Abstract: The present invention extends to methods, systems, and computer program products for tailoring administration of aerosolized bioactive material. Aspects include communicating biological and subjective information to support formulation of personalized bioactive material compositions. Aerosolized bioactive materials can be administered to humans, via inhalation, using a vaporizer device which is engineered for real time data capture, and communication, with a software application and backend computational system. Smart vaporizer cartridges can be identified and their contents recalled. Based at least on contents, appropriate (e.g., precision) doses of bioactive material can be aerosolized and administered.

Abstract: A surgical device for clipping tissue is disclosed. The surgical device comprises a housing comprising a motor configured to output rotary motions, a shaft, and a clip applier head. The clip applier head comprises a clip magazine, an end effector, a jaw closure cam, and a clip advancing member. The clip magazine comprises a plurality of clips. The end effector comprises a first jaw and a second jaw movable relative to each other between an unclamped position and a clamped position. The jaw closure cam is configured to move the first jaw and the second jaw toward the clamped position. The clip advancing member is operably attachable to the jaw closure cam. The clip advancing member is configured to move a clip from the clip magazine into a firing position. The jaw closure cam and the clip advancing member are configured to move in opposite directions at the same time.

Abstract: A system that provides automated and semi-automated tools and methods that may be used by providers in the death care industry to manage time sensitive tasks and share information with third party providers of goods and services.

Abstract: A surgical stapling instrument for use with a staple cartridge including a sled and staples is disclosed. The surgical stapling instrument comprises a firing system. The firing system comprising a motor and a driving member operably coupled to the motor. The motor is configured to cause the driving member to advance the sled to deploy the staples into tissue grasped by the surgical stapling instrument. The driving member is movable by the motor along a predefined firing path. The surgical stapling instrument further comprises a control circuit that is configured to detect a location of the sled along the firing path, and adjust a motor control program based on the location of the sled.

Abstract: An apparatus includes a handle assembly having a body, a shaft assembly having an outer tube member, an end effector, an anvil, a first trocar closure system, and a second trocar closure system. The end effector has having a staple deck fixed relative to the body, a staple driver operable to actuate relative to the staple deck between an unfired position and a fired position, and the trocar configured to selectively couple with the anvil and actuate relative to the staple dreck. The first trocar closure assembly can actuate in a first motion to drive the trocar between a distal position and a first closed position. The second trocar closure assembly can actuate in a second motion between the first closed position and a second closed position.

Abstract: A surgical device for clipping tissue is disclosed. The surgical device comprises a housing comprising an electric motor, a shaft defining a central shaft axis, a clip magazine, and a clip crimping system. The clip magazine comprises a plurality of clips removably stored therein. The clip crimping system comprises a first jaw, a second jaw, and a distal portion comprising a clip receiving chamber defined between said first jaw and said second jaw. The distal portion is offset from said central shaft axis. The clip crimping system further comprises a proximal connection portion connecting said first jaw and said second jaw. The proximal connection portion is positioned along said central shaft axis. The clip crimping system further comprises a clamp operably coupled with said electric motor. The clamp is movable distally by said electric motor to perform a crimping stroke and engage said first jaw and said second jaw.

Abstract: Provided herein are diagnostic and therapeutic methods for the treatment of cancer using polygenic risk scores (PRSs) for dermatological autoimmune diseases. In particular, the invention provides methods for patient selection and methods of treatment.

Abstract: A load binding tool for securing a load, the load binder comprising an elongated threaded contraction expansion assembly including an elongated threaded member and opposing threaded end screws, with the elongated threaded member having opposing ends with opposite screw threading, wherein the threading in the elongated threaded contraction expansion assembly is constructed and arranged to provide common contraction or extension of the respective opposing threaded screws when the elongated threaded member is rotated one direction or another and the opposing threaded screws, a driven link chain sheave, a drive shaft, a primary link chain drive sheave, an external hex drive, and a link chain movably engaged with the driven link chain sheave and the primary link chain drive sheave, wherein the external hex drive can be rotated to turn the primary link chain drive sheave to draw the ends of the threaded screws closer together or further apart.

Abstract: A surgical stapling assembly that includes a surgical stapling device that has a lockout that is movable between a locked position and an unlocked position. The assembly further includes a staple cartridge with a first cam surface configured to cammingly engage a primary portion of the lockout to move the lockout laterally from the locked position and a second cam surface configured cammingly engage a secondary portion of the lockout to further move the lockout laterally into the locked position when the cartridge is operably seated in the device.

