second staple cartridge is at least partially seated within the cartridge jaw with the second sled in a proximal undisplaced position, the knife advances distally into a lockout position before causing any staples to be deployed from the second cartridge body.

Abstract: A stapling assembly for a surgical instrument includes a body extending along a longitudinal axis and having an upper deck, a plurality of pockets extending through the upper deck for receiving respective staples and arranged in at least two longitudinal rows, a plurality of staple drivers, and a staple driver actuator. The stapling assembly also includes a plurality of pocket extenders extending upwardly from the upper deck. Each pocket extender has a respective top surface. The stapling assembly further includes at least one upwardly-facing surface configured to contact an adhesive of an adjunct for securing the adjunct to the stapling assembly. The at least one upwardly-facing surface is disposed at least partially between at least a portion of the upper deck and the top surfaces of the plurality of pocket extenders, and spans laterally at least partially across at least two longitudinal rows of the plurality of pockets.

Abstract: An apparatus includes a cartridge body, a deck, an elongate slot, a plurality of pockets, and a plurality of engagement protrusions. The plurality of pockets include first and second pockets. The plurality of engagement protrusions extend from the deck and are configured to grip tissue or an adjunct material. The plurality of engagement protrusions include first and second engagement protrusions. The first engagement protrusion is associated with the first pocket. The first engagement protrusion includes a lateral portion extending longitudinally along a lateral side of the first pocket. The first engagement protrusion does not extend along a second lateral side of the first pocket such that the second lateral side opens directly to the deck. The second engagement protrusion is associated with the second pocket. The second engagement protrusion includes a lateral portion extending longitudinally along the second lateral side of the second pocket.