Abstract: Disclosed herein are methods for personalized treatment of individual patient tumors. A computer software configured to integrate with a radiation therapy treatment planning system is presented. The computer software is configured to: assign a radiation sensitivity index (RSI) of a subject's tumor based at least in part on expression levels of one or more signature genes in the tumor; calculate a recommended personalized radiation dosage (RxRSI) for the subject based at least in part on a pre-determined genomic adjusted radiation dose (GARD) value and the RSI; and provide, to the radiation therapy treatment planning system, the recommended RxRSI as a radiation therapy dose for a radiation plan.

Abstract: A building structure comprising a first film and a second film. The first film and the second film are each impregnated with L-Dopa. The building structure further includes regolith bulk material between the first film and the second film.

Abstract: A surgical suturing system is disclosed. The surgical suturing system comprises a shaft comprising a shaft diameter, a firing drive, and an end effector extending distally from the shaft. The end effector comprises a needle track and a needle comprising suturing material attached thereto, wherein the needle is configured to be guided by the needle track and actuated by the firing drive through a firing stroke, and wherein the needle is movable along a needle path comprising a maximum capture width which is greater than the shaft diameter.

Abstract: A golf club head with a sole having a low stiffness compliance zone, which allows the face to deflect downward upon impact with a golf ball, is disclosed herein. The compliance zone comprises a plurality of through openings that are filled with one or more filler pieces comprising a low modulus material, all of which are located within three inches of a face section measured along a front-to-back axis of the golf club head.

Abstract: A surgical clip applier is provided that includes first and second jaws on a distal end of an elongate shaft, a clip advancing assembly extending through the shaft and configured to advance a distal-most clip from a plurality of clips in the shaft into the first and second jaws. The jaws have opposed inward facing surfaces, and each inward facing surface has a clip track defined therein for receiving and guiding legs of a clip into the first and second jaws. The clip track of at least one of the jaws has at least one deflectable clip retention member disposed therein and configured to apply a biasing force to a leg of a clip disposed within the jaws to thereby retain the clip within the jaws and maintain alignment of the clip with respect to the jaws. The clip track of at least one of the jaws may also have at least one recess or protrusion designed to be complementary to and mate with a protrusion or recess in a clip.

Abstract: A method for adjusting control parameters of a clip applier using a surgical hub is disclosed. The method comprises gathering data during a first surgical procedure, evaluating the gathered data to determine the appropriate operation of a clip applier in a subsequent surgical procedure, gathering data during the operation of the clip applier in the subsequent surgical procedure, determining if the operation of the clip applier needs to be adjusted based on the data gathered during the subsequent surgical procedure, and adjusting the operation of the clip applier based on the data gathered during the subsequent surgical procedure.

Abstract: A method includes training a machine learning model on a training data set, that describes input parameters to and corresponding output parameters from manufacturing equipment, using at least one learning algorithm to obtain a physics model that describes evolution of a state space of the manufacturing equipment, configuring a machine-learning-based controller agent to generate commands for the physics model that modify settings of a simulation of the manufacturing equipment by the physics model such that, responsive to input data, the physics model generates corresponding predicted output parameters, and training the machine-learning-based controller agent on the settings and corresponding predicted output parameters using at least one other learning algorithm.

Abstract: Disclosed herein are methods for personalized treatment of individual patient tumors. A computer software configured to integrate with a radiation therapy treatment planning system is presented. The computer software is configured to: assign a radiation sensitivity index (RSI) of a subject's tumor based at least in part on expression levels of one or more signature genes in the tumor; calculate a recommended personalized radiation dosage (RxRSI) for the subject based at least in part on a pre-determined genomic adjusted radiation dose (GARD) value and the RSI; and provide, to the radiation therapy treatment planning system, the recommended RxRSI as a radiation therapy dose for a radiation plan.

Abstract: A system for stapling tissue is disclosed. The system can include a channel and a compatible staple cartridge comprising a plurality of staples. The channel and the compatible staple cartridge comprise mating or cooperating alignment features for permitting complete insertion of the compatible staple cartridge and for preventing an incompatible staple cartridge from being completely inserted in the channel.

Abstract: Provided herein are diagnostic and therapeutic methods for the treatment of cancer using polygenic risk scores (PRSs) for endocrine diseases, including hypothyroidism. In particular, the invention provides methods for patient selection and methods of treatment.

Abstract: A load binder for securing a load, the load binder comprising an elongated threaded contraction expansion assembly including an elongated threaded member and opposing threaded end screws, with the elongated threaded member having opposing ends with opposite screw threading, wherein the threading in the elongated threaded contraction expansion assembly is constructed and arranged to provide common contraction or extension of the respective opposing threaded screws when the elongated threaded member is rotated one direction or another and the opposing threaded screws, a driven link chain sheave, a drive shaft, a primary link chain drive sheave, an external hex drive, and a link chain movably engaged with the driven link chain sheave and the primary link chain drive sheave, wherein the external hex drive can be rotated to turn the primary link chain drive sheave to either draw the ends of the threaded screws closer together or drive them further apart.