Abstract: A system is disclosed. The system can comprise a replaceable staple cartridge comprising a plurality of staples, a proximal laterally-protruding lug, and a distal laterally-protruding lug. The system can further comprise a channel configured to receive the replaceable staple cartridge, wherein the channel comprises a sidewall comprising a proximal receptacle positioned and dimensioned to receive the proximal laterally-protruding lug and a distal receptacle positioned and dimensioned to receive the distal laterally-protruding lug.

Abstract: An apparatus includes a handle assembly having a body, a shaft assembly having an outer tube member, an end effector, an anvil, a first trocar closure system, and a second trocar closure system. The end effector has having a staple deck fixed relative to the body, a staple driver operable to actuate relative to the staple deck between an unfired position and a fired position, and the trocar configured to selectively couple with the anvil and actuate relative to the staple dreck. The first trocar closure assembly can actuate in a first motion to drive the trocar between a distal position and a first closed position. The second trocar closure assembly can actuate in a second motion between the first closed position and a second closed position. The staple drive is inoperable at least until the first trocar closure assembly actuates the trocar to the first closed position.

Abstract: A surgical instrument end effector includes a first jaw, a second jaw, a staple cartridge, and a retention cap. The second jaw including an anvil having a plurality of staple forming pockets. The first and second jaws are operable to clamp and staple tissue positioned therebetween. The staple cartridge is configured for receipt within the first jaw. The staple cartridge includes a cartridge body, a lower tray, and a plurality of staples. The cartridge body and the lower tray are configured to couple together. The retention cap is configured to fasten to a proximal end of the cartridge body and to engage the lower tray. The retention cap is further configured to fix the position of the lower tray relative to the cartridge body.

Abstract: A surgical instrument comprising a touchscreen display is disclosed.

Abstract: A surgical access device includes a proximal end portion configured to support a seal assembly having an insufflation port. The device includes a cannula tube extending distally from the proximal end portion and having an inner surface that defines a lumen extending longitudinally through the cannula tube. The cannula tube is configured to be inserted distally through a body cavity wall of a patient, and the lumen is configured to guide a surgical instrument shaft distally through the cannula tube for accessing a body cavity of the patient. The device includes a channel formed in the inner surface of the cannula tube. The channel extends longitudinally between a proximal end of the lumen and a distal end of the lumen, and the channel is configured to direct a gas therethrough to or from the insufflation port of the seal assembly while a surgical instrument shaft is disposed within the lumen.

Abstract: A surgical access device includes a cannula assembly and an obturator. The obturator is configured to removable couple with the cannula assembly along a central axis of the cannula assembly to facility inversion of the surgical access device through a body wall of the patient. The obturator includes an elongated shaft extending along a longitudinal axis, a tapered distal tip located at a distal portion of the elongated shaft, and an obturator head located at a proximal portion of the elongated shaft. The obturator head includes an interference fit feature capable of inhibiting proximal movement between the obturator and the cannula assembly via a frictional force against a surface of the cannula assembly.

Abstract: A depth limiter that is configured to couple with a cannula of a surgical access device. The depth limiter includes first and second user contact portions and first and second biasing features. The first biasing feature includes a first resilient portion and a first gripping surface. The second biasing feature includes a second resilient portion and a second gripping surface. The first and second resilient portions are configured to move the respective first and second gripping surfaces from a fixed configuration to a movable configuration when the respective first and second user contact portions are actuated. In the fixed configuration, the first and second gripping surfaces collectively restrict axial movement of the depth limiter by directly contacting the cannula. In the movable configuration, the first and second gripping surfaces extend parallel to a longitudinal axis and allow for axial movement of the depth limiter relative to the cannula.

Abstract: Methods of manufacturing a golf club head comprising one or more stiffening members proximate the face, and particularly solid rods or a plate with one or more cutouts, is disclosed herein. One method comprises the steps of preparing a wax mold of a golf club head including a plate stiffening member with excess material, casting the golf club head, and machining away the excess material. Another method comprises the steps of casting a golf club body, providing a plate stiffening member, providing a face component such as a face cup, tack welding the plate stiffening member and the face component to the golf club body, and welding these parts together.

Abstract: A surgical access device assembly. The assembly includes a cannula having a working channel and a helical tissue engagement feature disposed along an outer surface of the cannula and configured to stabilize the cannula relative to a body cavity wall of a patient. The assembly also includes a depth limiter movably coupled with the cannula. The depth limiter includes a body portion extending about a central axis of the depth limiter and including a protrusion extending radially inwardly relative to the central axis. The body portion is movable angularly relative to the cannula between a fine adjustment configuration and a coarse adjustment configuration. In the fine adjustment configuration the protrusion is configured to selectively threadably engage the helical tissue engagement feature. In the coarse adjustment configuration the protrusion is configured to selectively threadably disengage the helical tissue engagement feature such that the depth limiter is translatable axially along the cannula.