Abstract: A golf club head with a sole having a low stiffness compliance zone, which allows the face to deflect downward upon impact with a golf ball, is disclosed herein. The compliance zone comprises a plurality of through openings that are filled with one or more filler pieces comprising a low modulus material, all of which are located within three inches of a face section measured along a front-to-back axis of the golf club head.

Abstract: A load binding tool for securing a load, the load binder including an elongated threaded contraction expansion assembly including an elongated threaded member having opposing ends with opposite screw threading, and having opposing engaging ends, and enabling common contraction or extension of the respective opposing engaging ends when the elongated threaded member is rotated one direction or another, and a driven sheave, a drive shaft, a primary drive sheave, and a closed loop of chain or other flexible coupler movably engaged with the driven sheave and the primary drive sheave, wherein the drive shaft can be rotated to turn the primary drive sheave and move the opposing engaging ends closer together or further apart. The drive shaft is can be coupled with an external drive coupling that can be engaged with a separate drive tool to rotate the drive shaft and operate the load binding tool.

Abstract: A loading unit for use with a surgical stapling instrument is disclosed. The loading unit comprises a shaft and an end effector extending from the shaft. The end effector comprises a first jaw that comprising an anvil, and a second jaw. At least one of the first jaw and the second jaw is movable relative to the other to grasp tissue. The second jaw comprises an elongated channel comprising retaining features, and a staple cartridge insertable into the elongated channel for assembly therewith. The staple cartridge comprises a cartridge pan, and a sled translatable relative to the cartridge pan from a first position toward a second position. The retaining features are configured to resist a movement by the sled beyond the first position up to a predetermined force.

Abstract: A surgical stapling assembly that comprises a stapling device is disclosed. The stapling device includes an authentication lockout that is movable between a locked position wherein the stapling device is inoperable and an unlocked position wherein the stapling device is operable. The assembly further includes a deactivator tool that includes a deactivation key that is configured to move the authentication lockout into the unlocked position prior to seating a staple cartridge into the device.

Abstract: Disclosed herein are methods for personalized treatment of individual patient tumors. A computer software configured to integrate with a radiation therapy treatment planning system is presented. The computer software is configured to: assign a radiation sensitivity index (RSI) of a subject’s tumor based at least in part on expression levels of one or more signature genes in the tumor; calculate a recommended personalized radiation dosage (RxRSI) for the subject based at least in part on a pre-determined genomic adjusted radiation dose (GARD) value and the RSI; and provide, to the radiation therapy treatment planning system, the recommended RxRSI as a radiation therapy dose for a radiation plan.

Abstract: Methods of manufacturing a golf club head comprising one or more stiffening members proximate the face, and particularly solid rods or a plate with one or more cutouts, is disclosed herein. One method comprises the steps of preparing a wax mold of a golf club head including a plate stiffening member with excess material, casting the golf club head, and machining away the excess material. Another method comprises the steps of casting a golf club body, providing a plate stiffening member, providing a face component such as a face cup, tack welding the plate stiffening member and the face component to the golf club body, and welding these parts together.

Abstract: A depth limiter that is configured to couple with a cannula of a surgical access device. The depth limiter includes first and second user contact portions and first and second biasing features. The first biasing feature includes a first resilient portion and a first gripping surface. The second biasing feature includes a second resilient portion and a second gripping surface. The first and second resilient portions are configured to move the respective first and second gripping surfaces from a fixed configuration to a movable configuration when the respective first and second user contact portions are actuated. In the fixed configuration, the first and second gripping surfaces collectively restrict axial movement of the depth limiter by directly contacting the cannula. In the movable configuration, the first and second gripping surfaces extend parallel to a longitudinal axis and allow for axial movement of the depth limiter relative to the cannula.

Abstract: A surgical access device assembly includes a cannula hub and a cannula tube. The cannula tube extends distally from the cannula hub along a longitudinal axis. The cannula tube defines a working channel. The cannula tube includes a tissue engagement feature and a balancing feature. The balancing feature is configured to promote lateral stability of the cannula tube and the cannula hub relative to the body cavity wall of the patient. The balancing feature includes a proximal portion of the cannula tube having a first wall thickness. The balancing feature also includes a distal portion of the cannula tube having a second wall thickness that is greater than the first wall thickness. At least a portion of the proximal portion is proximal relative to the tissue engagement feature. At least a portion of the distal portion is distal relative to the tissue engagement feature.

Abstract: A surgical instrument end effector includes a first jaw, a second jaw, a staple cartridge, and a retention cap. The second jaw including an anvil having a plurality of staple forming pockets. The first and second jaws are operable to clamp and staple tissue positioned therebetween. The staple cartridge is configured for receipt within the first jaw. The staple cartridge includes a cartridge body, a lower tray, and a plurality of staples. The cartridge body and the lower tray are configured to couple together. The retention cap is configured to fasten to a proximal end of the cartridge body and to engage the lower tray. The retention cap is further configured to fix the position of the lower tray relative to the cartridge body.